<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>629</id>
    <completedYear>2015</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>887</issue>
    <volume>15</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case</title>
    <abstract language="eng">Approximately 10–15 % of gastrointestinal stromal tumors (GISTs) lack gain of function mutations in the KIT and platelet-derived growth factor receptor alpha (PDGFRA) genes. An alternate mechanism of oncogenesis through loss of function of the succinate-dehydrogenase (SDH) enzyme complex has been identified for a subset of these “wild type” GISTs.</abstract>
    <parentTitle language="eng">BMC Cancer</parentTitle>
    <identifier type="issn">1471-2407</identifier>
    <identifier type="urn">urn:nbn:de:kobv:526-opus4-6292</identifier>
    <enrichment key="SourceTitle">Belinsky et al. Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case. BMC Cancer (2015) 15:887</enrichment>
    <enrichment key="DOI_VoR">https://doi.org/10.1186/s12885-015-1872-y</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Martin G. Belinsky</author>
    <author>Lori Rink</author>
    <author>Kathy Q. Cai</author>
    <author>Stephen J. Capuzzi</author>
    <author>Yen Hoang</author>
    <author>Jeremy Chien</author>
    <author>Andrew K. Godwin</author>
    <author>Margaret von Mehren</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>gastrointestinal stromal tumor (GIST)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>wild type</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>KIT</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>PDGFRA</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>succinate dehydrogenase (SDH)</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>NF1</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MAX</value>
    </subject>
    <collection role="ddc" number="616">Krankheiten</collection>
    <collection role="institutes" number="">Fachbereich Ingenieur- und Naturwissenschaften</collection>
    <collection role="open_access" number="">open_access</collection>
    <collection role="green_open_access" number="1">Gold Open Access</collection>
    <thesisPublisher>Technische Hochschule Wildau</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-th-wildau/files/629/Fs12885-015-1872-y.pdf</file>
  </doc>
</export-example>
