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  <doc>
    <id>1390</id>
    <completedYear>2019</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>4533</pageFirst>
    <pageLast>4540</pageLast>
    <pageNumber/>
    <edition/>
    <issue>17</issue>
    <volume>6</volume>
    <type>article</type>
    <publisherName>Wiley</publisherName>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Electrochemical Activity Determination of Catechol-O-methyl Transferase by Selective Dopamine Detection</title>
    <abstract language="eng">For the treatment of Parkinson's disease, as one of the most frequent diseases of the central nervous system, several key enzymes for dopamine metabolism [e. g. catechol-O-methyl transferase (COMT)] are drug targets. For an efficient and long-lasting treatment, the activity of this enzyme should be monitored. In this study, an electrochemical approach using differential pulse voltammetry (DPV) is introduced for the activity determination. The applied electrode material, fluorine-doped tin oxide (FTO), is characterized by a clear discrimination between substrate and product of COMT, a high stability of the dopamine signal during consecutive measurements, and a linear dependency on the dopamine concentration in the range of the maximum reaction rate of COMT. Despite these advantageous results, dopamine detection in the complete activity assay is influenced by each of the added essential assay components, even though none of the added components reveal a current signal at the FTO electrode itself. After adjusting the potential range and the assay composition, these effects can be circumvented. By following the dopamine concentrations during COMT action, it can be shown that the activity of COMT can be detected by using differential pulse voltammetry (DPV) at an FTO electrode and, by analyzing different COMT amounts, quantification can be demonstrated.</abstract>
    <parentTitle language="eng">ChemElectroChem</parentTitle>
    <identifier type="urn">urn:nbn:de:kobv:526-opus4-13900</identifier>
    <enrichment key="opus.import.date">2021-04-07T08:20:21+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">sword</enrichment>
    <enrichment key="opus.import.file">filename=phpOrq1vv</enrichment>
    <enrichment key="opus.import.checksum">b1a5d427c690597d93daf1cd17822d4d</enrichment>
    <enrichment key="SourceTitle">G. Göbel, A. Talke, U. Ahnert, F. Lisdat, ChemElectroChem 2019, 6, 4533.</enrichment>
    <enrichment key="DOI_VoR">https://doi.org/10.1002/celc.201900856</enrichment>
    <licence>Creative Commons - CC BY - Namensnennung 4.0 International</licence>
    <author>Gero Göbel</author>
    <author>Anja Talke</author>
    <author>Uwe Ahnert</author>
    <author>Fred Lisdat</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>catechol-O-methyl transferase</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>dopamine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>flow system</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>fluorine-doped tin oxide</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>sensing</value>
    </subject>
    <collection role="ddc" number="541">Physikalische Chemie</collection>
    <collection role="institutes" number="">Fachbereich Ingenieur- und Naturwissenschaften</collection>
    <collection role="open_access" number="">open_access</collection>
    <collection role="Import" number="import">Import</collection>
    <collection role="Funding" number="">Projekt DEAL</collection>
    <collection role="green_open_access" number="4">Hybrid Open Access</collection>
    <thesisPublisher>Technische Hochschule Wildau</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-th-wildau/files/1390/celc.201900856.pdf</file>
  </doc>
  <doc>
    <id>1235</id>
    <completedYear>2019</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>6151</pageFirst>
    <pageLast>6169</pageLast>
    <pageNumber/>
    <edition/>
    <issue>6</issue>
    <volume>13</volume>
    <type>article</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald</title>
    <abstract language="eng">Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the memory of ACS Nano associate editor Prof. Dr. Helmuth Möhwald, we discuss the developments and applications that are to come in LbL assembly, focusing on coatings, bulk materials, membranes, nanocomposites, and delivery vehicles.</abstract>
    <parentTitle language="eng">ACS Nano</parentTitle>
    <identifier type="issn">1936-086X</identifier>
    <identifier type="urn">urn:nbn:de:kobv:526-opus4-12356</identifier>
    <enrichment key="CopyrightInfo">This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.</enrichment>
    <enrichment key="SourceTitle">Zhao, S., Caruso, F., Dähne, L., Decher, G., De Geest, B., Fan, J., et al. (2019). The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth Möhwald ACS Nano. 13 (6), 6151-6169. 10.1021/acsnano.9b03326</enrichment>
    <enrichment key="DOI_VoR">https://doi.org/10.1021/acsnano.9b03326</enrichment>
    <licence>ACS AuthorChoice/Editors’ Choice</licence>
    <author>Shuang Zhao</author>
    <author>Frank Caruso</author>
    <author>Lars Dähne</author>
    <author>Gero Decher</author>
    <author>Bruno G. De Geest</author>
    <author>Jinchen Fan</author>
    <author>Neus Feliu</author>
    <author>Yury Gogotsi</author>
    <author>Paula T. Hammond</author>
    <author>Mark C. Hersam</author>
    <author>Ali Khademhosseini</author>
    <author>Nicholas Kotov</author>
    <author>Stefano Leporatti</author>
    <author>Yan Li</author>
    <author>Fred Lisdat</author>
    <author>Luis M. Liz-Marzán</author>
    <author>Sergio Moya</author>
    <author>Paul Mulvaney</author>
    <author>Andrey L. Rogach</author>
    <author>Sathi Roy</author>
    <author>Dmitry G. Shchukin</author>
    <author>Andre G. Skirtach</author>
    <author>Molly M. Stevens</author>
    <author>Gleb B. Sukhorukov</author>
    <author>Paul S. Weiss</author>
    <author>Zhao Yue</author>
    <author>Dingcheng Zhu</author>
    <author>Wolfgang J. Parak</author>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="institutes" number="">Fachbereich Ingenieur- und Naturwissenschaften</collection>
    <collection role="open_access" number="">open_access</collection>
    <collection role="green_open_access" number="4">Hybrid Open Access</collection>
    <thesisPublisher>Technische Hochschule Wildau</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-th-wildau/files/1235/acsnano.9b03326.pdf</file>
  </doc>
  <doc>
    <id>1077</id>
    <completedYear>2019</completedYear>
    <publishedYear/>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst>11</pageFirst>
    <pageLast>17</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume>23</volume>
    <type>articlewildau</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>1</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Quantum Dot-modifizierte TiO2-Strukturen für die Licht-gesteuerte Bioelektrokatalyse</title>
    <abstract language="deu">Die funktionale Kopplung von photoaktiven Nanostrukturen mit Enzymen stellt eine neue Strategie zum Aufbau lichtgesteuerter biohybrider Systeme dar. Hier sind Untersuchungen zusammengefasst, welche die effiziente Kontaktierung der FAD-abhängigen Glukosedehydrogenase (FAD-GDH) mit Hilfe eines Osmium-Redoxpolymers (P Os ) an PbS-Quantum Dots (PbS QDs) zeigen, welche direkt auf dreidimensionalen TiO 2 -Elektrodenstrukturen synthetisiert wurden. Diese biohybriden Strukturen erlauben die Licht-induzierte Oxidation von Glukose. Dazu wird zunächst ein Verfahren vorgestellt, bei welchem durch den Aufbau invers-opaler TiO 2 (IO-TiO 2 ) Strukturen hohe Bindungskapazitäten für die Integration von QDs, Redoxpolymer und Enzym erreicht werden. In Folge wird gezeigt wie elektrochemische Signalketten durch Licht gesteuert werden können, indem Ladungsträger in den QDs unter Beleuchtung erzeugt werden. Diese Aktivierung ermöglicht dann die Ausbildung einer Elektrontransferkaskade vom Enzym über das Redoxpolymer zu den QDs und final zur IO-TiO 2 -Elektrode. Die resultierenden anodischen Photoströme können durch das Potential, die Lichtintensität und die Glukosekonzentration moduliert werden. So können in Anwesenheit von Glukose Photoströme von bis zu 207 μA/cm2 und erste Oxidationssignale bereits bei einem Potential von -540 mV vs Ag/AgCl, 1 M KCl erhalten werden. Dies entspricht einem Potentialgewinn von über 500  mV im Vergleich zu nicht lichtsensitiven Elektroden. Das vorgestellte biohybride System kombiniert Vorteile einer großen Oberfläche (durch IO-TiO 2 -Struktur), die effiziente Ladungsträgergenerierung und -trennung an der QD/TiO 2 -Schnittstelle sowie die effiziente Kontaktierung von FAD-GDH mit den QDs mit Hilfe eines Redoxpolymers. Die Ergebnisse verdeutlichen das Potential dieser leistungsfähigen Photobioanode für die Sensorik und die Erzeugung von Energie aus Licht und Glukose.</abstract>
    <abstract language="eng">The combination of photoactive nanostructures with enzymes represents a new strategy for the construction of light-directed biohybrid systems. The study demonstrates the efficient linkage of FAD-dependent glucose dehydrogenase (FAD-GDH) to PbS quantum dot (QD)-sensitized inverse opal TiO 2 (IO-TiO 2 ) electrodes using an osmium redox polymer (P Os ). How these biohybrid structures can oxidize glucose in a light-directed fashion is highlighted in detail. For this purpose, firstly a method for the construction of IO-TiO 2 electrodes is presented, which gives rise to high binding capacities for the integration of QDs, redox polymer and enzyme. It can be shown how electrochemical signal chains can be controlled with light, resulting in a generation of charge carriers within the QDs. The activation of the electron transfer cascade then allows for an electron transfer from the enzyme via the redox polymer to the QDs and finally to the IO-TiO 2 electrode. The resulting anodic photocurrents can be modulated by potential, light intensity and glucose concentration. In the presence of glucose, photocurrents of up to 207 μA/cm 2 can be generated and first electron withdrawal from the biocatalytic&#13;
sugar oxidation already proceeds at a potential of -540 mV vs Ag/AgCl (1 M KCl). This corresponds to a potential gain of over 500 mV compared to light-insensitive electrodes. The proposed biohybrid system combines the advantages of a large surface area (IO-TiO 2 ), efficient charge carrier generation (PbS QDs) and separation at the TiO 2 /QDs interface and the efficient linkage of FAD-GDH to the QDs using a redox polymer. This illustrates the potential of this powerful photobioanode for sensing and power supply.</abstract>
    <parentTitle language="deu">Wissenschaftliche Beiträge 2019</parentTitle>
    <identifier type="doi">10.15771/0949-8214_2019_2</identifier>
    <identifier type="issn">0949-8214</identifier>
    <identifier type="urn">urn:nbn:de:kobv:526-opus4-10773</identifier>
    <enrichment key="ZSTiteliD">16238</enrichment>
    <enrichment key="DataCiteUrl">https://commons.datacite.org/doi.org/10.15771/0949-8214_2019_2</enrichment>
    <licence>Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International</licence>
    <author>Marc Riedel</author>
    <author>Daniel Schäfer</author>
    <author>Wolfgang J. Parak</author>
    <author>Adrian Ruff</author>
    <author>Wolfgang Schuhmann</author>
    <author>Fred Lisdat</author>
    <collection role="ddc" number="620">Ingenieurwissenschaften und zugeordnete Tätigkeiten</collection>
    <collection role="ddc" number="660">Chemische Verfahrenstechnik</collection>
    <collection role="Publikationen_der_TH_Wildau" number="">Wissenschaftliche Beiträge</collection>
    <collection role="institutes" number="">Fachbereich Ingenieur- und Naturwissenschaften</collection>
    <collection role="open_access" number="">open_access</collection>
    <collection role="green_open_access" number="3">Diamond Open Access</collection>
    <thesisPublisher>Technische Hochschule Wildau</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-th-wildau/files/1077/0949-8214_2019_2.pdf</file>
  </doc>
</export-example>
