TY - JOUR A1 - Neumann, Anja A1 - Jahn, Rebecca A1 - Diehm, Curt A1 - Driller, Elke A1 - Hessel, Franz A1 - Ommen, Oliver A1 - Pfaff, Holger A1 - Siebert, Uwe A1 - Pittrow, David A1 - Wasem, Jürgen T1 - Outcomes of medical management of peripheral arterial disease in general practice: follow-up results of the PACE-PAD Study JF - Journal of Public Health N2 - Peripheral arterial disease (PAD), a marker of elevated vascular risk, is highly prevalent in general practice. We aimed to investigate patient characteristics and outcomes of PAD patients treated according to the guidelines versus those who were not. Methods. PACE-PAD was a multicentre, cluster - randomised prospective, longitudinal cohort study of patients with PAD in primary care, who were followed-up for death or vascular events over 18 months. Guideline-orientation was assumed, if patients received anti¬coagu¬lant/antiplatelet therapy, exercise training, and (if applicable) advice for smoking cessation and therapy of diabetes mellitus, hypertension, or hypercholesterolemia, respectively. Results. The 5099 PAD patients (mean age 68.0 ± 9.0 years, 68.5% males) who were followed-up were in Fontaine stages I, IIa, IIb, III, and IV in 22.5%, 34.6%, 30.1%, 7.8%, and 3.5% (1.5% not specified). Comprehensive guideline orientation was reported in 28.4% only, however, patients in lower Fontaine stages received more often guideline-oriented therapy (I: 30.3%; IIa: 31.6%, IIb: 29.1%, III: 9.8%, IV: 18.0%). During 18 months, 457 patients died (224 due to cerebrovascular or coronary deaths), 319 had instable angina pectoris, 116 myocardial infarction, and 140 an ischemic stroke event. In total, 24% of patients had experienced any vascular event (19.1% a first event). Event rates did not differ between patients treated according to guidelines, and those who were not. Conclusion. The present PAD cohort was a high-risk sample with an unexpectedly high rate of deaths and vascular events. While physicians appear to focus on the treatment of individual risk factors, rates of comprehensive PAD management in line with guideline recommendations are still suboptimal. Factors contributing to the lacking difference between outcomes in the guideline-oriented and non-guideline-oriented groups may comprise low treatment intensity or other reasons for unsatisfactory effect of treatment, misclassification of events, patient's non-compliance with therapy. KW - Guideline Orientation KW - Peripheral Arterial Disease KW - Observational Study Y1 - 2010 N1 - Online: https://www.ssoar.info/ssoar/handle/document/23313 VL - 18 SP - 523 EP - 532 ER - TY - JOUR A1 - Hessel, Franz A1 - Jahn, Rebecca A1 - Diehm, Curt A1 - Lux, Gerald A1 - Driller, Elke A1 - Ommen, Oliver A1 - Pfaff, Holger A1 - Siebert, Uwe A1 - Pittrow, David A1 - Wasem, Jürgen A1 - Neumann, Anja T1 - Effect of Guideline Orientation on the Outcomes of Peripheral Arterial Disease in Primary Care JF - Current Medical Research and Opinion N2 - Peripheral arterial disease (PAD), an established marker of premature death and cardiovascular risk in general, is highly prevalent. We analysed factors associated with poor outcomes in an observational cohort, with particular focus on the effect of guideline orientation in the management of these patients. KW - Peripheral Arterial Disease KW - Primary Care Y1 - 2011 N1 - Online: https://www.researchgate.net/publication/51032982_Effect_of_guideline_orientation_on_the_outcomes_of_peripheral_arterial_disease_in_primary_care VL - 27 IS - 6 SP - 1183 EP - 1190 ER -