@article{MuellerStroblJahnetal.2014, author = {M{\"u}ller, Martin and Strobl, R. and Jahn, K. and Linkohr, B. and Ladwig, K.H. and Mielk, A. and Grill, E.}, title = {Impact of vertigo and dizziness on self-perceived participation and autonomy in older adults: Results from the KORA-Age study}, series = {Quality of life research}, journal = {Quality of life research}, editor = {Springer Link,}, year = {2014}, abstract = {Purpose The impact of vertigo and dizziness on healthy ageing, and especially on participation, is not fully understood. The objective of this study was to investigate the association of vertigo and dizziness with self-perceived participation and autonomy in older non-institutionalised individuals, adjusted for the presence of other health conditions. Specifically, we wanted to investigate the different effects of vertigo and dizziness on specific components of participation, i.e. restrictions in indoor and outdoor autonomy, family role, social life and relationships, and work and education. Methods Data originate from the second wave of the German KORA-Age cohort study collected in 2012. Participation and autonomy was investigated with the Impact on Participation and Autonomy Questionnaire. We used robust regression to analyse the association of vertigo and dizziness with self-perceived participation and autonomy adjusted for covariates. Results A total of 822 participants (49.6 \% female) had a mean age of 78.1 years (SD 6.39). Participation and autonomy were significantly lower in participants with vertigo and dizziness across all domains. Adjusted for age, sex, and chronic conditions, vertigo and dizziness were significantly associated with participation restrictions in all domains except social life and relationships. Conclusion The results of our study indicate that vertigo and dizziness contribute to restrictions in participation and autonomy in individuals of older age. Recognising vertigo and dizziness as independent contributors to loss of autonomy and decreased chances for independent living may create new options for patient care and population health, such as the designing of complex interventions to maintain participation and autonomy.}, language = {en} } @article{MuellerPetersDoringetal.2011, author = {M{\"u}ller, Martin and Peters, A. and Doring, A. and Ladwig, K.-H. and Holle, R. and Meisinger, C. and Linkohr, B. and Autenrieth, C. and Baumeister, S. and Behr, J. and Bergner, A. and Bickel, H. and Bidlingmaier, M. and Dias, A. and Emeny, R.T. and Fischer, B. and Grill, E. and Gorzelniak, L. and Hansch, H. and Heidbreder, S. and Heier, M. and Horsch, A. and Huber, D. and Huber, R.M. and Jorres, R.A. and Kaab, S. and Karrasch, and Kirchberger, and Klug, and Kranz, and Kruch, and Lacruz, and Lang, and Mielk, and Nowak, and Schneider, and Schulz, and Seidel, and Strobl, and Thorand, and Wende, and Weidenhammer, and Zimmermann, and Wichmann,}, title = {Multimorbidity and successful aging: the population-based KORA-Age study}, series = {Zeitschrift f{\"u}r Gerontologie und Geriatrie}, journal = {Zeitschrift f{\"u}r Gerontologie und Geriatrie}, editor = {Springer Nature,}, year = {2011}, abstract = {Background Multimorbidity in the older population is well acknowledged to negatively affect health-related quality of life (HRQL). Several studies have examined the independent effects of single diseases; however, little research has focused on interaction between diseases. The purpose of this study was to assess the impact of six self-reported major conditions and their combinations on HRQL measured by the EQ-5D. Methods The EQ-5D was administered in the population-based KORA-Age study of 4,565 Germans aged 65 years or older. A generalised additive regression model was used to assess the effects of chronic conditions on HRQL and to account for the nonlinear associations with age and body mass index (BMI). Disease interactions were identified by a forward variable selection method. Results The conditions with the greatest negative impact on the EQ-5D index were the history of a stroke (regression coefficient -11.3, p < 0.0001) and chronic bronchitis (regression coefficient -8.1, p < 0.0001). Patients with both diabetes and coronary disorders showed more impaired HRQL than could be expected from their separate effects (coefficient of interaction term -8.1, p < 0.0001). A synergistic effect on HRQL was also found for the combination of coronary disorders and stroke. The effect of BMI on the mean EQ-5D index was inverse U-shaped with a maximum at around 24.8 kg/m2. Conclusions There are important interactions between coronary problems, diabetes mellitus, and the history of a stroke that negatively affect HRQL in the older German population. Not only high but also low BMI is associated with impairments in health status.}, language = {en} } @article{PetersDoringLadwigetal.2011, author = {Peters, A. and Doring, A. and Ladwig, K.-H. and Meisinger, C. and Linkohr, B. and Autenrieth, C. and Baumeister, S.E. and Behr, J. and Bergner, A. and Bickel, H. and Bidlingmaier, M. and Dias, A. and Emeny, R.T. and Fischer, B. and Grill, E. and Gorzelniak, L. and Hansch, H. and Heidbreder, S. and Heier, M. and Horsch, A. and Huber, D. and R. M., Huber and Jorres, R.A. and Kaab, S. and Karrasch, S. and Kirchberger, I. and Klug, G. and Kranz, B. and Kuch, B. and Lacruz, M.E. and Lang, O. and Mielck, A. and Nowak, D. and Perz, S. and Schneider, A. and Schulz, H. and M{\"u}ller, Martin and Seidl, H. and Strobl, R. and Thorand, B. and Wende, R. and Weidenhammer, W. and Zimmermann, A.-K. and Wichmann, H.-E. and Holle, R.}, title = {Multimorbidity and successful aging: the population-based KORA-Age study}, series = {Health and quality of life outcomes}, journal = {Health and quality of life outcomes}, editor = {BioMed Central,}, year = {2011}, abstract = {Background Multimorbidity in the older population is well acknowledged to negatively affect health-related quality of life (HRQL). Several studies have examined the independent effects of single diseases; however, little research has focused on interaction between diseases. The purpose of this study was to assess the impact of six self-reported major conditions and their combinations on HRQL measured by the EQ-5D. Methods The EQ-5D was administered in the population-based KORA-Age study of 4,565 Germans aged 65 years or older. A generalised additive regression model was used to assess the effects of chronic conditions on HRQL and to account for the nonlinear associations with age and body mass index (BMI). Disease interactions were identified by a forward variable selection method. Results The conditions with the greatest negative impact on the EQ-5D index were the history of a stroke (regression coefficient -11.3, p < 0.0001) and chronic bronchitis (regression coefficient -8.1, p < 0.0001). Patients with both diabetes and coronary disorders showed more impaired HRQL than could be expected from their separate effects (coefficient of interaction term -8.1, p < 0.0001). A synergistic effect on HRQL was also found for the combination of coronary disorders and stroke. The effect of BMI on the mean EQ-5D index was inverse U-shaped with a maximum at around 24.8 kg/m2. Conclusions There are important interactions between coronary problems, diabetes mellitus, and the history of a stroke that negatively affect HRQL in the older German population. Not only high but also low BMI is associated with impairments in health status.}, language = {en} }