TY - JOUR A1 - Schlegel, Volker A1 - Engels, Andreas A1 - Bifaretti, Stefano A1 - Foitzik, Andreas T1 - Validation of Material Parameters of Collagen Compositions for the Application as a Bioink JF - Materials Science Forum N2 - The novel approach of an individualized medicine affects nowadays various areas of therapeutic treatment. Primarily, these include the application of pharmaceuticals, private point-of-care solutions, surgical procedures as well as steps of rehabilitation. However, beside these existing strategies the development of patient specific models for the training of clinical personal is currently insufficient. Such models are essential to prepare a personalized approach of medical care. One possible solution to address this problem could be the adaption of the established 3d printing technology for the processing of suitable biopolymers. The presented work is focused on the development of a printing system utilizing collagen. Therefore, it is intended to design multiple extrusion heads in accordance with the material parameters. In order to achieve the aspired physiological properties of the final model, a first set of experiments will be performed with several compositions of collagen to validate the fundamental mechanical characteristics. Hereby, the elasticity, thermal stability, force resistance as well as the haptic behaviour are of most interest. Afterwards, these obtained experimental results should be used to simulate the extrusion process and to validate the extruder concepts. In case of a positive evaluation these concepts are realized by using rapid prototyping technologies. Finally, this novel 3d printer will be used to print first organic test structures with collagen. KW - bio-ink KW - bioprinting KW - collagen KW - validation of material parameters Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18764 SN - 0255-5476 SN - 1662-9752 VL - 941 SP - 2437 EP - 2441 PB - Trans Tech Publications ER - TY - JOUR A1 - Engels, Andreas A1 - Zinn, Steffen A1 - Bonaiuto, Vincenzo A1 - Foitzik, Andreas T1 - Improved Syringe Extruder for Improved Processing of Biological Materials JF - Materials Science Forum N2 - 3 dimensional (3D) printing evolved during the last decade to a consumer friendly and affordable craft. Furthermore, implementations of this techniques in the field of biotechnological research and development within laboratories is a very expansive process. Bio-printers’ prices cover a wide spectrum and most basic models are available for around 5000€. On the other end, high-end printer machines with a vast variety of features are available for several hundreds of thousands of euros. Thus, due to the immense potential in the field of Biotechnology the availability of this technology for research purpose should be enhanced. A developed ecological syringe extruder prototype for processing of biological based gels has been further improved. The original prototype was capable to processing multiple layers of agar with concentrations of 1% and 2.5%. Based on these results the prototype was revised regarding printing process parameter, which include among others applied forces to the substrate, air-ventilation, and heating of the substrate. The process behavior will be simulated with computational fluid dynamics for the processing of biological based substrate. After a concluding validation these results are intended to be implemented into a new design for improved processing of a variety of bioinks. KW - biofabrication KW - bio-ink KW - bioprinting KW - Open Source KW - process parameter improvement Y1 - 2018 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-18701 SN - 0255-5476 SN - 1662-9752 VL - 941 SP - 2442 EP - 2447 PB - Trans Tech Publications ER -