TY - JOUR A1 - Engels, Andreas A1 - Zinn, Steffen A1 - Bonaiuto, Vincenzo A1 - Foitzik, Andreas T1 - Improved Syringe Extruder for Improved Processing of Biological Materials JF - Materials Science Forum N2 - 3 dimensional (3D) printing evolved during the last decade to a consumer friendly and affordable craft. Furthermore, implementations of this techniques in the field of biotechnological research and development within laboratories is a very expansive process. Bio-printers’ prices cover a wide spectrum and most basic models are available for around 5000€. On the other end, high-end printer machines with a vast variety of features are available for several hundreds of thousands of euros. Thus, due to the immense potential in the field of Biotechnology the availability of this technology for research purpose should be enhanced. A developed ecological syringe extruder prototype for processing of biological based gels has been further improved. The original prototype was capable to processing multiple layers of agar with concentrations of 1% and 2.5%. Based on these results the prototype was revised regarding printing process parameter, which include among others applied forces to the substrate, air-ventilation, and heating of the substrate. The process behavior will be simulated with computational fluid dynamics for the processing of biological based substrate. After a concluding validation these results are intended to be implemented into a new design for improved processing of a variety of bioinks. KW - biofabrication KW - bio-ink KW - bioprinting KW - Open Source KW - process parameter improvement Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18701 SN - 0255-5476 SN - 1662-9752 VL - 941 SP - 2442 EP - 2447 PB - Trans Tech Publications ER - TY - JOUR A1 - Engels, Andreas A1 - Schlegel, Volker A1 - Jacobs, Hannes A1 - Großelindemann, Niklas A1 - Morshed, Md. Niaz A1 - Stenglein, Antonia Sigrid A1 - Bonaiuto, Vincenzo A1 - Foitzik, Andreas T1 - 3d Printer Heads for Extrusion of Biologicals Gels JF - Materials Science Forum N2 - Processing biological materials with 3-dimensional (3D) printers has attracted increasing interest in several research areas. At the same time, off-the-shelf solutions are increasingly available in a wider variety to meet the current market demand. However, most of the available bioprinters are closed source, thus, modifications are quite challenging or require an avoidable consultation process with the manufacturer. Furthermore, the entry prices for basic machines amount to several thousands of euros. Whereas, high-end 3D bio printers with a vast array of features are available for several hundred thousand euros. Due to the immense potential of this tool in the field of biotechnology it is important to extend the availability of this technology for research purposes in terms of adaptability and price. This ongoing work focuses on open-source 3D printer heads with the ability to extrude biological materials. The print heads include several techniques to process low as well as high viscose biomaterials such as agar and gelatin. Additionally, obstacles such as continuous substrate tempering or integration into existing 3D printers are addressed. The work presented is open source and thus freely adaptable to any user’s specific needs. Our goal is to process a diverse range of biomaterials with different print techniques. KW - biofabrication KW - bioprinting KW - Open Source KW - process parameter improvement Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18773 SN - 0255-5476 SN - 1662-9752 VL - 1016 SP - 435 EP - 439 PB - Trans Tech Publications ER -