TY - JOUR A1 - Schlegel, Susanne A1 - Krumnow, Erik A1 - Böhme, Andrea A1 - Minieri, Marilena A1 - Foitzik, Andreas T1 - Miniaturized Blood Sampling System with Integrated Sample Preparation JF - Materials Science Forum N2 - Blood sampling as well as sample preparation are time consuming and requires a strict procedure, which is generally performed by medical trained personal. Not carrying out the procedure correctly could result in an infection of the patient or contamination of the sample itself. These limitations should be especially considered in case of pandemic outbreaks. In order to handle such a high number of patients a novel sample preparation system paired with modern blood sampling procedure is necessary. For this reason, a new device for blood sampling and preparation is designed containing an integrated microfluidic system. The fabrication is carried out by utilizing micro moulding of PDMS as well as micro milling. A first set of initial experiments as part of a first-generation study shows promising results. However, further steps of optimisation considering flow time and preparation cycle are part of a second-generation study. KW - mechanical system KW - polymer material KW - sample preparation Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18812 SN - 0255-5476 SN - 1662-9752 VL - 1016 SP - 1280 EP - 1284 PB - Trans Tech Publications ER - TY - JOUR A1 - Gottschalk, Josefine Johanna A1 - Krumnow, Erik A1 - Lietzau, Kai-Henning A1 - Foitzik, Andreas A1 - Richetta, Maria T1 - Monitoring of Cytotoxic Induced Cellular Displacements by Utilizing Electronic Speckle Pattern Interferometry JF - Materials Science Forum N2 - Modern medical science delivers through innovative chemical or mechanical/physical means new strategies to treat patients mildly and fight diseases accurately. In line with this development a screening procedure for tissue samples under usage of the electronic speckle pattern interferometry is developed at the University of Applied Science Wildau. The paper at hand provides the corner stone for such a procedure in form of an incubation system that is adapted to the properties of an electronic speckle pattern interferometer and allows the incubation as well as study of samples over time. As a result the developed system can regulate its own temperature and is constructed for use in an electronic speckle pattern interferometry (ESPI) setup. Its design allows a simple modular approach for further development. KW - advance manufacturing KW - application KW - fabrication KW - processing Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18728 SN - 0255-5476 SN - 1662-9752 VL - 941 SP - 2513 EP - 2517 PB - Trans Tech Publications ER - TY - CHAP A1 - Welzel, Felix A1 - Hauschultz, Mike Thomas A1 - Krumnow, Erik A1 - Foitzik, Andreas A1 - Richetta, Maria ED - Stolzenburg, Frieder ED - Reinboth, Christian ED - Lohr, Thomas ED - Vogel, Kathleen T1 - Concept and simulation of micromixers and aliquoting for PCR systems T2 - NWK 2023 - Tagungsband zur 23. Nachwuchswissenschaftler*innenkonferenz N2 - In this paper, different concepts for mixing sample and master mix by means of simulation are discussed. The main focus was on mixers with a low dead volume, because of their relevance to PCR. In addition, a concept for aliquoting the mixed solution was elaborated and simulated. The simulation showed very good mixing with serpentineand tesla-mixers at flow rates of 1-16 µL/s. Furthermore, a uniform distribution with aliquoting could be achieved, while a slight dependence between flow rate and pressure was observed. In the further course, these concepts are to be combined and tested on a microfluidic chip. This can then be integrated into the workflow of existing PCR protocols. Y1 - 2023 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18611 UR - https://www.hs-harz.de/nwk2023/tagungsband-nwk-2023 UR - https://www.hs-harz.de/dokumente/extern/Forschung/NWK2023/Beitraege/Concept_and_simulation_of_micromixers_and_aliquoting_for_PCR_systems.pdf SN - 2627-5708 SP - 303 EP - 306 PB - Hochschule Harz CY - Wernigerode ER -