@article{SchlegelKrumnowBoehmeetal.2021, author = {Schlegel, Susanne and Krumnow, Erik and B{\"o}hme, Andrea and Minieri, Marilena and Foitzik, Andreas}, title = {Miniaturized Blood Sampling System with Integrated Sample Preparation}, series = {Materials Science Forum}, volume = {1016}, journal = {Materials Science Forum}, publisher = {Trans Tech Publications}, issn = {0255-5476}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-18812}, pages = {1280 -- 1284}, year = {2021}, abstract = {Blood sampling as well as sample preparation are time consuming and requires a strict procedure, which is generally performed by medical trained personal. Not carrying out the procedure correctly could result in an infection of the patient or contamination of the sample itself. These limitations should be especially considered in case of pandemic outbreaks. In order to handle such a high number of patients a novel sample preparation system paired with modern blood sampling procedure is necessary. For this reason, a new device for blood sampling and preparation is designed containing an integrated microfluidic system. The fabrication is carried out by utilizing micro moulding of PDMS as well as micro milling. A first set of initial experiments as part of a first-generation study shows promising results. However, further steps of optimisation considering flow time and preparation cycle are part of a second-generation study.}, language = {en} } @article{GottschalkKrumnowLietzauetal.2018, author = {Gottschalk, Josefine Johanna and Krumnow, Erik and Lietzau, Kai-Henning and Foitzik, Andreas and Richetta, Maria}, title = {Monitoring of Cytotoxic Induced Cellular Displacements by Utilizing Electronic Speckle Pattern Interferometry}, series = {Materials Science Forum}, volume = {941}, journal = {Materials Science Forum}, publisher = {Trans Tech Publications}, issn = {0255-5476}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-18728}, pages = {2513 -- 2517}, year = {2018}, abstract = {Modern medical science delivers through innovative chemical or mechanical/physical means new strategies to treat patients mildly and fight diseases accurately. In line with this development a screening procedure for tissue samples under usage of the electronic speckle pattern interferometry is developed at the University of Applied Science Wildau. The paper at hand provides the corner stone for such a procedure in form of an incubation system that is adapted to the properties of an electronic speckle pattern interferometer and allows the incubation as well as study of samples over time. As a result the developed system can regulate its own temperature and is constructed for use in an electronic speckle pattern interferometry (ESPI) setup. Its design allows a simple modular approach for further development.}, language = {en} } @inproceedings{WelzelHauschultzKrumnowetal.2023, author = {Welzel, Felix and Hauschultz, Mike Thomas and Krumnow, Erik and Foitzik, Andreas and Richetta, Maria}, title = {Concept and simulation of micromixers and aliquoting for PCR systems}, series = {NWK 2023 - Tagungsband zur 23. Nachwuchswissenschaftler*innenkonferenz}, booktitle = {NWK 2023 - Tagungsband zur 23. Nachwuchswissenschaftler*innenkonferenz}, editor = {Stolzenburg, Frieder and Reinboth, Christian and Lohr, Thomas and Vogel, Kathleen}, publisher = {Hochschule Harz}, address = {Wernigerode}, issn = {2627-5708}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-18611}, pages = {303 -- 306}, year = {2023}, abstract = {In this paper, different concepts for mixing sample and master mix by means of simulation are discussed. The main focus was on mixers with a low dead volume, because of their relevance to PCR. In addition, a concept for aliquoting the mixed solution was elaborated and simulated. The simulation showed very good mixing with serpentineand tesla-mixers at flow rates of 1-16 µL/s. Furthermore, a uniform distribution with aliquoting could be achieved, while a slight dependence between flow rate and pressure was observed. In the further course, these concepts are to be combined and tested on a microfluidic chip. This can then be integrated into the workflow of existing PCR protocols.}, language = {en} }