TY - JOUR A1 - Steglich, Patrick A1 - Lecci, Giulia A1 - Mai, Andreas T1 - Surface Plasmon Resonance (SPR) Spectroscopy and Photonic Integrated Circuit (PIC) Biosensors: A Comparative Review TI - Sensors N2 - Label-free direct-optical biosensors such as surface-plasmon resonance (SPR) spectroscopy has become a gold standard in biochemical analytics in centralized laboratories. Biosensors based on photonic integrated circuits (PIC) are based on the same physical sensing mechanism: evanescent field sensing. PIC-based biosensors can play an important role in healthcare, especially for point-of-care diagnostics, if challenges for a transfer from research laboratory to industrial applications can be overcome. Research is at this threshold, which presents a great opportunity for innovative on-site analyses in the health and environmental sectors. A deeper understanding of the innovative PIC technology is possible by comparing it with the well-established SPR spectroscopy. In this work, we shortly introduce both technologies and reveal similarities and differences. Further, we review some latest advances and compare both technologies in terms of surface functionalization and sensor performance. KW - surface-plasmon resonance KW - photonic integrated circuits KW - biosensor KW - surface functionalization KW - label-free detection Y1 - 2022 UR - https://opus4.kobv.de/opus4-th-wildau/frontdoor/index/index/docId/1601 UR - https://nbn-resolving.org/urn:nbn:de:kobv:526-opus4-16018 SN - 1424-8220 VL - 22 IS - 8 PB - MDPI ER -