@inproceedings{OberleSailer2024, author = {Oberle, Christina and Sailer, Marcel}, title = {Reducing the gap between theoretical and practical learning by means of complex simulation scenarios in health sciences.}, series = {Refereed Proceedings of the 5th WACE International Research Symposium on Cooperative and Work-Integrated Education, 2024, University West, Sweden}, booktitle = {Refereed Proceedings of the 5th WACE International Research Symposium on Cooperative and Work-Integrated Education, 2024, University West, Sweden}, editor = {Zegwaard, Karsten and Flemming, Jenny}, publisher = {WACE Inc.}, address = {Waterloo, CA}, pages = {207 -- 213}, year = {2024}, abstract = {Diagnostic skills and decision-making processes are a substantial part of nursing and midwifery education. In a real-life clinical setting, the situation is complex and time-critical with a major impact on patient safety. The goal of simulation-based training allows the reduction of the complexity and offers the focus on new skills, diagnostic steps, engaging evidence-based-practice and receiving real-time feedback. According to Work-integrated-learning (WIL) it is an ideal method fostering authentic work-focused experience, students learning through doing and students discipline of professional development (Zegwaard et al., 2023). Simulation in nursing and midwifery education as a pedagogical tool has been used widely in the clinical health-care of students (WHO Regional office for Europe, 2018). Within complex scenario-based-simulation students may be engaged and immersed by working with the "patient or women" as autonomous clinicians, making their own diagnoses, clinical-decisions and evaluating their interventions (Olaussen, Heggdal \& Tvedt, 2019). For the evaluating process a two-fold process that focuses on the assessment of students performance and the simulation process per se is recommended (World Health Organization, 2018). However, the research findings in competence development and learning outcomes during complex scenario-based simulations are limited in nursing (Koukourikos et al., 2021) and especially in the midwifery profession (Changuiti et al., 2021). The aim of this study was to evaluate the competence progress in midwifery-students through complex simulation scenarios. Thus to define, if the scenarios are an improved teaching and learning method.}, language = {en} } @article{HoepflSchellhorn2025, author = {H{\"o}pfl, Felix and Schellhorn, Marina}, title = {Balancing innovation and trust: Assessing artificial intelligence's role in medical history taking and physician perspectives on patient care}, series = {DESGIN+}, volume = {2025}, journal = {DESGIN+}, publisher = {AccScience Publishing (ASP) DESIGN+}, address = {Singapur}, doi = {10.36922/dp.7675}, url = {http://nbn-resolving.de/urn:nbn:de:bvb:861-opus4-29528}, pages = {1}, year = {2025}, abstract = {This study explores the potential of artificial intelligence (AI) in medical history taking (anamnesis) and assesses its acceptance using technology acceptance models. Through nine expert interviews with physicians from diverse medical backgrounds, the study aims to understand concerns and anticipated benefits of AI in the doctor-patient relationship. To demonstrate AI's applications, digital anamnesis surveys were conducted with two actual patients, and the resulting data were interpreted by AI and reviewed by physicians. Findings indicate that physicians view AI as potentially beneficial, expecting that AI can facilitate improvements in care quality, efficiency, and time savings. Despite initial concerns about AI's ability to address individual patient needs and its impact on the doctor-patient relationship, there is significant interest in integrating AI tools into daily practice. Key issues include patient constitution, the effort-to-benefit ratio, and potential risks to patient trust. The study identifies six areas for further research: Economic impact and cost-benefit analysis, patient acceptance and trust, stress reduction and job satisfaction, effects on doctor-patient relationships, development of verification mechanisms, and ethical and legal considerations. These findings underscore the complexities of AI integration in health care, emphasizing the need to address concerns about patient individuality, data privacy, and interpersonal relationships while harnessing AI's potential.}, language = {en} } @misc{Sailer2024, author = {Sailer, Marcel}, title = {Video-based patient monitoring in long-term inpatient care}, series = {Sustainability and Crises - Challenges and Innovation for Gerontechnology}, journal = {Sustainability and Crises - Challenges and Innovation for Gerontechnology}, year = {2024}, abstract = {Purpose Video-based monitoring systems in long-term inpatient care represent an opportunity to increase patient safety. Technologies using infrared technology, as well as video and sound transmission are used to recognize movement to prevent falls and enable the continuous recording of vital parameters. Individual assessment of the necessity and limits of application from a nursing care perspective is essential due to the restriction on the patient's privacy and autonomy. As an example, the Oxevision monitoring system is analysed in more detail in this project. Care professionals as well as the public were asked about the potentials and risk factors of video-based monitoring systems using semi-structured interviews and an online survey. This paper intends to provide a basis for discussion for the use of video-based monitoring systems in long-term inpatient care facilities. The aim is to conduct qualitative and quantitative fundamental research as a basis for generating data and a critical analysis of the topic. In addition to displaying the opinion of the general public, the limitations and potential benefits of these technologies are illustrated and ethical aspects are discussed. Method The research was conducted in a mixed-method design by a student research group. All surveys are based on prior literature research however, the analysis is based on defined criteria. Interviews were conducted with nursing care professionals (n=4) and people from the public (n=244) were surveyed on the topic of video-based monitoring systems via an online survey. The interviews were analysed using inductive, structured content analysis methods as Mayring describes to be a suitable analysis method. The online survey was analysed using statistical methods to draw credible quantitative results. Results and Discussion The results clearly show that video-based monitoring systems have both advantages and disadvantages as well as ethical aspects and factors that influence the acceptance of video-based monitoring which must be weighed up individually. From the total responses of n=244, 47,1\% (n=115) of survey participants are in favour of the use of monitoring systems in nursing, while 40,1\% are undecided. The most frequently mentioned advantages from the interviews included continual vital sign monitoring, faster reactions in emergencies, a reduction in the workload of nursing staff and an increase in patient safety, for example through improved fall prevention for patients. In contrast, 185 people (75,8\%) of the survey participants are of the opinion that video monitoring systems should not be used across the board and that specific groups of people should be considered differentially. Frequently cited reasons for this are data protection, restriction of privacy and self-determination, as well as the fear of data abuse. The hereby collected data suggests that a general interest in the implementation of video-based monitoring systems is apparent among the population. In order to increase acceptance, of aspects such as data protection, privacy and possible abuse of data, further research is needed to establish a reliable conclusion to this matter.}, subject = {active assisted living}, language = {en} } @article{SkudlikLueftlThalhammeretal.2025, author = {Skudlik, Steffi and L{\"u}ftl, Katharina and Thalhammer, Regina and Zaglacher, Melina and M{\"u}ller, Martin}, title = {Experiences of members of the care triad on transitioning from home to a nursing home: a qualitative study}, series = {BMC Geriatrics}, volume = {25}, journal = {BMC Geriatrics}, number = {1}, publisher = {Springer Nature}, doi = {10.1186/s12877-025-06586-1}, year = {2025}, language = {en} } @misc{ThalhammerZaglacherSolfLeipoldetal., author = {Thalhammer, Regina and Zaglacher, Melina and Solf-Leipold, Barbara and L{\"u}ftl, Katharina}, title = {Development, piloting, and feasibility of a complex intervention to prevent insufficient home care of community-dwelling older adults (Prev-It)}, language = {en} } @article{SecklerRegauerRotteretal.2020, author = {Seckler, Eva and Regauer, Verena and Rotter, Thomas and Bauer, Petra and M{\"u}ller, Martin}, title = {Barriers to and facilitators of the implementation of multi-disciplinary care pathways in primary care: a systematic review}, series = {BMC Family Practice}, volume = {21}, journal = {BMC Family Practice}, pages = {113}, year = {2020}, abstract = {Background: Care pathways (CPWs) are complex interventions that have the potential to reduce treatment errors and optimize patient outcomes by translating evidence into local practice. To design an optimal implementation strategy, potential barriers to and facilitators of implementation must be considered. The objective of this systematic review is to identify barriers to and facilitators of the implementation of CPWs in primary care (PC). Methods: A systematic search via Cochrane Library, CINAHL, and MEDLINE via PubMed supplemented by hand searches and citation tracing was carried out. We considered articles reporting on CPWs targeting patients at least 65 years of age in outpatient settings that were written in the English or German language and were published between 2007 and 2019. We considered (non-)randomized controlled trials, controlled before-after studies, interrupted time series studies (main project reports) as well as associated process evaluation reports of either methodology. Two independent researchers performed the study selection; the data extraction and critical appraisal were duplicated until the point of perfect agreement between the two reviewers. Due to the heterogeneity of the included studies, a narrative synthesis was performed. Results: Fourteen studies (seven main project reports and seven process evaluation reports) of the identified 8154 records in the search update were included in the synthesis. The structure and content of the interventions as well as the quality of evidence of the studies varied. The identified barriers and facilitators were classified using the Context and Implementation of Complex Interventions framework. The identified barriers were inadequate staffing, insufficient education, lack of financial compensation, low motivation and lack of time. Adequate skills and knowledge through training activities for health professionals, good multi-disciplinary communication and individual tailored interventions were identified as facilitators. Conclusions: In the implementation of CPWs in PC, a multitude of barriers and facilitators must be considered, and most of them can be modified through the careful design of intervention and implementation strategies. Furthermore, process evaluations must become a standard component of implementing CPWs to enable other projects to build upon previous experience.}, language = {en} } @article{BergmannKrewerBaueretal.2018, author = {Bergmann, Jeannine and Krewer, Carmen and Bauer, Petra and K{\"o}nig, Alexander and Riener, Robert and M{\"u}ller, Friedemann}, title = {Virtual reality to augment robot-assisted gait training in non-ambulatory patients with a subacute stroke: a pilot randomized controlled trial}, series = {European Journal of Physical and Rehabilitation Medicine}, volume = {2018}, journal = {European Journal of Physical and Rehabilitation Medicine}, number = {3}, edition = {54}, pages = {397 -- 407}, year = {2018}, abstract = {BACKGROUND: Active performance is crucial for motor learning, and, together with motivation, is believed to be associated with a better rehabilitation outcome. Virtual reality (VR) is an innovative approach to engage and motivate patients during training. There is promising evidence for its efficiency in retraining upper limb function. However, there is insufficient proof for its effectiveness in gait training. AIM: To evaluate the acceptability of robot-assisted gait training (RAGT) with and without VR and the feasibility of potential outcome measures to guide the planning of a larger randomized controlled trial (RCT). DESIGN: Single-blind randomized controlled pilot trial with two parallel arms. SETTING: Rehabilitation hospital. POPULATION: Twenty subacute stroke patients (64±9 years) with a Functional Ambulation Classification (FAC) ≤2. METHODS: Twelve sessions (over 4 weeks) of either VR-augmented RAGT (intervention group) or standard RAGT (control group). Acceptability of the interventions (drop-out rate, questionnaire), patients' motivation (Intrinsic Motivation Inventory [IMI], individual mean walking time), and feasibility of potential outcome measures (completion rate and response to interventions) were determined. RESULTS: We found high acceptability of repetitive VR-augmented RAGT. The drop-out rate was 1/11 in the intervention and 4/14 in the control group. Patients of the intervention group spent significantly more time walking in the robot than the control group (per session and total walking time; P<0.03). In both groups, motivation measured with the IMI was high over the entire intervention period. The felt pressure and tension significantly decreased in the intervention group (P<0.01) and was significantly lower than in the control group at the last therapy session (r=-0.66, P=0.005). The FAC is suggested as a potential primary outcome measure for a definitive RCT, as it could be assessed in all patients and showed significant response to interventions (P<0.01). We estimated a sample size of 44 for a future RCT. CONCLUSIONS: VR-augmented RAGT resulted in high acceptability and motivation, and in a reduced drop-out rate and an extended training time compared to standard RAGT. This pilot trial provides guidance for a prospective RCT on the effectiveness of VR-augmented RAGT. CLINICAL REHABILITATION IMPACT: VR might be a promising approach to enrich and improve gait rehabilitation after stroke.}, language = {en} } @article{HoeslSchupfingerKlichetal.2023, author = {H{\"o}sl, Matthias and Schupfinger, Alexander and Klich, Luisa and Geest, Linda and Bauer, Petra and V. Bonfert, Michaela and Afifi, Faik K. and Nader, Sean and Berweck, Steffen}, title = {Relationship between kinematic gait quality and caregiver-reported everyday mobility in children and youth with spastic Cerebral Palsy}, series = {European Journal of Paediatric Neurology}, volume = {42}, journal = {European Journal of Paediatric Neurology}, pages = {88 -- 96}, year = {2023}, abstract = {Background: 3D gait analysis (3DGA) is a common assessment in Cerebral Palsy (CP) to quantify the extent of movement abnormalities. Yet, 3DGA is performed in laboratories and may thus be of debatable significance to everyday life. Aim The aim was to assess the relationship between kinematic gait abnormality and everyday mobility in ambulatory children and youth with spastic CP. Methods: 73 paediatric and juvenile patients with uni- or bilateral spastic CP (N = 21 USCP, N = 52, BSCP, age: 4-20 y, GMFCS I-III) underwent a 3DGA, while the MobQues47 Questionnaire quantified caregiver-reported mobility. We calculated the Gait Profile Score (GPS), a metric that summarizes how far the lower limb joint angles during walking deviate from those of matched controls. Results: The GPS correlated well with indoor and outdoor mobility (rho = -0.69 and -0.70, both p < 0.001) and the relationships were not significantly different for USCP and BSCP. Still, mobility was lower in BSCP (p < 0.001) and more compromised outdoors (p = 0.002). Indoor mobility could be predicted by walking speed, GPS and age (adj. R2 = 0.62). Outdoor mobility was best predicted by walking speed and GPS (adj. R2 = 0.60). The additive explained variance by the GPS was even higher outdoors than indoors (17.1\% vs. 11.4\%). Conclusions: Measuring movement deviations with 3DGA seems equally meaningful in uni- and bilaterally affected children and has considerable relevance for real-life ambulation, particurlarly outdoors, where children with spastic CP typically face greater difficulties. Therapeutic strategies that achieve faster walking and reduction of kinematic deviations may increase outdoor mobility.}, language = {en} } @inproceedings{BergmannBauerVolkeningetal.2011, author = {Bergmann, Jeannine and Bauer, Petra and Volkening, Katharina and Krewer, Carmen and M{\"u}ller, Friedemann}, title = {Virtual reality-enriched gait training to improve motivation and rehabilitation outcome in subacute stroke patients}, series = {20th European Stroke Conference, Hamburg, Germany, May 2011}, booktitle = {20th European Stroke Conference, Hamburg, Germany, May 2011}, year = {2011}, language = {en} } @article{BauerKrewerGolaszweskietal.2015, author = {Bauer, Petra and Krewer, Carmen and Golaszweski, Stefan and K{\"o}nig, Eberhard and M{\"u}ller, Friedemann}, title = {Functional electrical stimulation assisted active cycling - Therapeutic effects in patients with hemiparesis from 7 days to 6 months after stroke. A randomized controlled pilot study.}, series = {Archives of Physical Medicine and Rehabilitation}, journal = {Archives of Physical Medicine and Rehabilitation}, number = {96/2}, pages = {188 -- 196}, year = {2015}, language = {en} } @inproceedings{BauerKrewerGolaszweskietal.2012, author = {Bauer, Petra and Krewer, Carmen and Golaszweski, Stefan and K{\"o}nig, Eberhard and M{\"u}ller, Friedemann}, title = {Functional electrical stimulation assisted cycling - Therapeutic effects on patients with subacute hemiparesis after stroke}, series = {Paracelsus Universit{\"a}t Salzburg, Science get together, Juni 2012}, booktitle = {Paracelsus Universit{\"a}t Salzburg, Science get together, Juni 2012}, year = {2012}, language = {en} } @article{HorstmannshoffSkudlikPetermannetal.2023, author = {Horstmannshoff, Caren and Skudlik, Stefanie and Petermann, Jenny and Kiesel, Theresia and D{\"o}ringer, Tobias and Crispin, Alexander and Hermsd{\"o}rfer, Joachim and K{\"o}berlein‑Neu, Juliane and Jahn, Klaus and Sch{\"a}dler, Stefan and Bauer, Petra and Voigt, Karen and M{\"u}ller, Martin}, title = {Effectiveness of an evidence-based care pathway to improve mobility and participation in older patients with vertigo and balance disorders in primary care (MobilE-PHY2): study protocol for a multicentre cluster-randomised controlled trial}, series = {BMC Trials}, volume = {24}, journal = {BMC Trials}, pages = {91}, year = {2023}, abstract = {Background Vertigo, dizziness or balance disorders (VDB) are common leading symptoms in older people, which can have a negative impact on their mobility and participation in daily live, yet, diagnosis is challenging and specific treatment is often insufficient. An evidence-based, multidisciplinary care pathway (CPW) in primary care was developed and pilot tested in a previous study. The aim of the present study is to evaluate the effectiveness and safety of the CPW in terms of improving mobility and participation in community-dwelling older people with VDB in primary care. Methods For this multicentre cluster randomised controlled clinic trial, general practitioners (GP) will be recruited in two regions of Germany. A total of 120 patients over 60 years old with VDB will be included. The intervention is an algorithmized CPW. GPs receive a checklist for standardise clinical decision making regarding diagnostic screening and treatment of VDB. Physiotherapists (PT) receive a decision tree for evidence-based physiotherapeutic clinical reasoning and treatment of VDB. Implementation strategies comprises educational trainings as well as a workshop to give a platform for exchange for the GPs and PTs, an information meeting and a pocket card for home care nurses and informal caregivers and telephone peer counselling to give all participants the capability, opportunity and the motivation to apply the intervention. In order to ensure an optimised usual care in the control group, GPs get an information meeting addressing the national guideline. The primary outcome is the impact of VDB on participation and mobility of patients after 6 month follow-up, assessed using the Dizziness Handicap Inventory (DHI) questionnaire. Secondary outcomes are physical activity, static and dynamic balance, falls and fear of falling as well as quality of life. We will also evaluate safety and health economic aspects of the intervention. Behavioural changes of the participants as well as barriers, facilitating factors and mechanisms of impact of the implementation will be investigated with a comprehensive process evaluation in a mixed-methods design. Discussion With our results, we aim to improve evidence-based health care of community-dwelling older people with VDB in primary care.}, language = {en} } @article{PottDreischulteKolleretal.2024, author = {Pott, Claudia and Dreischulte, Tobias and Koller, Daniela and Fegl, Marlene and Langemeyer, J{\"u}rgen and Bauer, Petra}, title = {Development of an interprofessional diagnostic toolkit to enhance outside walking gait-related participation of people after stroke in Germany: study protocol of an ongoing multi-methods study}, series = {BMJ Open}, volume = {14}, journal = {BMJ Open}, number = {9}, doi = {10.1136/bmjopen-2024-084316}, pages = {7}, year = {2024}, abstract = {Introduction: Persons after stroke experience limitations in activities of daily living even in the chronic phase. Many patients who had a stroke report mobility limitations with loss of social roles such as reduced gait- related participation. International best- practice recommendations for patients who had a stroke include interprofessional diagnostics as a core element for goal setting and intervention planning to improve social participation. Interprofessional diagnostics has not yet been implemented in Germany. Methods and analysis: The aim is to develop an interprofessional diagnostic toolkit. This will be done in a multi- step process: first, an integrative review is conducted to synthesise the literature. Second, the experiences regarding diagnostics and walking outside is captured in focus groups with persons after stroke, relatives and health professionals. Third, a toolkit for the interprofessional diagnostic process of gait- related- participation will be developed based on the results of the previous steps in a future workshop. Fourth, the results of each work package will be integrated into the iterative development process for evaluation and implementation. All steps will be performed in accordance with the respective reporting guidelines. Ethics and dissemination: This study has been approved by the ethics committee at the Ludwig Maximilians University (LMU), Germany and is overseen by LMU-Medical Institutional Review Board. Written informed consent will be obtained from all participants. Results will be disseminated through knowledge exchange with stakeholders and in peer- reviewed journal publications, scientific conferences, formal and informal reports. Stakeholders, patients and providers will be involved in most steps of the development from the beginning, which will facilitate later implementation at a larger scale. Trial registration number: German Register Clinical Trials/Deutsches Register Klinischer Studien DRKS00032389.}, language = {en} } @misc{HorstmannshoffSchmidleBaueretal.2025, author = {Horstmannshoff, Caren and Schmidle, Stephanie and Bauer, Petra and M{\"u}ller, Martin}, title = {Impact of an evidence-based care pathway on the physical activity level in older adults with vertigo, dizziness, and balance disorders}, doi = {10.3205/25ebm053}, year = {2025}, language = {en} } @article{HammerschmidtGoertzWagenpfeiletal.2003, author = {Hammerschmidt, Thomas and Goertz, A. and Wagenpfeil, S. and Neiss, A. and Wutzler, P. and Banz, K.}, title = {Validation of Health Economic Models: The Example of EVITA}, series = {Value in Health}, journal = {Value in Health}, number = {6 / 5}, pages = {551 -- 559}, year = {2003}, language = {en} } @article{BanzWagenpfeilNeissetal.2004, author = {Banz, K. and Wagenpfeil, S. and Neiss, A. and Hammerschmidt, Thomas and Wutzler, P.}, title = {The burden of varicella in Germany}, series = {The European Journal of Health Economics}, volume = {2004}, journal = {The European Journal of Health Economics}, number = {5 / 1}, pages = {46 -- 53}, year = {2004}, language = {en} } @article{Kastl2025, author = {Kastl, Andrea}, title = {Empathy mapping and hybrid persona creation: Understanding older adults' needs in technology design for ageing in place}, series = {Computational and structural biotechnology journal}, volume = {28}, journal = {Computational and structural biotechnology journal}, publisher = {Elsevier}, doi = {10.1016/j.csbj.2025.11.044}, pages = {552 -- 563}, year = {2025}, abstract = {Background: Technology yields the potential to support independence in later life and facilitate ageing in place. Barriers such as limited usability, varying levels of digital literacy, and persistent age-related stereotypes are documented to hinder technology adoption among older adults. User-centered design approaches, such as the persona method, offer strategies to address these challenges. Objective: Personas were created to inform the development of technologies supporting ageing in place by enhancing stakeholders' understanding of needs and technology experience among older adults. Methods: The personas were developed through an iterative process, with this paper detailing the last stage, which employed the a PATHY technique as conceptual framework for content analysis. Eleven focus group discussions were conducted in southern Germany, of which nine were included in the analysis. These involved older adults in need of support, with orthopedic and neurological conditions, and in informal caregiving roles. Results: Five hybrid personas were created to represent the target groups' experiences related to ageing in place, each reflecting needs, problems, existing solutions, habits, sociodemographic characteristics, and dimensions of technology experience. Key factors influencing technology experience and uptake among the personas were identified, including the social context and availability of support, the perceived trade-off between safety and digital privacy, and the persistence of the digital divide. Conclusion: The findings underscore the necessity of adaptable, context-sensitive technology solutions, displayed by the personas' needs, pains, routines and technology experiences. Thereby, the hybrid personas reinforce the importance of a more relational and context-aware approach in user-centered design.}, language = {en} } @article{HammerschmidtBanzWagenpfeiletal.2004, author = {Hammerschmidt, Thomas and Banz, K. and Wagenpfeil, S. and Neiss, A. and Wutzler, P.}, title = {Economic Evaluation of Varicella Vaccination Programmes: A Review of the Literature}, series = {Pharmaco Economics}, journal = {Pharmaco Economics}, year = {2004}, abstract = {Chickenpox infections are generally mild but due to their very high incidence among healthy children they give rise to considerable morbidity and occasional mortality. With the development of a varicella vaccine in the early 1970s and its progressive licensing in many countries, interest in the efficiency of varicella immunisation programmes grew. The objective of this review was to discuss the methodological aspects and results of published economic evaluations of varicella vaccination. From this, we attempted to make recommendations. A computerised search was carried out; 17 full economic evaluations of varicella vaccination were retrieved. The review identified the methodological divergences and similarities between the articles in four areas: study design, epidemiological data, economic data and model characteristics. We assessed to what extent the applied methods conform to general guidelines for the economic evaluation of healthcare interventions and compared the studies' results. The desirability of a universal vaccination programme depends on whose perspective is taken. Despite variability in data and model assumptions, the studies suggest that universal vaccination of infants is attractive to society because large savings occur from averted unproductive days for parents. For the healthcare payer, universal vaccination of infants does not generate savings. Vaccination of susceptible adolescents has been proposed by some authors as a viable alternative; the attractiveness of this is highly dependent on the negative predictive value of anamnestic screening. Targeted vaccination of healthcare workers and immunocompromised individuals appears relatively cost effective. Findings for other target groups are either contradictory or provide insufficient evidence for any unequivocal recommendations to be made. High sensitivity to vaccine price was reported in most studies. This review highlights that some aspects of these studies need to be further improved before final recommendations can be made. First, more transparency, completeness and compliance to general methodological guidelines are required. Second, because of the increasing severity of varicella with age, it is preferable and in some cases essential to use dynamic models for the assessment of universal vaccination strategies. Third, most studies focused on the strategy of vaccinating children only while their results depended heavily on disputable assumptions (regarding vaccine effectiveness and impact on herpes zoster). Since violation of these assumptions could have important adverse public health effects, we suggest pre-adolescent vaccination as a more secure alternative. This option deserves more attention in future analyses.}, language = {en} } @misc{HorstmannshoffBorchersVoigtetal.2025, author = {Horstmannshoff, Caren and Borchers, Peggy and Voigt, Karen and M{\"u}ller, Martin and Bauer, Petra}, title = {The Impact of Physiotherapy in a Care Pathway on the Impairment of Mobility and Participation in Older Individuals with Vertigo}, doi = {10.82161/fbn5-pg94}, pages = {1}, year = {2025}, language = {en} } @article{HammerschmidtehemKloseLeidlBuchmannetal.2000, author = {Hammerschmidt (ehem. Klose), Thomas and Leidl, R. and Buchmann, I. and Brams, HJ and Reske, SN}, title = {Primary staging of lymphomas: cost-effectiveness of FDG-PET versus computed tomography}, series = {European Journal of Nuclear Medicine}, journal = {European Journal of Nuclear Medicine}, number = {27 / 10}, pages = {1457 -- 1464}, year = {2000}, language = {en} } @article{StratmannSchoeneHammerschmidtehemKlose2001, author = {Stratmann-Sch{\"o}ne, Diana and Hammerschmidt (ehem. Klose), Thomas}, title = {Health values and prospect theory: a comment}, series = {Medical Decision Making}, journal = {Medical Decision Making}, number = {21 / 1}, pages = {57 -- 59}, year = {2001}, language = {en} } @article{HammerschmidtBarth2012, author = {Hammerschmidt, Thomas and Barth, J.}, title = {European Reference Pricing for Vaccines in Germany: Mechanics and Effects}, series = {Value in Health}, journal = {Value in Health}, year = {2012}, abstract = {OBJECTIVES: Previous studies have documented the impact of bacteremia involving Methicillin-resistance (MRSA) in patients with Staphylococcus aureus bacteremia, but recent estimates using nationally representative data are not available. This study compares in-hospital mortality, length of stay (LOS) and total costs between hospital discharges for MRSA and methicillin-susceptible (MSSA) S. aureus bacteremia. METHODS: Using the 2008-2009 Nationwide Inpatient Sample (NIS) data of the Healthcare Cost and Utilization Project, we developed two groups (age� 18 years): MRSA bacteremia (ICD-9-CM codes: 041.12, V09.0 and 790.7) and MSSA bacteremia (ICD-9-CM codes: 041.11 and 790.7). Given the skewed distributionofin-hospitalcostsandover-dispersionofLOS,generalizedlinearmodel(GLM) withgammaandnegativebinomialvariancefunctionswereevaluatedtocompare in-hospital costs and LOS, respectively, between groups. Logit model was used to compare in Patient mortality between groups. Gender,age,payer,11comorbidities, and hospital characteristics, including hospital location, teaching status, bed size, ownership type, and hospital region served as covariates in all regression models. RESULTS: Patients with MRSA (vs. MSSA) bacteremia were reported as a discharge diagnosis for 0.06\% (vs. 0.05\%) or 44,157 (vs. 37,653) of all hospital inpatient stays amongadults. MRSAbacteremiainpatientshadrelativelylongerlengthofhospital stay (12.5 vs. 11.1 days;P� 0.01), higher total costs (\$22,263 vs. \$21,330;P� 0.02), and increased risk of in-hospital death (2.97\% vs. 2.71\%;P� 0.29) than inpatients with MSSAbacteremia. After adjustment for Patient and Hospital characteristics, MRSA bacteremia incurred 10.5\% (CI:7.2-14.0\%;P� 0.01) longer stays, 5.6\% (CI:2.0-9.4\%; P� 0.01) higher inpatient costs, and 0.3\% (CI:17.5-22.0\%;P� 0.97) higher inpatient mortality than MSSA bacteremia. The annual adjusted mean incremental total inpatient cost associated with MRSA was \$1,159 (SE: \$379;P� 0.01) per patient-discharge. CONCLUSIONS:MRSAbacteremiarepresentsaconsiderableattributable burden relative to MSSA bacteremia in the US hospitals. Continued efforts towards preventing MRSA infections would provide significant potential benefits by reducing hospital resource use and costs.}, language = {en} } @article{MuellerStratmannSchoeneHammerschmidtehemKloseetal.2002, author = {M{\"u}ller, A. and Stratmann- Sch{\"o}ne, D. and Hammerschmidt (ehem. Klose), Thomas and Leidl, R.}, title = {Overview of economic evaluation of positron-emission-tomography}, series = {The European Journal of Health Economics}, journal = {The European Journal of Health Economics}, number = {3 / 1}, pages = {59 -- 65}, year = {2002}, language = {en} } @article{HammerschmidtZeitlerGulichetal.2004, author = {Hammerschmidt, Thomas and Zeitler, HP. and Gulich, M. and Leidl, R.}, title = {A Comparison of Different Strategies to Collect Standard Gamble Utilities}, series = {Medical Decision Making}, journal = {Medical Decision Making}, year = {2004}, abstract = {Objective. The authors performed a methodological comparison of the usual standard gamble with methods that could also be used in mailed questionnaires.Methods.Ninety-two diabetic patients valued diabetes-related health states twice. In face-to-face interviews, the authors used an iterative standard gamble (ISG) in which the probabilities were varied in a ping-pong manner and a self-completion method (SC) with top-down titration as search procedure (SC-TD) in 2 independent subsamples of 46 patients. Three months later, all patients received a mailed questionnaire in which the authors used the self-completion method with bottom-up (SCBU) and SC-TD as search procedures.Results.ISG and SCTD showed feasibility and consistency in the interviews. The ISG resulted in significantly higher utilities than the SC-TD. Two thirds of the mailed questionnaires provided useful results indicating some problems of feasibility. Utilities measured by SC-BU and SC-TD did not differ significantly showing procedural invariance. Further, patients indicated ambivalence when given the choice not to definitely state their preferences.Conclusions.The results show that different strategies to collect standard gamble utilities can yield different results. Compared with the usually applied ISG, the SC method is feasible in interviews and provides a consistent alternative that is less costly when used in mailed questionnaires, although its practicability has to be improved in this later setting.}, language = {en} } @article{HuppertzForsterHeiningeretal.2008, author = {Huppertz, HI and Forster, J. and Heininger, U. and Roos, R. and Neumann, H.U. and Hammerschmidt, Thomas}, title = {The Parental Appraisal of the Morbidity of Diarrhea in Infants and Toddlers (PAMODI) Survey}, series = {Clinical Pediatrics}, journal = {Clinical Pediatrics}, number = {47}, year = {2008}, abstract = {This study analyzed parental perception of the impact of diarrhea on quality of life of their children. A standardized questionnaire was completed by 2023 parents in Germany with children with diarrhea who were younger than 2 years old. Parents stated the most worrying aspects of diarrhea. A health score was measured using a visual analogue scale (0 = worst health, 100 = best health). Clinical symptoms were quoted by 72\% of parents as one of the most worrying dimensions, with duration/frequency of diarrhea and weight loss perceived most meaningful. Next were behavioral/physical symptoms (51\%), with an inflamed bottom for mild disease and pain for severe cases being most meaningful. Parental concern is characterized by sympathy and anxiety for the child. The health score for the diarrheal episode was 54.6 for mild and 33.9 for severe cases. Parents perceive a high disease burden of diarrhea and clinically less meaningful aspects play a significant role.}, language = {en} } @article{HammerschmidtBisanzWutzler2007, author = {Hammerschmidt, Thomas and Bisanz, H. and Wutzler, P.}, title = {Universal mass vaccination against varicella in Germany using an MMRV combination vaccine with a two-dose schedule: An economic analysis}, series = {Vaccine}, journal = {Vaccine}, publisher = {ELSEVIER}, year = {2007}, abstract = {Former economic analyses have shown that universal mass vaccination of infants against varicella using a one-dose schedule is cost-saving in Germany. In July 2006, an MMRV combination vaccine has been approved in Germany which shall be given in a two-dose schedule. We re-analysed our former analysis with the EVITA model in order to prove whether our former conclusion that universal mass vaccination against varicella is cost-saving is still valid when using a two-dose schedule vaccine. Indeed we found that universal mass vaccination of infants against varicella with a two-dose vaccine is cost-saving from societal as well as from health care perspective.}, language = {en} } @article{HammerschmidtZeitlerLeidl2004, author = {Hammerschmidt, Thomas and Zeitler, HP and Leidl, R.}, title = {A utility-theoretic approach to the aggregation of willingness to pay measured in decomposed scenarios: development and empirical test.}, series = {Health Econ}, journal = {Health Econ}, year = {2004}, abstract = {For cost-benefit analysis, health technologies with multiple effects should be valued in a single scenario by a holistic willingness-to-pay (WTP) measure. Recent studies instead used decomposed scenarios in which respondents report their WTP for each individual effect. Evidence can be found that the sum of such decomposed WTPs overestimates the holistic WTP, i.e. the holistic WTP is sub-additive. This sum of decomposed WTPs can lead to wrong conclusions on the efficiency of health technologies. This is also relevant in decision making about new technologies that are valued separately in different surveys. To date, no utility-theoretical and empirically validated aggregation function for decomposed WTPs exists. Within an expected utility model, this paper identifies as a reason for sub-additivity - beside risk aversion with respect to wealth - a negative influence of better health on the marginal utility of wealth, i.e. marginal utility of wealth is smaller in better health states. Assuming mutual utility independence of health and wealth, a theoretically founded aggregation function covering these two impacts is derived. In a contingent valuation study, 92 patients with diabetes were asked to state their WTP for reductions of the risk of several diabetic complications in decomposed as well as in holistic scenarios. The patients had preferences with a significant negative influence of health on the marginal utility of wealth. Sub-additivity occurred and theoretically founded aggregation could considerably lower the degree of overestimation. These results suggest that the theoretically founded aggregation function might reduce problems of sub-additivity that can be economically relevant. Further empirical testing of the approach is indicated.}, language = {en} } @article{HammerschmidtZeitlerLeidl2003, author = {Hammerschmidt, Thomas and Zeitler, H. P. and Leidl, R.}, title = {Unexpected yes- and no-answering behaviour in the discrete choice approach to elicit willingness to pay: a methodological comparison with payment cards}, series = {International Journal of Health Care Finance and Economics}, journal = {International Journal of Health Care Finance and Economics}, number = {3 / 3}, pages = {147 -- 166}, year = {2003}, language = {en} } @article{HammerschmidtehemKlose2002, author = {Hammerschmidt (ehem. Klose), Thomas}, title = {Life-cycle preferences over consumption and health: a comment on Bleichrodt and Quiggin}, series = {Journal of Health Economics}, journal = {Journal of Health Economics}, number = {21 / 1}, pages = {161 -- 166}, year = {2002}, language = {en} } @article{HammerschmidtehemKlose2003, author = {Hammerschmidt (ehem. Klose), Thomas}, title = {A utility-theoretic model for QALYs and willingness to pay}, series = {Health Economics}, journal = {Health Economics}, number = {12 / 1}, pages = {17 -- 31}, year = {2003}, language = {en} }