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  <doc>
    <id>1964</id>
    <completedYear>2024</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue>45</issue>
    <volume>20</volume>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Quantum Dot/TiO2 Nanocomposite-Based Photoelectrochemical Sensor for Enhanced H2O2 Detection Applied for Cell Monitoring and Visualization</title>
    <abstract language="eng">This work exploits the possibility of using CdSe/ZnS quantum dot (QD)-electrodes to monitor the metabolism of living cells based on photoelectrochemical (PEC) measurements. To realize that, the PEC setup is improved with respect to an enhanced photocurrent signal, better stability, and an increased signal-to-noise ratio, but also for a better biocompatibility of the sensor surface on which cells have been grown. To achieve this, a QD-TiO2 heterojunction is introduced with the help of atomic layer deposition (ALD). The heterojunction reduces the charge carrier recombination inside the semiconductor nanoparticles and improves the drift behavior. The PEC performance is carefully analyzed by adjusting the TiO2 thickness and combining this strategy with multilayer immobilizations of QDs. The optimal thickness of this coating is ≈5 nm; here, photocurrent generation can be enhanced significantly (e.g., for a single QD layer electrode by more than one order of magnitude at 0 V vs Ag/AgCl). The resulting optimized electrode is used for hydrogen peroxide (H2O2) sensing with a good sensitivity down to µmolar concentrations, reusability, stability, response rate, and repeatability. Finally, the sensing system is applied to monitor the activity of cells directly grown on top of the electrode surface.</abstract>
    <parentTitle language="eng">Small</parentTitle>
    <identifier type="urn">urn:nbn:de:kobv:526-opus4-19642</identifier>
    <enrichment key="opus.import.data">@articlehttps://doi.org/10.1002/smll.202401703, author = Zhao, Shuang and Yue, Zhao and Zhu, Dingcheng and Harberts, Jann and Blick, Robert H. and Zierold, Robert and Lisdat, Fred and Parak, Wolfgang J., title = Quantum Dot/TiO2 Nanocomposite-Based Photoelectrochemical Sensor for Enhanced H2O2 Detection Applied for Cell Monitoring and Visualization, journal = Small, volume = 20, number = 45, pages = 2401703, keywords = biocompatible interface with atomic layer deposition, biosensor, detection of cellular metabolism, light addressable potentiometric sensor, photocurrent measurements, doi = https://doi.org/10.1002/smll.202401703, url = https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.202401703, eprint = https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.202401703, abstract = Abstract This work exploits the possibility of using CdSe/ZnS quantum dot (QD)-electrodes to monitor the metabolism of living cells based on photoelectrochemical (PEC) measurements. To realize that, the PEC setup is improved with respect to an enhanced photocurrent signal, better stability, and an increased signal-to-noise ratio, but also for a better biocompatibility of the sensor surface on which cells have been grown. To achieve this, a QD-TiO2 heterojunction is introduced with the help of atomic layer deposition (ALD). The heterojunction reduces the charge carrier recombination inside the semiconductor nanoparticles and improves the drift behavior. The PEC performance is carefully analyzed by adjusting the TiO2 thickness and combining this strategy with multilayer immobilizations of QDs. The optimal thickness of this coating is ≈5 nm; here, photocurrent generation can be enhanced significantly (e.g., for a single QD layer electrode by more than one order of magnitude at 0 V vs Ag/AgCl). The resulting optimized electrode is used for hydrogen peroxide (H2O2) sensing with a good sensitivity down to µmolar concentrations, reusability, stability, response rate, and repeatability. Finally, the sensing system is applied to monitor the activity of cells directly grown on top of the electrode surface., year = 2024</enrichment>
    <enrichment key="opus.import.dataHash">md5:796e847dc9eff714a32890afdc7957fc</enrichment>
    <enrichment key="opus.import.date">2024-11-13T07:11:31+00:00</enrichment>
    <enrichment key="opus.import.file">/tmp/phpyXWzpI</enrichment>
    <enrichment key="opus.import.format">bibtex</enrichment>
    <enrichment key="opus.import.id">67345123ddc930.66025178</enrichment>
    <enrichment key="DOI_VoR">https://doi.org/10.1002/smll.202401703</enrichment>
    <enrichment key="SourceTitle">S. Zhao, Z. Yue, D. Zhu, J. Harberts, R. H. Blick, R. Zierold, F. Lisdat, W. J. Parak, Quantum Dot/TiO2 Nanocomposite-Based Photoelectrochemical Sensor for Enhanced H2O2 Detection Applied for Cell Monitoring and Visualization. Small 2024, 20, 2401703. https://doi.org/10.1002/smll.202401703</enrichment>
    <licence>Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International</licence>
    <author>Shuang Zhao</author>
    <author>Zhao Yue</author>
    <author>Dingcheng Zhu</author>
    <author>Jann Harberts</author>
    <author>Robert H. Blick</author>
    <author>Robert Zierold</author>
    <author>Fred Lisdat</author>
    <author>Wolfgang J. Parak</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>biocompatible interface with atomic layer deposition</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>biosensor</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>detection of cellular metabolism</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>light addressable potentiometric sensor</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>photocurrent measurements</value>
    </subject>
    <collection role="ddc" number="541">Physikalische Chemie</collection>
    <collection role="ddc" number="571">Physiologie und verwandte Themen</collection>
    <collection role="institutes" number="">Fachbereich Ingenieur- und Naturwissenschaften</collection>
    <collection role="open_access" number="">open_access</collection>
    <collection role="green_open_access" number="4">Hybrid Open Access</collection>
    <thesisPublisher>Technische Hochschule Wildau</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-th-wildau/files/1964/1964.pdf</file>
  </doc>
</export-example>
