@article{LobsteinZinnMinierietal.2018, author = {Lobstein, Susanne and Zinn, Steffen and Minieri, Marilena and Foitzik, Andreas}, title = {Sample Analysis for Novel Medical Applications}, series = {Materials Science Forum}, volume = {941}, journal = {Materials Science Forum}, publisher = {Trans Tech Publications}, issn = {0255-5476}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-18749}, pages = {2518 -- 2521}, year = {2018}, abstract = {The sample preparation for biological and chemical probes involves following a strict workflow to eliminate any contamination to the sample beforehand. Furthermore, it is time consuming and must be carried out by trained personnel such as a nurse or other supervisors, making it therefore expensive. The development of novel sample preparation techniques paired with modern sample analysis systems is focused on improving the operability while keeping a constant quality of results. This is important to analyse samples, which cannot be determined with current screening conditions. The analysis of analytes is required to receive a more detailed picture of the patient and to fully understand its complexity. Possible samples for in-depth analysis of chemical origin can be cholesterol or glucose. More complex samples, such as blood or saliva, require a sophisticated system, which analyses the samples for their individual compounds.}, language = {en} } @article{EngelsSchlegelJacobsetal.2021, author = {Engels, Andreas and Schlegel, Volker and Jacobs, Hannes and Großelindemann, Niklas and Morshed, Md. Niaz and Stenglein, Antonia Sigrid and Bonaiuto, Vincenzo and Foitzik, Andreas}, title = {3d Printer Heads for Extrusion of Biologicals Gels}, series = {Materials Science Forum}, volume = {1016}, journal = {Materials Science Forum}, publisher = {Trans Tech Publications}, issn = {0255-5476}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-18773}, pages = {435 -- 439}, year = {2021}, abstract = {Processing biological materials with 3-dimensional (3D) printers has attracted increasing interest in several research areas. At the same time, off-the-shelf solutions are increasingly available in a wider variety to meet the current market demand. However, most of the available bioprinters are closed source, thus, modifications are quite challenging or require an avoidable consultation process with the manufacturer. Furthermore, the entry prices for basic machines amount to several thousands of euros. Whereas, high-end 3D bio printers with a vast array of features are available for several hundred thousand euros. Due to the immense potential of this tool in the field of biotechnology it is important to extend the availability of this technology for research purposes in terms of adaptability and price. This ongoing work focuses on open-source 3D printer heads with the ability to extrude biological materials. The print heads include several techniques to process low as well as high viscose biomaterials such as agar and gelatin. Additionally, obstacles such as continuous substrate tempering or integration into existing 3D printers are addressed. The work presented is open source and thus freely adaptable to any user's specific needs. Our goal is to process a diverse range of biomaterials with different print techniques.}, language = {en} } @article{GottschalkStollfussLietzauetal.2017, author = {Gottschalk, Josefine Johanna and Stollfuß, Carsten and Lietzau, Kai-Henning and Foitzik, Andreas and Richetta, Maria}, title = {Conceptual study for long-term monitoring of chemotherapeutic induced cell reactions by ESPI}, series = {tm - Technisches Messen}, volume = {85}, journal = {tm - Technisches Messen}, number = {2}, issn = {2196-7113}, doi = {10.1515/teme-2017-0100}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-10676}, pages = {111 -- 118}, year = {2017}, abstract = {During the last years, various approaches on an individualized drug therapy for benign cells have been researched. However, due to the complex topic a universal approach has not been found up until this point. Commonly, the effect of cytotoxic drugs on benign cells is in most cases the same compared to regular cells while the actual effect on patient still can't be predicted. In order to reduce unwanted side effects or unspecific drug reactions a test system for patients which allows to analyse the interaction between cytotoxic agents and the targeted cells is needed. Furthermore, this should also include an adequate measurement system which is capable to work in a natural environment and without any additional preparation. In terms of this work, a first proof of concept with different benign cells and cytotoxic agents is presented while monitoring the obtained displacement using electronic speckle pattern interferometry (ESPI).}, language = {en} }