TY - CONF A1 - Kirchner, Thomas A1 - Villringer, Claus A1 - Gutke, Marko A1 - Laufer, Jan T1 - Plano-concave optical sensor for transcranial photoacoustic measurements TI - Opto-Acoustic Methods and Applications in Biophotonics VI N2 - Biomedical photoacoustics is usually used to image absorption-based contrast in soft tissues up to depths of several centimeters and with sub-millimeter resolution. By contrast, measuring Photoacoustic (PA) signals through hard bone tissue shows severe signal degradation due to aberration and high attenuation of high frequency acoustic signal components. This is particularly noticeable when measuring through thicker, human, skull bone. Which is the main reason why transcranial PA imaging in humans has so far proved challenging to implement. To tackle this challenge, we developed an optical resonator sensor based on a previous planar-concave design. This sensor was found to be highly suitable for measuring the low-pressure amplitude and low acoustic frequency signals that are transmitted through human cranial bone. A plano-concave optical resonator sensor was fabricated to provide high sensitivity in the acoustic frequency range of DC to around 2 MHz, a low noise equivalent pressure and a small active element size enabling it to significantly outperform conventional piezoelectric transducers when measuring PA waves transmitted through ex vivo human cranial bones. KW - transcranial KW - ex vivo KW - human KW - brain KW - optical resonator KW - photoacoustic KW - optoacoustic Y1 - 2023 UR - https://opus4.kobv.de/opus4-th-wildau/frontdoor/index/index/docId/1784 UR - https://nbn-resolving.org/urn:nbn:de:kobv:526-opus4-17840 PB - Society of Photo-Optical Instrumentation Engineers (SPIE) ER -