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  <doc>
    <id>400</id>
    <completedYear/>
    <publishedYear>2019</publishedYear>
    <thesisYearAccepted>2019</thesisYearAccepted>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2019-08-03</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2019-06-17</thesisDateAccepted>
    <title language="eng">Reconstructing a Genome-scale Metabolic Model of a Chinese Hamster Ovary Cell and Analyzing its Properties</title>
    <abstract language="eng">This work is based on reconstructing a genome-scale metabolic model of a Chinese hamster (CHO) cell and evaluating the model’s properties and explain why it has the potential to be a great asset for future testing. It is very useful to have a mathematical model because it can be used to run simulations. These simulations would give an accurate representation of the outcome when alterations of a certain metabolic mechanism or compound are changed. The main goal is to reconstruct a working model without dead ends to be used as a teaching tool in an academic environment. It can give students, and alike, a chance to reference what a CHO cell model could resemble. Another goal is for the model to be used to run simulations. This work wants to give access to something that is currently kept under confidentiality by larger industries and allow those who wish to learn a chance to use it. The last CHO cell model was created 2 years ago, and it was never published. Therefore, this work focuses on constructing a new model with the software ‘Insilico’ by using literature, KEGG and the CHO genome database. With the aid of programs like ‘Matlab,’ ‘Excel,’ and ‘XML Notepad,’ scripts are created to be suitable for ‘Insilico.’ After many laborious trials and errors, a complete, working and full CHO cell model is reconstructed with ~1800 reactions and transporters. The FBA analysis works by showing that the model can run simulations and prove that biomass has an output.</abstract>
    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Haya Essa</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
  </doc>
</export-example>
