@inproceedings{PianowskiKamenzkyBlaschke2022, author = {Pianowski, Robin and Kamenzky, Robert and Blaschke, Peter}, title = {Schwingungsbasierte Schadensdetektion an Eisenbahnradreifen}, series = {Open Conference Proceedings}, volume = {2}, booktitle = {Open Conference Proceedings}, publisher = {TIB Open Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-17639}, pages = {181 -- 186}, year = {2022}, abstract = {Die Verkehrswende bedingt einen Ausbau des Schienen-Personenverkehrs. Eine in situ Schadenserkennung w{\"a}hrend des Betriebs kann einen Beitrag zur Kapazit{\"a}tserh{\"o}hung und Sicherheit im Schienenverkehr liefern. Im Vortrag werden Forschungen bez{\"u}glich einer schwingungsbasierten, zerst{\"o}rungsfreien Methode zur Detektion von Radreifensch{\"a}den vorgestellt. {\"U}ber eine Transferpfadanalyse (TPA) wird auf den K{\"o}rperschall jedes Rades w{\"a}hrend der {\"U}berfahrt r{\"u}ckberechnet. Mit dem synthetisierten K{\"o}rperschall wird mittels des akustischen Resonanztests die Schadensidentifikation durchgef{\"u}hrt.}, language = {de} } @inproceedings{DoehlerBoehmeHofmannetal.2022, author = {D{\"o}hler, Torsten and B{\"o}hme, Andrea and Hofmann, Mandy and Neumann, Jens and Bochem, Reinhard and Foitzik, Andreas and Geißler, Ute}, title = {Mikrogalvanische Kennzeichnung als Kopierschutz}, series = {Open Conference Proceedings}, volume = {2}, booktitle = {Open Conference Proceedings}, publisher = {TIB Open Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-17624}, pages = {157 -- 161}, year = {2022}, abstract = {In order to achieve good product quality in electroplating, disturbance variables such as the "dog bone" effect must be avoided. In this work, this approach was used to develop a method for marking as product protection. With a defined structure and optimal parameters, it is possible to deposit unique visually non-differentiable layers on suitable substrates. The deposited layers and their local distribution were characterized by confocal laser microscopy, X-ray fluorescence analysis and laser interference measurements and analyzed qualitatively as well as quantitatively. It thus provides interested parties with an essentially traditional process that can lead to new innovations with the chosen approach.}, language = {de} } @inproceedings{WelzelHauschultzFriedoetal.2022, author = {Welzel, Felix and Hauschultz, Mike Thomas and Friedo, Maria Helene and Just, Verena and Richetta, Maria and Foitzik, Andreas}, title = {Concept for a Portable Measuring Device for the Quantitative Detection of Legionella}, series = {Open Conference Proceedings}, volume = {2}, booktitle = {Open Conference Proceedings}, publisher = {TIB Open Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-17616}, pages = {15 -- 17}, year = {2022}, abstract = {According to the drinking water regulation, drinking water systems must be tested for harmful contamination at specified intervals. To meet the legal requirements and save costs and time, a portable analysis method is to be developed. For this purpose, a concept study was conducted. It describes a portable measuring device for the quantitative detection of legionella using real-time PCR. The study includes the construction elements and conditions that are necessary for the collection, processing, and evaluation of the sample. It was found that commercially available PCR systems do not meet the size requirements and can only be represented by an in-house development. In addition, a microfluidic system must be developed that is designed for one-time use and low production cost.}, language = {en} } @inproceedings{Herold2022, author = {Herold, Marcel}, title = {Digitalisierung des Gesundheitssektor: Analyse der digitalen Kompetenzen von {\"A}rzten}, series = {Open Conference Proceedings}, volume = {2}, booktitle = {Open Conference Proceedings}, publisher = {TIB Open Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-17600}, pages = {9 -- 13}, year = {2022}, abstract = {The shortage of skilled workers in the health sector is accelerating digitalisation, which is increasing the demands on staff. The increasing technical possibilities are changing the necessary competences required of physicians in the direction of digitalisation. Therefore, in personnel recruitment, digital competences should already be considered in job advertisements in order to be able to cope with the future challenges. This paper investigates to what extent a) digital competences have already found their way into the job profiles of physicians on the market and b) whether these can be meaningfully extracted through a data-driven methodological approach. For this purpose, 1707 job advertisements are evaluated using Latent Semantic Analysis (LSA). The different methodological approaches within the LSA show that there is hardly any focus on digital competences in the health sector in job advertisements.}, language = {de} } @inproceedings{FriedoHauschultzJacobsetal.2022, author = {Friedo, Maria Helene and Hauschultz, Mike Thomas and Jacobs, Hannes and Lafta, Mohammad and Engels, Andreas and Foitzik, Andreas}, title = {Steuerungstechnik f{\"u}r das Auftragen von fluiden Haftvermittlern}, series = {Open Conference Proceedings}, volume = {2}, booktitle = {Open Conference Proceedings}, publisher = {TIB Open Publishing}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-17670}, pages = {217 -- 219}, year = {2022}, abstract = {The goal of this project was to enable an automated solution for the application of bonding agents to metallic bodies in the nanoliter range. For the automated application of adhesion promoters, a new control unit based on a mainboard for controlling 3D printers was used, with Marlin serving as the firmware. Adaptations were necessary in the area of motor currents, speeds, acceleration, sensitivity, print bed size and selection of mainboard and display. For the traverse paths, G-code was generated using a program in Python. For homogeneous and uniform wetting, the individual objects to be wetted are approached and the pipetting process is controlled. It was possible to establish the complete functionality.}, language = {de} } @article{PraiaHerkenhoffBroedeletal.2022, author = {Praia, Ana Beatriz and Herkenhoff, Marcos Edgar and Br{\"o}del, Oliver and Frohme, Marcus and Saad, Susana Marta Isay}, title = {Sour Beer with Lacticaseibacillus paracasei subsp. paracasei F19: Feasibility and Influence of Supplementation with Spondias mombin L. Juice and/or By-Product}, series = {Foods}, volume = {11}, journal = {Foods}, number = {24}, publisher = {MDPI}, issn = {2304-8158}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-16852}, year = {2022}, abstract = {This study aimed to evaluate the probiotic strain Lacticaseibacillus (L.) paracasei subsp. paracasei F19 (F19) with the yeast Saccharomyces cerevisiae US-05 (US-05), using Spondias mombin L. ('tapereb{\´a}' or 'caj{\´a}') juice and by-product, in four sour-type beer formulations: control, with bagasse, juice, and juice and bagasse. The viability of F19 was evaluated by pour-plating and PMA-qPCR. Fermentability, in addition to physicochemical and sensory parameters, and aroma and flavor, were evaluated during brewery by using Headspace Solid-Phase Microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS). F19 was successful in fermenting bagasse in a MRS medium (9.28 log CFU/mL in 24 h) but had a low viability in hopped wort, growing better in formulations without bagasse or juice. No difference between formulations was observed regarding sensory acceptability, and the HS-SPME/GC-MS revealed different flavors and aroma compounds. In conclusion, the production of a potential probiotic sour beer with F19 and US-05 is feasible regarding probiotic viability. However, S. mombin, as juice or bagasse, threatened probiotic survival. Different flavors and aroma compounds were detected, whereas no difference between formulations was found regarding sensory acceptability. The moderate alcohol content achieved is important for bacterial survival and for the development of a probiotic beer with health claims.}, language = {en} } @article{FrickePsarianosSabbanetal.2022, author = {Fricke, Anna and Psarianos, Marios and Sabban, Jakob and Fitzner, Maria and Reipsch, Riccardo and Schl{\"u}ter, Oliver K. and Dreyer, Christian and Vogt, Julia H.-M. and Schreiner, Monika and Baldermann, Susanne}, title = {Composite materials for innovative urban farming of alternative food sources (macroalgae and crickets)}, series = {Frontiers in Sustainable Food Systems}, volume = {6}, journal = {Frontiers in Sustainable Food Systems}, publisher = {Frontiers}, issn = {2571-581X}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-16822}, year = {2022}, abstract = {Facing an inexorable growth of the human population along with substantial environmental changes, the assurance of food security is a major challenge of the present century. To ensure responsible food consumption and production (SDG 12), new approaches in the food system are required. Thus, environmentally controlled, sustainable production of alternative food sources are of key interest for both urban agriculture and food research. To face the current challenge of integrating food production systems within existing structures, multidisciplinary discourses are required. Here, we bring together novel technologies and indoor farming techniques with the aim of supporting the development of sustainable food production systems. For this purpose, we investigated the feasibility of 10 composite materials for their innovative use as structural support in macroalgal cultivation (settlement substrates) and cricket rearing (housing). Considering material resistance, rigidity, and direct material-organism interactions, the bio-based composite polylactic acid (PLA) was identified as a suitable material for joint farming. For macroalgae cultivation, PLA sustained the corrosive cultivation conditions and provided a suitable substrate without affecting the macroalgal physiology or nutritional composition (carotenoids and chlorophylls). For cricket rearing, PLA provided a suitable and recyclable shelter, which was quickly accepted by the animals without any observed harm. In contrast, other common composite components like phenolic resin or aramid were found to be unsuitable due to being harmful for the cultivated organisms or instable toward the applied sterilization procedure. This multidisciplinary study not only provides profound insights in the developing field of urban indoor food production from a new perspective, but also bridges material science and farming approaches to develop new sustainable and resilient food production systems.}, language = {en} } @article{MorlockSubramanianZounietal.2022, author = {Morlock, Sascha and Subramanian, Senthil Kumar and Zouni, Athina and Lisdat, Fred}, title = {Bio-inorganic hybrid structures for direct electron transfer to photosystem I in photobioelectrodes}, series = {Biosensors and Bioelectronics}, volume = {204}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, issn = {1873-4235}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-16770}, year = {2022}, abstract = {Synthetic materials can be combined with biological components in many ways. One example that provides scientists with multiple challenges is a photobioelectrode that converts sunlight into electrons in a biohybrid approach. In the present study several key parameters are evaluated concerning their influence on the direct electron transfer from a 3D indium tin oxide (ITO) electrode material to photosystem I (PSI) as a light-harvesting biomolecule. In contrast to previous investigations, no mediating molecule is added to shuttle the electrons to the luminal side of PSI. Thus, this setup is less complex than foregoing ones. The solution composition drastically influences the interaction of PSI with the ITO surface. Here, the application of higher buffer concentrations and the addition of salts are advantageous, whereas the nature of the buffer ions plays a minor role. The artificial electrode material's thickness is adjustable since a spin-coating procedure is used for preparation. With a 30 μm thick structure and immobilized PSI cathodic photocurrents up to 10.1 μA cm-2 are obtained at 100 mW cm-2 illumination intensity and an applied potential of -0.1V vs. Ag/AgCl. Over a period of three days the photobioelectrodes are illuminated for a total of 90 min and stored between the measurements at ambient temperature. The stability of the setup is noteworthy as still about 90\% of the photocurrent is retained. The photocathode described here offers many positive features, including a high onset potential for the photocurrent starting sligthly above the redox potentail of P700, and applicability in a wide pH range from pH 5 to 8.}, language = {en} } @article{GrebinykPrylutskaGrebinyketal.2022, author = {Grebinyk, Anna and Prylutska, Svitlana and Grebinyk, Sergii and Ponomarenko, Stanislav and Virych, Pavlo and Chumachenko, Vasyl and Kutsevol, Nataliya and Prylutskyy, Yuriy and Ritter, Uwe and Frohme, Marcus}, title = {Drug delivery with a pH-sensitive star-like dextran-graft polyacrylamide copolymer}, series = {Nanoscale Advances}, volume = {4}, journal = {Nanoscale Advances}, number = {23}, publisher = {Royal Society of Chemistry (RSC)}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-16749}, pages = {5077 -- 5088}, year = {2022}, abstract = {The development of precision cancer medicine relies on novel formulation strategies for targeted drug delivery to increase the therapeutic outcome. Biocompatible polymer nanoparticles, namely dextran-graft-polyacrylamide (D-g-PAA) copolymers, represent one of the innovative non-invasive approaches for drug delivery applications in cancer therapy. In this study, the star-like D-g-PAA copolymer in anionic form (D-g-PAAan) was developed for pH-triggered targeted drug delivery of the common chemotherapeutic drugs - doxorubicin (Dox) and cisplatin (Cis). The initial D-g-PAA copolymer was synthesized by the radical graft polymerization method, and then alkaline-hydrolyzed to get this polymer in anionic form for further use for drug encapsulation. The acidification of the buffer promoted the release of loaded drugs. D-g-PAAan nanoparticles increased the toxic potential of the drugs against human and mouse lung carcinoma cells (A549 and LLC), but not against normal human lung cells (HEL299). The drug-loaded D-g-PAAan-nanoparticles promoted further oxidative stress and apoptosis induction in LLC cells. D-g-PAAan-nanoparticles improved Dox accumulation and drugs' toxicity in a 3D LLC multi-cellular spheroid model. The data obtained indicate that the strategy of chemotherapeutic drug encapsulation within the branched D-g-PAAan nanoparticle allows not only to realize pH-triggered drug release but also to potentiate its cytotoxic, prooxidant and proapoptotic effects against lung carcinoma cells.}, language = {en} } @article{OsdobaLehnert2022, author = {Osdoba, Anne-Katrin and Lehnert, Martin}, title = {Welche Erwartungen hat die Eisenbahnbranche an neueingestellte Mitarbeitende?}, series = {Eisenbahntechnische Rundschau (ETR)}, volume = {2022}, journal = {Eisenbahntechnische Rundschau (ETR)}, number = {4}, publisher = {DVV Media Group}, issn = {0013-2845}, url = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-16725}, pages = {23 -- 27}, year = {2022}, abstract = {Dieser Fragestellung geht das EU-Projekt ASTONRail in einem ersten Projektteil nach. In einer Umfrage wurde die Eisenbahnbranche in Deutschland und Europa hinsichtlich ihrer Erwartungen an die Hochschulausbildung neueingestellter Eisenbahningenieurinnen und -ingenieure befragt. Erkenntnisse und Schlussfolgerungen f{\"u}r die Hochschulausbildung werden nachfolgend vorgestellt.}, language = {de} }