@article{VrabelStopkaRievajetal.2016, author = {Vrabel, Jan and Stopka, Ondrej and Rievaj, Vladimir and Sarkan, Branislav and Pruskova, Kristyna and Michalk, Philip}, title = {Measuring the Resistance of Tires for Passenger Vehicle against the Rolling and Sliding on Loading Area of the Flatbed Truck when Providing the Transport Services}, series = {Communications - Scientific Letters of the University of Zilina}, volume = {18}, journal = {Communications - Scientific Letters of the University of Zilina}, number = {2}, publisher = {University of Žilina}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21168}, pages = {124 -- 128}, year = {2016}, abstract = {This paper deals with the size of the forces affecting the vehicle during the transportation on a flatbed truck, railway wagon or container. It is necessary to secure the vehicle against these forces properly in order to prevent vehicles replacement. The laboratory measurements were performed in order to find out the size of coefficient of friction between the tire and the vehicles loading area. During the measurements, vehicle had different gears in order to determine to what extent the size of mechanical resistances affects the fixing and securing the vehicle against its replacement on the loading area. However, this paper does not propose the solution for securing the passenger vehicle on the loading area of a truck, railway wagon or container.}, language = {en} } @article{KubanovaSchmidt2016, author = {Kubanova, Jaroslava and Schmidt, Conrad}, title = {Multimodal and Intermodal Transportation Systems}, series = {Communications - Scientific Letters of the University of Zilina}, volume = {18}, journal = {Communications - Scientific Letters of the University of Zilina}, number = {2}, publisher = {University of Žilina}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21177}, pages = {104 -- 108}, year = {2016}, abstract = {The aim of this paper is to provide information on the general characterization of multimodal transport, intermodal and combined transport. There is also mentioned the distribution of basic transport processes and types of transhipment. Finally, this paper describes the practical examples of multimodal transport.}, language = {en} } @article{LizbetinVejsCahaetal.2016, author = {Lizbetin, Jan and Vejs, Petr and Caha, Zdenek and Lizbetinova, Lenka and Michalk, Philip}, title = {The Possibilities of Dynamic Shipment Weighing in Rail Freight Transport}, series = {Communications - Scientific Letters of the University of Zilina}, volume = {18}, journal = {Communications - Scientific Letters of the University of Zilina}, number = {2}, publisher = {University of Žilina}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21186}, pages = {113 -- 117}, year = {2016}, abstract = {This article deals with an analysis of the methods of the dynamic weighing of rail vehicles. The measurement of axle load (both static and dynamic) is one of the current standard processes within the technical specifications for interoperability (TSI).}, language = {en} } @article{LehnertLiebchenSchiefelbuschetal.2026, author = {Lehnert, Martin and Liebchen, Christian and Schiefelbusch, Martin and Bruder, Peter and Harmann, Dennis}, title = {Insights into Ridepooling efficiency: A case study analysis using a novel operational performance measure framework}, series = {Journal of Urban Mobility}, volume = {9}, journal = {Journal of Urban Mobility}, publisher = {Elsevier}, issn = {2667-0917}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-20971}, year = {2026}, abstract = {The efficiency of demand responsive transport (DRT) services, such as ridepooling, has garnered significant attention across various (simulation) studies. However, a deeper look into the metrics employed to assess system performance exposes notable discrepancies in their utilization. Notably, certain indicators, such as the pooling rate, demonstrate a susceptibility to manipulation based on input parameters, potentially skewing results to give a more favorable impression of service performance. In this paper, we show that, under such circumstances, achieving a fair comparison between study outcomes and with traditional (public) transport modes becomes challenging. In light of these challenges, this study introduces a novel operational performance indicator: Operational System Efficiency (OSE). OSE is tailored to evaluate the operational efficiency of ridepooling systems in a holistic way. In particular, it combines important operational indicators such as detour factor and empty kilometers share, which are considered in numerous analyses. Hereby, OSE is fostering a more equitable assessment of service performance. We applied this methodology and calculated the indicators provided in other studies to two real-world trip datasets from ridepooling services in Berlin and M{\"u}nster, Germany, and compared the results. Distinct disparities emerge in comparison with conventional efficiency indicators. Consequently, the proposed OSE holds promise for stakeholders, including service providers, public transport companies, and regulatory authorities, as a valuable tool for determining the suitability of a ridepooling service for a given locale relative to other transport modalities, while also providing a transparent assessment of its efficiency.}, language = {en} } @article{HerkenhoffBroedelFrohme2024, author = {Herkenhoff, Marcos Edgar and Br{\"o}del, Oliver and Frohme, Marcus}, title = {Hops across Continents: Exploring How Terroir Transforms the Aromatic Profiles of Five Hop (Humulus lupulus) Varieties Grown in Their Countries of Origin and in Brazil}, series = {Plants}, volume = {13}, journal = {Plants}, number = {19}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-19470}, year = {2024}, abstract = {Humulus lupulus, or hops, is a vital ingredient in brewing, contributing bitterness, flavor, and aroma. The female plants produce strobiles rich in essential oils and acids, along with bioactive compounds like polyphenols, humulene, and myrcene, which offer health benefits. This study examined the aromatic profiles of five hop varieties grown in Brazil versus their countries of origin. Fifty grams of pelletized hops from each strain were collected and analyzed using HS-SPME/GC-MS to identify volatile compounds, followed by statistical analysis with PLS-DA and ANOVA. The study identified 330 volatile compounds and found significant aromatic differences among hops from different regions. For instance, H. Mittelfr{\"u}her grown in Brazil has a fruity and herbaceous profile, while the German-grown variety is more herbal and spicy. Similar variations were noted in the Magnum, Nugget, Saaz, and Sorachi Ace varieties. The findings underscore the impact of terroir on hop aromatic profiles, with Brazilian-grown hops displaying distinct profiles compared to their counterparts from their countries of origin, including variations in aromatic notes and α-acid content.}, language = {en} } @article{HerkenhoffBroedelDilarrietal.2026, author = {Herkenhoff, Marcos Edgar and Br{\"o}del, Oliver and Dilarri, Guilherme and Bajay, Miklos Maximiliano and Frohme, Marcus and Costamilan, Carlos Andr{\´e} da Veiga Lima Rosa}, title = {Characterization of Volatile Compounds in Amarillo, Ariana, Cascade, Centennial, and El Dorado Hops Using HS-SPME/GC-MS}, series = {Compounds}, volume = {6}, journal = {Compounds}, number = {1}, publisher = {MDPI}, issn = {2673-6918}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21029}, year = {2026}, abstract = {Humulus lupulus L. (hops) is essential in brewing due to its contributions to bitterness, flavor, and aroma. This study compared the volatile profiles of five commercially important hop varieties—Amarillo, Ariana, Cascade, Centennial, and El Dorado—grown in their main regions of origin (United States for Amarillo, Cascade, and El Dorado; Germany for Ariana; and Brazil for Centennial). Headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry (HS-SPME/GC-MS) enabled the identification of 312 volatile compounds, including monoterpenes (e.g., myrcene, linalool, geraniol), sesquiterpenes (e.g., humulene, caryophyllene), esters, alcohols, aldehydes, and ketones. Amarillo showed the highest myrcene content (22.61\% of the total volatile area), while Centennial was distinguished by elevated γ-muurolene (20.59\%), and El Dorado by the highest level of undecan-2-one (10.47\%), highlighting marked varietal differences in key aroma-active constituents. Multivariate, including principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA), clearly discriminated the five varieties: PC1 (41.04\% of the variance) separated samples enriched in fruity/floral monoterpenes and esters from those dominated by woody/resinous sesquiterpenes, whereas PC2 (25.93\% of the variance) reflected variation in medium-chain esters, ketones, and waxy compounds. These chemometric patterns demonstrate that both genetic background and growing region terroir strongly shape hop volatile composition and, consequently, aroma potential, providing brewers with objective criteria for selecting hop varieties to achieve specific sensory profiles in beer.}, language = {en} } @article{KsianzouVillringerGrytsenkoetal.2025, author = {Ksianzou, Viachaslau and Villringer, Claus and Grytsenko, Kostyantyn and Pekur, Demyd and Lytvyn, Peter and Sopinskyy, Mykola and Lebedyeva, Iryna and Niemczyk, Agata and Baranowska, Jolanta}, title = {Structural and Optical Anomalies in Thin Films Grown in a Magnetic Field by Electron-Assisted Vacuum Deposition of PTFE}, series = {Macromolecular Materials and Engineering}, volume = {310}, journal = {Macromolecular Materials and Engineering}, number = {3}, publisher = {Wiley}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-19712}, year = {2025}, abstract = {Polytetrafluoroethylene (PTFE) films are deposited in parallel and perpendicular magnetic fields (MF) by electron-enhanced vacuum deposition (EVD) and EVD + low-temperature plasma (LTP) methods. The structure, morphology, and nanomechanical properties of the films are studied by infrared spectroscopy (IRS), atomic force microscopy (AFM), and spectroscopic ellipsometry. The structure of the thicker films is closer to that of bulk PTFE than that of thin films. The films' crystallinity and surface roughness are higher than those deposited without MF. The birefringence of the refractive index (n) of the films deposited in the MF is inverse to the anisotropy of the n of the films deposited without MF. The hardness of the films is close to that of bulk PTFE.}, language = {en} } @article{SishodiaBenLtaiefScheeletal.2026, author = {Sishodia, Keshav and Ben Ltaief, Ltaief and Scheel, Niklas and F{\"o}ldes, Istv{\´a}n B. and Roos, Andreas Hult and Albrecht, Martin and Staněk, Maty{\´a}š and Jurkovičov{\´a}, Lucie and Hort, Ondrej and Nejdl, Jaroslav and Garc{\´i}a-Alfonso, Ernesto and Halberstadt, Nadine and Andreasson, Jakob and Klimešov{\´a}, Eva and Krikunova, Maria and Krishnan, Sivarama and Heidenreich, Andreas and Mudrich, Marcel}, title = {XUV fluorescence as a probe of interatomic coulombic decay of resonantly excited He nanodroplets}, series = {Scientific Reports}, volume = {16}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21050}, year = {2026}, abstract = {Superfluid He nanodroplets resonantly excited by extreme ultraviolet (XUV) pulses can relax via interatomic coulombic decay (ICD), generally considered an ultrafast process. Here, we introduce a novel approach to probe the dynamics of ICD in He nanodroplets over timescales ranging from femtoseconds to nanoseconds. Our method relies on detecting XUV fluorescence emitted from the nanodroplets as they are driven into a nanoplasma by subsequent intense infrared pulses. Nanoplasma ignition is facilitated by tunnel ionization of XUV-excited He∗ atoms attached to the droplets; it thus serves as a sensitive probe of their relaxation dynamics. The observed nanosecond-scale decay is attributed to ICD between pairs of He∗ atoms undergoing roaming motion on the droplet surface, as supported by quantum-mechanical and classical model calculations.}, language = {en} } @inproceedings{GrossKuhlStephanetal.2023, author = {Gross, Matthias and Kuhl, Thorsten and Stephan, Frank and Li, Xiangkun and Philipp, Sebastian and Grebinyk, Anna and Khachatryan, Vitali and Qian, Houjun and Aboulbanine, Zakaria and Amirkhanyan, Zohrab and Riemer, Felix and Oppelt, Anne and Krasilnikov, Mikhail}, title = {A beam line setup for flash radiation therapy with focused electron beams at the Pitz facility at DESY in Zeuthen: basic concept and dosimetry simulations}, series = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, booktitle = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, editor = {Istituto Nazionale Di Fisca Nucleare,}, publisher = {JACoW Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21132}, pages = {5000 -- 5003}, year = {2023}, abstract = {The aim of this work is to demonstrate the principal possibility to enhance the electron beam dose deposition in the depth of the sample for radiation therapy purposes. Trains of electron bunches of 22 MeV generated at PITZ are focused inside the sample using a dedicated fast deflector and a solenoid magnet. To explore the capabilities of the proposed setup, dose distributions are calculated for multiple electron bunches focused in a single point inside a water phantom. Electron beam focusing produces dose peaks with a tunable maximal dose depth which is interesting for healthy tissue sparing at the surface and enhancing treatment quality. The duration of the full bunch train is 1 ms. During this time interval, the FLASH effect could be efficiently triggered inside the irradiated target volume. Monte Carlo simulations based on the FLUKA code were performed to evaluate the depth dose curves distributions in a water phantom. Using the PITZ electron beam parameters, simulations have shown the possibility to produce a peak dose in water seven times higher than compared to the dose at the surface. Moreover, the RMS size homogeneous area around the maximal dose is approximately 25 mm.}, language = {en} } @inproceedings{KrasilnikovAboulbanineAdhikarietal.2023, author = {Krasilnikov, Mikhail and Aboulbanine, Zakaria and Adhikari, Gowri and Aftab, Namra and Asoyan, Aida and Davtyan, Hakob and Georgiev, Georgi and Good, James and Grebinyk, Anna and Gross, Matthias and Hoffmann, Andreas and Kongmon, Ekkachai and Li, Xiangkun and Lueangaramwong, Anusorn and Melkumyan, David and Mohanty, Sandeep and Niemczyk, Raffael and Oppelt, Anne and Qian, Houjun and Richard, Christopher and Schneidmiller, Evgeny and Stephan, Frank and Vashchenko, Grygorii}, title = {THz SASE FEL at PITZ: lasing at a wavelength of 100μm}, series = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, booktitle = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, editor = {Istituto Nazionale Di Fisca Nucleare,}, publisher = {JACoW Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21113}, pages = {3948 -- 3951}, year = {2023}, abstract = {Development of an accelerator-based tunable THz source prototype for pump-probe experiments at the European XFEL is ongoing at the Photo Injector Test facility at DESY in Zeuthen (PITZ). The proof-of-principle experiments on the THz SASE FEL are performed utilizing the LCLS-I undulator installed in the PITZ beamline. The first lasing at a center wavelength of 100 µm was observed in the summer of 2022. The lasing of the narrowband THz source was achieved using an electron beam with an energy of ~17 MeV and a bunch charge up to several nC. Optimization of beam transport and matching resulted in the measurement of THz radiation with a pulse energy of tens of µJ, measured with pyroelectric detectors. The THz FEL gain curves were measured by means of specially designed short coils along the undulator. The results of the first characterization of the THz source at PITZ will be presented.}, language = {en} } @article{SpeckVeronaReiffStephanetal.2026, author = {Speck, Sandy and Verona, Claudio and Reiff-Stephan, J{\"o}rg and B{\"o}hme, Andrea and Foitzik, Andreas}, title = {Development of a Realistic Brain Phantom for Medical Education: An Ethical and Technical Alternative to Animal Testing}, series = {Key Engineering Materials}, volume = {1038}, journal = {Key Engineering Materials}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21070}, pages = {67 -- 72}, year = {2026}, abstract = {This study presents the development of a realistic brain phantom as a humane, practical alternative to animal use in medical training, in line with the 3R principles and Directive 2010/63/EU. The phantom is designed to support ultrasound-based education for diagnostic and interventional procedures while improving patient safety through controlled, repeatable practice. High‑resolution CT data were converted to CAD models and additively manufactured as moulds; a gelatin‑based soft‑tissue matrix with glycerin and potassium sorbate provides elasticity and durability. Functional features include fluid‑fillable ventricular structures enabling drainage and puncture simulations, and an integrated high‑density tumour insert to model advanced scenarios. Ultrasound evaluation demonstrated clear echogenic differentiation between tumour, ventricles, and surrounding tissue, confirming the model's imaging fidelity and suitability for hands‑on training. The phantom proved cost‑efficient and reusable, facilitating standardised teaching of complex procedures without ethical approval barriers. A limitation is the material's gradual mechanical instability under repeated probe contact, motivating investigations into synthetic or hybrid matrices to enhance longevity and reuse. Overall, the brain phantom constitutes an ethical, technically robust, and resource‑efficient training tool that addresses critical needs in healthcare quality and safety by reducing avoidable errors through simulation‑based competence development.}, language = {en} } @inproceedings{GrossHoffmannGeorgievetal.2023, author = {Gross, Matthias and Hoffmann, Andreas and Georgiev, Georgi and Kuhl, Thorsten and Li, Xiangkun and Oppelt, Anne and Boonpornprasert, Prach and Philipp, Sebastian and Grebinyk, Anna and Vashchenko, Grygorii and Aftab, Namra and Adhikari, Gowri and Richard, Christopher and Stephan, Frank and Khachatryan, Vitali and Riemer, Felix and Krasilnikov, Mikhail and Amirkhanyan, Zohrab}, title = {Comparison of measurements and simulation results of dose for the FLASH radiation therapy beamline at PITZ}, series = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, booktitle = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, editor = {Istituto Nazionale Di Fisca Nucleare,}, publisher = {JACoW Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21126}, pages = {4996 -- 4999}, year = {2023}, abstract = {The high-brightness electron beam at the Photo Injector Test facility at DESY in Zeuthen (PITZ) is now also used for FLASHlab@PITZ: an R\&D platform for studying radiation biology and the FLASH effect in radiation therapy. The available parameter space of the electron beam with a momentum of 22 MeV/c allows bunch charges from 10 pC up to 5nC, bunch durations of 0.1-60ps, and bunch train lengths up to 1 ms. The number of bunches in the single train can currently be varied between 1 and 1000 bunches, with an upgrade to 4500 foreseen in 2023. Radiation biology studies require accurate dose prediction, therefore Monte Carlo simulations based on the FLUKA code were performed. According to estimations, dose delivery of 0.002 Gy (low charge case 0.1pC) and 10Gy (high charge case 5nC) is possible, if the beam is confined to a circular area with a radius of 5 mm with a lead collimator. For the Monte Carlo simulations, the experimental setup was accurately modeled, including the exit window, lead collimator, etc. Dose measurements were used to compare simulations with experiments. Dose profiles were experimentally measured with Gafchromic films and then compared with Monte Carlo simulations. The first experiments at FLASHlab@PITZ in 2023 have demonstrated flexible dose options for studying the FLASH effect and radiation biology studies.}, language = {en} } @article{RoggeZinnProspositoetal.2017, author = {Rogge, Christian and Zinn, Steffen and Prosposito, Paolo and Francini, Roberto and Foitzik, Andreas}, title = {Transmitted light pH optode for small sample volumes}, series = {Journal of Sensors and Sensor Systems}, volume = {6}, journal = {Journal of Sensors and Sensor Systems}, number = {2}, issn = {2194-878X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-10093}, pages = {351 -- 359}, year = {2017}, abstract = {An innovative concept of a low-cost pH optode with working volumes of less than 150 µL is presented. The pH monitoring is based on the color changing effect of pH indicators. The optode includes an RGB color sensor patch TCS34725 from Adafruit, a controllable LED and reactor slides and is addressed by a self-written LabVIEW© software. Utilizing the hue value of the HSV color model, it is possible to analyze the color change of the indicator and estimate the pH value of the analyzed samples by exploiting sigmoidal fit models. Measurements carried out with phenol red and DMEM (Dulbecco's Modified Eagle's Medium) reported a standard error of calibration in the physiologic pH range (6.5-7.5) of ±0.04 pH units.}, language = {en} } @article{KrausBoehmeRinati2026, author = {Kraus, Mirjam and B{\"o}hme, Andrea and Rinati, Gianluca Verona}, title = {Verification of a Novel Mathematical Model for Determination of the Biomass Specific Growth Rate in Bioprocesses Using Relative Change in Biomass Measurements}, series = {Defect and Diffusion Forum}, volume = {446}, journal = {Defect and Diffusion Forum}, publisher = {Trans Tech Publications}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21081}, pages = {57 -- 62}, year = {2026}, abstract = {This study presents a new mathematical model for determining the specific growth rate of biomass in biotechnological production processes, which aims to optimize the production of biotechnological products such as the advanced material polyhydroxyalkanoates. The specific growth rate is classified by the FDA as a critical process parameter that affects product quality and quantity, but is difficult for laboratory personnel to determine. Therefore, a simple and robust method for real-time monitoring and control is crucial. According to the current state of the art, the established Luedeking-Piret model for determining the specific growth rate requires the determination of the biomass as an absolute value to initialize the model and to determine two further model parameters. However, determining the biomass is time-consuming and error-prone. The new relative model replaces this value with the relative change in biomass, which can be easily recorded using standard laboratory methods such as optical density measurement. This eliminates the need for time-consuming and resource-intensive preliminary work. Despite this simplification, simulation tests have shown that the new model delivers identical results to the established model. It represents an independent, precise alternative and offers advantages in terms of handling. The results underline the model's potential to make bioprocesses more sustainable and efficient. Especially in research, material consumption, laboratory time and costs can be reduced compared to the established model. Future experiments will further investigate the performance of the new approach compared to the established model.}, language = {en} } @article{RoedenbeckHerold2026, author = {Roedenbeck, Marc and Herold, Marcel}, title = {Personality Profiles in Online Job Advertisements: Applying a Weighted Closed Vocabulary Approach to Identify Generic Profiles and Clusters}, series = {SAGE Open}, volume = {16}, journal = {SAGE Open}, number = {1}, publisher = {Sage}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21282}, year = {2026}, abstract = {On the background of the supplementary applicant-job fit theory, this study tests the application of a weighted closed vocabulary approach as introduced by Ostendorf on a large corpus of online job advertisements (OJA). Therefore, a large dataset of online job advertisements (OJAs) was scraped from a German job portal (N = 151k), and a sample (n = 3,239) was selected based upon Porter's Value Chain and corresponding job functions. The dataset was pre-processed with techniques of natural language processing, and the predefined words extracted from the OJAs were weighted with the average subject matter expert rating, as offered in the vocabulary of Ostendorf. The results reveal that, first, 0 to 12 words describing personality are used across OJAs, second, that HR, sales, and finance positions show values higher than sample mean (3.22), third, that HR positions show loadings across all dimensions of personality above the sample means (extroversion: 2.32, agreeableness: 3.98, conscientiousness: 4.28, emotional stability: 3.54, openness: 2.0) followed by sales. The job profiles being significantly parallel on equal levels are HR clerk and referee, as well as IT, R\&D, and procurement. While conscientiousness is reported to be an important predictor of performance, our study showed only low to average importance in OJAs.}, language = {en} } @article{ShamsSchmitzSmekhovaetal.2021, author = {Shams, S. Fatemeh and Schmitz, Detlef and Smekhova, Alevtina and Ghazanfari, Mohammad Reza and Giesen, Margret and Weschke, Eugen and Chen, Kai and Luo, Chen and Radu, Florin and Schmitz-Antoniak, Carolin}, title = {Element-specific contributions to improved magnetic heating of theranostic CoFe2O4 nanoparticles decorated with Pd}, series = {Scientific Reports}, volume = {11}, journal = {Scientific Reports}, issn = {2045-2322}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-14756}, year = {2021}, abstract = {Decoration with Pd clusters increases the magnetic heating ability of cobalt ferrite (CFO) nanoparticles by a factor of two. The origin of this previous finding is unraveled by element-specific X-ray absorption spectroscopy (XAS) and magnetic circular dichroism (XMCD) combined with atomic multiplet simulations and density functional theory (DFT) calculations. While the comparison of XAS spectra with atomic multiplet simulations show that the inversion degree is not affected by Pd decoration and, thus, can be excluded as a reason for the improved heating performance, XMCD reveals two interrelated responsible sources: significantly larger Fe and Co magnetic moments verify an increased total magnetization which enhances the magnetic heating ability. This is accompanied by a remarkable change in the field-dependent magnetization particularly for Co ions which exhibit an increased low-field susceptibility and a reduced spin canting behavior in higher magnetic fields. Using DFT calculations, these findings are explained by reduced superexchange between ions on octahedral lattice sites via oxygen in close vicinity of Pd, which reinforces the dominating antiparallel superexchange interaction between ions on octahedral and tetrahedral lattice sites and thus reduces spin canting. The influence of the delocalized nature of Pd 4d electrons on the neighboring ions is discussed and the conclusions are illustrated with spin density isosurfaces of the involved ions. The presented results pave the way to design nanohybrids with tailored electronic structure and magnetic properties.}, language = {en} } @article{KalishettyhalliMahadevaiahPerezLiskeretal.2022, author = {Kalishettyhalli Mahadevaiah, Mamathamba and P{\´e}rez, Eduardo and Lisker, Marco and Schubert, Markus Andreas and Perez-Bosch Quesada, Emilio and Wenger, Christian and Mai, Andreas}, title = {Modulating the Filamentary-Based Resistive Switching Properties of HfO₂ Memristive Devices by Adding Al₂O₃ Layers}, series = {Electronics}, volume = {11}, journal = {Electronics}, number = {10}, address = {MDPI}, issn = {2079-9292}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-16172}, year = {2022}, abstract = {The resistive switching properties of HfO₂ based 1T-1R memristive devices are electrically modified by adding ultra-thin layers of Al₂O₃ into the memristive device. Three different types of memristive stacks are fabricated in the 130 nm CMOS technology of IHP. The switching properties of the memristive devices are discussed with respect to forming voltages, low resistance state and high resistance state characteristics and their variabilities. The experimental I-V characteristics of set and reset operations are evaluated by using the quantum point contact model. The properties of the conduction filament in the on and off states of the memristive devices are discussed with respect to the model parameters obtained from the QPC fit.}, language = {en} } @article{HooglandBoettcherVerhoefetal.2016, author = {Hoogland, A. Marije and B{\"o}ttcher, Ren{\´e} and Verhoef, Esther and Jenster, Guido and van Leenders, Geert J.L.H.}, title = {Gene-expression analysis of gleason grade 3 tumor glands embedded in low- and high-risk prostate cancer}, series = {Oncotarget}, volume = {7}, journal = {Oncotarget}, number = {25}, issn = {1949-2553}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-6573}, pages = {37846 -- 37856}, year = {2016}, abstract = {The Gleason score (GS) of prostate cancer on diagnostic biopsies is an important parameter for therapeutic decision-making. Biopsy GS under-estimates the actual GS at radical prostatectomy in a significant number of patients due to samplingartifact. The aim of this study was to identify markers that are differentially expressed in Gleason grade 3 (GG3) tumor glands embedded in GS 4 + 3 = 7 and GS 3 + 3 = 6 prostate cancer using laser capture microdissection and RNA sequencing. GG3 tumor glands embedded in nine GS 3 + 3 = 6 and nine GS 4 + 3 = 7 prostate cancers were isolated by laser capture microdissection of frozen radical prostatectomy specimens. After RNA amplification and RNA sequencing, differentially expressed genes in both GG3 components were identified by a 2log fold change > 1.0 and p-value < 0.05. We applied immunohistochemistry on a tissue micro-array representing 481 radical prostatectomy samples for further validation on protein level. A total of 501 genes were up-regulated and 421 down-regulated in GG3 glands embedded in GS 4 + 3 = 7 as compared to GS 3 + 3 = 6 prostate cancer. We selected HELLS, ZIC2 and ZIC5 genes for further validation. ZIC5 mRNA was up-regulated 17 fold (p = 8.4E-07), ZIC2 8 fold (p = 1.3E-05) and HELLS 2 fold (p = 0.006) in GG3 glands derived from GS 4 + 3 = 7. HELLS expression of ≥ 1\% occurred in 10\% GS < 7, 17\% GS 7 and 43\% GS >7 prostate cancer (p < 0.001). Using a cut-off of ≥ 1\%, protein expression of ZIC5 was present in 28\% GS < 7, 43\% GS 7 and 57\% GS > 7 cancer (p < 0.001). ZIC2 was neither associated with GS nor outcome in our validation set. HELLS was independently predictive for biochemical-recurrence after radical prostatectomy (HR 2.3; CI 1.5-3.6; p < 0.01). In conclusion, HELLS and ZIC5 might be promising candidate markers for selection of biopsy GS 6 prostate cancer being at risk for up-grading at prostatectomy.}, language = {en} } @article{GrebinykPrylutskaBuchelnikovetal.2019, author = {Grebinyk, Anna and Prylutska, Svitlana and Buchelnikov, Anatoliy and Tverdokhleb, Nina and Grebinyk, Sergii and Evstigneev, Maxim and Matyshevska, Olga and Cherepanov, Vsevolod and Prylutskyy, Yuriy and Yashchuk, Valeriy and Naumovets, Anton and Ritter, Uwe and Dandekar, Thomas and Frohme, Marcus}, title = {C60 Fullerene as an Effective Nanoplatform of Alkaloid Berberine Delivery into Leukemic Cells}, series = {Pharmaceutics}, volume = {11}, journal = {Pharmaceutics}, number = {11}, publisher = {MDPI}, issn = {1999-4923}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12932}, year = {2019}, abstract = {A herbal alkaloid Berberine (Ber), used for centuries in Ayurvedic, Chinese, Middle-Eastern, and native American folk medicines, is nowadays proved to function as a safe anticancer agent. Yet, its poor water solubility, stability, and bioavailability hinder clinical application. In this study, we have explored a nanosized carbon nanoparticle—C60 fullerene (C60)—for optimized Ber delivery into leukemic cells. Water dispersions of noncovalent C60-Ber nanocomplexes in the 1:2, 1:1, and 2:1 molar ratios were prepared. UV-Vis spectroscopy, dynamic light scattering (DLS), and atomic force microscopy (AFM) evidenced a complexation of the Ber cation with the negatively charged C60 molecule. The computer simulation showed that π-stacking dominates in Ber and C60 binding in an aqueous solution. Complexation with C60 was found to promote Ber intracellular uptake. By increasing C60 concentration, the C60-Ber nanocomplexes exhibited higher antiproliferative potential towards CCRF-CEM cells, in accordance with the following order: free Ber < 1:2 < 1:1 < 2:1 (the most toxic). The activation of caspase 3/7 and accumulation in the sub-G1 phase of CCRF-CEM cells treated with C60-Ber nanocomplexes evidenced apoptosis induction. Thus, this study indicates that the fast and easy noncovalent complexation of alkaloid Ber with C60 improved its in vitro efficiency against cancer cells.}, language = {en} } @article{KoeberleinBankRothetal.2022, author = {K{\"o}berlein, Jana and Bank, Lukas and Roth, Stefan and K{\"o}se, Ekrem and Kuhlmann, Timm and Prell, Bastian and Stange, Maximilian and M{\"u}nnich, Marc and Flum, Dominik and Moog, Daniel and Ihlenfeldt, Steffen and Sauer, Alexander and Weigold, Matthias and Schilp, Johannes}, title = {Simulation Modeling for Energy-Flexible Manufacturing: Pitfalls and How to Avoid Them}, series = {Energies}, volume = {15}, journal = {Energies}, number = {10}, publisher = {MDPI}, issn = {1996-1073}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-16152}, year = {2022}, abstract = {Due to the high share of industry in total electricity consumption, industrial demand-side management can make a relevant contribution to the stability of power systems. At the same time, companies get the opportunity to reduce their electricity procurement costs by taking advantage of increasingly fluctuating prices on short-term electricity markets, the provision of system services on balancing power markets, or by increasing the share of their own consumption from on-site generated renewable energy. Demand-side management requires the ability to react flexibly to the power supply situation without negatively affecting production targets. It also means that the management and operation of production must consider not only production-related parameters but also parameters of energy availability, which further increase the complexity of decision-making. Although simulation studies are a recognized tool for supporting decision-making processes in production and logistics, the simultaneous simulation of material and energy flows has so far been limited mainly to issues of energy efficiency as opposed to energy flexibility, where application-oriented experience is still limited. We assume that the consideration of energy flexibility in the simulation of manufacturing systems will amplify already known pitfalls in conducting simulation studies. Based on five representative industrial use cases, this article provides practitioners with application-oriented experiences of the coupling of energy and material flows in simulation modeling of energy-flexible manufacturing, identifies challenges in the simulation of energy-flexible production systems, and proposes approaches to face these challenges. Seven pitfalls that pose a particular challenge in simulating energy-flexible manufacturing have been identified, and possible solutions and measures for avoiding them are shown. It has been found that, among other things, consistent management of all parties involved, early clarification of energy-related, logistical, and resulting technical requirements for models and software, as well as the application of suitable methods for validation and verification are central to avoiding these pitfalls. The identification and characterization of challenges and the derivation of recommendations for coping with them can raise awareness of typical pitfalls. This paper thus helps to ensure that simulation studies of energy-flexible production systems can be carried out more efficiently in the future.}, language = {en} } @article{KoelschRadonGolubetal.2020, author = {K{\"o}lsch, Adrian and Radon, C. and Golub, M. and Baumert, A. and B{\"u}rger, J{\"o}rg and Mielke, Thorsten and Lisdat, Fred and Feoktystov, Artem and Pieper, J{\"o}rg and Zouni, Athina and Wendler, Petra}, title = {Current limits of structural biology: The transient interaction between cytochrome c6 and photosystem I}, series = {Current Research in Structural Biology}, volume = {2}, journal = {Current Research in Structural Biology}, issn = {2665-928X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-13628}, pages = {171 -- 179}, year = {2020}, abstract = {Trimeric photosystem I from the cyanobacterium Thermosynechococcus elongatus (TePSI) is an intrinsic membrane protein, which converts solar energy into electrical energy by oxidizing the soluble redox mediator cytochrome c6 (Cyt c6) and reducing ferredoxin. Here, we use cryo-electron microscopy and small angle neutron scattering (SANS) to characterize the transient binding of Cyt c6 to TePSI. The structure of TePSI cross-linked to Cyt c6 was solved at a resolution of 2.9 {\AA} and shows additional cofactors as well as side chain density for 84\% of the peptide chain of subunit PsaK, revealing a hydrophobic, membrane intrinsic loop that enables binding of associated proteins. Due to the poor binding specificity, Cyt c6 could not be localized with certainty in our cryo-EM analysis. SANS measurements confirm that Cyt c6 does not bind to TePSI at protein concentrations comparable to those for cross-linking. However, SANS data indicate a complex formation between TePSI and the non-native mitochondrial cytochrome from horse heart (Cyt cHH). Our study pinpoints the difficulty of identifying very small binding partners (less than 5\% of the overall size) in EM structures when binding affinities are poor. We relate our results to well resolved co-structures with known binding affinities and recommend confirmatory methods for complexes with KM values higher than 20 μM.}, language = {en} }