@article{SchneiderSeligKeiletal.2018, author = {Schneider, Sylvio and Selig, Martina and Keil, Verena and Lehmann, Matthias and Foitzik, Andreas and Casalboni, Mauro and Richetta, Maria}, title = {Development of a Smartphone Based Reader for the Quantitative Analysis of Lateral Flow Assays}, series = {Materials Science Forum}, volume = {941}, journal = {Materials Science Forum}, publisher = {Trans Tech Publications}, issn = {0255-5476}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-18688}, pages = {2522 -- 2527}, year = {2018}, abstract = {Smartphones are developing into all-purposes devices. In the present work, the employment/application of smartphones as medical devices in home care and point-of-care (POC) diagnostics are investigated in the analysis of Lateral Flow Assays (LFA). A smartphone-based LFA reader was developed for the quantitative analysis of D-Dimer - a biomarker indicating e.g. thrombotic event or danger of embolism.The proof-of-concept has been shown with multiple smartphones in establishing: (I) Optimal dimensions of the LFA cell of 72.11mm distance of smartphone to D-Dimer test leading to a coefficients of variances (CV) between 0.8\% and 4.2\%. (II) Inter-device investigations: CVs around 13.5\%; a limit of detection (LOD) of 100ng/ml (DDU) D-Dimer. (III) Inter-smartphone investigations: CV about 16\%, a limit of detection (LOD) at 66.4ng/ml (DDU). (IV) Calibrations: CV and LOD of three smartphones are comparable to the commercial available LFA reader. Further development to put the multiple smartphone-based LFA reader on the market.}, language = {en} }