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Generalized Ng–Kundu–Chan model of adaptive progressive Type-II censoring and related inference
(2024)
The model of adaptive progressive Type-II censoring introduced by Ng et al. (2009) (referred to as Ng–Kundu–Chan model) is extended to allow switching from a given initial censoring plan to any arbitrary given plan of the same length. In this generalized model, the joint distribution of the failure times and the corresponding likelihood function is derived. It is illustrated that the computation of maximum likelihood and Bayesian estimates are along the same lines as for standard progressive Type-II censoring. However, the distributional properties of the estimators will usually be different since the censoring plan actually applied in the (generalized) Ng–Kundu–Chan model is random. As already mentioned in Cramer and Iliopoulos (2010), we directly show that the normalized spacings are independent and identically exponentially distributed. However, it turns out that the spacings themselves are generally dependent with mixtures of exponential distributions as marginals. These results are used to study linear estimators. Finally, we propose an algorithm for generating random numbers in the generalized Ng–Kundu–Chan model and present some simulation results. The results obtained also provide new findings in the original Ng–Kundu–Chan model; the corresponding implications are highlighted.
Driving forest machines on wet soils causes irreversible soil compaction, often associated with intensive rut formation and inaccessibility of wheeled forest machines for future forest operations. The German forestry equipment manufacturer FHS, Forsttechnik Handel & Service GmbH, engineered a forwarder, the Trac 81/11, equipped with conventional, well-proved bogie-axles embraced by a closed rubber track. At the center of the bogie-axle, four additional supportive rollers are placed to increase the load-carrying section between the tires of the bogie-axle. The study aimed to characterize the principle concept and the trafficability of the forwarder by analyzing the footprint area, the contact pressure, the rut formation on forest sites and the slippage during driving. Therefore, the effective contact area was measured on steel plates and rut formation was analyzed on a case study basis. Results showed that the supportive rollers increase the contact surface area by about 1/3. By this, a decrease of peak loads below the wheels and a more homogenous load distribution were observed. However, the contact surface area is still clearly divided into three parts; the area between the supportive rollers and the wheels does not take any load. Results of the rut formation were diverse: After 20 passes with 26,700 kg total mass, rut depth varied between 12.6 and 212.5 mm. Overall, the new undercarriage concept of FHS demonstrated a generally positive performance. The engineered forwarder contributes to reduce the environmental impact associated with log extraction.
Background Personalized mRNA vaccines are promising new therapeutic options for patients with cancer. Because mRNA vaccines are not yet approved for first-line therapy, the vaccines are presently applied to individuals that received prior therapies that can have immunocompromising effects. There is a need to address how prior treatments impact mRNA vaccine outcomes.
Method Therefore, we analyzed the response to BioNTech/Pfizer’s anti-SARS-CoV-2 mRNA vaccine in 237 oncology outpatients, which cover a broad spectrum of hematologic malignancies and solid tumors and a variety of treatments. Patients were stratified by the time interval between the last treatment and first vaccination and by the presence or absence of florid tumors and IgG titers and T cell responses were analyzed 14 days after the second vaccination.
Results Regardless of the last treatment time point, our data indicate that vaccination responses in patients with checkpoint inhibition were comparable to healthy controls. In contrast, patients after chemotherapy or cortisone therapy did not develop an immune response until 6 months after the last systemic therapy and patients after Cht-immune checkpoint inhibitor and tyrosine kinase inhibitor therapy only after 12 months.
Conclusion Accordingly, our data support that timing of mRNA-based therapy is critical and we suggest that at least a 6-months or 12-months waiting interval should be observed before mRNA vaccination in systemically treated patients.
Virtual meeting recordings have become a common part of virtual and hybrid workplace environments. Meeting recordings offer potential benefits (speedy transcript production, expedited information sharing, searchable information, inclusion of visual and tonal expressions) and drawbacks (difficulty discussing sensitive issues, employee privacy, limited off-the-record capabilities, and employee concerns over sharing recordings). Given this variance, policies for virtual meetings are a necessity. Managers can successfully implement a policy by co-creating policy preferences with employees in open-ended and nonjudgmental conversations that openly discuss potential benefits, drawbacks, and employee concerns. Topics such as when to record, when not to record, how to gain consent, and who will have administrative and sharing rights should be covered. Accessibility concerns, use or rejection of software features, for how long and where meeting recordings should be stored, and emerging issues such as use of virtual reality meetings and AI tools are areas of less urgency that may be part of the conversations. Managers should deliver policy preferences to a group of representatives from Human Resources, Information Technology, and the executive team to compose the policy, request a legal review, then introduce and implement it in the organization.
This study investigates the impact of generative AI systems like ChatGPT on semi-structured decision-making, specifically in evaluating undergraduate dissertations. We propose using Davis’ technology acceptance model (TAM) and Schulz von Thun’s four-sides communication model to understand human–AI interaction and necessary adaptations for acceptance in dissertation grading. Utilizing an inductive research design, we conducted ten interviews with respondents having varying levels of AI and management expertise, employing four escalating-consequence scenarios mirroring higher education dissertation grading. In all scenarios, the AI functioned as a sender, based on the four-sides model. Findings reveal that technology acceptance for human–AI interaction is adaptive but requires modifications, particularly regarding AI’s transparency. Testing the four-sides model showed support for three sides, with the appeal side receiving negative feedback for AI acceptance as a sender. Respondents struggled to accept the idea of AI, suggesting a grading decision through an appeal. Consequently, transparency about AI’s role emerged as vital. When AI supports instructors transparently, acceptance levels are higher. These results encourage further research on AI as a receiver and the impartiality of AI decision-making without instructor influence. This study emphasizes communication modes in learning-ecosystems, especially in semi-structured decision-making situations with AI as a sender, while highlighting the potential to enhance AI-based decision-making acceptance.
Exploring stakeholder perspectives: Enhancing robot acceptance for sustainable healthcare solutions
(2023)
The pandemic has highlighted the fact that healthcare systems around the world are under pressure. Demographic change is leading to an increasing shortage of care workers in most countries, and the demographic challenge is only just beginning in most societies. While robots are widely used in industry, robotic support in healthcare is still limited to very specialized robots in the operating theatre. The question of what type of deployment is likely to be successful in a healthcare scenario is not only a technological or economical question but also one of technology acceptance. The answer to this question supports entrepreneurial opportunities to develop sustainable healthcare solutions.
In this paper, we analyze the acceptance of robots in elderly care from the perspective of patients, patient families, and geriatric care professionals. To understand the various positions and to identify the suitability of existing acceptance models, we applied stakeholder mapping to conduct qualitative interviews with 14 people with different knowledge backgrounds and levels of involvement in care situations, based on 9 videos showing different robots and application scenarios.
The results confirmed that existing technology acceptance models need to be extended by factors such as robot appearance. We found that the background knowledge of the respondents influences the results of the questions about e.g. safety concerns. In addition, we found that the contribution to patients' self-determination and independence is an important factor that is not included in existing technology acceptance models. Finally, the discovery of a significant discrepancy between the self-perception and the external perception of the different stakeholders regarding the acceptance of a service robot can be explained by the stakeholder positions involved in caring for the benefit of a specific patient.
These findings encourage further research, especially with the underlying assumption that technology acceptance in healthcare is not just a patient issue, but a stakeholder issue. Stakeholder mapping is a valid tool to analyze the interdependencies for the acceptance of robots. Therefore, we suggest using a tool such as stakeholder mapping to further analyze these issues.
Recently, the SQL standardization Committee published a specification for support of the concept called Row Pattern Recognition in SQL. That way, the focus for the members of the Committee turned back to a kernel issue of the language, after standardizing the storage and manipulation of data formats, such as XML and JSON. In this paper we discuss the specified features using several examples and show to what extent different relational database systems as well as Data Analytics tools have integrated them. At the end of the paper, we describe the main inaccuracies of the proposal and the ways how to solve them. From our point of view, the following should be modified in one of the future proposals of the standard in relation to this concept: (a) Naming of several pattern navigation operations is inappropriate and should be changed; (b) The concept of implicit definition for row pattern variables in DEFINE should be changed to explicit; (c) The set of existing functions should be extended.