@article{MaiMaiSteglich2022, author = {Mai, Andreas and Mai, Christian and Steglich, Patrick}, title = {From Lab-on-chip to Lab-in-App: Challenges towards silicon photonic biosensors product developments}, series = {Results in Optics}, volume = {9}, journal = {Results in Optics}, publisher = {Elsevier}, issn = {2666-9501}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-16687}, year = {2022}, abstract = {This work presents and evaluates different approaches of integrated optical sensors based on photonic integrated circuit (PIC) technologies for refractive index sensing. Bottlenecks in the fabrication flow towards an applicable system are discussed that hinder a cost-effective mass-production for disposable sensor chips. As sensor device, a waveguide coupled micro-ring based approach is chosen which is manufactured in an 8" wafer level process. We will show that the co-integration with a reproducible, scalable and low-cost microfluidic interface is the main challenge which needs to be overcome for future application of silicon technology based PIC sensor chips.}, language = {en} } @inproceedings{TannenbergPaulFuenningetal.2025, author = {Tannenberg, Robert and Paul, Martin and F{\"u}nning, Tabea and Schumann, Christoph and Weller, Michael G. and Steglich, Patrick}, title = {Multichannel real-time detection of biomarkers with highly miniaturized photonic microchips}, series = {Proceedings of SPIE : Optical Sensors 2025}, volume = {13527}, booktitle = {Proceedings of SPIE : Optical Sensors 2025}, editor = {Baldini, Francesco and Homola, Jiri and Lieberman, Robert A.}, publisher = {SPIE}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-20456}, year = {2025}, abstract = {The development of novel photonic integrated microchips (PIC) is a promising approach to allow for the convenient detection of key biomarkers in complex matrices through multichannel real-time analysis in a highly compact package. This study reports the successful development and application of a backside released CMOS chip designed for the multichannel real-time detection of biomarkers. Operating at the C-band at approx. 1550 nm, the microchip features three dedicated detection sensors in addition to a reference sensor, enabling simultaneous analysis of multiple biomarkers. The compact and highly miniaturized design of this microchip, with a footprint of just 1 mm², positions it as promising candidate for point-of-care diagnostics and personalized medicine applications. This technology opens a path to transform biomarker detection across various medical fields, offering rapid, reliable, and cost-effective diagnostic solutions. In conclusion, the presented multichannel photonic microchips signify a substantial leap forward in real-time biomarker detection, providing a highly capable platform for future research and clinical applications.}, language = {en} }