Open Access

Leonardo Henrique Dos Santos

• Oxidative stress is a common hallmark observed in neurodegenerative diseases, acting either as a triggering factor or as a consequence of the neurodegenerative process. Astrocytes play a crucial role in mediating oxidative stress caused by physiological processes, such as the byproducts of mitochondrial function during cellular respiration. Given the critical role of oxidative stress in the progression of many neurodegenerative diseases, identifying molecules capable of modulating this response and mitigating oxidative damage is of considerable interest. Cannabinoids such as cannabidiol (CBD) and WIN 55.212-2, known for their capability of influencing the endocannabinoid system through their interaction with cannabinoid receptors (namely, CB1R and CB2R), and therefore the Central Nervous System, are promising candidates for such modulation. This work aimed to explore, through proteomics, the potential effect that the mentioned cannabinoids might have against oxidative stress induced by hydrogen peroxide in astrocytes, possibly mitigating some of the oxidative damage.