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  <doc>
    <id>1481</id>
    <completedYear>2020</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4509</pageFirst>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>11</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A moonlighting role for enzymes of glycolysis in the co-localization of mitochondria and chloroplasts</title>
    <abstract language="eng">Glycolysis is one of the primordial pathways of metabolism, playing a pivotal role in energy metabolism and biosynthesis. Glycolytic enzymes are known to form transient multi-enzyme assemblies. Here we examine the wider protein-protein interactions of plant glycolytic enzymes and reveal a moonlighting role for specific glycolytic enzymes in mediating the co-localization of mitochondria and chloroplasts. Knockout mutation of phosphoglycerate mutase or enolase resulted in a significantly reduced association of the two organelles. We provide evidence that phosphoglycerate mutase and enolase form a substrate-channelling metabolon which is part of a larger complex of proteins including pyruvate kinase. These results alongside a range of genetic complementation experiments are discussed in the context of our current understanding of chloroplast-mitochondrial interactions within photosynthetic eukaryotes.</abstract>
    <parentTitle language="eng">Nature Communications</parentTitle>
    <identifier type="issn">2041-1723</identifier>
    <identifier type="urn">urn:nbn:de:kobv:526-opus4-14812</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="SourceTitle">Zhang, Y., Sampathkumar, A., Kerber, S.ML. et al. A moonlighting role for enzymes of glycolysis in the co-localization of mitochondria and chloroplasts. Nat Commun 11, 4509 (2020). https://doi.org/10.1038/s41467-020-18234-w</enrichment>
    <enrichment key="DOI_VoR">https://doi.org/10.1038/s41467-020-18234-w</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Youjun Zhang</author>
    <author>Arun Sampathkumar</author>
    <author>Sandra Mae-Lin Kerber</author>
    <author>Corné Swart</author>
    <author>Carsten Hille</author>
    <author>Kumar Seerangan</author>
    <author>Alexander Graf</author>
    <author>Lee Sweetlove</author>
    <author>Alisdair R. Fernie</author>
    <collection role="ddc" number="570">Biowissenschaften; Biologie</collection>
    <collection role="open_access" number="">open_access</collection>
    <collection role="green_open_access" number="1">Gold Open Access</collection>
    <collection role="institutes" number="">Zentrum für Forschung und Transfer</collection>
    <thesisPublisher>Technische Hochschule Wildau</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-th-wildau/files/1481/s41467-020-18234-w.pdf</file>
  </doc>
</export-example>
