@article{GrebinykPrylutskaChepurnaetal.2019, author = {Grebinyk, Anna and Prylutska, Svitlana and Chepurna, Oksana and Grebinyk, Sergii and Prylutskyy, Yuriy and Ritter, Uwe and Ohulchanskyy, Tymish Y. and Matyshevska, Olga and Dandekar, Thomas and Frohme, Marcus}, title = {Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex}, series = {Nanomaterials}, volume = {9}, journal = {Nanomaterials}, number = {11}, publisher = {MDPI}, issn = {2079-4991}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12940}, year = {2019}, abstract = {A nanosized drug complex was explored to improve the efficiency of cancer chemotherapy, complementing it with nanodelivery and photodynamic therapy. For this, nanomolar amounts of a non-covalent nanocomplex of Doxorubicin (Dox) with carbon nanoparticle C60 fullerene (C60) were applied in 1:1 and 2:1 molar ratio, exploiting C60 both as a drug-carrier and as a photosensitizer. The fluorescence microscopy analysis of human leukemic CCRF-CEM cells, in vitro cancer model, treated with nanocomplexes showed Dox's nuclear and C60's extranuclear localization. It gave an opportunity to realize a double hit strategy against cancer cells based on Dox's antiproliferative activity and C60's photoinduced pro-oxidant activity. When cells were treated with 2:1 C60-Dox and irradiated at 405 nm the high cytotoxicity of photo-irradiated C60-Dox enabled a nanomolar concentration of Dox and C60 to efficiently kill cancer cells in vitro. The high pro-oxidant and pro-apoptotic efficiency decreased IC50 16, 9 and 7 × 103-fold, if compared with the action of Dox, non-irradiated nanocomplex, and C60's photodynamic effect, correspondingly. Hereafter, a strong synergy of therapy arising from the combination of C60-mediated Dox delivery and C60 photoexcitation was revealed. Our data indicate that a combination of chemo- and photodynamic therapies with C60-Dox nanoformulation provides a promising synergetic approach for cancer treatment.}, language = {en} } @article{RoeschTolkiehnLehnert2019, author = {R{\"o}sch, Olga and Tolkiehn, G{\"u}nter-Ulrich and Lehnert, Ralph}, title = {Die Landessprache in der Lehre - welche Bedeutung kommt ihr bei der Internationalisierung zu?}, series = {Die neue Hochschule : DNH}, volume = {2019}, journal = {Die neue Hochschule : DNH}, number = {6}, issn = {0340-488X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12984}, pages = {12 -- 15}, year = {2019}, abstract = {Der Artikel setzt sich kritisch mit dem Trend auseinander, ganze Studieng{\"a}nge von Landessprache auf Englisch umzustellen und dies als "Internationaliserung" zu bezeichnen.}, language = {de} } @article{SteglichMaiVillringeretal.2020, author = {Steglich, Patrick and Mai, Christian and Villringer, Claus and Mai, Andreas}, title = {Direct observation and simultaneous use of linear and quadratic electro-optical effects}, series = {Journal of Physics D: Applied Physics}, volume = {53}, journal = {Journal of Physics D: Applied Physics}, number = {12}, issn = {1361-6463}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-13032}, year = {2020}, abstract = {We report on the direct observation and simultaneous use of the linear and quadratic electro-optical effect and propose a method by which higher-order susceptibilities of electro-optical materials can be determined. The evaluation is based on the separation of the second- and third-order susceptibilities and the experimental technique uses a slot waveguide ring resonator fabricated in integrated photonic circuit technology, which is embedded by a guest-host polymer system consisting of the azobenzene dye Disperse Red 1 in a poly(methyl methacrylate) matrix as an active electro-optical material. The contribution of both effects on the electro-optical response under the influence of static and time-varying electrical fields is investigated. We show that the quadratic electro-optical effect has a significant influence on the overall electro-optical response even with acentric molecular orientated molecules. Our findings have important implications for developing electro-optical devices based on polymer-filled slot waveguides and give rise to advanced photonic circuits.}, language = {en} } @article{LuxEdlingLuccietal.2019, author = {Lux, Helge and Edling, Matthias and Lucci, Massimiliano and Kitzmann, Julia and Villringer, Claus and Siemroth, Peter and De Matteis, Fabio and Schrader, Sigurd}, title = {The Role of Substrate Temperature and Magnetic Filtering for DLC by Cathodic Arc Evaporation}, series = {Coatings}, volume = {9}, journal = {Coatings}, number = {5}, issn = {2079-6412}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12295}, pages = {345}, year = {2019}, abstract = {Diamond-like carbon (DLC) films were deposited using two different types of high current arc evaporation. The first process used a magnetic particle filter to remove droplets from the plasma. For the second process, the samples were put into a metallic cage which was placed directly above the plasma source. For both processes, we varied the substrate temperature from 21 to 350 °C in order to investigate the temperature effect. The samples were characterized using SEM, AFM, XPS, Raman Spectroscopy, Ellipsometry, Photometry, and Nano Indentation in order to compare both methods of deposition and provide a careful characterization of such DLC films. We found that the sp3 content and the hardness can be precisely adjusted by changing the substrate temperature. Furthermore, in the case of unfiltered deposition, the optical constants can be shifted in the direction of higher absorbance in order to produce black and hard carbon coatings.}, language = {en} } @article{SteglichVillringerDietzeletal.2019, author = {Steglich, Patrick and Villringer, Claus and Dietzel, Birgit and Mai, Christian and Schrader, Sigurd and Casalboni, Mauro and Mai, Andreas}, title = {On-Chip Dispersion Measurement of the Quadratic Electro-Optic Effect in Nonlinear Optical Polymers Using a Photonic Integrated Circuit Technology}, series = {IEEE Photonics Journal}, volume = {11}, journal = {IEEE Photonics Journal}, number = {3}, issn = {1943-0655}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12307}, year = {2019}, abstract = {A novel method to determine the dispersion of the quadratic electro-optic effect in nonlinear optical materials by using a silicon-on-insulator microring resonator is presented. The microring consists of a silicon slot waveguide enabling large dc electric field strength at low applied voltages. The dispersion of third-order hyperpolarizability of a linear conjugated dye is approximated by using a two-level model for the off-resonant spectral region. As an example, the dispersion of the resonance wavelength of the resonator filled with a dye doped polymer was measured in dependence of the applied dc voltage. The polymer was poly (methylmethacrylate) doped with 5 wt\% disperse red 1 (DR1), and the measurements have been carried out at the telecommunication wavelength band around 1550 nm (optical C-band). The described measurements represent a new technique to determine the dispersion of the third-order susceptibility and molecular hyperpolarizability of the material filled into the slot of the ring-resonator.}, language = {en} } @article{MikayelyanGroddKsianzouetal.2019, author = {Mikayelyan, Eduard and Grodd, Linda and Ksianzou, Viachaslau and Wesner, Daniel and Rodygin, Alexander I. and Sch{\"o}nherr, Holger and Luponosov, Yuriy N. and Ponomarenko, Sergei A. and Ivanov, Dimitri A. and Pietsch, Ullrich and Grigorian, Souren}, title = {Phase Transitions and Formation of a Monolayer-Type Structure in Thin Oligothiophene Films: Exploration with a Combined In Situ X-ray Diffraction and Electrical Measurements}, series = {Nanoscale Research Letters}, volume = {14}, journal = {Nanoscale Research Letters}, issn = {1556-276X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12314}, year = {2019}, abstract = {A combination of in situ electrical and grazing-incidence X-ray diffraction (GIXD) is a powerful tool for studies of correlations between the microstructure and charge transport in thin organic films. The information provided by such experimental approach can help optimizing the performance of the films as active layers of organic electronic devices. In this work, such combination of techniques was used to investigate the phase transitions in vacuum-deposited thin films of a common organic semiconductor dihexyl-quarterthiophene (DH4T). A transition from the initial highly crystalline phase to a mesophase was detected upon heating, while only a partial backward transition was observed upon cooling to room temperature. In situ electrical conductivity measurements revealed the impact of both transitions on charge transport. This is partly accounted for by the fact that the initial crystalline phase is characterized by inclination of molecules in the plane perpendicular to the π-π stacking direction, whereas the mesophase is built of molecules tilted in the direction of π-π stacking. Importantly, in addition to the two phases of DH4T characteristic of the bulk, a third interfacial substrate-stabilized monolayer-type phase was observed. The existence of such interfacial structure can have important implications for the charge mobility, being especially favorable for lateral two-dimensional charge transport in the organic field-effect transistors geometry.}, language = {en} } @article{ZhaoCarusoDaehneetal.2019, author = {Zhao, Shuang and Caruso, Frank and D{\"a}hne, Lars and Decher, Gero and De Geest, Bruno G. and Fan, Jinchen and Feliu, Neus and Gogotsi, Yury and Hammond, Paula T. and Hersam, Mark C. and Khademhosseini, Ali and Kotov, Nicholas and Leporatti, Stefano and Li, Yan and Lisdat, Fred and Liz-Marz{\´a}n, Luis M. and Moya, Sergio and Mulvaney, Paul and Rogach, Andrey L. and Roy, Sathi and Shchukin, Dmitry G. and Skirtach, Andre G. and Stevens, Molly M. and Sukhorukov, Gleb B. and Weiss, Paul S. and Yue, Zhao and Zhu, Dingcheng and Parak, Wolfgang J.}, title = {The Future of Layer-by-Layer Assembly: A Tribute to ACS Nano Associate Editor Helmuth M{\"o}hwald}, series = {ACS Nano}, volume = {13}, journal = {ACS Nano}, number = {6}, issn = {1936-086X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12356}, pages = {6151 -- 6169}, year = {2019}, abstract = {Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the memory of ACS Nano associate editor Prof. Dr. Helmuth M{\"o}hwald, we discuss the developments and applications that are to come in LbL assembly, focusing on coatings, bulk materials, membranes, nanocomposites, and delivery vehicles.}, language = {en} } @article{KoberHollertFrohme2019, author = {Kober, Liane and Hollert, Henner and Frohme, Marcus}, title = {Quantification of nitroaromatic explosives in contaminated soil using MALDI-TOF mass spectrometry}, series = {Analytical and Bioanalytical Chemistry}, volume = {411}, journal = {Analytical and Bioanalytical Chemistry}, number = {23}, issn = {1618-2650}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12388}, pages = {5993 -- 6003}, year = {2019}, abstract = {Contamination from various sources is a global environmental and health threat, with mining and military activities in particular having spread nitroaromatic compounds, such as 2,4,6-trinitrotoluene and its degradation products and by-products, to the soil. The investigation and monitoring of large contaminated areas requires new detection methods since the established ones are expensive and time-consuming. Hence, we established a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI--TOF MS) method using 1,5-diaminonaphthalene as the matrix substance and an internal standard for quantification. Analyzing standard substances, we found specific signals for radical and fragment ions of different nitrotoluenes and nitrobenzenes with good reproducibility and detection limits down to 0.25 ng/μL. The analysis of soil sample extracts from a former production site showed clear signals for 2,4,6-trinitrotoluene and the primary degradation products aminodinitrotoluenes. Furthermore, quantification gave results comparable to those obtained by conventional liquid chromatography--tandem mass spectrometry analysis. The MALDI-TOF MS method has a comparatively lower reproducibility, with relative standard deviations of 6\% to 20\% for multiple measurements of standard solutions and soil sample extracts. Nevertheless, a comparison of both methods revealed the advantages of MALDI-TOF MS analysis of explosive-contaminated areas with regard to costs, time, and handling. Finally, our MALDI-TOF MS method fulfills all the needs for high sample throughput and can therefore be a valuable screening tool for explosive-contaminated areas.}, language = {en} } @article{GottschalkStollfussLietzauetal.2017, author = {Gottschalk, Josefine Johanna and Stollfuß, Carsten and Lietzau, Kai-Henning and Foitzik, Andreas and Richetta, Maria}, title = {Conceptual study for long-term monitoring of chemotherapeutic induced cell reactions by ESPI}, series = {tm - Technisches Messen}, volume = {85}, journal = {tm - Technisches Messen}, number = {2}, issn = {2196-7113}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-10676}, pages = {111 -- 118}, year = {2017}, abstract = {During the last years, various approaches on an individualized drug therapy for benign cells have been researched. However, due to the complex topic a universal approach has not been found up until this point. Commonly, the effect of cytotoxic drugs on benign cells is in most cases the same compared to regular cells while the actual effect on patient still can't be predicted. In order to reduce unwanted side effects or unspecific drug reactions a test system for patients which allows to analyse the interaction between cytotoxic agents and the targeted cells is needed. Furthermore, this should also include an adequate measurement system which is capable to work in a natural environment and without any additional preparation. In terms of this work, a first proof of concept with different benign cells and cytotoxic agents is presented while monitoring the obtained displacement using electronic speckle pattern interferometry (ESPI).}, language = {en} } @article{BondarenkoVillringerSteglich2019, author = {Bondarenko, Siegfried and Villringer, Claus and Steglich, Patrick}, title = {Comparative Study of Nano-Slot Silicon Waveguides Covered by Dye Doped and Undoped Polymer Cladding}, series = {Applied Sciences}, volume = {9}, journal = {Applied Sciences}, number = {1}, publisher = {MDPI}, issn = {2076-3417}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-10716}, year = {2019}, abstract = {Nonlinear optical dyes doped in optical polymer matrices are widely used for electro-optical devices. Linear optical properties change with dye concentration, which leads to a change in modal properties, especially in nano-structured integrated waveguides such as silicon slot-waveguides. Here, we investigate the influence of a nonlinear optical dye on the performance of a silicon-organic hybrid slot-waveguide. A simulation study of the modal and optical confinement properties is carried out and dependence of the structural parameters of the slot-waveguide and the organic cladding material is taken into account. As cladding material, a guest-host polymer system is employed comprising the nonlinear optical dye Disperse Red 1 (DR1) doped in a poly[methyl methacrylate] (PMMA) matrix. The refractive indices of doped and undoped PMMA were deduced from ellipsometric data. We present a guideline for an optimized slot-waveguide design for the fabrication in silicon-on-insulator technology giving rise to scalable, high-performance integrated electro-optical modulators.}, language = {en} } @inproceedings{Roesch2008, author = {R{\"o}sch, Olga}, title = {Zum Thema Technik und Kultur - Anstelle eines Vorwortes}, series = {Technik und Kultur}, booktitle = {Technik und Kultur}, editor = {R{\"o}sch, Olga}, publisher = {News \& Media}, address = {Berlin}, isbn = {978-3-936527-12-4}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12071}, pages = {10 -- 15}, year = {2008}, abstract = {Das Thema der Tagung »Technik und Kultur« hat insbesondere im Kontext einer technischen Hochschule eine unbestreitbare Aktualit{\"a}t. Die technologische Pr{\"a}gung der modernen Welt und der Gegenwartsgesellschaft ist evident: Von den modernen Kommunikationsmedien {\"u}ber die Verkehrsinstrumente, die Errungenschaften der Medizin und Hygiene, die Sicherheitselemente, den Umweltschutz bis hin zur Energie- bzw. Wasserversorgung, zur Ern{\"a}hrung und zur Alltagskultur ist unsere Lebenswelt mittlerweile so sehr von technischen Faktoren gepr{\"a}gt und auch abh{\"a}ngig, dass wir die eigene Geschichte verleugneten, wollten wir diese Dimensionen der Gegenwartskultur(en) ignorieren.}, language = {de} } @article{SteglichHuelsemannDietzeletal.2019, author = {Steglich, Patrick and H{\"u}lsemann, Marcel and Dietzel, Birgit and Mai, Andreas}, title = {Optical Biosensors Based on Silicon-On-Insulator Ring Resonators: A Review}, series = {Molecules}, volume = {24}, journal = {Molecules}, number = {3}, issn = {1420-3049}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-10822}, year = {2019}, abstract = {Recent developments in optical biosensors based on integrated photonic devices are reviewed with a special emphasis on silicon-on-insulator ring resonators. The review is mainly devoted to the following aspects: (1) Principles of sensing mechanism, (2) sensor design, (3) biofunctionalization procedures for specific molecule detection and (4) system integration and measurement set-ups. The inherent challenges of implementing photonics-based biosensors to meet specific requirements of applications in medicine, food analysis, and environmental monitoring are discussed.}, language = {en} } @article{Roesch2015, author = {R{\"o}sch, Olga}, title = {Internationalisierung der Hochschule - was sind unsere Ziele?}, series = {Die Neue Hochschule}, volume = {2015}, journal = {Die Neue Hochschule}, number = {1}, issn = {0340-448x}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-10879}, pages = {18 -- 24}, year = {2015}, abstract = {Als ein komplexes Feld l{\"a}sst sich das Thema Internationalisierung der Hochschulen nach Kehm (2003, S. 8 f.) auf mehreren Bezugsebenen verorten: - Internationalisierung von Studium und Lehre. Hier geht es um die Entwicklung von interkultureller Kompetenz der Beteiligten, um neue Ans{\"a}tze in der Lehre sowie um Fragen der Qualit{\"a}t. - Herstellung international transparenter und kompatibler Strukturen und Standards. Damit sind die Umstellungen von Studienprogrammen auf gestufte Abschl{\"u}sse, qualitative Vergleichbarkeit von Studienleistungen und Akkreditierung von Studieng{\"a}ngen gemeint. - Anpassungen in der Organisation der Hochschulen. Es handelt sich hierbei um die Umstrukturierungen von Akademischen Auslands{\"a}mtern und die Einf{\"u}hrung einer Leitungsfunktion f{\"u}r Internationale Angelegenheiten. - Internationalisierung des Politikfeldes Hochschulen. Hiermit sind die externen Einwirkungen auf die nationale Bildungspolitik gemeint, beispielsweise durch Organisationen wie OECD, UNESCO, World Bank und Europ{\"a}ische Union mit ihren jeweils „eigenen Definitionen der Funktionen von Hochschulen und der Ziele von Hochschulbildung" (Kehm 2003, S. 9). Mit diesen Ebenen der Internationalisierung kommen die Lehrenden in unterschiedlicher Intensit{\"a}t in Ber{\"u}hrung.}, language = {de} } @article{GrebinykPrylutskaGrebinyketal.2019, author = {Grebinyk, Anna and Prylutska, Svitlana and Grebinyk, Sergii and Prylutskyy, Yuriy and Ritter, Uwe and Matyshevska, Olga and Dandekar, Thomas and Frohme, Marcus}, title = {Complexation with C60 Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro}, series = {Nanoscale Research Letters}, volume = {14}, journal = {Nanoscale Research Letters}, issn = {1556-276X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-10966}, year = {2019}, abstract = {Conventional anticancer chemotherapy is limited because of severe side effects as well as a quickly evolving multidrug resistance of the tumor cells. To address this problem, we have explored a C60 fullerene-based nanosized system as a carrier for anticancer drugs for an optimized drug delivery to leukemic cells. Here, we studied the physicochemical properties and anticancer activity of C60 fullerene noncovalent complexes with the commonly used anticancer drug doxorubicin. C60-Doxorubicin complexes in a ratio 1:1 and 2:1 were characterized with UV/Vis spectrometry, dynamic light scattering, and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The obtained analytical data indicated that the 140-nm complexes were stable and could be used for biological applications. In leukemic cell lines (CCRF-CEM, Jurkat, THP1 and Molt-16), the nanocomplexes revealed ≤ 3.5 higher cytotoxic potential in comparison with the free drug in a range of nanomolar concentrations. Also, the intracellular drug's level evidenced C60 fullerene considerable nanocarrier function. The results of this study indicated that C60 fullerene-based delivery nanocomplexes had a potential value for optimization of doxorubicin efficiency against leukemic cells.}, language = {en} } @article{GrebinykPrylutskaGrebinyketal.2019, author = {Grebinyk, Anna and Prylutska, Svitlana and Grebinyk, Sergii and Prylutskyy, Yuriy and Ritter, Uwe and Matyshevska, Olga and Dandekar, Thomas and Frohme, Marcus}, title = {Complexation with C60 Fullerene Increases Doxorubicin Efficiency against Leukemic Cells In Vitro}, series = {Nanoscale Research Letters}, volume = {14}, journal = {Nanoscale Research Letters}, issn = {1556-276X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-11415}, year = {2019}, abstract = {Conventional anticancer chemotherapy is limited because of severe side effects as well as a quickly evolving multidrug resistance of the tumor cells. To address this problem, we have explored a C60 fullerene-based nanosized system as a carrier for anticancer drugs for an optimized drug delivery to leukemic cells. Here, we studied the physicochemical properties and anticancer activity of C60 fullerene noncovalent complexes with the commonly used anticancer drug doxorubicin. C60-Doxorubicin complexes in a ratio 1:1 and 2:1 were characterized with UV/Vis spectrometry, dynamic light scattering, and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The obtained analytical data indicated that the 140-nm complexes were stable and could be used for biological applications. In leukemic cell lines (CCRF-CEM, Jurkat, THP1 and Molt-16), the nanocomplexes revealed ≤ 3.5 higher cytotoxic potential in comparison with the free drug in a range of nanomolar concentrations. Also, the intracellular drug's level evidenced C60 fullerene considerable nanocarrier function. The results of this study indicated that C60 fullerene-based delivery nanocomplexes had a potential value for optimization of doxorubicin efficiency against leukemic cells.}, language = {en} } @article{IdaChanGloekleretal.2019, author = {Ida, Jeunice and Chan, Soo Khim and Gl{\"o}kler, J{\"o}rn and Lim, Yee Ying and Choong, Yee Siew and Lim, Theam Soon}, title = {G-Quadruplexes as An Alternative Recognition Element in Disease-Related Target Sensing}, series = {Molecules}, volume = {24}, journal = {Molecules}, number = {6}, issn = {1420-3049}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-11438}, year = {2019}, abstract = {G-quadruplexes are made up of guanine-rich RNA and DNA sequences capable of forming noncanonical nucleic acid secondary structures. The base-specific sterical configuration of G-quadruplexes allows the stacked G-tetrads to bind certain planar molecules like hemin (iron (III)-protoporphyrin IX) to regulate enzymatic-like functions such as peroxidase-mimicking activity, hence the use of the term DNAzyme/RNAzyme. This ability has been widely touted as a suitable substitute to conventional enzymatic reporter systems in diagnostics. This review will provide a brief overview of the G-quadruplex architecture as well as the many forms of reporter systems ranging from absorbance to luminescence readouts in various platforms. Furthermore, some challenges and improvements that have been introduced to improve the application of G-quadruplex in diagnostics will be highlighted. As the field of diagnostics has evolved to apply different detection systems, the need for alternative reporter systems such as G-quadruplexes is also paramount.}, language = {en} } @inproceedings{Roesch2008, author = {R{\"o}sch, Olga}, title = {Deutsche und russische Spiegelbilder}, series = {Deutsche und russische Spiegelbilder : Was halten, was erwarten wir voneinander?}, booktitle = {Deutsche und russische Spiegelbilder : Was halten, was erwarten wir voneinander?}, editor = {R{\"o}sch, Olga}, publisher = {Dt.-Russ. Forum}, address = {Berlin}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12177}, pages = {91 -- 96}, year = {2008}, abstract = {„Deutsche und russische Spiegelbilder - eine Reflexion", in: Publikation des Deutsch-Russischen Forums e.V. zu den 10. Potsdamer Begegnungen: „Deutsche und russische Spiegelbilder. Was halten, was erwarten wir voneinander?"}, language = {de} } @inproceedings{Roesch2004, author = {R{\"o}sch, Olga}, title = {Neue Identit{\"a}t Polens}, series = {Identit{\"a}ten und interkulturelle Verst{\"a}ndigung im Wirtschaftsleben}, booktitle = {Identit{\"a}ten und interkulturelle Verst{\"a}ndigung im Wirtschaftsleben}, editor = {R{\"o}sch, Olga}, publisher = {SSIP}, address = {Berlin}, isbn = {3-932231-10-4}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12186}, pages = {56 -- 62}, year = {2004}, abstract = {Eine neue Selbstdefinition Polens in einem ver{\"a}nderten gesellschaftlich-politischen Kontext der erweiterten Europ{\"a}ischen Union, ist eine schl{\"u}ssige Folge nach den grundlegenden Transformationen der letzten zwei Jahrzehnte in Osteuropa. Die im Land vorherrschende Aufbruchstimmung steht im Einklang mit einem gewachsenen Selbstvertrauen der Polen, was sich u.a. auch in einer nach außen neuen Darstellung der eigenen Identit{\"a}t {\"a}ußert. Allerdings scheint der Wahrnehmung dieses Wandels auf der deutschen Seite etwas Zwiesp{\"a}ltiges anzuhaften. Der Beitritt Polens zur EU hat hierzulande in der Tat ein neues bzw. anderes Interesse f{\"u}r den {\"o}stlichen Nachbarn geweckt: Polen - als ein Kooperationspartner in politisch ruhigen Zeiten, ein Partner, der einen ganz besonderen Wert darauf legt, in jeder Hinsicht als Gleichberechtigter behandelt zu werden. Das Gebot der Symmetrie in der Kommunikation ist zwar f{\"u}r alle Teilnehmer als Ideal erstrebenswert. Die Realit{\"a}t in der Gesch{\"a}ftskommunikation, vor allem im Wirtschaftsbereich, entspricht verst{\"a}ndlicherweise diesem Denkbild noch nicht. Was die deutsch-polnische Kooperation betrifft, so k{\"o}nnen wir leider nicht sagen, daß die Beziehung so unbeschwert ist wie z.B. zu Portugal oder traditionell so gut funktioniert wie z.B. zu Ungarn. Die Trag{\"o}dien des 20. Jahrhunderts haben das heutige Selbstverst{\"a}ndnis der Deutschen und der Polen nachhaltig gepr{\"a}gt.}, language = {de} } @incollection{RoeschvonHoerschelmann2003, author = {R{\"o}sch, Olga and von Hoerschelmann, Axel}, title = {{\"U}ber kulturelle Grenzen - Nachdenken vor der EU-Erweiterung}, series = {Osterweiterung der Europ{\"a}ischen Union und kulturelle Grenzen : zur Ausgangslage}, booktitle = {Osterweiterung der Europ{\"a}ischen Union und kulturelle Grenzen : zur Ausgangslage}, editor = {R{\"o}sch, Olga}, publisher = {Verl. News und Media}, address = {Berlin}, isbn = {3-936527-06-7}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12206}, publisher = {Technische Hochschule Wildau}, pages = {8 -- 18}, year = {2003}, abstract = {In den gesellschaftspolitischen wie akademischen Debatten {\"u}ber Globalisierung ist oft von der zunehmenden Bedeutungslosigkeit der Grenzen von Nationalstaaten die Rede. Diese Feststellung erscheint aus der (welt)- wirtschaftlichen Perspektive auch manifest. Die neuen Informationstechnologien und globalisierten Wirtschaftst{\"a}tigkeiten f{\"u}hrten in den letzten Jahrzehnten dazu, dass - in Worten von Ralf Dahrendorf - „Grenzen fielen, Grenzen der Zeit und des Raumes".}, language = {de} } @article{Roesch1996, author = {R{\"o}sch, Olga}, title = {Anredeformen im Russischen: soziale Dom{\"a}nen und soziale Bedeutungen}, series = {Fremdsprachenunterricht : fsu ; die Zeitschrift f{\"u}r das Lehren und Lernen fremder Sprachen}, volume = {4}, journal = {Fremdsprachenunterricht : fsu ; die Zeitschrift f{\"u}r das Lehren und Lernen fremder Sprachen}, issn = {0016-0989}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12248}, pages = {292 -- 296}, year = {1996}, abstract = {Die Vermittlung der fremdkulturellen Kompetenz ist ein integraler Bestandteil des kommunikativen Fremdsprachenunterrichts. Sie beginnt bereits mit dem Erlernen der in der Zielsprache vorhandenen Begr{\"u}ßungs- und Anredeformen, in denen sich teilweise die Spezifik einer Kultur (Mentalit{\"a}t, soziale Hierarchien, verhaltensbestimmende Wertesysteme, durch Religion gepr{\"a}gte Traditionen) sprachlich manifestiert. Das Anredeverhalten in verschiedenen Sprechergemeinschaften wird von Linguisten und Kommunikationswissenschaftlern vielfach zum Untersuchungsgegenstand gemacht. Die Besch{\"a}ftigung mit dem Ph{\"a}nomen der Andere und des Begr{\"u}ßungsrituals der Zielsprache ist aus sprach- und kulturkontrastiver Sicht auch f{\"u}r den Fremdsprachenunterricht von nicht zu untersch{\"a}tzender Bedeutung.}, language = {de} } @inproceedings{Roesch1994, author = {R{\"o}sch, Olga}, title = {Deutsch-Deutsch-Deutsches : Rußlanddeutsche in Berlin}, series = {Deutsch in Osteuropa : ein Tagungsbericht}, booktitle = {Deutsch in Osteuropa : ein Tagungsbericht}, editor = {R{\"o}sch, Olga}, publisher = {PHVT, Provinciale Hogeschool voor Vertalers en Tolken}, address = {Gent}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12257}, pages = {43 -- 68}, year = {1994}, abstract = {Die vereinigte, aber noch nicht v{\"o}llig geinte Berlin ist neben den Problemen des deutsch-deutschen Zusammenwachsens auch mit der Integration eines bemerkbaren Migrantenstroms konfrontiert. Einen nicht geringen Teil der neuen Zuwanderer machen die in der Stadt vor kurzem noch wenig bekannten Rußlanddeutschen aus. Ihre wunschgem{\"a}ße Zuordnung zum deutschen Kulturkreis ist f{\"u}r einen erheblichen Teil der Berliner problematisch, denn vor allem die sprachlichen Differenzen bis Defizite bei Aussiedlern in bezug auf das Hochdeutsche indizieren, daß es andere, also "fremde" Deutsche sind. Den Aussiedlern f{\"a}llt es ihrerseits nicht leicht, sich sowohl in der Variet{\"a}ten des Deutschen als auch in den beiden deutschen Identit{\"a}ten zurechtzufinden und dabei mit dem Wandlungen ihrer eigenen deutschen - ethnischen, kulturellen und sprachlichen - Selbsverst{\"a}ndnissen klarzukommen.}, language = {de} } @inproceedings{Roesch1991, author = {R{\"o}sch, Olga}, title = {Gibt es ein Medium im Deutschen der Gegenwart?}, series = {Neue Fragen der Linguistik}, booktitle = {Neue Fragen der Linguistik}, editor = {R{\"o}sch, Olga}, publisher = {Niemeyer}, address = {T{\"u}bingen}, isbn = {3-484-30270-4}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-12265}, pages = {253 -- 261}, year = {1991}, abstract = {Das deutsche verbale Genussystem ist in der Grammatikschreibung zweigliedrig. Den grammatischen Verbformen Aktiv und Passiv werden entsprechend aktivische und passivische Bedeutungen zugeordnet, und somit gelten die semantischen Kategorien Aktiv und Passiv im Gegenwartdeutsch als grammatikalisiert. Der semantischen Kategorie Medium entsprechen im Deutschen keine grammatischen Formparadigmen. Aber auch die Darstellungen des semantischen Begriffes Medium selbst werden in der Literatur eher universalgrammatisch und im engeren Sinne sogar universalsemantisch als einzelsprachlich verstanden. In meiner Untersuchung geht es jedoch nicht prim{\"a}r um das Verst{\"a}ndnis des Mediums, sondern um das Verst{\"a}ndnis einer bestimmten Konstruktion, die einige Ber{\"u}hrungspunkte mit dem fr{\"u}heren Medium aufweist. Die Rede ist von einer formal gekennzeichneten Klasse der Funktionsverbgef{\"u}ge (FVG), die vielfach als passivische bzw. passivwertige (pw) FVG bezeichnet werden.}, language = {de} } @article{HornemannSinningCortesetal.2017, author = {Hornemann, Andrea and Sinning, Denise and Cortes, Sofia and Campino, Lenea and Emmer, Peggy and Kuhls, Katrin and Ulm, Gerhard and Frohme, Marcus and Beckhoff, Burkhard}, title = {A pilot study on fingerprinting Leishmania species from the Old World using Fourier transform infrared spectroscopy}, series = {Analytical and Bioanalytical Chemistry}, journal = {Analytical and Bioanalytical Chemistry}, issn = {1432-1130}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-10080}, year = {2017}, abstract = {Leishmania species are protozoan parasites and the causative agents of leishmaniasis, a vector borne disease that imposes a large health burden on individuals living mainly in tropical and subtropical regions. Different Leishmania species are responsible for the distinct clinical patterns, such as cutaneous, mucocutaneous, and visceral leishmaniasis, with the latter being potentially fatal if left untreated. For this reason, it is important to perform correct species identification and differentiation. Fourier transform infrared spectroscopy (FTIR) is an analytical spectroscopic technique increasingly being used as a potential tool for identification of microorganisms for diagnostic purposes. By employing mid-infrared (MIR) spectral data, it is not only possible to assess the chemical structures but also to achieve differentiation supported by multivariate statistic analysis. This work comprises a pilot study on differentiation of Leishmania species of the Old World (L. major, L. tropica, L. infantum, and L. donovani) as well as hybrids of distinct species by using vibrational spectroscopic fingerprints. Films of intact Leishmania parasites and their deoxyribonucleic acid (DNA) were characterized comparatively with respect to their biochemical nature and MIR spectral patterns. The strains' hyperspectral datasets were multivariately examined by means of variance-based principal components analysis (PCA) and distance-based hierarchical cluster analysis (HCA). With the implementation of MIR spectral datasets we show that a phenotypic differentiation of Leishmania at species and intra-species level is feasible. Thus, FTIR spectroscopy can be further exploited for building up spectral databases of Leishmania parasites in view of high-throughput analysis of clinical specimens.}, language = {en} }