TY - JOUR A1 - Nechyporenko, Alina A1 - Nazaryan, Rosana A1 - Semko, Galyna A1 - Lupyr, Andrii A1 - Yurevych, Nadiia A1 - Fomenko, Yuliia A1 - Kostiukov, Eduard A1 - Alekseeva, Victoriia T1 - Application of spiral computed tomography for determination of the minimal bone density variability of the maxillary sinus walls in chronic odontogenic and rhinogenic sinusitis JF - Ukrainian Journal of Radiology and Oncology N2 - Background. There are many questions regarding the peculiarities of the course of odontogenic maxillary sinusitis, the likelihood of complications and the correct dosage of load during dental implantation. Purpose – to identify changes in minimal bone density in chronic odontogenic maxillary sinusitis and to compare it with chronic rhinogenic catarrhal maxillary sinusitis and physiological state of maxillary sinus. Materials and Methods. Our study involved 10 patients with chronic odontogenic maxillary sinusitis, 10 patients with chronic maxillary non-polyposis sinusitis of rhinogenic etiology, combined with hyperplasia of the sinus mucosa up to 1 cm. The control group comprised 10 patients with physiological condition of maxillary sinuses. In all subjects minimal bone density of superior, medial and inferior walls of maxillary sinus was analyzed. Results. The study showed that the maximum in physiological conditions is the minimal density of the upper wall of the maxillary sinus, the minimum is the lower wall. The minimal density of the lower wall was shown to undergo a statistically significant reduction in chronic catarrhal maxillary sinusitis only by 2%, the upper by 5%, the medial by 4% compared with the intact sinus, but with the odontogenic nature of maxillary sinusitis, this figure was 31% in the lower wall, 27% in the medial region. Only the density of the upper wall of the maxillary sinus remained quite stable, it decreased relative to the physiological one only by 6%. Conclusions. Minimal physiological densitometric parameters of lower, medial and upper walls were calculated. The reduction of minimal density of bone tissue in the cases of rhinogenic chronic catarrhal maxillary sinusitis. In the cases of chronic odontogenic maxillary sinusitis, maximum significant decrease of minimal density of both lower and medial walls is determined. KW - bone density KW - computed tomography KW - maxillary sinus KW - odontogenic maxillary sinusitis Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-19121 SN - 2708-7166 VL - 29 IS - 4 SP - 65 EP - 75 ER - TY - JOUR A1 - Schlegel, Susanne A1 - Krumnow, Erik A1 - Böhme, Andrea A1 - Minieri, Marilena A1 - Foitzik, Andreas T1 - Miniaturized Blood Sampling System with Integrated Sample Preparation JF - Materials Science Forum N2 - Blood sampling as well as sample preparation are time consuming and requires a strict procedure, which is generally performed by medical trained personal. Not carrying out the procedure correctly could result in an infection of the patient or contamination of the sample itself. These limitations should be especially considered in case of pandemic outbreaks. In order to handle such a high number of patients a novel sample preparation system paired with modern blood sampling procedure is necessary. For this reason, a new device for blood sampling and preparation is designed containing an integrated microfluidic system. The fabrication is carried out by utilizing micro moulding of PDMS as well as micro milling. A first set of initial experiments as part of a first-generation study shows promising results. However, further steps of optimisation considering flow time and preparation cycle are part of a second-generation study. KW - mechanical system KW - polymer material KW - sample preparation Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18812 SN - 0255-5476 SN - 1662-9752 VL - 1016 SP - 1280 EP - 1284 PB - Trans Tech Publications ER - TY - JOUR A1 - Schlegel, Volker A1 - Engels, Andreas A1 - Stoycheva, Vesela A1 - Bifaretti, Stefano A1 - Foitzik, Andreas T1 - From Biomaterial to Organoid - Bioprinting for Practice JF - Materials Science Forum N2 - The current state of technology for 3D printing with biomaterials is based on the extrusion of viscous materials. Mostly, extrusion heads utilize pneumatic pressure systems or stepper motors to force the substrate onto a surface. These methods are well developed for high viscouse materials. However, processing low viscous liquids may cause leakages in the system. This could be solved by applying continuous extrusion. Additionally, in order to process gelable substrates, such as gelatine and agar, tempered print heads in combination with a multi stage tempering system are required to prevent the system from clogging. The ongoing work presented in this paper focuses on the development of an extrusion system, which should be able to process multiple viscosities of gelatine sequentially. In order to achieve this, several measurements to examine the properties, as well as the material parameters of different biomaterials are performed. In this process gel point, force resistance and elasticity are the factors of particularly interest. Due to their ability to gel and their availability, the most relevant biomaterials are gelatine and agar. Using this data, an extrusion system involving a peristaltic pump, a heated tube and a nozzle, has been developed. The next step envisaged is to calibrate the extruder based on the obtained data and finally to validate the printing process by printing simple geometric structures. Assuming that a positive evaluation is obtained, the printing system will be tested for printing first organic test structures from patient data using the examined biomaterials. KW - agar KW - biomaterial KW - bioprinting KW - gelatin KW - validation of material parameters Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18802 SN - 0255-5476 SN - 1662-9752 VL - 1016 SP - 1285 EP - 1290 PB - Trans Tech Publications ER - TY - JOUR A1 - Böhme, Andrea A1 - Nemak, Detlef A1 - Lietzau, Kai-Henning A1 - Wolf, Eckart A1 - Foitzik, Andreas T1 - Adaption of 3D Printing for Rapid Tooling JF - Materials Science Forum N2 - Over the course of the last decade 3D printing has become a more established technology in terms of prototype development (rapid prototyping). The current effort is focused on transferring this knowhow into a product driven approach in order to manufacture even small batch sizes more economic. In terms of this work, this idea is adapted for the development of injection molds (rapid manufacturing). Hereby, a hardened polymer is used to create a forming cavity instead of tool-steel. In order to fulfil the mechanical process requirements of micro injection molding such as form stability under temperature and pressure this cavity is nevertheless integrated into a metal housing. A first set of experiments has been carried out using this develop mold to verify the capabilities of the developed prototype as well as molding process. Based on these first results, an optimization is carried out to improve the next iteration of this molding tool. KW - CAD/CAM KW - mold KW - parametrization KW - rapid manufacturing KW - rapid tooling Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18784 SN - 0255-5476 SN - 1662-9752 VL - 1016 SP - 280 EP - 285 PB - Trans Tech Publications ER - TY - JOUR A1 - Engels, Andreas A1 - Schlegel, Volker A1 - Jacobs, Hannes A1 - Großelindemann, Niklas A1 - Morshed, Md. Niaz A1 - Stenglein, Antonia Sigrid A1 - Bonaiuto, Vincenzo A1 - Foitzik, Andreas T1 - 3d Printer Heads for Extrusion of Biologicals Gels JF - Materials Science Forum N2 - Processing biological materials with 3-dimensional (3D) printers has attracted increasing interest in several research areas. At the same time, off-the-shelf solutions are increasingly available in a wider variety to meet the current market demand. However, most of the available bioprinters are closed source, thus, modifications are quite challenging or require an avoidable consultation process with the manufacturer. Furthermore, the entry prices for basic machines amount to several thousands of euros. Whereas, high-end 3D bio printers with a vast array of features are available for several hundred thousand euros. Due to the immense potential of this tool in the field of biotechnology it is important to extend the availability of this technology for research purposes in terms of adaptability and price. This ongoing work focuses on open-source 3D printer heads with the ability to extrude biological materials. The print heads include several techniques to process low as well as high viscose biomaterials such as agar and gelatin. Additionally, obstacles such as continuous substrate tempering or integration into existing 3D printers are addressed. The work presented is open source and thus freely adaptable to any user’s specific needs. Our goal is to process a diverse range of biomaterials with different print techniques. KW - biofabrication KW - bioprinting KW - Open Source KW - process parameter improvement Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18773 SN - 0255-5476 SN - 1662-9752 VL - 1016 SP - 435 EP - 439 PB - Trans Tech Publications ER - TY - JOUR A1 - Morlock, Sascha A1 - Subramanian, Senthil Kumar A1 - Zouni, Athina A1 - Lisdat, Fred T1 - Scalable Three-Dimensional Photobioelectrodes Made of Reduced Graphene Oxide Combined with Photosystem I JF - ACS Applied Materials & Interfaces N2 - Photobioelectrodes represent one of the examples where artificial materials are combined with biological entities to undertake semi-artificial photosynthesis. Here, an approach is described that uses reduced graphene oxide (rGO) as an electrode material. This classical 2D material is used to construct a three-dimensional structure by a template-based approach combined with a simple spin-coating process during preparation. Inspired by this novel material and photosystem I (PSI), a biophotovoltaic electrode is being designed and investigated. Both direct electron transfer to PSI and mediated electron transfer via cytochrome c from horse heart as redox protein can be confirmed. Electrode preparation and protein immobilization have been optimized. The performance can be upscaled by adjusting the thickness of the 3D electrode using different numbers of spin-coating steps during preparation. Thus, photocurrents up to ∼14 μA/cm2 are measured for 12 spin-coated layers of rGO corresponding to a turnover frequency of 30 e– PSI–1 s–1 and external quantum efficiency (EQE) of 0.07% at a thickness of about 15 μm. Operational stability has been analyzed for several days. Particularly, the performance at low illumination intensities is very promising (1.39 μA/cm2 at 0.1 mW/cm2 and −0.15 V vs Ag/AgCl; EQE 6.8%). KW - biophotovoltaics KW - reduced graphene oxide (rGO) KW - scalable template process KW - spin-coating KW - 3D electrode structure KW - carbon material Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-16760 VL - 13 IS - 9 SP - 11237 EP - 11246 PB - American Chemical Society (ACS) ER - TY - JOUR A1 - Kebdani, Zaki A1 - Lehnert, Martin A1 - Michael, Sabrina T1 - Hygienisch sicher reisen? – Der öffentliche Verkehr in der Pandemie – JF - Eisenbahntechnische Rundschau (ETR) N2 - Entsprechend aktueller wissenschaftlicher Studien ist das Risiko, sich mit SARS-CoV-2 im öffentlichen Verkehr zu infizieren, nicht höher als im häuslichen Umfeld. Besonders in Verkehrsmittelinnenräumen kann durch eine ausreichende Frischluftzufuhr, Umluftfilterung, Einhaltung von Abständen und dem richtigen Tragen von geeigneten Schutzmasken das Ansteckungsrisiko effektiv reduziert werden. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-16716 SN - 0013-2845 VL - 2021 IS - 9 SP - 16 EP - 21 PB - DVV Media Group ER - TY - JOUR A1 - Geißler, René A1 - Wortmann, Marcus T1 - Auswirkungen der Finanzkrise auf die kommunalen Ebenen Europas JF - VM Verwaltung & Management N2 - Die Finanzkrise hat enorme Auswirkungen auf die öffentlichen Sektoren weltweit gezeigt. Während für die Ebene der Staaten und einzelne Kommunalverwaltungen einige Forschungsarbeiten vorliegen, wurden die Auswirkungen auf die kommunalen Ebenen in Gänze bis dato kaum untersucht. Dieser Artikel schließt diese Forschungslücke und entwickelt aus der Literatur Kategorien von „direkten" und „indirekten" Auswirkungen auf die Kommunalebenen. Im zweiten Schritt werden diese auf 21 europäische Länder angewandt. Die „direkten" fiskalischen Auswirkungen machten sich in Haushaltsdefiziten und einem meist erheblichen Anstieg der Verschuldung deutlich. Die „indirekten" Auswirkungen gehen auf staatliche Maßnahmen im Umgang mit der Finanzkrise zurück, welche die institutionellen Rahmenbedingungen der Kommunen strukturell veränderten. Solche Maßnahmen betrafen Zuweisungen, die lokale Struktur oder die Aufgabenverteilung zwischen Kommunen und Staaten. Die häufigste „indirekte" Auswirkung ist die Intensivierung der Haushaltsregeln und der Überwachung. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15939 SN - 0947-9856 PB - Nomos ER - TY - JOUR A1 - Petrillo, Mauro A1 - Fabbri, Marco A1 - Kagkli, Dafni Maria A1 - Querci, Maddalena A1 - Van den Eede, Guy A1 - Alm, Erik A1 - Aytan-Aktug, Derya A1 - Capella-Gutierrez, Salvador A1 - Carrillo, Catherine A1 - Cestaro, Alessandro A1 - Chan, Kok-Gan A1 - Coque, Teresa A1 - Endrullat, Christoph A1 - Gut, Ivo A1 - Hammer, Paul A1 - Kay, Gemma L. A1 - Madec, Jean-Yves A1 - Mather, Alison E. A1 - McHardy, Alice Carolyn A1 - Naas, Thierry A1 - Paracchini, Valentina A1 - Peter, Silke A1 - Pightling, Arthur A1 - Raffael, Barbara A1 - Rossen, John A1 - Ruppé, Etienne A1 - Schlaberg, Robert A1 - Vanneste, Kevin A1 - Weber, Lukas M. A1 - Westh, Henrik A1 - Angers-Loustau, Alexandre T1 - A roadmap for the generation of benchmarking resources for antimicrobial resistance detection using next generation sequencing [version 1; peer review: 2 approved with reservations] JF - F1000Research N2 - Next Generation Sequencing technologies significantly impact the field of Antimicrobial Resistance (AMR) detection and monitoring, with immediate uses in diagnosis and risk assessment. For this application and in general, considerable challenges remain in demonstrating sufficient trust to act upon the meaningful information produced from raw data, partly because of the reliance on bioinformatics pipelines, which can produce different results and therefore lead to different interpretations. With the constant evolution of the field, it is difficult to identify, harmonise and recommend specific methods for large-scale implementations over time. In this article, we propose to address this challenge through establishing a transparent, performance-based, evaluation approach to provide flexibility in the bioinformatics tools of choice, while demonstrating proficiency in meeting common performance standards. The approach is two-fold: first, a community-driven effort to establish and maintain “live” (dynamic) benchmarking platforms to provide relevant performance metrics, based on different use-cases, that would evolve together with the AMR field; second, agreed and defined datasets to allow the pipelines’ implementation, validation, and quality-control over time. Following previous discussions on the main challenges linked to this approach, we provide concrete recommendations and future steps, related to different aspects of the design of benchmarks, such as the selection and the characteristics of the datasets (quality, choice of pathogens and resistances, etc.), the evaluation criteria of the pipelines, and the way these resources should be deployed in the community. KW - antimicrobial resistance KW - bioinformatics KW - next-generation sequencing KW - benchmarking Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15699 ER - TY - JOUR A1 - Gerhard, Christoph A1 - Dobis, Alexander T1 - Manufacturing-induced surface contaminations JF - Vakuum in Forschung und Praxis N2 - Summary In the course of classical optics manufacturing glass components are in permanent direct contact with aqueous operating materials. Such contact leads to a certain absorption of water and hydrogenous compounds that may induce severe glass defects. In this contribution, absorption of hydrogen and other contaminants during grinding of glass was observed and qualitatively detected via laser-induced breakdown spectroscopy. It is shown that hydrogen, calcium, magnesium, and carbon are implanted into the glass surface where the contaminant concentration increases over grinding time or contact time of the glass surface with water and the grinding tool, respectively. The contaminants hydrogen, calcium, and magnesium can be attributed to the water used as lubricant. In contrast, carbon most likely originates from wear debris of the used silicon carbide grinding pads. Several possible mechanisms that lead to such surface contamination of glasses during grinding – diffusion, accumulation in micro cracks as well as the formation of hydrated silica – are finally introduced. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15656 VL - 33 IS - 1 SP - 33 EP - 37 PB - Wiley ER - TY - JOUR A1 - Wieland, Ralf A1 - Kuhls, Katrin A1 - Lentz, Hartmut H.K. A1 - Conraths, Franz A1 - Kampen, Helge A1 - Werner, Doreen T1 - Combined climate and regional mosquito habitat model based on machine learning JF - Ecological Modelling N2 - Besides invasive mosquito species also several native species are proven or suspected vectors of arboviruses as West Nile or Usutu virus in Western Europe. Habitat models of these native vectors can be a helpful tool for assessing the risk of autochthonous occurrence, outbreaks and spread of diseases caused by such arboviruses. Modelling native mosquitoes is complicated because of the perfect adaptation to the climatic and landscape conditions and their high abundance in contrast to invasive species. Here we present a new approach for such a habitat model for native mosquito species in Germany, which are considered as vectors of West Nile virus (WNV). Epizootic emergence of WNV was registered in Germany since 2018. The models are based on surveillance data of mosquitoes from the German citizen science project “Mückenatlas” complemented by data from systematic trap monitoring in Germany, and on data freely available from the Deutscher Wetterdienst (DWD) and OpenStreetMap (OSM). While climatic factors still play an important role, we could show that habitat suitability is predictable only by the combination of the climate model with a regional model. Both models were based on a machine-learning approach using XGBoost. Evaluation of the accuracy of the models was done by statistical analysis, determining among others feature importances using the SHAP-Library. Final output of the combined climatic and regional models are maps showing the superposed habitat suitability which are generated through a number of steps described in detail. These maps also include the registered cases of WNV infections in the selected region of Germany. KW - citizen science data KW - mosquito habitat modelling KW - machine learning KW - XGBoost KW - West Nile virus KW - vector borne disease Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15649 SN - 0304-3800 VL - 452 CY - Elsevier ER - TY - JOUR A1 - Lopes Martínez, Igor A1 - Cuesta Santos, Armando A1 - Neumann, Gaby A1 - Günzel, Marcus A1 - Marrero Durán, Sonia Patricia A1 - Noya Domínguez, Lilian A1 - Martínez Pérez, Evert A1 - Cruz Ruiz, Alegna A1 - Machado de Armas, Dayli A1 - Diaz Pereira, Danhiz T1 - La transformación del talento humano en el marco de la Industria 4.0 T1 - The transformation of human talent within the framework of Industry 4.0 JF - Revista cubana de transformación digital N2 - Human capital within the framework of Industry 4.0 must undergo a necessary transformation, acquiring high cognition skills that guarantee the assimilation of enabling technologies in Industry 4.0 for the substantial improvement of processes in any Industry. The objective of this work is to review part of the enabling technologies in Industry 4.0, along with other elements, and their possible implementation in the practice of experiential learning, in route to the development of the concept of Education 4.0 in Industrial Engineering. In addition, elements that influence their insertion in a learning environment in a laboratory are identified, which guarantees the experiential component in teaching. A case of intervention with students of Industrial Engineering from CUJAE is documented, where from the experiential experience of a group of students with the aforementioned technologies, a faster and more consolidated assimilation of these competences is identified when compared with students who are subjected to a traditional education. N2 - El capital humano en el marco de la Industria 4.0 debe sufrir una transformación necesaria, adquiriendo competencias de alta cognición que garanticen la asimilación de las tecnologías habilitadoras en la Industria 4.0 para la mejora sustancial de los procesos en cualquier Industria. El objetivo de este trabajo es reseñar parte de las tecnologías habilitadoras en la Industria 4.0, junto a otros elementos, y su implementación posible en la práctica del aprendizaje experiencial, en ruta para el desarrollo del concepto de una Educación 4.0 en la Ingeniería Industrial. Se identifican, además, elementos que influyen en la inserción de las mismas en un entorno de aprendizaje en un laboratorio, que garantice el componente vivencial en la enseñanza. Se documenta un caso de intervención con estudiantes de Ingeniería Industrial de la CUJAE, donde a partir de la experiencia vivencial de un grupo de estudiantes con las tecnologías mencionadas, se identifica una asimilación más rápida y consolidada de estas competencias cuando se compara con estudiantes que están sometidos a una educación tradicional. KW - aprendizaje por experiencia KW - capital humano KW - competencias KW - Industria 4.0 KW - experiential learning KW - human capital KW - competences KW - Industry 4.0 Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15634 UR - https://rctd.uic.cu/rctd/article/view/122 SN - 2708-3411 VL - 2 IS - 2 SP - 118 EP - 133 PB - Unión de Informáticos de Cuba ER - TY - JOUR A1 - Steglich, Mike T1 - LogisticsLab: An academic software for decision-making in logistics JF - Anwendungen und Konzepte der Wirtschaftsinformatik N2 - Logistical decision problems are a part of many courses in the field of logistics, management and operations research. It makes sense to illustrate these optimisation problems using case studies, which can be reproduced by students using suitable software. Often, solver add-ins in spreadsheets programs or general optimisation software are used, which on the one hand requires a high level of knowledge in Operations Research and on the other hand does not always allow an intuitive approach. This article describes the academic software LogisticsLab with which the distributors tie in with the idea of interactive decision support systems to systematically combine the experiences and intuitions of human decision-makers with the possibilities of computer-assisted modelling and optimisation of a wide range of logistical decisions. KW - logistical decision-making KW - transportation problem KW - network flow problem KW - traveling salesman problem KW - Chinese postman problem KW - vehicle routing planning problem KW - location problem KW - problem-based learning and teaching Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15621 UR - https://ojs-hslu.ch/ojs3211/index.php/akwi/article/view/88 SN - 2296-4592 VL - 14 SP - 42 EP - 52 PB - Arbeitskreis Wirtschaftsinformatik (AKWI) ER - TY - JOUR A1 - Reinhardt, Heiner A1 - Münnich, Marc A1 - Prell, Bastian A1 - Arnold, Roman A1 - Krippner, Fabian A1 - Weber, Marek A1 - Seifert, Frank A1 - Putz, Matthias T1 - Retrieving properties of manufacturing systems from traceability data for performance evaluation and material flow simulation JF - Procedia CIRP N2 - The operation of manufacturing systems is increasingly accompanied by data-driven continuous improvement processes and product traceability is required. Commonly, radio-frequency identification (RFID) technology is applied to track the flow of a uniquely-identifiable workpiece along various stations or waypoints within a factory. Based on an automotive use case, this paper describes how to analyze the resulting traceability data in order to identify several properties of a manufacturing system. The acquired knowledge can support performance evaluation and facilitate model building for material flow simulation as a foundation for digital twins and cyber-physical production systems. KW - knowledge management KW - algorithm KW - analysis KW - condition monitoring KW - manufacturing system KW - complexity KW - man-machine system KW - pattern recognition Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15600 SN - 2212-8271 VL - 104 SP - 20 EP - 25 PB - Elsevier ER - TY - JOUR A1 - Rosendorff, André A1 - Hodes, Alexander A1 - Fabian, Benjamin T1 - Artificial intelligence for last-mile logistics - Procedures and architecture JF - The Online Journal of Applied Knowledge Management (OJAKM) N2 - Artificial Intelligence (AI) is becoming increasingly important in many industries due to its diverse areas of application and potential. In logistics in particular, increasing customer demands and the growth in shipment volumes are leading to difficulties in forecasting delivery times, especially for the last mile. This paper explores the potential of using AI to improve delivery forecasting. For this purpose, a structured theoretical solution approach and a method for improving delivery forecasting using AI are presented. In doing so, the important phases of the Cross-Industry Standard Process for Data Mining (CRISP-DM) framework, a standard process for data mining, are adopted and discussed in detail to illustrate the complexity and importance of each task such as data preparation or evaluation. Subsequently, by embedding the described solution into an overall system architecture for information systems, ideas for the integration of the solution into the complexity of real information systems for logistics are given. KW - supply chain management KW - logistics KW - artificial intelligence KW - machine learning KW - business intelligence Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15586 SN - 2325-4688 VL - 9 IS - 1 SP - 46 EP - 61 PB - The International Institute for Applied Knowledge Management ER - TY - JOUR A1 - Herkenhoff, Marcos Edgar A1 - Bovolenta, Luiz A. A1 - Brödel, Oliver A1 - dos Santos, Lucilene Delazari A1 - de Oliveira, Arthur C. A1 - Chuffa, Luiz G.A. A1 - Ribeiro, Amanda O. A1 - Lupi, Luiz A. A1 - Dias, Marco A.D. A1 - Hilsdorf, Alexandre W.S. A1 - Frohme, Marcus A1 - Pinhal, Danillo T1 - Variant expression signatures of microRNAs and protein related to growth in a crossbreed between two strains of Nile tilapia (Oreochromis niloticus) JF - Genomics N2 - Nile tilapia (Oreochromis niloticus) is a species of worldwide importance for aquaculture. A crossbred lineage was developed through introgressive backcross breeding techniques and combines the high growth performance of the Chitralada (CHIT) lwith attractive reddish color of the Red Stirling (REDS) strains. Since the crossbreed has an unknown genetically improved background, the objective of this work was to characterize expression signatures that portray the advantageous phenotype of the crossbreeds. We characterized the microRNA transcriptome by high throughput sequencing (RNA-seq) and the proteome through mass spectrometry (ESI-Q-TOF-MS) and applied bioinformatics for the comparative analysis of such molecular data on the three strains. Crossbreed expressed a distinct set of miRNAs and proteins compared to the parents. They comprised several microRNAs regulate traits of economic interest. Proteomic profiles revealed differences between parental and crossbreed in expression of proteins associated with glycolisis. Distinctive miRNA and protein signatures contribute to the phenotype of crossbreed. KW - Nile tilapia KW - growth KW - RNA-seq KW - miRNA KW - ESI-Q-TOF KW - proteome Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15571 SN - 0888-7543 VL - 113 IS - 6 SP - 4303 EP - 4312 PB - Elsevier ER - TY - JOUR A1 - Zhou, Yuefang A1 - Kornher, Tristan A1 - Mohnke, Janett A1 - Fischer, Martin H. T1 - Tactile Interaction with a Humanoid Robot: Effects on Physiology and Subjective Impressions JF - International Journal of Social Robotics N2 - This study investigated how touching and being touched by a humanoid robot affects human physiology, impressions of the interaction, and attitudes towards humanoid robots. 21 healthy adult participants completed a 3 (touch style: touching, being touched, pointing) × 2 (body part: hand vs buttock) within-subject design using a Pepper robot. Skin conductance response (SCR) was measured during each interaction. Perceived impressions of the interaction (i.e., friendliness, comfort, arousal) were measured per questionnaire after each interaction. Participants’ demographics and their attitude towards robots were also considered. We found shorter SCR rise times in the being touched compared to the touching condition, possibly reflecting psychological alertness to the unpredictability of robot-initiated contacts. The hand condition had shorter rise times than the buttock condition. Most participants evaluated the hand condition as most friendly and comfortable and the robot-initiated interactions as most arousing. Interacting with Pepper improved attitudes towards robots. Our findings require future studies with larger samples and improved procedures. They have implications for robot design in all domains involving tactile interactions, such as caring and intimacy. KW - human–robot tactile interaction KW - skin conductance KW - buttocks KW - robot Pepper KW - human–robot intimate relationships Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15524 SN - 1875-4805 VL - 13 SP - 1657 EP - 1677 PB - Springer Nature ER - TY - JOUR A1 - Villringer, Claus A1 - Steglich, Patrick A1 - Pulwer, Silvio A1 - Schrader, Sigurd A1 - Laufer, Jan T1 - Electro-optical properties of doped polymers with high transparency in the visible wavelength range JF - Optical Materials Express N2 - The electro-optical (EO) properties of poly(methyl methacrylate) and the photopolymer poly(vinyl cinnamate) doped with varying concentrations of the EO chromophore 2-Methyl-4-nitroaniline were measured. The EO polymers were embedded in Fabry-Pérot etalons for the simultaneous determination of the Pockels and Kerr coefficients from measurements of the fringe shift induced by an external electric field. It was found that the host polymer has a significant impact on the EO performance and that the undoped host polymers exhibit a significant Pockels effect. Moreover, the Kerr effect provides a substantial contribution of 27% to the total change of the refractive index at relatively high electric field strengths of E = 91.2 MV m−1. KW - Bragg reflector KW - fiber optic coupler KW - refractive index KW - spatial light modulator KW - transparency KW - tunable filter Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15480 VL - 11 IS - 11 SP - 3801 EP - 3811 PB - Optica Publishing Group ER - TY - JOUR A1 - Tarabrin, Mikhail K. A1 - Bushunov, Andrey A. A1 - Teslenko, Andrei A. A1 - Sakharova, Tatiana A1 - Hinkel, Jonas A1 - Usenov, Iskander A1 - Döhler, Torsten A1 - Geißler, Ute A1 - Artyushenko, Viacheslav A1 - Lazarev, Vladimir A. T1 - Fabrication of an antireflection microstructure on AgClBr polycrystalline fiber by single pulse femtosecond laser ablation JF - Optical Materials Express N2 - Polycrystalline infrared (PIR) fibers are used for numerous applications, one of those being power delivery for CO2 lasers. However, the fiber tip surface's transmittance cannot be increased with conventional antireflection coatings due to the surface unevenness. Antireflection microstructures (ARMs) offer an alternative way of increasing transmittance. In this work, ARMs were fabricated on the fiber tip surface of an AgClBr fiber by single-pulse femtosecond laser ablation. A single-surface transmittance of 92.8% at 10.6 μm, a CO2 laser operation wavelength, was achieved. The proposed method can help significantly improve the systems' efficiency, where power delivery for CO2 lasers or sources operating in the wide wavelength range is required. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15384 VL - 11 IS - 2 SP - 487 EP - 496 PB - Optical Society of America ER - TY - JOUR A1 - Glökler, Jörn A1 - Lim, Theam Soon A1 - Ida, Jeunice A1 - Frohme, Marcus T1 - Isothermal amplifications – a comprehensive review on current methods JF - Critical Reviews in Biochemistry and Molecular Biology N2 - AbstractThe introduction of nucleic acid amplification techniques has revolutionized the field of medical diagnostics in the last decade. The advent of PCR catalyzed the increasing application of DNA, not just for molecular cloning but also for molecular based diagnostics. Since the introduction of PCR, a deeper understanding of molecular mechanisms and enzymes involved in DNA/RNA replication has spurred the development of novel methods devoid of temperature cycling. Isothermal amplification methods have since been introduced utilizing different mechanisms, enzymes, and conditions. The ease with which isothermal amplification methods have allowed nucleic acid amplification to be carried out has had a profound impact on the way molecular diagnostics are being designed after the turn of the millennium. With all the advantages isothermal amplification brings, the issues or complications surrounding each method are heterogeneous making it difficult to identify the best approach for an end-user. This review pays special attention to the various isothermal amplification methods by classifying them based on the mechanistic characteristics which include reaction formats, amplification information, promoter, strand break, and refolding mechanisms. We would also compare the efficiencies and usefulness of each method while highlighting the potential applications and detection methods involved. This review will serve as an overall outlook on the journey and development of isothermal amplification methods as a whole. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15154 SP - 1 EP - 44 PB - Taylor & Francis ER - TY - JOUR A1 - Seeliger, Frank A1 - Puppe, Frank A1 - Ewerth, Ralph A1 - Koch, Thorsten A1 - Kasprzik, Anna A1 - Maas, Jan Frederik A1 - Poley, Christoph A1 - Mödden, Elisabeth A1 - Degkwitz, Andreas A1 - Greifeneder, Elke T1 - «Work in progress» – Zum erfolgversprechenden Einsatz von KI in Bibliotheken : Diskussionsstand eines White Papers in progress – Teil 2 JF - B.I.T. online N2 - Ist der Suchschlitz ein Vintage Look&Feel des letzten Jahrhunderts? Oder - die Frage sei erlaubt, - unter welchen Bedingungen es Bibliotheken schaffen könnten, dass Nutzerinnen und Nutzer die Erstsuche nach Informationen über sie laufen lassen? Das sind beispielhafte Fragen, die man sich angesichts gewonnener Erfahrungen aus bisherigen Innovationen stellen kann, aber ebenfalls mit Blick auf das, was Neues an Technologien sich auf dem Markt befindet und zunehmend viele Lebensbereiche durchdringt. Das Forschungsgebiet der Künstlichen Intelligenz (KI) ist in aller Munde und fordert von Informationseinrichtungen eine Antwort darauf, ob der Einsatz von KI-Technologien als weitere Facette der Automatisierung und Digitalisierung von Workflows und Service in Bibliotheken sinnvoll und hilfreich, und ob Engagement auf dieser Linie notwendig ist. Auch wenn sich Bibliotheken in ihrem steten Bemühen um Innovation mit ihrer Belegschaft und Leitungen noch differenziert bis reserviert zu KI bekennen, ist ein weiterer Verlauf der Entwicklungen gemäß dem chinesischen Sprichwort "Was du nicht aufhalten kannst, solltest du begrüßen", absehbar. Was heißt das aber für Bibliotheken, den Wandel zu gestalten bis hin zu dem Moment, wenn ein Dienst über die Pilot-, Prototyp- und damit Projektphase hinaus als fester Bestandteil des Serviceangebots fest etabliert und verstetigt werden soll? Welche Ressourcen und Kompetenzen sind z.B. in der Konsequenz von der Einrichtung selbst vorzuhalten? Weitere Fragen betreffen die Bewältigung der Masse an Daten und ihre Offenheit für die Anwendung von KI-Algorithmen. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15148 UR - https://www.b-i-t-online.de/heft/2021-03-fachbeitrag-seeliger SN - 2193-4193 VL - 24 IS - 3 SP - 290 EP - 299 ER - TY - JOUR A1 - Seeliger, Frank A1 - Puppe, Frank A1 - Ewerth, Ralph A1 - Koch, Thorsten A1 - Kasprzik, Anna A1 - Maas, Jan Frederik A1 - Poley, Christoph A1 - Mödden, Elisabeth A1 - Degkwitz, Andreas A1 - Greifeneder, Elke T1 - «Work in progress» – Zum erfolgversprechenden Einsatz von KI in Bibliotheken : Diskussionsstand eines White Papers in progress – Teil 1 JF - B.I.T. online N2 - Ist die Suche im Bibliothekskatalog ein Auslaufmodell? Oder die Frage sei erlaubt, unter welchen Bedingungen es Bibliotheken schaffen könnten, dass Nutzer/-innen die Erstsuche nach Informationen über sie laufen lassen? Das sind beispielhafte Fragen, die man sich angesichts gewonnener Erfahrungen aus bisherigen Innovationen stellen kann, aber ebenfalls mit Blick auf das, was Neues an Technologien sich auf dem Markt befindet und zunehmend viele Lebensbereiche durchdringt. Das Forschungsgebiet der Künstlichen Intelligenz (KI) ist in aller Munde und fordert von Informationseinrichtungen eine Antwort darauf, ob der Einsatz von KI-Technologien als weitere Facette der Automatisierung und Digitalisierung von Workflows und Service in Bibliotheken sinnvoll und hilfreich, und ob Engagement auf dieser Linie notwendig ist. Auch wenn sich Bibliotheken in ihrem steten Bemühen um Innovation mit ihrer Belegschaft und Leitungen noch differenziert bis reserviert zu KI bekennen, ist ein weiterer Verlauf der Entwicklungen gemäß dem chinesischen Sprichwort: Was du nicht aufhalten kannst, solltest du begrüßen, absehbar. Was heißt das aber für Bibliotheken, den Wandel zu gestalten bis hin zu dem Moment, wenn ein Dienst über die Pilot-, Prototyp- und damit Projektphase hinaus als fester Bestandteil des Serviceangebots fest etabliert und verstetigt werden soll? Welche Ressourcen und Kompetenzen sind z.B. in der Konsequenz von der Einrichtung selbst vorzuhalten? Weitere Fragen betreffen die Bewältigung der Masse an Daten und ihre Offenheit für die Anwendung von KI-Algorithmen. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-15130 UR - https://www.b-i-t-online.de/heft/2021-02-fachbeitrag-seeliger SN - 2193-4193 VL - 24 IS - 2 SP - 173 EP - 178 ER - TY - JOUR A1 - Njuguna, James K. A1 - Muchiri, Peter A1 - Mwema, Fredrick M. A1 - Karuri, Nancy W. A1 - Herzog, Michael A1 - Dimitrov, Kiril T1 - Determination of thermo-mechanical properties of recycled polyurethane from glycolysis polyol JF - Scientific African N2 - Polyurethane foam is one of the most versatile polymers widely used in the automotive industry. However, due to the rising amount of polyurethane foam waste in the environment, there is growing research attention focusing on circular economy solutions to closing the material loop. This study aimed to determine the possible changes in thermo-mechanical properties between rigid polyurethane prepared using polyols derived from depolymerization of commercial polyurethane foam with benchmark rigid polyurethane (Ben PU). Polyurethane foams containing dispersion polyol were reacted with dipropylene glycol (DPG) and diethylene glycol (DEG) with a ratio of DPG: DEG of 1:1 in the presence of a consumable catalyst (Di-n-butyl amine). The recovered polyol was used as a raw material replacing 100% benchmark rigid polyurethane petroleum-based polyester polyol to produce the recycled polyurethane (Rec PU). Thermal analysis was conducted to measure the recycled polyurethane's glass transition temperatures (Tg) using differential scanning calorimetry (DSC). Tensile strength, elastic modulus, toughness, and hardness test of the recycled polyurethane were conducted under three different temperatures; 24°C, 40°C, and 60°C. From the DSC results, the glass transition temperatures for the recycled and the benchmark rigid polyurethane occurred at 43°C and 50.4°C, respectively. Both polymers showed the brittle-ductile transition from 24°C to 40°C. Tensile strength for recycled polyurethane was lower than that of benchmark rigid polyurethane by 29-43% and a corresponding 24-50% decrease in elastic modulus. Recycled polyurethane recorded lower toughness than petroleum-based pure polyurethane by 13-16%. However, the recycled polymer recorded high shored D values than the benchmark rigid polyurethane by 9-29%. This study reveals that recycled polyol could be used as feedstock for polyurethane production with applications tailored to its mechanical properties. KW - polyurethane foam KW - recycling KW - glycolysis KW - rigid polyurethane KW - thermo-mechanical property KW - circular economy Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14911 SN - 2468-2276 VL - 12 ER - TY - JOUR A1 - Haklay, Muki A1 - Fraisl, Dilek A1 - Greshake Tzovaras, Bastian A1 - Hecker, Susanne A1 - Gold, Margaret A1 - Hager, Gerid A1 - Ceccaroni, Luigi A1 - Kieslinger, Barbara A1 - Wehn, Uta A1 - Woods, Sasha A1 - Nold, Christian A1 - Balázs, Bálint A1 - Mazzonetto, Marzia A1 - Rüfenacht, Simone A1 - Shanley, Lea A. A1 - Wagenknecht, Katherin A1 - Motion, Alice A1 - Sforzi, Andrea A1 - Riemenschneider, Dorte A1 - Dorler, Daniel A1 - Heigl, Florian A1 - Schaefer, Teresa A1 - Lindner, Ariel A1 - Weißpflug, Maike A1 - Mačiulienė, Monika A1 - Vohland, Katrin T1 - Contours of citizen science: a vignette study JF - Royal Society Open Science N2 - Citizen science has expanded rapidly over the past decades. Yet, defining citizen science and its boundaries remained a challenge, and this is reflected in the literature—for example in the proliferation of typologies and definitions. There is a need for identifying areas of agreement and disagreement within the citizen science practitioners community on what should be considered as citizen science activity. This paper describes the development and results of a survey that examined this issue, through the use of vignettes—short case descriptions that describe an activity, while asking the respondents to rate the activity on a scale from ‘not citizen science’ (0%) to ‘citizen science’ (100%). The survey included 50 vignettes, of which five were developed as clear cases of not-citizen science activities, five as widely accepted citizen science activities and the others addressing 10 factors and 61 sub-factors that can lead to controversy about an activity. The survey has attracted 333 respondents, who provided over 5100 ratings. The analysis demonstrates the plurality of understanding of what citizen science is and calls for an open understanding of what activities are included in the field. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14781 VL - 8 IS - 8 ER - TY - JOUR A1 - Shams, S. Fatemeh A1 - Schmitz, Detlef A1 - Smekhova, Alevtina A1 - Ghazanfari, Mohammad Reza A1 - Giesen, Margret A1 - Weschke, Eugen A1 - Chen, Kai A1 - Luo, Chen A1 - Radu, Florin A1 - Schmitz-Antoniak, Carolin T1 - Element-specific contributions to improved magnetic heating of theranostic CoFe2O4 nanoparticles decorated with Pd JF - Scientific Reports N2 - Decoration with Pd clusters increases the magnetic heating ability of cobalt ferrite (CFO) nanoparticles by a factor of two. The origin of this previous finding is unraveled by element-specific X-ray absorption spectroscopy (XAS) and magnetic circular dichroism (XMCD) combined with atomic multiplet simulations and density functional theory (DFT) calculations. While the comparison of XAS spectra with atomic multiplet simulations show that the inversion degree is not affected by Pd decoration and, thus, can be excluded as a reason for the improved heating performance, XMCD reveals two interrelated responsible sources: significantly larger Fe and Co magnetic moments verify an increased total magnetization which enhances the magnetic heating ability. This is accompanied by a remarkable change in the field-dependent magnetization particularly for Co ions which exhibit an increased low-field susceptibility and a reduced spin canting behavior in higher magnetic fields. Using DFT calculations, these findings are explained by reduced superexchange between ions on octahedral lattice sites via oxygen in close vicinity of Pd, which reinforces the dominating antiparallel superexchange interaction between ions on octahedral and tetrahedral lattice sites and thus reduces spin canting. The influence of the delocalized nature of Pd 4d electrons on the neighboring ions is discussed and the conclusions are illustrated with spin density isosurfaces of the involved ions. The presented results pave the way to design nanohybrids with tailored electronic structure and magnetic properties. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14756 SN - 2045-2322 VL - 11 ER - TY - JOUR A1 - Grebinyk, Anna A1 - Prylutska, Svitlana A1 - Grebinyk, Sergii A1 - Evstigneev, Maxim A1 - Krysiuk, Iryna A1 - Skaterna, Tetiana A1 - Horak, Iryna A1 - Sun, Yanfang A1 - Drobot, Liudmyla A1 - Matyshevska, Olga A1 - Prylutskyy, Yuriy A1 - Ritter, Uwe A1 - Frohme, Marcus T1 - Antitumor efficiency of the natural alkaloid berberine complexed with C60 fullerene in Lewis lung carcinoma in vitro and in vivo JF - Cancer Nanotechnology N2 - Background Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and a high anticancer potency in particular. However, due to its low bioavailability, the difficulty in reaching a target and choosing the right dose, there is a need to improve approaches of Ber use in anticancer therapy. In this study, Ber, noncovalently bound to a carbon nanostructure C60 fullerene (C60) at various molar ratios of the components, was explored against Lewis lung carcinoma (LLC). Methods C60–Ber noncovalent nanocomplexes were synthesized in 1:2, 1:1 and 2:1 molar ratios. Ber release from the nanocomplexes was studied after prolonged incubation at different pH with the liquid chromatography–mass spectrometry analysis of free Ber content. Biological effects of the free and C60-complaxated Ber were studied in vitro towards LLC cells with phase-contrast and fluorescence microscopy, flow cytometry, MTT reduction, caspase activity and wound closure assays. The treatment with C60–Ber nanocomplex was evaluated in vivo with the LLC-tumored C57Bl mice. The mice body weight, tumor size, tumor weight and tumor weight index were assessed for four groups, treated with saline, 15 mg C60/kg, 7.5 mg Ber/kg or 2:1 C60-Ber nanocomplex (15 mg C60/kg, 7.5 mg Ber/kg). Results Ber release from C60–Ber nanocomplexes was promoted with medium acidification. LLC cells treatment with C60–Ber nanocomplexes was followed by enhanced Ber intracellular uptake as compared to free Ber. The cytotoxicity of the studied agents followed the order: free Ber < 1:2 < 1:1 < 2:1 C60–Ber nanocomplex. The potency of cytotoxic effect of 2:1 C60–Ber nanocomplex was confirmed by 21.3-fold decrease of IC50 value (0.8 ± 0.3 µM) compared to IC50 for free Ber (17 ± 2 µM). C60–Ber nanocomplexes induced caspase 3/7 activation and suppressed the migration activity of LLC cells. The therapeutic potency of 2:1 C60–Ber nanocomplex was confirmed in a mouse model of LLC. The tumor growth in the group treated with 2:1 C60–Ber nanocomplex is suppressed by approximately 50% at the end of experiment, while in the tumor-bearing group treated with free Ber no therapeutic effect was detected. Conclusions This study indicates that complexation of natural alkaloid Ber with C60 may be a novel therapeutic strategy against lung carcinoma. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14749 SN - 1868-6966 VL - 12 SP - 24 PB - BioMed Central ER - TY - JOUR A1 - Boettcher, Florian A1 - Freier, Ronny A1 - Geißler, René T1 - Bundesbeteiligung an den Kosten der Unterkunft — ein „pragmatischer“ Transfer JF - Wirtschaftsdienst N2 - Die Beteiligung des Bundes an den Kosten der Unterbringung und Heizung (KdU) erfolgt seit der Einführung des SGB II 2005 mit dem Ziel, die Kommunen finanziell zu entlasten. Seitdem wurde die Bundesbeteiligung in Höhe, Struktur, Berechnung und Zweck beständig verändert. Der Beitrag zeigt, wie sich dieser Transfer im Zeitablauf entwickelt hat, aus welchen Komponenten er heute besteht und welche Kritikpunkte sich um die KdU ergeben. Die Autoren schlussfolgern, dass die Bundesbeteiligung vereinfacht werden sollte, indem regionale Privilegien auslaufen und sachfremde Leistungen auf anderen Wegen finanziert werden. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14734 SN - 1613-978X VL - 101 IS - 7 SP - 552 EP - 558 ER - TY - JOUR A1 - Baumann, Elisabeth A1 - Pohle, Ulrike A1 - Zhang, Edward A1 - Allen, Thomas A1 - Villringer, Claus A1 - Pulwer, Silvio A1 - Gerhardt, Holger A1 - Laufer, Jan T1 - A backward-mode optical-resolution photoacoustic microscope for 3D imaging using a planar Fabry-Pérot sensor JF - Photoacoustics N2 - Optical-resolution photoacoustic microscopy (OR-PAM) combines high spatial resolution and strong absorption-based contrast in tissue, which has enabled structural and spectroscopic imaging of endogenous chromophores, primarily hemoglobin. Conventional piezoelectric ultrasound transducers are typically placed far away from the photoacoustic source due to their opacity, which reduces acoustic sensitivity. Optical ultrasound sensors are an alternative as their transparency allows them to be positioned close to the sample with minimal source-detector distances. In this work, a backward-mode OR-PAM system based on a planar Fabry-Pérot ultrasound sensor and coaxially aligned excitation and interrogation beams was developed. Two 3D imaging modes, using raster-scanning for enhanced image quality and continuous-scanning for fast imaging, were implemented and tested on a leaf skeleton phantom. In fast imaging mode, a scan-rate of 100,000 A-lines/s was achieved. 3D images of a zebrafish embryo were acquired in vivo in raster-scanning mode. The transparency of the FP sensor in the visible and near-infrared wavelength region makes it suitable for combined functional and molecular imaging applications using OR-PAM and multi-photon fluorescence microscopy. KW - optical-resolution photoacoustic microscopy KW - backward-mode imaging KW - dual-wavelength KW - continuous scanning KW - in vivo imaging KW - optical ultrasound sensing KW - planar Fabry-Pérot interferometer Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14701 SN - 2213-5979 VL - 24 SP - 100293 PB - Elsevier ER - TY - JOUR A1 - Maier, Petra A1 - Clausius, Benjamin A1 - Richter, Asta A1 - Bittner, Benjamin A1 - Hort, Norbert A1 - Menze, Roman T1 - Crack Propagation in As-Extruded and Heat-Treated Mg-Dy-Nd-Zn-Zr Alloy Explained by the Effect of LPSO Structures and Their Micro- and Nanohardness JF - Materials N2 - The investigation of the crack propagation in as-extruded and heat-treated Mg-Dy-Nd-Zn-Zr alloy with a focus on the interaction of long-period stacking-ordered (LPSO) structures is the aim of this study. Solution heat treatment on a hot extruded Mg-Dy-Nd-Zn-Zr (RESOLOY®) was done to change the initial fine-grained microstructure, consisting of grain boundary blocky LPSO and lamellar LPSO structures within the matrix, into coarser grains of less lamellar and blocky LPSO phases. C-ring compression tests in Ringer solution were used to cause a fracture. Crack initiation and propagation is influenced by twin boundaries and LPSO lamellae. The blocky LPSO phases also clearly hinder crack growth, by increasing the energy to pass either through the phase or along its interface. The microstructural features were characterized by micro- and nanohardness as well as the amount and location of LPSO phases in dependence on the heat treatment condition. By applying nanoindentation, blocky LPSO phases show a higher hardness than the grains with or without lamellar LPSO phases and their hardness decreases with heat treatment time. On the other hand, the matrix increases in hardness by solid solution strengthening. The microstructure consisting of a good balance of grain size, matrix and blocky LPSO phases and twins shows the highest fracture energy. KW - magnesium KW - Mg-Dy-Nd-Zn-Zr KW - RESOLOY® KW - LPSO phases KW - crack propagation KW - hardness KW - nanoindentation Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14194 SN - 1996-1944 VL - 14 IS - 13 PB - MDPI ER - TY - JOUR A1 - Lukose, Rasuole A1 - Lisker, Marco A1 - Akhtar, Fatima A1 - Fraschke, Mirko A1 - Grabolla, T. A1 - Mai, Andreas A1 - Lukosius, Mindaugas T1 - Influence of plasma treatment on SiO2/Si and Si3N4/Si substrates for large-scale transfer of graphene JF - Scientific Reports N2 - One of the limiting factors of graphene integration into electronic, photonic, or sensing devices is the unavailability of large-scale graphene directly grown on the isolators. Therefore, it is necessary to transfer graphene from the donor growth wafers onto the isolating target wafers. In the present research, graphene was transferred from the chemical vapor deposited 200 mm Germanium/Silicon (Ge/Si) wafers onto isolating (SiO2/Si and Si3N4/Si) wafers by electrochemical delamination procedure, employing poly(methylmethacrylate) as an intermediate support layer. In order to influence the adhesion properties of graphene, the wettability properties of the target substrates were investigated in this study. To increase the adhesion of the graphene on the isolating surfaces, they were pre-treated with oxygen plasma prior the transfer process of graphene. The wetting contact angle measurements revealed the increase of the hydrophilicity after surface interaction with oxygen plasma, leading to improved adhesion of the graphene on 200 mm target wafers and possible proof-of-concept development of graphene-based devices in standard Si technologies. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14179 SN - 2045-2322 VL - 11 ER - TY - JOUR A1 - Wagenknecht, Katherin A1 - Woods, Tim A1 - García Sanz, Francisco A1 - Gold, Margaret A1 - Bowser, Anne A1 - Rüfenacht, Simone A1 - Ceccaroni, Luigi A1 - Piera, Jaume T1 - EU-Citizen.Science: A Platform for Mainstreaming Citizen Science and Open Science in Europe JF - Data Intelligence N2 - Citizen Science (CS) is a prominent field of application for Open Science (OS), and the two have strong synergies, such as: advocating for the data and metadata generated through science to be made publicly available [1]; supporting more equitable collaboration between different types of scientists and citizens; and facilitating knowledge transfer to a wider range of audiences [2]. While primarily targeted at CS, the EU-Citizen. Science platform can also support OS. One of its key functions is to act as a knowledge hub to aggregate, disseminate and promote experience and know-how; for example, by profiling CS projects and collecting tools, resources and training materials relevant to both fields. To do this, the platform has developed an information architecture that incorporates the public participation in scientific research (PPSR)—Common Conceptual Model①. This model consists of the Project Metadata Model, the Dataset Metadata Model and the Observation Data Model, which were specifically developed for CS initiatives. By implementing these, the platform will strengthen the interoperating arrangements that exist between other, similar platforms (e.g., BioCollect and SciStarter) to ensure that CS and OS continue to grow globally in terms of participants, impact and fields of application. KW - citizen science KW - metadata KW - Open Science KW - public participation in scientific research (PPSR) Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14113 SN - 2641-435X VL - 3 IS - 1 SP - 136 EP - 149 ER - TY - JOUR A1 - Goldenberg, Leonid A1 - Köhler, Mathias A1 - Dreyer, Christian T1 - SiO2 Nanoparticles-Acrylate Formulations for Core and Cladding in Planar Optical Waveguides JF - Nanomaterials N2 - A combination of acrylate formulations and SiO2 nanoparticles is investigated with the aim to improve the optical properties of low-refractive index polymers that are used for the fabrication of planar optical waveguides. A decrease in refractive index and also in the thermo-optic coefficient of nanocomposite materials is clearly demonstrated, while some formulations exhibit an increase in the glass transition temperature. The possibility of using these nanocomposite materials to fabricate waveguiding layers with low optical propagation losses at telecommunication wavelengths around 1550 nm is also shown. The nanomaterials can be applied in optical microchips on polymer platforms. KW - fluorinated acrylate KW - silica nanoparticle KW - nanocomposite KW - thermo-optic coefficient KW - optical propagation loss Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14057 SN - 2079-4991 VL - 11 IS - 5 PB - MDPI ER - TY - JOUR A1 - Oehlers, Milena A1 - Fabian, Benjamin T1 - Graph Metrics for Network Robustness—A Survey JF - Mathematics N2 - Research on the robustness of networks, and in particular the Internet, has gained critical importance in recent decades because more and more individuals, societies and firms rely on this global network infrastructure for communication, knowledge transfer, business processes and e-commerce. In particular, modeling the structure of the Internet has inspired several novel graph metrics for assessing important topological robustness features of large complex networks. This survey provides a comparative overview of these metrics, presents their strengths and limitations for analyzing the robustness of the Internet topology, and outlines a conceptual tool set in order to facilitate their future adoption by Internet research and practice but also other areas of network science. KW - network science KW - Internet KW - graph KW - robustness KW - metric Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-13954 SN - 2227-7390 VL - 9 IS - 8 PB - MDPI ER - TY - JOUR A1 - Wagenknecht, Katherin A1 - Woods, Tim A1 - Nold, Christian A1 - Rüfenacht, Simone A1 - Voigt-Heucke, Silke A1 - Caplan, Anne A1 - Hecker, Susanne A1 - Vohland, Katrin T1 - A question of dialogue? Reflections on how citizen science can enhance communication between science and society JF - JCOM: Journal of Science Communication N2 - Citizen science is a transdisciplinary approach that responds to the current science policy agenda: in terms of supporting open science, and by using a range of science communication instruments. In particular, it opens up scientific research processes by involving citizens at different phases; this also creates a range of opportunities for science communication to happen This article explores methodological and practical characteristics of citizen science as a form of science communication by examining three case studies that took different approaches to citizens' participation in science. Through these, it becomes clear that communication in citizen science is ‘÷always’ science communication and an essential part of “doing science”. KW - citizen science KW - science communication in the developing world KW - science communication: theory and models KW - Wissenschaftskommunikation Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14035 SN - 1824-2049 VL - 20 IS - 03 ER - TY - JOUR A1 - Kuhls, Katrin A1 - Moskalenko, Olga A1 - Sukiasyan, Anna A1 - Manukyan, Dezdemonia A1 - Melik-Andreasyan, Gayane A1 - Atshemyan, Liana A1 - Apresyan, Hripsime A1 - Strelkova, Margarita V. A1 - Jaeschke, Anja A1 - Wieland, Ralf A1 - Frohme, Marcus A1 - Cortes, Sofia A1 - Keshishyan, Ara T1 - Microsatellite based molecular epidemiology of Leishmania infantum from re-emerging foci of visceral leishmaniasis in Armenia and pilot risk assessment by ecological niche modeling JF - PLoS Neglected Tropical Diseases N2 - Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania. In Armenia visceral leishmaniasis (VL) is re-emerging since 1999 after a long break of 30 years, with 167 cases recorded until 2019. Molecular diagnosis of VL was implemented only in 2016, and the causative agent was identified as L. infantum. In the present study we expanded the investigation of the causative agent to a characterization at strain level and the identification of its phylogenetic position among the L. infantum genotypes circulating worldwide. This is the first study addressing genetic diversity and population structure of L. infantum in Armenia and in Transcaucasia. Armenia is an extremely interesting region due to its bio-geographic specificities e.g. the high number of different climates in this small mountainous country and the observed high diversity of sand fly species, part of which occurring in very high altitudes. Ecological niche modeling based on registered VL cases and sand fly vectors collected in active VL foci revealed that the risk of further spread of VL is very high due to climate change. Studies of this region should be expanded to enable targeted control measures. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-14004 SN - 1935-2735 VL - 15 IS - 4 SP - e0009288 PB - Public Library of Science (PLoS) ER - TY - JOUR A1 - Steglich, Patrick A1 - Mai, Christian A1 - Villringer, Claus A1 - Dietzel, Birgit A1 - Bondarenko, Siegfried A1 - Ksianzou, Viachaslau A1 - Villasmunta, Francesco A1 - Zesch, Christoph A1 - Pulwer, Silvio A1 - Burger, Martin A1 - Bauer, Joachim A1 - Heinrich, Friedhelm A1 - Schrader, Sigurd A1 - Vitale, Francesco A1 - De Matteis, Fabio A1 - Prosposito, Paolo A1 - Casalboni, Mauro A1 - Mai, Andreas T1 - Silicon-organic hybrid photonics: an overview of recent advances, electro-optical effects and CMOS integration concepts JF - Journal of Physics: Photonics N2 - In recent decades, much research effort has been invested in the development of photonic integrated circuits, and silicon-on-insulator technology has been established as a reliable platform for highly scalable silicon-based electro-optical modulators. However, the performance of such devices is restricted by the inherent material properties of silicon. An approach to overcoming these deficiencies is to integrate organic materials with exceptionally high optical nonlinearities into a silicon-on-insulator photonic platform. Silicon–organic hybrid photonics has been shown to overcome the drawbacks of silicon-based modulators in terms of operating speed, bandwidth, and energy consumption. This work reviews recent advances in silicon–organic hybrid photonics and covers the latest improvements to single components and device concepts. Special emphasis is given to the in-device performance of novel electro-optical polymers and the use of different electro-optical effects, such as the linear and quadratic electro-optical effect, as well as the electric-field-induced linear electro-optical effect. Finally, the inherent challenges of implementing non-linear optical polymers on a silicon photonic platform are discussed and a perspective for future directions is given. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-13882 SN - 2515-7647 VL - 3 IS - 2 ER - TY - JOUR A1 - Gossing, Wilhelm A1 - Radke, Lars A1 - Biering, Henrik A1 - Diederich, Sven A1 - Mai, Knut A1 - Frohme, Marcus T1 - The ElonginB/C-Cullin5-SOCS-Box-Complex Is a Potential Biomarker for Growth Hormone Disorders JF - Biomedicines N2 - Insulin-like growth factor 1 (IGF-1) is the standard biochemical marker for the diagnosis and treatment control of acromegaly and growth hormone deficiency (GHD). However, its limitations necessitate the screening for new specific and sensitive biomarkers. The elonginB/C-cullin5-SOCS-box-complex (ECS-complex) (an intracellular five-protein complex) is stimulated by circulating growth hormone (GH) and regulates GH receptor levels through a negative feedback loop. It mediates the cells’ sensitivity for GH and therefore, represents a potent new biomarker for those diseases. In this study, individual ECS-complex proteins were measured in whole blood samples of patients with acromegaly (n = 32) or GHD (n = 12) via ELISA and compared to controls. Hierarchical clustering of the results revealed that by combining the three ECS-complex proteins suppressor of cytokine signaling 2 (SOCS2), cullin-5 and ring-box protein 2 (Rbx-2), 93% of patient samples could be separated from controls, despite many patients having a normal IGF-1 or not receiving medical treatment. SOCS2 showed the best individual diagnostic performance with an overall accuracy of 0.93, while the combination of the three proteins correctly identified all patients and controls. This resulted in perfect sensitivity and specificity for all patient groups, which demonstrates potential benefits of the ECS-complex proteins as clinical biomarkers for the diagnostics of GH-related diseases and substantiates their important role in GH metabolism. KW - acromegaly KW - growth hormone deficiency KW - biomarker KW - SOCS2 KW - liquid biopsy KW - pituitary Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-13802 SN - 2227-9059 VL - 9 IS - 2 PB - MDPI ER - TY - JOUR A1 - Grytsenko, Kostyantyn A1 - Ksianzou, Viachaslau A1 - Kolomzarov, Yurii A1 - Lytvyn, Peter A1 - Dietzel, Birgit A1 - Schrader, Sigurd T1 - Fluoropolymer Film Formation by Electron Activated Vacuum Deposition JF - Surfaces N2 - Polytetrafluoroethylene (PTFE), polyhexafluoropropylene (PHFP) and polychlorotrifluoroethylene (PCTFE) were heated to their decomposition temperature in a high vacuum. The emitted fragments passed an electron cloud, condensed on a substrate and formed fluoropolymer film. Growth rate of PTFE and PHFP films increased up to a factor five in the presence of the electron cloud. Mass spectrometry revealed changes in the mass spectra of fragments generated by thermal decomposition only and formed under electron activation. The observed changes were different for each fluoropolymer. Infrared spectroscopy (IRS) showed that the structure of the films was close to the structure of the bulk polymers. Atomic force microscopy (AFM) has revealed different morphologies of PTFE, PHFP and PCTFE films, suggesting a Volmer–Weber growth mechanism for PTFE and PHFP but a Frank-van der Merwe one for PCTFE. All films were smooth at nanoscale and transparent from ultraviolet to near-infrared region. Additional radio frequency (RF) plasma ignited in the emitted fragments at a low pressure increased mechanical characteristics of the films without losing their optical transparency and smoothness. KW - fluoropolymer thin film KW - vacuum deposition KW - polymerization KW - plasma KW - surface Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-13786 SN - 2571-9637 VL - 4 IS - 1 SP - 66 EP - 80 PB - MDPI ER - TY - JOUR A1 - Bondarenko, Siegfried A1 - Hülsemann, Marcel A1 - Mai, Andreas A1 - Steglich, Patrick T1 - Fiber-to-chip light coupling using a graded-index lensed fiber collimator JF - Optical Engineering N2 - Fiber-to-chip light coupling using a graded-index (GRIN) fiber collimator is investigated. Our experiments with grating couplers and strip waveguides fabricated in a photonic integrated circuit technology reveal that the peak coupling efficiency of a GRIN fiber collimator is 7.8 dB lower than that of a single-mode fiber. However, the 3-dB alignment tolerance is improved by a factor of about 5.7 giving rise to pluggable sensor solutions. This work opens a path toward a cost-effective and portable sensor platform based on pluggable photonic biosensors using GRIN fiber collimators. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-13749 SN - 1560-2303 VL - 60 IS - 1 PB - SPIE ER - TY - JOUR A1 - Riedel, Marc A1 - Höfs, Soraya A1 - Ruff, Adrian A1 - Schuhmann, Wolfgang A1 - Lisdat, Fred T1 - A Tandem Solar Biofuel Cell: Harnessing Energy from Light and Biofuels JF - Angewandte Chemie International Edition N2 - We report on a photobioelectrochemical fuel cell consisting of a glucose‐oxidase‐modified BiFeO3 photobiocathode and a quantum‐dot‐sensitized inverse opal TiO2 photobioanode linked to FAD glucose dehydrogenase via a redox polymer. Both photobioelectrodes are driven by enzymatic glucose conversion. Whereas the photobioanode can collect electrons from sugar oxidation at rather low potential, the photobiocathode shows reduction currents at rather high potential. The electrodes can be arranged in a sandwich‐like manner due to the semi‐transparent nature of BiFeO3, which also guarantees a simultaneous excitation of the photobioanode when illuminated via the cathode side. This tandem cell can generate electricity under illumination and in the presence of glucose and provides an exceptionally high OCV of about 1 V. The developed semi‐artificial system has significant implications for the integration of biocatalysts in photoactive entities for bioenergetic purposes, and it opens up a new path toward generation of electricity from sunlight and (bio)fuels. Y1 - 2021 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-13680 SN - 1521-3773 VL - 60 IS - 4 SP - 2078 EP - 2083 PB - Wiley ER -