@article{LiAmirkhanyanGrebinyketal.2025, author = {Li, Xiangkun and Amirkhanyan, Zohrab and Grebinyk, Anna and Gross, Matthias and Komar, Yuliia and Riemer, Felix and Asoyan, Aida and Boonpornprasert, Prach and Borchert, Paul and Davtyan, Hakob and Dmytriiev, Dmytro and Frohme, Marcus and Hoffmann, Andreas and Krasilnikov, Mikhail and Loisch, Gregor and Lotfi, Zahra and M{\"u}ller, Frieder and Schmitz, Michael and Obier, Frank and Oppelt, Anne and Philipp, Sebastian and Richard, Christopher and Vashchenko, Grygorii and Villani, Daniel and Worm, Steven and Stephan, Frank}, title = {Demonstration of ultra-high dose rate electron irradiation at FLASHlab@PITZ}, series = {Physics in Medicine \& Biology}, volume = {70}, journal = {Physics in Medicine \& Biology}, number = {5}, publisher = {Institute of Physics Publishing (IOP)}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-20092}, year = {2025}, abstract = {Objective. The photo injector test facility at DESY in Zeuthen (PITZ) is building up an R\&D platform, known as FLASHlab@PITZ, for systematically studying the FLASH effect in cancer treatment with its high-brightness electron beams, which can provide a uniquely large dose parameter range for radiation experiments. In this paper, we demonstrate the capabilities by experiments with a reduced parameter range on a startup beamline and study the potential performance of the full beamline by simulations. Approach. To measure the dose, Gafchromic films are installed both in front of and after the samples; Monte Carlo simulations are conducted to predict the dose distribution during beam preparation and help understand the dose distribution inside the sample. Plasmid DNA is irradiated under various doses at conventional and ultra-high dose rate (UHDR) to study the DNA damage by radiations. Start-to-end simulations are performed to verify the performance of the full beamline. Main results. On the startup beamline, reproducible irradiation has been established with optimized electron beams and the delivered dose distributions have been measured with Gafchromic films and compared to FLUKA simulations. The functionality of this setup has been further demonstrated in biochemical experiments at conventional dose rate of 0.05 Gy s-1 and UHDR of several 105 Gy s-1 and a varying dose up to 60 Gy, with the UHDR experiments finished within a single RF pulse (less than 1 millisecond); the observed conformation yields of the irradiated plasmid DNA revealed its dose-dependent radiation damage. The upgrade to the full FLASHlab@PITZ beamline is justified by simulations with homogeneous radiation fields generated by both pencil beam scanning and scattering beams. Significance. With the demonstration of UHDR irradiation and the simulated performance of the new beamline, FLASHlab@PITZ will serve as a powerful platform for studying the FLASH effects in cancer treatment.}, language = {en} } @inproceedings{LiAmirkhanyanAftabetal.2024, author = {Li, Xiangkun and Amirkhanyan, Zohrab and Aftab, Namra and Boonpornprasert, Prach and Dmytriiev, Dmytro and Frohme, Marcus and Georgiev, Georgi and Grebinyk, Anna and Gross, Matthias and Hoffmann, Andreas and Komar, Yuliia and Krasilnikov, Mikhail and Loisch, Gregor and Oppelt, Anne and Richard, Christopher and Riemer, F. and Philipp, Sebastian and Schmitz, Michael and M{\"u}ller, Frieder and Obier, Frank and Vashchenko, Grygorii and Worm, Steven and Stephan, Frank}, title = {Overview of FLASHlab@PITZ: the new R\&D platform for FLASH radiation therapy and radiation biology}, series = {Journal of Physics: Conference Series, Volume 2687, Applications of Accelerators, Technology Transfer and Industrial Relations and Outreach}, volume = {2687}, booktitle = {Journal of Physics: Conference Series, Volume 2687, Applications of Accelerators, Technology Transfer and Industrial Relations and Outreach}, publisher = {Institute of Physics Publishing (IOP)}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-18474}, year = {2024}, abstract = {An R\&D platform for electron FLASH radiation therapy and radiation biology is being prepared at the Photo Injector Test facility at DESY in Zeuthen (FLASHlab@PITZ). This platform is based on the unique beam parameters available at PITZ: ps scale electron bunches of up to 22 MeV with up to 5 nC bunch charge at MHz bunch repetition rate in bunch trains of up to 1 ms in length repeating at 1 to 10 Hz. It works together with the Technical University of Applied Sciences Wildau (TH Wildau) as partner in close vicinity for the biological resources. A startup beamline has been installed to allow dosimetry studies and irradiation experiments on chemical, biochemical and biological samples after a 60-degree dispersive arm. The measured dose and dose rates under different beam conditions and first experimental results will be reported in this paper. In addition, a dedicated beamline for FLASHlab@PITZhas been designed for better control of the high brightness electron beams. This includes a dogleg to translate the beam and a 2D kicker system to scan the tiny beam focused by quadrupoles across the samples within less than 1 ms. Simulation studies will be presented to demonstrate the extremely flexible dose parameters with various irradiation options for electron FLASH radiation therapy and radiation biology studies.}, language = {en} } @inproceedings{GrossKuhlStephanetal.2023, author = {Gross, Matthias and Kuhl, Thorsten and Stephan, Frank and Li, Xiangkun and Philipp, Sebastian and Grebinyk, Anna and Khachatryan, Vitali and Qian, Houjun and Aboulbanine, Zakaria and Amirkhanyan, Zohrab and Riemer, Felix and Oppelt, Anne and Krasilnikov, Mikhail}, title = {A beam line setup for flash radiation therapy with focused electron beams at the Pitz facility at DESY in Zeuthen: basic concept and dosimetry simulations}, series = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, booktitle = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, editor = {Istituto Nazionale Di Fisca Nucleare,}, publisher = {JACoW Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21132}, pages = {5000 -- 5003}, year = {2023}, abstract = {The aim of this work is to demonstrate the principal possibility to enhance the electron beam dose deposition in the depth of the sample for radiation therapy purposes. Trains of electron bunches of 22 MeV generated at PITZ are focused inside the sample using a dedicated fast deflector and a solenoid magnet. To explore the capabilities of the proposed setup, dose distributions are calculated for multiple electron bunches focused in a single point inside a water phantom. Electron beam focusing produces dose peaks with a tunable maximal dose depth which is interesting for healthy tissue sparing at the surface and enhancing treatment quality. The duration of the full bunch train is 1 ms. During this time interval, the FLASH effect could be efficiently triggered inside the irradiated target volume. Monte Carlo simulations based on the FLUKA code were performed to evaluate the depth dose curves distributions in a water phantom. Using the PITZ electron beam parameters, simulations have shown the possibility to produce a peak dose in water seven times higher than compared to the dose at the surface. Moreover, the RMS size homogeneous area around the maximal dose is approximately 25 mm.}, language = {en} } @inproceedings{KrasilnikovAboulbanineAdhikarietal.2023, author = {Krasilnikov, Mikhail and Aboulbanine, Zakaria and Adhikari, Gowri and Aftab, Namra and Asoyan, Aida and Davtyan, Hakob and Georgiev, Georgi and Good, James and Grebinyk, Anna and Gross, Matthias and Hoffmann, Andreas and Kongmon, Ekkachai and Li, Xiangkun and Lueangaramwong, Anusorn and Melkumyan, David and Mohanty, Sandeep and Niemczyk, Raffael and Oppelt, Anne and Qian, Houjun and Richard, Christopher and Schneidmiller, Evgeny and Stephan, Frank and Vashchenko, Grygorii}, title = {THz SASE FEL at PITZ: lasing at a wavelength of 100μm}, series = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, booktitle = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, editor = {Istituto Nazionale Di Fisca Nucleare,}, publisher = {JACoW Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21113}, pages = {3948 -- 3951}, year = {2023}, abstract = {Development of an accelerator-based tunable THz source prototype for pump-probe experiments at the European XFEL is ongoing at the Photo Injector Test facility at DESY in Zeuthen (PITZ). The proof-of-principle experiments on the THz SASE FEL are performed utilizing the LCLS-I undulator installed in the PITZ beamline. The first lasing at a center wavelength of 100 µm was observed in the summer of 2022. The lasing of the narrowband THz source was achieved using an electron beam with an energy of ~17 MeV and a bunch charge up to several nC. Optimization of beam transport and matching resulted in the measurement of THz radiation with a pulse energy of tens of µJ, measured with pyroelectric detectors. The THz FEL gain curves were measured by means of specially designed short coils along the undulator. The results of the first characterization of the THz source at PITZ will be presented.}, language = {en} } @inproceedings{GrossHoffmannGeorgievetal.2023, author = {Gross, Matthias and Hoffmann, Andreas and Georgiev, Georgi and Kuhl, Thorsten and Li, Xiangkun and Oppelt, Anne and Boonpornprasert, Prach and Philipp, Sebastian and Grebinyk, Anna and Vashchenko, Grygorii and Aftab, Namra and Adhikari, Gowri and Richard, Christopher and Stephan, Frank and Khachatryan, Vitali and Riemer, Felix and Krasilnikov, Mikhail and Amirkhanyan, Zohrab}, title = {Comparison of measurements and simulation results of dose for the FLASH radiation therapy beamline at PITZ}, series = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, booktitle = {IPAC'23 : 14th International Particle Accelerator Conference, 7-12 May 2023, Venice, Italy : proceedings}, editor = {Istituto Nazionale Di Fisca Nucleare,}, publisher = {JACoW Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21126}, pages = {4996 -- 4999}, year = {2023}, abstract = {The high-brightness electron beam at the Photo Injector Test facility at DESY in Zeuthen (PITZ) is now also used for FLASHlab@PITZ: an R\&D platform for studying radiation biology and the FLASH effect in radiation therapy. The available parameter space of the electron beam with a momentum of 22 MeV/c allows bunch charges from 10 pC up to 5nC, bunch durations of 0.1-60ps, and bunch train lengths up to 1 ms. The number of bunches in the single train can currently be varied between 1 and 1000 bunches, with an upgrade to 4500 foreseen in 2023. Radiation biology studies require accurate dose prediction, therefore Monte Carlo simulations based on the FLUKA code were performed. According to estimations, dose delivery of 0.002 Gy (low charge case 0.1pC) and 10Gy (high charge case 5nC) is possible, if the beam is confined to a circular area with a radius of 5 mm with a lead collimator. For the Monte Carlo simulations, the experimental setup was accurately modeled, including the exit window, lead collimator, etc. Dose measurements were used to compare simulations with experiments. Dose profiles were experimentally measured with Gafchromic films and then compared with Monte Carlo simulations. The first experiments at FLASHlab@PITZ in 2023 have demonstrated flexible dose options for studying the FLASH effect and radiation biology studies.}, language = {en} } @inproceedings{QuadtGuentherReiffStephan2026, author = {Quadt, Frank and G{\"u}nther, Norman and Reiff-Stephan, J{\"o}rg}, title = {Anwendung von YOLO zur kombinierten Objekterkennung, Personenz{\"a}hlung und Distanzabsch{\"a}tzung}, series = {Tagungsband AALE 2026: Mechatronische Systeme f{\"u}r die Automatisierung: Fortschritt durch Pr{\"a}zision und Qualit{\"a}t : Mechatronische Systeme f{\"u}r die Automatisierung: Fortschritt durch Pr{\"a}zision und Qualit{\"a}t}, booktitle = {Tagungsband AALE 2026: Mechatronische Systeme f{\"u}r die Automatisierung: Fortschritt durch Pr{\"a}zision und Qualit{\"a}t : Mechatronische Systeme f{\"u}r die Automatisierung: Fortschritt durch Pr{\"a}zision und Qualit{\"a}t}, publisher = {Hochschule f{\"u}r Technik, Wirtschaft und Kultur Leipzig}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-21454}, pages = {319 -- 326}, year = {2026}, abstract = {In der modernen Produktionstechnik ist die Minimierung von Produktionszeiten von zentraler Bedeutung f{\"u}r die Steigerung der Wirtschaftlichkeit. Eine nachhaltige Prozessoptimierung erfordert die Identifizierung und Beseitigung von Schwachstellen und Engstellen innerhalb der Produktionsabl{\"a}ufe. Hierbei spielt die Analyse der Verweildauer von Personen und fahrerlosen Transportsystemen (FTS) an Arbeitsstationen eine entscheidende Rolle. Diese Daten dienen als Indikator f{\"u}r verschiedene Faktoren, darunter die Effizienz der Arbeitsabl{\"a}ufe, die Notwendigkeit von Wartungsintervallen und die Komplexit{\"a}t der Prozesse.Umdiese versteckten Herausforderungen innerhalb der Produktion zu identifizieren, wird in dieser Arbeit ein System zur optischen Datenerfassung vorgestellt. Durch die Erfassung und Analyse der Bewegungen von Personen und FTS in Produktionsumfeld, k{\"o}nnen wertvolle Erkenntnisse gewonnen werden. Ziel ist es, hierdurch ein tiefgreifendes Verst{\"a}ndnis der Produktionsprozesse zu erlangen und fundierte Entscheidungsgrundlagen f{\"u}r gezielte Optimierungsmaßnahmen zu schaffen, die zu einer nachhaltigen Effizienzsteigerung f{\"u}hren.}, language = {de} }