TY - CHAP A1 - Tannenberg, Robert A1 - Paul, Martin A1 - Fünning, Tabea A1 - Schumann, Christoph A1 - Weller, Michael G. A1 - Steglich, Patrick ED - Baldini, Francesco ED - Homola, Jiri ED - Lieberman, Robert A. T1 - Multichannel real-time detection of biomarkers with highly miniaturized photonic microchips T2 - Proceedings of SPIE : Optical Sensors 2025 N2 - The development of novel photonic integrated microchips (PIC) is a promising approach to allow for the convenient detection of key biomarkers in complex matrices through multichannel real-time analysis in a highly compact package. This study reports the successful development and application of a backside released CMOS chip designed for the multichannel real-time detection of biomarkers. Operating at the C-band at approx. 1550 nm, the microchip features three dedicated detection sensors in addition to a reference sensor, enabling simultaneous analysis of multiple biomarkers. The compact and highly miniaturized design of this microchip, with a footprint of just 1 mm², positions it as promising candidate for point-of-care diagnostics and personalized medicine applications. This technology opens a path to transform biomarker detection across various medical fields, offering rapid, reliable, and cost-effective diagnostic solutions. In conclusion, the presented multichannel photonic microchips signify a substantial leap forward in real-time biomarker detection, providing a highly capable platform for future research and clinical applications. KW - photonic biosensor KW - silicon photonics KW - photonic integrated circuit KW - immunosensor KW - biochemical sensor KW - optical biosensor KW - surface functionalization Y1 - 2025 U6 - http://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:kobv:526-opus4-20456 VL - 13527 PB - SPIE ER -