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Your one-stop solution for getting up and running with SQL Server 2000
Develop and deploy large-scale applications with SQL Server 2000. In this book, database expert Dusan Petkovic explains how to use all the features of this powerful, scaleable relational database management system. You'll learn to configure SQL Server 2000, use T-SQL, execute efficient database queries, and enable secure transactions. Troubleshooting, data warehousing, and optimization are also covered. You'll find complete details on Microsoft Analysis Services, managing multiple servers, maximizing uptime, and performance tuning. With SQL Server 2000: A Beginner's Guide, your mission-critical database applications will be up-and-running in no time!
Learn to:
Setup, manage, and customize SQL Server 2000
Administer multiple instances of SQL Server 2000 using the SQL Server Enterprise Manager
Perform simple and complex database queries
Tune the performance of your SELECT statements
Use SQL extensions, stored procedures, transactions, views, and triggers
Implement the SQL Server 2000 security model
Find and fix database problems by capturing and replaying server activity
Import, export, and transform data types using DTS
Construct data warehouses to collect, organize, and distribute information efficiently
The main focus of this work is the development of new methods for the self-calibration of a rigid stereo camera system. However, many of the algorithms introduced here have a wider impact, particularly in robot hand-eye calibration with all its different areas of application. Stereo self-calibration refers to the computation of the intrinsic and extrinsic parameters of a stereo rig using neither a priori knowledge on the movement of the rig nor on the geometry of the observed scene.
The stereo parameters obtained by self-calibration, namely rotation and translation from left to right camera, are used for computing depth maps for both images, which are applied for rendering correctly occluded virtual objects into a real scene (Augmented Reality).
The proposed methods were evaluated on real and synthetic data and compared to algorithms from the literature. In addition to a stereo rig, an optical tracking system with a camera mounted on an endoscope was calibrated without a calibration pattern using the proposed extended hand-eye calibration algorithm.
The self-calibration methods developed in this work have a number of features, which make them easily applicable in practice: They rely on temporal feature tracking only, as this monocular tracking in a continuous image sequence is much easier than left-to-right tracking when the camera parameters are still unknown.
Intrinsic and extrinsic camera parameters are computed during the self-calibration process, i.e., no calibration pattern is required. The proposed stereo self-calibration approach can also be used for extended hand-eye calibration, where the eye poses are obtained by structure-from-motion rather than from a calibration pattern.
An inherent problem to hand-eye calibration is that it requires at least two general movements of the cameras in order to compute the rigid transformation.
If the motion is not general enough, only a part of the parameters can be obtained, which would not be sufficient for computing depth maps. Therefore, a main part of this work discusses methods for data selection that increase the robustness of hand-eye calibration. Different new approaches are shown, the most successful ones being based on vector quantization.
The data selection algorithms developed in this work can not only be used for stereo self-calibration, but also for classic robot hand-eye calibration, and they are independent of the actually used hand-eye calibration algorithm.
Deploy and manage SQL Server 2005 with easeLearn to use all the powerful features available in SQL Server 2005 from this straightforward, hands-on guide.
Set up SQL Server 2005, automate system administration tasks, execute simple and complex database queries, and use the robust analysis, business intelligence, and reporting tools. Troubleshooting, data partitioning, replication, and query optimization are also covered.
With SQL Server 2005: A Beginner's Guide, you'll be able to set up a secure, reliable, and productive data management platform in no time.
Essential Skills for Database Professionals
- Install and customize SQL Server 2005
- Create, alter, and remove database objects with Transact-SQL statements
- Use SQL Server as a native XML database system - Tune your database system for optimal performance
- Use the new SQL Server Management Studio tool for executing and analyzing ad hoc queries
- Retrieve data from more than one source using join operations and SELECT statements
- Secure your database using two different authentication modes--Windows and mixed
- Restore databases using transaction logs and backup and recovery methods
- Streamline system administration tasks using the SQL Server Agent service tool
- Analyze and manage information stored in a data warehouse with Microsoft Analysis Services
Background
To date, targeted tyrosine kinase inhibitors have been approved for FGFR2 and FGFR3 fusions (pemigatinib and erdafitinib, respectively), but the importance of FGFR2 mutations for transformation activity and as a druggable gene variant with response to different FGFR inhibitors is poorly understood. FGFR2 inhibitors present a mainstay of treatment for locally advanced or metastatic intrahepatic cholangiocellular carcinoma (iCCA).
Methods
A 74-year-old male was diagnosed with iCCA in liver segments seven and eight with infiltration of the hepatic veins and inferior vena cava revealed a C382R mutation of the intramembrane domain of FGRR2 receptor. We performed an in-silico study to understand the potential mode-of-action of the mutant FGFR2 targets. Based on experimentally determined structures we then used a structure generated by AlphaFold2 as the variation in question is located at a position not determined well in the experiments. This revealed that the C382R mutation is located in the trans-membranal domain at a position crucial for signal transduction, both for activation and inhibition of downstream-signaling. The Molecular Tumor Board decided to start the treatment with 13.5 mg pemigatinib once daily for 14 days, followed by 7 days of free therapy interval resulting in a sustained partial response. The patient continues to be treated of 13.5 mg as described above.
Results
In our case report, we were able to show that the patient in whom an C382R mutation was detected responded to the therapy with pemigatinib. This shows that real-world scenarios differ from the data of the approval studies, thereby illustrating how complex data on patients with FGFR mutations is. One of the main problems of large approval studies is that the functionality of the respective alterations is often disregarded.
Conclusions
Our results suggest that respective mutation may be successfully targeted by FGFR-selective tyrosine-kinase inhibitors, demonstrating the importance of the functional characterization of mutations.
no conflicts of interest.
Get Started on Microsoft SQL Server 2008 in No TimeLearn to use all of the powerful features available in SQL Server 2008 quickly and easily.
Microsoft SQL Server 2008: A Beginner's Guide explains the fundamentals of each topic alongside examples and tutorials that walk you through real-world database tasks.
Install SQL Server 2008, construct high-performance databases, use powerful Transact-SQL statements, create stored procedures and triggers, and execute simple and complex database queries. Performance tuning, Database Engine security, Business Intelligence, and XML are also covered.
Set up, configure, and maintain SQL Server 2008
Build and manage database objects using Transact-SQL statements Create stored procedures and user-defined functionsOptimize database performance, availability, and reliability
Implement solid security using authentication, encryption, and authorization Automate tasks using SQL Server Agent
Create reliable data backups and perform flawless system restores
Use all-new SQL Server 2008 Business Intelligence, development, and administration toolsLearn in detail the SQL Server XML technology (SQLXML)
Get Started on Microsoft SQL Server 2012 in No TimeLearn to use all of the powerful features available in SQL Server 2012 quickly and easily.
Microsoft SQL Server 2012: A Beginner's Guide explains the fundamentals of each topic alongside examples and tutorials that walk you through real-world database tasks.
Install SQL Server 2012, construct high-performance databases, use powerful Transact-SQL statements, create stored procedures and triggers, and execute simple and complex database queries.
Performance tuning, Database Engine security, Business Intelligence, and XML are also covered.
Set up, configure, and maintain SQL Server 20012 Build and manage database objects using Transact-SQL statements Create stored procedures and user-defined functionsOptimize database performance, availability, and reliabilityImplement solid security using authentication, encryption, and authorization
Automate tasks using SQL Server AgentCreate reliable data backups and perform flawless system restoresUse all-new SQL Server 2012 Business Intelligence, development, and administration toolsLearn in detail the SQL Server XML technology (SQLXML)
Get up and running on Microsoft SQL Server 2016 in no time with help from this thoroughly revised, practical resource. The book offers thorough coverage of SQL management and development and features full details on the newest business intelligence, reporting, and security features.
Filled with new real-world examples and hands-on exercises, Microsoft SQL Server 2016: A Beginner's Guide, Sixth Edition, starts by explaining fundamental relational database system concepts.
From there, you will learn how to write Transact-SQL statements, execute simple and complex database queries, handle system administration and security, and use the powerful analysis and BI tools. XML, spatial data, and full-text search are also covered in this step-by-step tutorial.
· Revised from the ground up to cover the latest version of SQL Server
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Recent development of GaN power transistors with blocking voltages up to 650V enables novel power electronics applications with outstanding performance in high-frequency operation. This paper demonstrates a class E power amplifier with 13.56MHz switching frequency for inductively coupled DC power supplies. Continuous wave output power up to 200W is achieved with 95% Power Added Efficiency (PAE).