@article{ReinholdBrueggenjuergenSchlanderetal.2010, author = {Reinhold, Thomas and Br{\"u}ggenj{\"u}rgen, Bernd and Schlander, Michael and Rosenfeld, Stephanie and Hessel, Franz and Willich, Stefan N.}, title = {Economic analysis based on multinational studies: methods for adapting findings to national contexts}, series = {Journal of Public Health}, volume = {18}, journal = {Journal of Public Health}, number = {4}, pages = {327 -- 335}, year = {2010}, abstract = {Background: Health economic parameters are increasingly considered as variables in health care decisions, but decision makers are interested in country-specific evaluations. However, a large number of studies are performed in foreign countries or in a multinational setting, which limits the transferability to a single nation's context. Objective: The present analysis summarises several of the most common international methods for generating health economic analyses based on clinical studies from different settings. Methods: A narrative literature review was performed to identify potential reasons for limited transferability of health economic evaluation results from one country to another. Based on these results, we searched the methodological literature for analytic approaches to handle the restrictions. Additionally we describe the possibility of transferring foreign economic study results to the country of interest by matching trial data with routine data of national databases. Results: The main factors for limited transferability of health economic findings were found in country-specific differences in resource consumption and the resulting costs. These differences are affected by a number of influencing cofactors (demography, epidemiology and individual patient's factors) and the overall health care system structures (e.g. payment systems, health provider incentives). However, despite the limitations country-specific health economic assessments could be realised using the pooled/split analyses approach, some statistical approaches and modelling approaches. Conclusion: A variety of methods for identifying and adjusting country-specific differences in costs, effects and cost-effectiveness was established during the past decades. Multinational studies will continue to play a crucial role in the evaluation of cost-effectiveness at national levels. It seems likely that the growing interest in multinational studies will lead to continued developments in adaptation methods.}, language = {en} } @misc{Hessel2012, author = {Hessel, Franz}, title = {Knorpelzellentransplantation aus Sicht der Gesundheits{\"o}konomie und Versorgungsforschung}, year = {2012}, abstract = {Keine Angabe No details}, language = {de} } @misc{Hessel2012, author = {Hessel, Franz}, title = {Verg{\"u}tung personalisierter Medizin}, year = {2012}, abstract = {Keine Angabe No details}, language = {de} } @misc{Hessel2012, author = {Hessel, Franz}, title = {Gesundheits{\"o}konomische Betrachtung kongenitaler Cytomegalie-Virus Infektionen}, year = {2012}, abstract = {Keine Angabe No details}, language = {de} } @misc{Hessel2012, author = {Hessel, Franz}, title = {Gesundheits{\"o}konomische Evaluation nicht nur f{\"u}r Arzneimittel: Diagnostika und Medizinprodukte}, year = {2012}, abstract = {Keine Angaben No details}, language = {de} } @misc{Hessel2012, author = {Hessel, Franz}, title = {Gesundheits{\"o}konomische Studien auf der Basis von Registerdaten}, year = {2012}, abstract = {Keine Angaben No details}, language = {de} } @misc{Hessel2012, author = {Hessel, Franz}, title = {Qualit{\"a}t der Versorgung von Substitutionspatienten anhand der Premos-Studie}, year = {2012}, abstract = {Keine Angabe No details}, language = {de} } @misc{Hessel2012, author = {Hessel, Franz}, title = {Auswirkungen des demografischen Wandels auf die Arbeitssituation von {\"A}rzten und Pflegekr{\"a}ften}, year = {2012}, abstract = {Keine Angabe No details}, language = {de} } @misc{Hessel2012, author = {Hessel, Franz}, title = {Aktuelle Aspekte der Pharma-{\"O}konomie}, year = {2012}, abstract = {Keine Angabe No details}, language = {de} } @article{NeumannJahnDiehmetal.2010, author = {Neumann, Anja and Jahn, Rebecca and Diehm, Curt and Driller, Elke and Hessel, Franz and Ommen, Oliver and Pfaff, Holger and Siebert, Uwe and Pittrow, David and Wasem, J{\"u}rgen}, title = {Outcomes of medical management of peripheral arterial disease in general practice: follow-up results of the PACE-PAD Study}, series = {Journal of Public Health}, volume = {18}, journal = {Journal of Public Health}, pages = {523 -- 532}, year = {2010}, abstract = {Peripheral arterial disease (PAD), a marker of elevated vascular risk, is highly prevalent in general practice. We aimed to investigate patient characteristics and outcomes of PAD patients treated according to the guidelines versus those who were not. Methods. PACE-PAD was a multicentre, cluster - randomised prospective, longitudinal cohort study of patients with PAD in primary care, who were followed-up for death or vascular events over 18 months. Guideline-orientation was assumed, if patients received anti¬coagu¬lant/antiplatelet therapy, exercise training, and (if applicable) advice for smoking cessation and therapy of diabetes mellitus, hypertension, or hypercholesterolemia, respectively. Results. The 5099 PAD patients (mean age 68.0 ± 9.0 years, 68.5\% males) who were followed-up were in Fontaine stages I, IIa, IIb, III, and IV in 22.5\%, 34.6\%, 30.1\%, 7.8\%, and 3.5\% (1.5\% not specified). Comprehensive guideline orientation was reported in 28.4\% only, however, patients in lower Fontaine stages received more often guideline-oriented therapy (I: 30.3\%; IIa: 31.6\%, IIb: 29.1\%, III: 9.8\%, IV: 18.0\%). During 18 months, 457 patients died (224 due to cerebrovascular or coronary deaths), 319 had instable angina pectoris, 116 myocardial infarction, and 140 an ischemic stroke event. In total, 24\% of patients had experienced any vascular event (19.1\% a first event). Event rates did not differ between patients treated according to guidelines, and those who were not. Conclusion. The present PAD cohort was a high-risk sample with an unexpectedly high rate of deaths and vascular events. While physicians appear to focus on the treatment of individual risk factors, rates of comprehensive PAD management in line with guideline recommendations are still suboptimal. Factors contributing to the lacking difference between outcomes in the guideline-oriented and non-guideline-oriented groups may comprise low treatment intensity or other reasons for unsatisfactory effect of treatment, misclassification of events, patient's non-compliance with therapy.}, language = {en} }