TY - JOUR A1 - Hempel, L.C. A1 - Lapa, C. A1 - Gaumann, A. A1 - Veloso de Oliveira, J. A1 - Scheiber, J. A1 - Philipp, P. A1 - Oyarzun, C. A1 - Wesarg, S. A1 - Robert, Sebastian A1 - Hempel, D. T1 - 36P A point mutation replacing cysteine with arginine at position 382 (C382R) in the transmembrane domain of FGFR2 leads to response to FGF2-inhibitor pemigatinib in chemo-refractory intrahepatic cholangiocarcinoma JF - Annals of Oncology N2 - Background To date, targeted tyrosine kinase inhibitors have been approved for FGFR2 and FGFR3 fusions (pemigatinib and erdafitinib, respectively), but the importance of FGFR2 mutations for transformation activity and as a druggable gene variant with response to different FGFR inhibitors is poorly understood. FGFR2 inhibitors present a mainstay of treatment for locally advanced or metastatic intrahepatic cholangiocellular carcinoma (iCCA). Methods A 74-year-old male was diagnosed with iCCA in liver segments seven and eight with infiltration of the hepatic veins and inferior vena cava revealed a C382R mutation of the intramembrane domain of FGRR2 receptor. We performed an in-silico study to understand the potential mode-of-action of the mutant FGFR2 targets. Based on experimentally determined structures we then used a structure generated by AlphaFold2 as the variation in question is located at a position not determined well in the experiments. This revealed that the C382R mutation is located in the trans-membranal domain at a position crucial for signal transduction, both for activation and inhibition of downstream-signaling. The Molecular Tumor Board decided to start the treatment with 13.5 mg pemigatinib once daily for 14 days, followed by 7 days of free therapy interval resulting in a sustained partial response. The patient continues to be treated of 13.5 mg as described above. Results In our case report, we were able to show that the patient in whom an C382R mutation was detected responded to the therapy with pemigatinib. This shows that real-world scenarios differ from the data of the approval studies, thereby illustrating how complex data on patients with FGFR mutations is. One of the main problems of large approval studies is that the functionality of the respective alterations is often disregarded. Conclusions Our results suggest that respective mutation may be successfully targeted by FGFR-selective tyrosine-kinase inhibitors, demonstrating the importance of the functional characterization of mutations. no conflicts of interest. Y1 - 2022 U6 - https://doi.org/https://doi.org/10.1016/j.annonc.2022.01.045 VL - 33 SP - S17 EP - S17 ER - TY - JOUR A1 - Prodinger, Birgit A1 - Weise, A. P. A1 - Shaw, L. A1 - Stamm, T. A. T1 - A Delphi study on Environmental Factors that impact work and social life participation of individuals with Multiple Sclerosis in Austria and Switzerland JF - Disability and Rehabilitation N2 - Purpose: This study aimed to gain knowledge about environmental factors (EFs) that impact work and social life participation of people with multiple sclerosis (MS) in Austria and Switzerland to extend the knowledge of participation and to identify key areas for measuring participation. Method: A three-round Delphi study was conducted defining patients as experts. In the 1st round, qualitative data was gathered through questionnaires, analyzed with content analysis, and factors were assigned to EFs as classified in the ICF. In the 2nd and 3rd round, experts judged EFs according to its relevance to obtain consensus (cut-off 75%). Categories were ranked on a scale from mostly important to important. Results: One hundred and twelve Austrian and 109 Swiss experts were recruited. The content analysis revealed 768 EFs. The study resulted in a list of 176 consensus factors for Austria and 177 Switzerland. Five categories revealed to be highly important, 12 moderately important, 6 fairly important, and 10 important. Conclusions: This study indicates that participation in work or social life is influenced by physical, social, attitudinal, and policy factors. Consensus factors afford insights into areas for consideration in the development of participation outcome measurements and support a comprehensive and inclusive rehabilitation approach. KW - Contextual factors KW - Patient perspective KW - Consensus method KW - ICF KW - Disability and health Y1 - 2010 UR - https://doi.org/10.3109/09638280903071883 VL - 32 IS - 3 SP - 183 EP - 195 ER - TY - JOUR A1 - Schulze, Achim A1 - Koentopp, M. B. A1 - Taubitz, C. T1 - A drift and diffusion model for PID-s in solar modules JF - IEEE Journal of Photovoltaics N2 - A quantitative physical model for potential induced degradation of the shunting type (PID-s) in solar modules is introduced. Based on a drift and diffusion approach for sodium ions and atoms, it gives insight into the kinetics of degradation and the corresponding regeneration. A simple drift/source term is used to describe the time-dependent flux of Na-ions towards stacking faults at the surface of the solar cell. The assumed transport mechanism for Na+ ions through the SiN-layer uses the modified Stern-Eyring rate theory but our approach can also be adapted to other mechanisms. Several PID-s and regeneration curves of one-cell solar modules at T = 49°C and T = 90°C with 1000V potential difference between modul frame and cell were measured and least-square fits of the in-situ measured parallel resistance Rsh to the model were performed giving very good accordance. Based on a few measurements, the model can predict PID-s and regeneration characteristics of solar modules under different conditions. KW - Photovoltaic cells, Photovoltaic systems, PID Y1 - 2020 UR - https://doi.org/10.1109/JPHOTOV.2020.3003776 VL - 2020 PB - IEEE CY - USA ER - TY - JOUR A1 - Gerber, M. A1 - Ferreira, J.A. A1 - Hofsajer, I.W. A1 - Seliger, Norbert T1 - A high-density heat-sink-mounted inductor for automotive applications JF - IEEE Transactions on Industry Applications KW - inductor Y1 - 2023 VL - 40 IS - 4 SP - 1031 EP - 1038 PB - IEEE ER - TY - JOUR A1 - Paolini, Alexander A1 - Kollmannsberger, Stefan A1 - Winter, Christoph A1 - Buchschmid, Martin A1 - Müller, Gerhard A1 - Rabold, Andreas A1 - Mecking, Simon A1 - Schanda, Ulrich A1 - Rank, Ernst T1 - A high-order finite element model for vibration analysis of cross-laminated timber assemblies JF - Building Acoustics N2 - The vibration behavior of cross-laminated timber components in the low-frequency range can be predicted with high accuracy by the finite element method. However, the modeling of assembled cross-laminated timber components has been studied only scarcely. The three-dimensional p-version of the finite element method, which is characterized by hierarchic high-order shape functions, is well suited to consider coupling and support conditions. Furthermore, a small number of degrees of freedom can be obtained in case of thin-walled structures using p-elements with high aspect ratios and anisotropic ansatz spaces. In this article, a model for cross-laminated timber assemblies made of volumetric high-order finite elements is presented. Two representative types of connections are investigated, one with an elastomer between the cross-laminated timber components and the other without. The model is validated, and suitable ranges for the stiffness parameters of the finite elements which represent the junctions are identified. KW - cross-laminated timber KW - finite element method Y1 - 2017 UR - https://doi.org/10.1177%2F1351010X17727126 VL - 2017 IS - 3 SP - 135 EP - 158 ET - 24 ER - TY - JOUR A1 - Seliger, Norbert A1 - Pogany, D. A1 - Fuerboeck, C. A1 - Habas, P. A1 - Gornik, E. T1 - A laser beam method for evaluation of thermal time constant in smart power devices JF - Microelectronics Reliability Y1 - 2023 U6 - https://doi.org/10.1016/S0026-2714(97)00149-2 VL - 37 IS - 10/11 SP - 1727 EP - 1730 ER - TY - JOUR A1 - Kellner, Florian A1 - Lienland, Bernhard A1 - Utz, Sebastian T1 - A multi-criteria decision-making approach for assembling optimal powertrain technology portfolios in low GHG emission environments JF - Journal of Industrial Ecology N2 - Environmental regulations force car manufacturers to renew the powertrain technology portfolio offered to the customer to comply with greenhouse gas (GHG) emission targets. In turn, automotive companies face the task of identifying the “right” powertrain technology portfolio consisting of, for example, internal combustion engines and electric vehicles, because the selection of a particular powertrain technology portfolio affects different company targets simultaneously. What makes this decision even more challenging is that future market shares of the different technologies are uncertain. Our research presents a new decision-support approach for assembling optimal powertrain technology portfolios while making decision-makers aware of the trade-offs between the achievable profit, the achievable market share, the market share risk, and the GHG emissions generated by the selected vehicle fleet. The proposed approach combines “a posteriori” decision-making with multi-objective optimization. In an application case, we feed the outlooks of selected market studies into the proposed decision-support system. The result is a visualization and analysis of the current real-world decision-making problem faced by many automotive companies. Our findings indicate that for the proposed GHG restriction at work in 2030 in the European Union, no optimal powertrain technology portfolio with less than 35% of vehicles equipped with an electric motor exists. KW - automotive sector KW - decision-support system KW - industrial ecology KW - portfolio optimization KW - power-train technologies KW - technology selection Y1 - 2021 U6 - https://doi.org/10.1111/jiec.13148 VL - 25 IS - 6 SP - 1412 EP - 1429 ER - TY - JOUR A1 - Rüthing, Justus A1 - Haupert, Frank A1 - Schmitz, Regine A1 - Sigrüner, Michael A1 - Strübbe, Nicole T1 - A new approach for the friction and wear characterisation of polymer fibres under dry, mixed and hydrodynamic sliding JF - Tribologie und Schmierungstechnik N2 - A new approach for the friction and wear characterisation of polymer fibres under dry, mixed, and hydrodynamic sliding conditions is developed. The production process of the tested polymer fibres is described and an introduction in fibre-reinforced concrete is given. Tribotesting is done on an optimised tribometer capable of measuring the friction and wear behaviour of polymer fibres with diameters of a few 100 µm under lubricated conditions. Three extruded polypropylene macro fibres with varying diameters are characterised under tribological conditions found in an industrial concrete mixing process. It is shown that detailed friction and wear data of polymer fibres can be gathered. KW - polymer-fibres KW - fibre reinforced concrete KW - Pin-on-Disc KW - abrasive wear KW - water lubrication KW - hyrodynamic sliding Y1 - 2022 UR - https://doi.org/10.24053/tus-2022-0034 VL - 69 IS - Sonderausgabe 2 SP - 18 EP - 25 ER - TY - JOUR A1 - Hempel, Louisa A1 - Lapa, Constantin A1 - Dierks, Alexander A1 - Gaumann, Andreas A1 - Scheiber, Josef A1 - Veloso de Oliveira, Julia A1 - Philipp, Patrick A1 - Oyarzun Laura, Cristina A1 - Wesarg, Stefan A1 - Robert, Sebastian A1 - Hempel, Dirk T1 - A new promising oncogenic target (p.C382R) for treatment with pemigatinib in patients with cholangiocarcinoma JF - Therapeutic Advances in Medical Oncology N2 - Point mutations of the fibroblast growth factor receptor (FGFR)2 receptor in intrahepatic cholangiocarcinoma (iCC) are mainly of unknown functional significance compared to FGFR2 fusions. Pemigatinib, a tyrosine kinase inhibitor, is approved for the treatment of cholangiocarcinoma with FGFR2 fusion/rearrangement. Although it is hypothesized that FGFR2 mutations may cause uncontrolled activation of the signaling pathway, the data for targeted therapies for FGFR2 mutations remain unclear. In vitro analyses demonstrated the importance of the p.C382R mutation for ligand-independent constitutive activation of FGFR2 with transforming potential. The following report describes the clinical case of a patient diagnosed with an iCC carrying a FGFR2 p.C382R point mutation which was detected in liquid, as well as in tissue-based biopsies. The patient was treated with pemigatinib, resulting in a sustained complete functional remission in fluorodeoxyglucose-positron emission tomography/computed tomography over 10 months to date. The reported case is the first description of a complete functional remission under the treatment with pemigatinib in a patient with p.C383R mutation. Y1 - 2022 U6 - https://doi.org/10.1177/17588359221125096 VL - 14 ER - TY - JOUR A1 - Woerthmann, B.M. A1 - Lindner, Johannes A. A1 - Kovacevic, T. A1 - Pergam, P. A1 - Schmid, F. A1 - Briesen, H. T1 - A novel method for assessing the coating uniformity of hot-melt coated particles using micro-computed tomography JF - Powder Technology N2 - The effectiveness of hot-melt coating depends on its uniformity and the extent to which the surface is completely covered. Compared with solvent-based coating, spreading is more limited in hot-melt coating; thus, the coating uniformity is more affected by the process parameters. This study presents a new method for identifying and quantifying factors influencing coating uniformity. The proposed method facilitates the determination of coating-thickness distribution and non-covered surface proportion based on micro-computed tomography measurements. The proposed method is based on particles that have undergone hot-melt coating in a fluidized bed, and it is compared to common methods for layer-thickness determination. The influencing factors are quantified in terms of the dependency of coating uniformity on the coating amount and material. Material properties have a significant impact because stearin and palm fat create different coating layers. The proposed method is confirmed to be well suited for analyzing coating qualities. KW - Wurster fluidized bed KW - Hot-melt coating KW - Micro-computed tomography KW - Layer-thickness distribution KW - Coating uniformity Y1 - 2021 UR - https://doi.org/10.1016/j.powtec.2020.09.065 VL - 378 IS - Part A SP - 51 EP - 59 ER -