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    <completedYear>2025</completedYear>
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    <pageLast/>
    <pageNumber>69</pageNumber>
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    <title language="eng">The Role of Online Marketplaces in Reshaping Agribusiness Sales and Distribution: Evidence from Ibadan and Lagos, Nigeria.</title>
    <abstract language="eng">1.1 Context and Background&#13;
Online marketplaces are applications or web sites on which products are advertised and sold. They are used in the agricultural sector to bring sellers and buyers together. Farmers advertise about their products and customers give their orders. The payment may be done prior or after delivery. The tools enable farmers to sell without traveling. They also decrease the number of intermediaries. There are sites that allow the customer to rate sellers. There are also people sharing updates on delivery or assisting with tracking goods (Eweoya et al., 2021). Trade in farm goods is evolving in Nigeria, owing to online trade. Most of the farmers would sell in open markets only. The prices were frequently low and middlemen absorbed the better part of the profit (Morepje et al., 2024).&#13;
It is now easier to connect farmers and buyers by way of mobile phones and enhanced internet. Through online, farmers are able to access directly to homes, stores and even export firms. They save time and minimize wastes because customers do not need to travel in order to make an order. This idea was tested with some of the pioneer platforms in Nigeria (Abubakar et al., 2019). Farmcrowdy began as an initiative to finance small growers and match them with consumers. Agricorp constructed a system to exchange crops such as ginger and grains between states. OjaNow also connects small farms with homes and restaurants who desire fresh food. The services are used to assist farmers in selling more as they remain on their farms. Customers are able to shop and deliver farm products to their front door by making an online order. The platforms also assist the farmers to know what is being demanded as well as the price that the buyers are willing to pay. They operate most of them on basic mobile phones and hence can be used even in places with poor internet connections (Ogbeide-Osaretin and Ebhote, 2020).&#13;
Online market places have changed the way farmers market their produce because they reach a greater distance than the local area. Most farmers used to sell within their towns only, but now digital platforms enable them to sell to the buyers in such cities&#13;
2&#13;
like Lagos, Abuja and Ibadan. By using such platforms, they are no longer restricted to set days of the market since sales may be carried out at any given time. This flexibility is time-saving, generates more turnover, and allows farmers to deliver food to a larger group of consumers, such as hotels, stores, and schools (Mani and Singh, 2022). Online tools have also decreased the price of selling farm produce in addition to increasing their markets. Farmers will have the opportunity to self-service their prices and deal directly with buyers by eliminating transport costs and bypassing several intermediaries. This enhanced control on prices does not only enhance their earnings, but also promotes fairness and transparency in trade. Buyers, in their turn, have an advantage of price comparison between various sellers prior to acquiring a particular good, which causes more competitive pricing and low fraud potential (Xiao, et al., 2021).&#13;
The use of online platforms in integrating with local logistics and transport networks has made delivery much faster. Today many platforms collaborate with professional drivers and delivery crews that provide the delivery of the orders and their transportation at the same time. This has been especially beneficial to perishable products like tomatoes, vegetables, and fruits, whose delivery must be done in a timely manner to preserve their freshness and quality. Consequently, fewer produce is wasted as it goes to waste prior to reaching the consumers hence less waste and the general efficiency of the supply chain. Buyers get healthier and fresher food, and sellers save some money and losses of unsold or spoilt products. This credibility also builds trust between the two parties, as customers get to trust merchants with quality goods, and sellers go out of their way to keep their standards (Agrawal et al., 2021). Farmcrowdy, Thrive Agric, OjaNow, and Agricorp are the ones that have introduced similar systems in Nigeria, where both large-scale and smallholder farmers can engage in an effective and efficient digital trade (Akinwale et al., 2023).&#13;
Most farmers access them via mobile phones as majority of the applications are phone-based. These sites are very popular in cities where there are greater internet connectivity. They are used by farmers to add the name of crops and buyers to make orders. During harvest, when there is plenty in supply, use is greatest. These tools are more acceptable by young farmers compared to the old. They are also common among traders and restaurants as they require constant supply. Information is also&#13;
3&#13;
useful on online platforms. Farmers are aware of the demand of crops and their price rates. This helps them plan better. They grow what people want. They also make the best decision regarding the time to sell. Buyers utilize the same information to determine whether the prices can increase or decrease. Other websites provide notifications to make fast decisions. This enhances better planning of farmers and reduces waste (Alkahtani et al., 2021).&#13;
Online sales have simplified the process of farming, but a number of issues also persist. Previous research has concentrated largely on the rural farmers with little attention paid to the use of these digital tools by the smallholder and urban farmers. Visiting the city like Ibadan and Lagos, farmers have special marketing and distribution issues that are not the same as found in the countryside (Sadiq et al., 2025). A large number of these urban farmers work on small pieces of land and depend on fast sales in order to avoid losses after harvest. Nevertheless, they have problems with the lack of storage facilities and the inadequacy of transport systems (Agri et al., 2020). Few studies have examined these particular constraints in the smallholder farmers (Kabo-Bah &amp; Bannor, 2025). The available research is rather inclined to investigate farmers access to the online platform instead of studying the impact of these tools on logistics, the speed of delivery, or storage (Trang et al., 2024; Olamide et al., 2024). Consequently, some critical questions will go unanswered, including the ways in which digital platforms can mitigate food wastage or make supply more efficient. Smallholder and urban farmers should be given more attention in future studies to offer a complete picture of the effects of online marketplaces (Akanni and Gabriel, 2020).&#13;
There are numerous impediments in agribusiness in online marketplaces. Trust is a major concern. Online payments are a worry to the farmers since they are not sure that they are safe. Customers are concerned with counterfeits that are sold via these sites. A lot of farmers also cannot access because of poor power supply and weak network. Other farmers are not phone savvy and like their traditional mode of selling (Eweoya et al., 2021). One of the concerns is capacity building. The farmers should be well trained on how to utilize online sales tools. In their absence, a number of them might not enjoy the use of digital platforms. Hence, further research is necessary that will help to investigate the ways these tools are applied in the day-to-day life of farmers and how they can be trained to achieve better results. Online sales can empower farm&#13;
4&#13;
markets in Nigeria, albeit, its implementation requires farmers to leverage it effectively. It will be possible to understand which areas these platforms are most effective and which ones provide difficulties and use this information to develop more effective training and support programmes by the government and agricultural support groups. It will contribute to reinforcing what is already effective and bridging the gaps that may still exist (Ogbeide-Osaretin and Ebhote, 2020). Therefore, online stores are influencing the movement of food between farms and Nigerian households. They create new sales opportunities and enhance crop planning but there are still numerous problems. The studies are required to observe the impact of these platforms on storage, transportation as well as urban agriculture. An explicit analysis of the areas will inform policies that can empower farmers and enhance food supply.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-23358</identifier>
    <enrichment key="opus.import.date">2026-03-13T11:00:21+00:00</enrichment>
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    <licence>CC BY-ND 4.0 International - Namensnennung-Keine Bearbeitungen</licence>
    <author>Balogun Joseph</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <collection role="Import" number="import">Import</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2335/9261_20250312090808_The Role of Online Marketplaces in Reshaping Agribusiness Sales and Distribution.pdf</file>
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  <doc>
    <id>2334</id>
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    <publishedYear>2025</publishedYear>
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    <language>eng</language>
    <pageFirst>44</pageFirst>
    <pageLast/>
    <pageNumber>80</pageNumber>
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    <publisherName>European Federation of Animal Science (EAAP)</publisherName>
    <publisherPlace>Zuerich</publisherPlace>
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    <completedDate>2025-06-04</completedDate>
    <publishedDate>2025-06-04</publishedDate>
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    <title language="eng">AI-Driven Approaches for Animal Welfare Monitoring in Agroforestry Systems</title>
    <abstract language="eng">Climate change and shifting agricultural practices require innovative methods to monitor and improve animal welfare for pasture-based and other outdoor livestock. Agroforestry systems, integrating livestock with trees,&#13;
shrubs and other woody vegetation, might provide shade, shelter, diversified feed and improved microclimates but require advanced monitoring to assess their impact on animal well-being. As part of the Agroforestry Living&#13;
Laboratory at Rhine-Waal University, we are developing AI-driven, sensor-based solutions to monitor livestock welfare, focusing on small ruminants as well as poultry. To achieve this, we are evaluating AI-based monitoring&#13;
methods to improve our understanding of animal welfare, while evaluating the role of different data sources. Sensors on animals collect data on movement patterns, and shade use, potentially providing insights into behavioral&#13;
adaptations and stress responses. Stationary non-invasive camera systems are tested using computer vision and AI to assess posture, interactions, and activity on individual and group levels. Additionally, microclimate sensors&#13;
might measure environmental conditions such as temperature, humidity, and radiation to evaluate their effects on animal behavior. As agroforestry systems are often in remote areas without external power, we also analyze&#13;
the potential of self-sustaining sensor networks powered by solar energy and edge computing. These systems minimize energy consumption through deep-sleep modes and decentralized data processing, ensuring continuous&#13;
monitoring without constant human intervention. By integrating AI-driven pattern recognition with agroforestry systems, we aim to establish an autonomous, energy-efficient monitoring network for further insights into animal welfare, behavioral changes, and environmental adaptation. Though still in development, early findings suggest these methods might enhance data-driven decision-making for sustainable pasture management, benefiting both animal welfare and agroforestry system resilience.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-23348</identifier>
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    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Jannis Menne</author>
    <author>Rolf Becker</author>
    <author>Jan Sonntag</author>
    <author>Anja Waldmann</author>
    <author>Ana C. Kreter</author>
    <author>Steffi Wiedemann</author>
    <subject>
      <language>eng</language>
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      <value>animal welfare monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>agroforestry systems</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sensor-based monitoring</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>pasture based livestock systems</value>
    </subject>
    <collection role="ddc" number="50">Naturwissenschaften</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2334/AI4AS_Poster_Zuerich_2025.pdf</file>
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  <doc>
    <id>2270</id>
    <completedYear>2025</completedYear>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>104</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>masterthesis</type>
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    <title language="deu">Entwicklung eines kardiovaskulären Präventionskonzeptes für den Kreis Kleve auf Grundlage eines 10- Jahres Vergleiches des Patientenkollektivs mit ST-Hebungs-Myokardinfarkt</title>
    <abstract language="deu">Trotz des medizinischen Fortschrittes gehören kardiovaskuläre Erkrankungen weiterhin zu den führenden Todesursachen in Deutschland. Der akute Herzinfarkt mit ST- Streckenhebung ist eine mögliche Manifestationsform.  Zu den Risikofaktoren für die Entstehung von Herz-Kreislauf-Erkrankungen zählen viele modifizierbare Parameter (Nikotinkonsum, Übergewicht, Bewegungsmangel usw.), so dass das Risiko an einem Herzinfarkt zu erkranken, zumindest teilweise beeinflussbar ist. Mit dem „Gesunde[n]-Herz-Gesetz“ wollte die 24. Bundesregierung der Bundesrepublik Deutschland auf diese Mechanismen aufmerksam machen und Präventionsprogramme zur Reduktion kardiovaskulärer Risikofaktoren etablieren.&#13;
&#13;
Die vorgestellte Arbeit befasst sich mit dem kardiovaskulären Risikoprofil sowie demographischen Daten der Herzinfarkt-Patienten in der Kardiologie des katholischen Karl-Leisner-Klinikums (St. Antonius Hospital Kleve und Marienhospital Kevelaer) im Vergleich der Jahre 2014 und 2024.  Es soll untersucht werden, wie das Risikoprofil der Herzinfarkt-Patienten in den beiden Krankenhäusern aussieht, und wie es sich im Vergleich der letzten 10 Jahre verändert hat.&#13;
&#13;
Ziel der Arbeit ist es, herauszufinden welches Patientenkollektiv in den kardiologischen Abteilungen des katholischen Karl-Leisner-Klinikums von Herzinfarkten betroffen ist, um gezielt Präventionsmaßnahmen abzuleiten. Hierfür wurden die Krankenakten aller Patienten, die im Jahr 2014 im Krankenhaus Kleve sowie im Jahr 2024 in den Krankenhäusern Kleve und Kevelaer mit einem ST-Hebungsmyokardinfarkt behandelt wurden, eingeschlossen. Mittels Student’s T-Test und Mann-Whitney-U-Test wurden demographische Parameter, Laborwerte und weitere kardiovaskuläre Risikofaktoren zwischen den beiden Zeiträumen verglichen.&#13;
&#13;
Es zeigt sich eine signifikante Zunahme von Gesamtcholesterin und LDL-Cholesterin im Jahr 2024 verglichen zu 2014. Außerdem besteht die Tendenz zur Abnahme der Nierenfunktion zwischen den untersuchten Jahren. Im Hinblick auf weitere Risikofaktoren wie manifeste Atherosklerose, Diabetes mellitus und arterielle Hypertonie zeigt sich eine Tendenz zur Entwicklung eines multimorbiden Patientenkollektives.&#13;
&#13;
Als Ansatzpunkte zur Optimierung des Risikoprofils seien Maßnahmen zur Raucherentwöhnung, Reduktion von Bewegungsmangel sowie eine Verbesserung der Gesundheitsvorsorge und -aufklärung zu nennen.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-22708</identifier>
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    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Selma Mietz</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>ST-Hebungsinfarkt</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Kardiovaskuläre Prävention</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Kreis Kleve</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
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    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
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    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2270/8935_20252807200157_Masterarbeit Selma Mietz.pdf</file>
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    <completedDate>2025-09-04</completedDate>
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    <title language="eng">Appendix Files of the Master’s Thesis “Experimental Determination of Microbial Preservation in Cosmetic Formulations Using Modified ISO 11930 Methods”</title>
    <abstract language="eng">This dataset contains the appendix files of the Master’s Thesis “Experimental Determination of Microbial Preservation in Cosmetic Formulations Using Modified ISO 11930 Methods.”&#13;
The files include raw experimental data in Excel format, covering microbial counts, preservative efficacy testing, and neutralizer validation across different formulations and bacterial strains. These supplementary materials provide detailed numerical results that support the analyses and figures presented in the main thesis document. They ensure transparency and reproducibility of the study by granting access to the complete underlying data.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-22557</identifier>
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    <licence>CC BY-ND 4.0 International - Namensnennung-Keine Bearbeitungen</licence>
    <author>Ghazaleh Fazlikhani</author>
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    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2255/Appendix.zip</file>
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  <doc>
    <id>2248</id>
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    <completedDate>2025-08-25</completedDate>
    <publishedDate>--</publishedDate>
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    <title language="deu">Luminescence and Raman spectroscopic data of bacteria with and without exposure to water-soluble polymers (WSPs)</title>
    <abstract language="eng">Data from luminescence measurements of bacteria exposed to water-soluble polymers (WSPs), as well as Raman spectra of bacteria with and without contact to the WSPs.&#13;
Polyacrylamide (PAM) – tested in different molecular weights (e.g., 40,000 g/mol, 150,000 g/mol, 15,000,000 g/mol). &#13;
Polyethylene glycol (PEG) – investigated at molecular weights such as 8,000 g/mol, 20,000 g/mol, and 35,000 g/mol. &#13;
Polyvinyl alcohol (PVOH) – studied at molecular weights like 16,000 g/mol, 47,000 g/mol, and 61,000 g/mol.&#13;
Polyvinylpyrrolidone (PVP) – analyzed in molecular weights such as 24,000 g/mol, 40,000 g/mol, and 360,000 g/mol.&#13;
The used bacteria was Aliivibrio fischeri.</abstract>
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    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Thomas Tewes</author>
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      <value>A. fischeri</value>
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      <language>eng</language>
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      <value>water-soluble polymers</value>
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    <pageFirst/>
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    <title language="eng">Identifying Policy Opportunities for the Costa Rican Cocoa Market: A Comparative Analysis with the Dominican Republic</title>
    <abstract language="eng">Cocoa is a crop native to Costa Rica that once thrived as one of the country’s principal exports. Its decline began in the late 1970s following severe disease outbreaks and has been further affected by a lack of sustained institutional support. This thesis presents a comparative analysis of the cocoa sectors in Costa Rica and the Dominican Republic due to the latter’s good positioning in the global cocoa market. It aims to identify policy opportunities that could support the revitalization of Costa Rican cocoa production. Semi-structured interviews were conducted with stakeholders across both countries and thematically analysed according to six key areas: general characteristics, exports and market access, labour conditions, public policy and framework, support framework, and growth potential. Findings suggest that the Dominican Republic’s success is due to continued governmental prioritization and support, alongside the presence of strong producer associations that facilitate access to post-harvest infrastructure, international markets, and organic certification. In contrast, Costa Rica’s sector remains fragmented, with limited coordination, restricted market access, and minimal governmental support. Nonetheless, recent increases in global cocoa prices and renewed institutional interest have created favourable conditions for reactivating and strengthening the sector. This study highlights the need for strengthened producer organization and culturally grounded support for Indigenous cocoa producers. The broader aim of the study is to enable producers to improve their quality of life through increased profitability.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-22308</identifier>
    <enrichment key="opus.import.date">2025-07-08T10:04:58+00:00</enrichment>
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    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Valentina Bernardita Moncada Torres</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cocoa production</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Costa Rica</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Dominican Republic</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Comparative study</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Agricultural Policy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Market Access</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Producer Support</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
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    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2230/9042_20252206001208_Moncada-Torres_Valentina-Bernardita_30976_Bachelor Thesis.pdf</file>
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    <completedDate>2025-06-11</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Comparative analysis of microbial community on apricot kernel shells and walnut shells influenced by post-harvest conditions.</title>
    <abstract language="eng">Apricot kernel shells (AKS) and walnut shells (WS) are byproducts from fruit processing lines and may serve as sustainable alternatives to microplastics in industrial applications due to their high content of natural polymers such as cellulose, hemicellulose, and lignin. Their use necessitates understanding the associated microbial risks to secure the quality of raw materials. This study investigates microbial communities on AKS and WS collected from Kyrgyzstan over a three-year period of harvests (2022-2024), using culture-dependent total viable count (TVC) as well as culture-independent shotgun metagenomic sequencing to explore the taxonomic and functional profile of microorganisms present on the shells. Results indicated higher microbial loads in more recent harvests with a  dominance of Proteobacteria on WS comprising Pantonea agglomerans and Xanthomonas arboricola. On AKS, the phylum Firmicutes was prevalent emphasizing on Weissella confusa and Weissella cibaria.   Incubation at humid conditions increased the fungal diversity in particular, especially Rhizopus microsporus in WS and Pichia membranifaciens in AKS, highlighting storage humidity as a critical factor which may induce microbial shifts. Functional metagenomic profiling based on Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, highlighted metabolic and relational pathways of microbial community present on AKS and WS. Furthermore, microbial similarities between shell samples and their respective storage environments suggest that handling and storage practices may significantly affect contamination profiles.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-22214</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Binal Dobariya</author>
    <author>Dirk P. Bockmühl</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Walnut shells, Apricot kernel shells, Alternatives to microplastics, Cosmetics, Microbial communities</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2221/Dobariya_AKS_WS_Rawdata.zip</file>
  </doc>
  <doc>
    <id>2218</id>
    <completedYear>2025</completedYear>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>42</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Effects of Sewage Sludge Biochar as a Growing Media Component and Phosphate Fertiliser on the Cultivation of Potted Ornamental Plants</title>
    <abstract language="eng">There is increasing pressure from the German government on its citizens to reduce dependency on phosphate rock and peat, in agriculture and horticulture. This is due to the phosphate rock oligopoly with associated political instabilities, and the environmental consequences of peat harvesting. Past studies on soilless crop cultivation have shown promising outcomes for the phosphorus (P)-rich sewage sludge biochar (SSB) as an answer to these issues. However, SSB remains as one of the least studied biochar types in soilless ornamental cultivation. The objectives of this study were to investigate the viability of SSB as a P fertiliser and growing media component in pot cultivation of lavender (Lavandula angustifolia), purple coneflower (Echinacea purpurea) and poinsettia (Euphorbia pulcherrima). The addition of SSB at a 10% (v/v) rate to coco peat (SSB 10) was determined as the best composition. Although it did not outperform the control, SSB 10 plants were not significantly lower than the control plants in height, dry aboveground biomass, and number of poinsettia stems across all three species – except in poinsettia biomass. Other rates (5%, 15%, 20%) had significantly lower values in more than one parameter. Physicochemical characterisation also revealed increased P with increasing SSB rates in the growing media. Contrary to other studies, the pH of all growing media did not exceed ideal growing media pH values (5.3-6.5), further solidifying SSB’s viability as a growing media component. The reliability of our results could be improved by recording water uptake of the media, and selection of species with quantifiable aesthetics.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-22189</identifier>
    <enrichment key="opus.import.date">2025-06-10T09:37:24+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">swordtest</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Ci Ern Katelyn Chng</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biochar</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>P recovery</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sewage sludge</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pyrolysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Ornamentals</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Substrate</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Growing media</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Peat reduction</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <collection role="Import" number="import">Import</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2218/8892_20250705181643_Katelyn Chng_30434_Thesis_25-05-07.pdf</file>
  </doc>
  <doc>
    <id>2217</id>
    <completedYear>2025</completedYear>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>78</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Artichoke (Cynara scolymus L.) and climate change: Assessing the potential in German agriculture with insights from Italian practices</title>
    <abstract language="eng">Artichoke (Cynara cardunculus var. scolymus) is a crop loved in the Mediterranean, particularly in Italy, where it has a long tradition holding both cultural and economic value. It has many different uses, from fresh consumption to medicinal use and potential in the energy and cheese-making industry. In northern European countries, such as Germany, artichoke cultivation has not been largely present up until now, mostly due to climate limitations, like very cold winters. However, climate change may offer new opportunities for its introduction. This study wants to assess the viability and potential of artichoke cultivation in Germany under current and future climate conditions, with the support of climate reports and literature sources. Past German trials, together with insights from the Italian artichoke cultivation, are integrated into the analysis to offer a better understanding of potential practices and implications for a future cultivation of the crop in Germany. The study concludes that winter cultivation is unfeasible without proper winter protection practices or the development of reliable frost-resistant varieties. However, annual cultivation with harvest within the same season represents a promising option in most German states. Locally grown artichokes could translate into economic and environmental advantages by answering the increasing interest in fresh, healthy, and regionally sourced products. It would also presents an opportunity for diversifying agricultural production in response to climate change and shifting market demands while also filling a gap in the artichoke offer on the market.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-22178</identifier>
    <enrichment key="opus.import.date">2025-06-10T09:33:06+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">swordtest</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC 4.0 International - Namensnennung-Nicht kommerziell</licence>
    <author>Roberta Rigotti</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Artichoke</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cynara scolymus</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Climate change</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Climate adaptation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Agriculture in Germany</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Agriculture in Italy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Crop cultivation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cultivation potential</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sustainable agriculture</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Carciofo</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>RCP</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <collection role="Import" number="import">Import</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2217/8889_20252204124123_Thesis_RobertaRigotti.pdf</file>
  </doc>
  <doc>
    <id>2215</id>
    <completedYear/>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>researchdata</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2025-10-31</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Unlocking the Power of Short Cycles: Enhancing Hygiene in Domestic Dishwashers</title>
    <abstract language="eng">This study investigated how factors associated with Sinner’s principle—namely temperature, time and the chemical composition of detergents—affected the antimicrobial efficacy of domestic dishwashers, particularly during short cycles. We chose a range of bacterial strains, including standard test strains such as Micrococcus luteus and Enterococcus faecium, as well as important foodborne pathogens such as Escherichia coli, Staphylococcus aureus, and Salmonella Typhimurium. To account for the complexity of dishwasher cycles, we correlated hygiene efficacy with area under the curve (AUC) measurements derived from the respective cycle profiles. Our findings revealed that the reductions in M. luteus and E. faecium were minimally affected by the reference detergent. In contrast, a high-tier market detergent demonstrated a significant decrease in bacterial counts. Notably, both strains exhibited reduced efficacy at a main cycle temperature of 45 °C, suggesting that temperatures below 50 °C might represent a critical threshold at which the hygiene efficacy of domestic dishwashing processes declines. However, since food-related pathogens were more susceptible to the dishwashing process, even lower temperatures might deliver a sufficient level of hygiene. Plotting the logarithmic reduction/AUC ratio against the AUC indicated that the main cycle contributed approximately 10-fold more to microbial reduction than the rinse cycle. Furthermore, the antimicrobial impact of detergents was greatest at the lowest AUC values (i.e. during short cycles). Taken together, our results suggest that the main wash temperature, the type of detergent, and the specific strain tested all impact bacterial hygiene performance.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-22153</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC0 1.0 Universell - Gemeinfreiheit (Public Domain)</licence>
    <author>Matthias Kudla</author>
    <author>Thomas Tewes</author>
    <author>Emma Gibbin-Lameira</author>
    <author>Laurence Harcq</author>
    <author>Dirk Bockmühl</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2215/Research-data-Matthias-Kudla.zip</file>
  </doc>
  <doc>
    <id>2192</id>
    <completedYear>2025</completedYear>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>72</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">The potential of direct marketing within the transformation process to sustainable farming in Lower Saxony, Germany</title>
    <abstract language="eng">Family farms present the majority of farms worldwide, and their survival is crucial to support the growing world population. Preventing those farms from disappearing is therefore very important. These family farms face many challenges like high investments and high price volatility. Diversification in form of direct marketing can be one way to reduce these risks. &#13;
Objective was to determine the state of direct marketing usage, faced challenges in a direct marketing system, which role counselling services play in that scenario and how farmers perceive sustainability in general and in context with direct marketing. These objectives were reviewed with a quantitative study conducted by an anonymous online survey. Provided to farmers of Lower Saxony by counselling rings, network “LandTouristik Niedersachsen”, network “Kompetenzzentrum Ökolandbau Niedersachsen” and the Chamber of Agriculture.&#13;
Direct marketing usage had increased over the last years and did not depend on the way of farming. On farm direct marketing solutions like a farm shop were most popular, most likely because it can be a low-cost solution. Bureaucracy, marketing and economic viability are the major challenges in direct marketing systems and correlate with reasons why direct marketing was not used. These presented a clear work order for government, science and counselling services, and show a high potential in increasing farm sustainability. Counselling services presented to be only used if free options were exploited, which emphasized the importance of high quality counselling offers. Overall, on-farm factors stood in favor for diversification and in combination with the as important stated status of sustainability for farmers, direct marketing most likely holds potential to positively impact the transformation to sustainable farming in Lower Saxony.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-21921</identifier>
    <enrichment key="opus.import.date">2025-04-30T09:03:34+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">swordtest</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Louiza Sund</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <collection role="Import" number="import">Import</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2192/8877_20251604140855_SAg_Bachelor_Thesis_Louiza_Sund_28518.pdf</file>
  </doc>
  <doc>
    <id>2166</id>
    <completedYear>2025</completedYear>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>92</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">The effects of cannabinoids CBD and WIN 55 212-2 against oxidative stress in BR1 Astrocytes from a proteomic viewpoint</title>
    <abstract language="eng">Oxidative stress is a common hallmark observed in neurodegenerative diseases, acting either as a triggering factor or as a consequence of the neurodegenerative process. Astrocytes play a crucial role in mediating oxidative stress caused by physiological processes, such as the byproducts of mitochondrial function during cellular respiration. Given the critical role of oxidative stress in the progression of many neurodegenerative diseases, identifying molecules capable of modulating this response and mitigating oxidative damage is of considerable interest. &#13;
Cannabinoids such as cannabidiol (CBD) and WIN 55.212-2, known for their &#13;
capability of influencing the endocannabinoid system through their interaction &#13;
with cannabinoid receptors (namely, CB1R and CB2R), and therefore the Central Nervous System, are promising candidates for such modulation. This work aimed to explore, through proteomics, the potential effect that the mentioned cannabinoids might have against oxidative stress induced by hydrogen peroxide in astrocytes, possibly mitigating some of the oxidative damage.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-21665</identifier>
    <enrichment key="opus.import.date">2025-03-17T08:49:42+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">swordtest</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Leonardo Henrique Dos Santos</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cannabis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>WIN 55.212-2</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>CBD</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Astrocytes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Proteomics</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Neurodegeneration</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Neurodegenerative Diseases</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>OmicScope</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oxidative Stress</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Hydrogen Peroxide</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>BR1 Astrocytes</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <collection role="Import" number="import">Import</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2166/8597_20251201223822_Signed Final Version Thesis Leonardo Henrique Dos Santos 25061.pdf</file>
  </doc>
  <doc>
    <id>2162</id>
    <completedYear>2025</completedYear>
    <publishedYear>2025</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>216</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>--</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Analyse gesundheitlicher Chancengleichheit und Prävention im Kreis Kleve anhand der Schuleingangsuntersuchung mit Ableitung von Präventionsmaßnahmen</title>
    <abstract language="deu">Das Thema dieser Arbeit ist „Analyse gesundheitlicher Chancengleichheit und Prävention im Kreis Kleve anhand der Schuleingangsuntersuchung mit Ableitung von  Präventionsmaßnahmen“ und betrachtet die Entwicklung ausgewählter Parameter der Schuleingangsuntersuchung und gesundheitlicher Chancengleichheit in den 16 Kommunen des Kreises Kleve über die Jahre 2018 bis 2024. Weiterhin werden die Kommunen und Parameter der Schuleingangsuntersuchung bestimmt, die unterhalb des Mittelwertes des Kreises Kleve liegen. Mit Hilfe dieser beiden Fragen werden Ansatzpunkte für Präventionsmaßnahmen bestimmt. Die nächsten beiden Forschungsfragen betrachten die Zusammenhänge zwischen den untersuchten Parametern. Die Ergebnisse werden mit dem aktuellen Forschungsstand verglichen und eingeordnet. Die erste Forschungsfrage wird graphisch mit Boxplots, Balkendiagrammen und Qualitätsregelkarten beantwortet. Bei der zweiten Forschungsfrage wird ein t-Test verwendet und diese Ergebnisse im Anschluss mit positiv und negativ bewertet. Bei der dritten und vierten Forschungsfrage werden Korrelationskoeffizienten nach Pearson und Spearman ermittelt. In der ersten Forschungsfrage können beim BMI eine schwache Entwicklung festgestellt werden sowie bei der Körperkoordination eine Verbesserung. Die Impfquote ist stabil und die Teilnahme an den U-Untersuchungen steigt. Der Anteil der Kinder mit der Erstsprache Deutsch steigt bis zum Jahr 2021/2022 und sinkt anschließend. Der Anteil der Bürgergeldempfänger sinkt bis zum Jahr 2021/2022 und steigt anschließend, auch der Mietspiegel steigt. Bei den Parametern Kinder- und Jugendärzte, Bewegungsangebote und Migrationsanteil kann keine Entwicklung ausgewertet werden. Bei der zweiten Forschungsfrage sind in den nördlichen Kommunen mehr negative Bewertungen als in den südlichen Kommunen ermittelt worden. Diese negativen Bewertungen zeigen sich bei der Teilnahme an den Impfungen, der Körperkoordination und den U-Untersuchungen. Bei der dritten Forschungsfrage können starke Zusammenhänge innerhalb der U-Untersuchungen und innerhalb der Impfungen erfasst werden. Zwischen diesen beiden Parametern besteht ein mittlerer Zusammenhang. Bei der Erstsprache kann ein geringer negativer Zusammenhang zu der Teilnahme an den U-Untersuchungen und den Impfungen bestimmt werden. Zu den Parametern Körperkoordination und BMI können keine Zusammenhänge analysiert werden. Bei der vierten Forschungsfrage können keine Korrelationen festgestellt werden. Insgesamt können mit Hilfe dieser Ergebnisse Präventionsmaßnahmen zur Verbesserung der Parameter BMI, Körperkoordination, Impfquote und U-Untersuchungen ermittelt werden.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-21623</identifier>
    <enrichment key="opus.import.date">2025-03-04T08:30:05+00:00</enrichment>
    <enrichment key="opus.source">sword</enrichment>
    <enrichment key="opus.import.user">swordtest</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-ND 4.0 International - Namensnennung-Keine Bearbeitungen</licence>
    <author>Natalie Bollig</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Prävention</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Gesundheitliche Chancengleichheit</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Schuleingangsuntersuchung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Kindergesundheit</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <collection role="Import" number="import">Import</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2162/8738_20250102111723_Bachelorarbeit Natalie Bollig.pdf</file>
  </doc>
  <doc>
    <id>2115</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>55</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-11-27</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A Systematic Review of Rapamycin- Mediated Fetal Hemoglobin Induction via the mTOR Pathway</title>
    <abstract language="eng">mTOR inhibitor rapamycin has been observed to induce fetal hemoglobin in patients of β-hemoglobinopathies, a group of disorders in which mutations in the gene responsible β-globin chains results in reduced or malformed RBC production, leading to anemia. The induction of fetal hemoglobin bypasses these mutations, as they are found on the gene responsible for adult hemoglobin. Following birth, the fetal hemoglobin gene is silenced, and the adult gene is activated through a process known as the hemoglobin switch. Rapamycin treatment reverses this hemoglobin switch but the mechanism by which it does so is currently unknown. Rapamycin functions through its inhibition of mTORC1, a protein complex responsible for nutrient- and growth factor-dependent cell growth and proliferation. This literature review seeks to collate existing information on the mTORC1 signalling pathway and the hemoglobin switch, allowing for a specific mechanism by which rapamycin induces fetal hemoglobin through its inhibition of mTORC1 to be hypothesized. Following the literature search, 55 studies on the mTORC1 pathway and 31 studies on the hemoglobin switch were summarized. Using the information gained from this, three hypotheses were put forward for the possible induction mechanism, out of which the primary hypothesis is based on the hemoglobin switching factor KLF1. This was based on the observation that the knockdown of Raptor, a crucial component of mTORC1, in mice caused a decreased expression of KLF1. As KLF1 is an essential component of the hemoglobin switch, this provides a direct link between the inhibition of mTORC1 and the reversal of the hemoglobin switch. Additionally, the efficiency of rapamycin in comparison to other methods of fetal hemoglobin was discussed, including newer generations of mTOR inhibitors developed using rapamycin as a foundation. Finally, possible avenues of research to confirm the validity of the proposed hypotheses and to address points of ignorance within each topic were discussed.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-21155</identifier>
    <enrichment key="opus.source">publish</enrichment>
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    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Hasiru Ratnayake</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2115/ratnayakerapamycin.pdf</file>
  </doc>
  <doc>
    <id>2112</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>76</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-12-20</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-10-23</thesisDateAccepted>
    <title language="deu">Entwicklung von Handlungsansätzen einer adressatenorientierten Förderung der psychischen Gesundheit jugendlicher Schülerinnen und Schüler in Ganztagsschulen</title>
    <abstract language="deu">Nicht nur die Covid-19-Pandemie wirkte auf die allgemeine Verschlechterung der psychischen Gesundheit von Jugendlichen in Deutschland. Das Erleben vielseitiger Entwicklungen in der Jugendzeit machen diese Lebensphase zu einer psychisch vulnerablen Zeit. Gleichzeitig haben Schulen einen großen Einfluss auf das Leben der Schülerinnen und Schüler und bilden für die psychische Gesundheitsförderung einen zentralen Wirkungsort. Besonders Ganztagsschulen zeichnen sich durch erweiterte Betreuungszeiten und Ressourcen aus. Wünsche und Interessen der Schülerinnen und Schüler werden sowohl in der Gesundheitsförderung als auch in der Ganztagsschule selten erhoben und einbezogen (vgl. BMFSFJ, 2017).&#13;
Die vorliegende Arbeit geht der Frage nach, welche adressatenorientierten Handlungsansätze aus der aktuellen Forschungslage zur Förderung der psychischen Gesundheit im Setting Schule für jugendliche Schülerinnen und Schüler an Ganztagsschulen abgeleitet werden können. Ziel ist die Ableitung adressatenorientierter, auf Ganztagsschulen ausgerichteter Handlungsansätze.&#13;
Zur Beantwortung der Forschungsfrage wurde mithilfe einer systematischen Literaturrecherche der aktuelle Forschungsstand der psychischen Gesundheitsförderung im Setting Schule erhoben. Auf Grundlage der analysierten Ergebnisse wurden adressatenorientierte Handlungsansätze diskutiert. &#13;
Die Ergebnisse zeigen den Bedarf der Edukation von Lehrkräften in der Früherkennung psychischer Krankheiten, die zusammen mit ganztagsschulischen Unterstützungsnetzwerken das Potenzial tragen, Schülerinnen und Schüler frühzeitig zu unterstützen. Des Weiteren hebt sich unter Orientierung am Adressaten die Dringlichkeit einer geschlechtersensibleren psychischen Gesundheitsförderung ab. Des Weiteren werden fehlende entwicklungsorientierte und partizipative Formen der psychischen Gesundheitsförderung festgestellt. Ganztagsschulen, die sich als Teil der Lebenswelt ihrer Schülerinnen und Schüler verstehen, können schulische und psychische Faktoren stärken. &#13;
Die erarbeiteten Handlungsansätze heben Diskrepanzen und Dringlichkeiten hervor und ergänzen die bestehende psychische Gesundheitsförderung um eine jugendorientierte Perspektive.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-21120</identifier>
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    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC 4.0 International - Namensnennung-Nicht kommerziell</licence>
    <author>Anne Trauernicht</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Psychische Gesundheitsförderung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Ganztagsschule</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Jugendliche</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Setting Schule</value>
    </subject>
    <collection role="ddc" number="61">Medizin und Gesundheit</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2112/Trauernicht_BAGesundheitsfoerderung.pdf.pdf</file>
  </doc>
  <doc>
    <id>2092</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>58</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-11-07</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-09-02</thesisDateAccepted>
    <title language="eng">Effects of the Agricultural Minimum Wage Increase on the Special Crop Sector in Germany</title>
    <abstract language="eng">This thesis explores the impact of rising labor costs, driven by minimum wage&#13;
increases, on Germany's specialty crop sector, with a focus on strawberries and asparagus. The thesis investigates how these cost pressures affect farm operations, particularly in light of labor shortages and substantial wage expenses. Combining market data, government statistics, and industry reports, the research highlights significant trends in production, cultivation practices, and market dynamics between 2015 and 2023. Through analysis of data, this work finds a notable reduction in the number of farms and cultivated areas for both strawberries and asparagus, alongside fluctuations in yield and production volumes. The results suggest that while mechanization offers some relief from rising labor costs, its adoption is limited by high initial investment requirements, technical complexity, and the need for crop-specific solutions. This effect is moderated by significant regional differences, and farm size.&#13;
Overall, this study contributes to the understanding of how minimum wage policies affect the German specialty crop sector, providing insights that are crucial for stakeholders aiming to navigate the evolving agricultural landscape.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-20925</identifier>
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    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Johannes Weinrich</author>
    <collection role="ddc" number="65">Management, Öffentlichkeitsarbeit</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2092/Weinrich_Johannes_Bachelorthesis.pdf</file>
  </doc>
  <doc>
    <id>2088</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>66</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-11-04</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-09-20</thesisDateAccepted>
    <title language="eng">Implementation of the Brain Imaging Data Structure (BIDS) with EEG Data for Machine Learning-Based applications in Schizophrenia patients</title>
    <abstract language="eng">Schizophrenia, a complex mental disorder characterized by delusions, hallucinations, and cognitive impairments, remains challenging to diagnose accurately due to the reliance on subjective clinical evaluations. This study aimed to develop a robust machine learning model for classifying schizophrenia patients using neurophysiological markers derived from Electroencephalography (EEG) data. The work explored multiple machine-learning architectures, including traditional Support Vector Machines (SVM) and deep learning models such as Long Short-Term Memory (LSTM) and CNN-LSTM hybrids.&#13;
EEG data was collected from schizophrenia patients and healthy controls, with preprocessing conducted using the Brain Imaging Data Structure (BIDS) framework to ensure consistency and standardization. Given the varying quality and structure of the EEG recordings—such as missing channels and differing recording lengths—the study employed several preprocessing techniques, including channel interpolation, zero-padding, and limiting data to the first three minutes of resting-state recordings for standardization. Data imbalance was addressed through the application of the Synthetic Minority Over-sampling Technique (SMOTE) to ensure balanced representation of both schizophrenia and control groups during model training.&#13;
The findings showed that the SVM model reached an accuracy of 88.8% in patient classification, whereas the LSTM model, after addressing data imbalances through SMOTE, achieved an improved classification accuracy of 99.3%. However, challenges arose when attempting to predict schizophrenia severity levels using MMN task data and a CNN-LSTM hybrid model. Despite efforts to standardize the number of epochs across subjects, the model achieved a more modest accuracy of 66.7%. This lower accuracy was largely attributed to the limited and unbalanced dataset, as some subjects had fewer than the target number of epochs.&#13;
Further challenges included BIDS conversion issues due to discrepancies in file naming conventions between .sdt and .set files, which required considerable time to resolve. The successful creation of a tailored BIDS conversion script ensured the data could be standardized and used effectively for analysis.&#13;
In conclusion, while the classification models achieved high accuracy, particularly the LSTM-based approach, predicting schizophrenia severity levels remains a challenge due to the limitations of the available dataset. Future research will focus on gathering larger and more balanced datasets, refining preprocessing methods, and optimizing model architectures to improve prediction accuracy. Ultimately, the goal is to apply these models in clinical settings to facilitate early diagnosis and intervention, providing timely medical care to schizophrenia patients before their symptoms worsen.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-20887</identifier>
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    <licence>CC BY-NC 4.0 International - Namensnennung-Nicht kommerziell</licence>
    <author>Lochana Chathuranatha Randeni Koralalage</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2088/RandeniKoralalage_BIDS.pdf</file>
  </doc>
  <doc>
    <id>2084</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>193</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>masterthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-11-02</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-10-23</thesisDateAccepted>
    <title language="deu">Über die Gesundheitskompetenz als individuelle Ressource für das Gesundheitsverhalten und Stresserleben von Akteurinnen und Akteuren in Gesundheitsfachberufen in Deutschland mit Handlungsempfehlung</title>
    <abstract language="deu">Einleitung: Gesundheitskompetentes Personal bildet die Grundlage für gesundheitskompetente Ge-sundheitsorganisationen. Im Rahmen der Vorbildfunktion wird erwartet, dass Berufstätige der Ge-sundheitsprofessionen eine hohe Gesundheitskompetenz aufweisen und sich entsprechend gesund-heitsförderlich verhalten. In einer zunehmend belastenden Arbeitswelt sind individuelle Ressourcen entscheidend für die Gesundheit und das Stresserleben des Gesundheitsfachpersonals. In der vorlie-genden Arbeit soll untersucht werden, inwieweit die Faktoren „gesundheitsbezogenes Verhalten“ und „Stresserleben“ durch das Level der Gesundheitskompetenz in Gesundheitsfachberufen beeinflusst wird. Da das berufliche Belastungsspektrum von Physiotherapeut:innen und Pflegekräften teilweise vergleichbar ist, wird in dieser Masterarbeit im Sinne einer quasi-explorativen Querschnittsstudie ein Vergleich zwischen diesen Gesundheitsfachberufen gezogen. Methodik: Zur Erhebung der Daten wurde vom 12.02.2024 bis 11.03.2024 eine quantitative Online-Umfrage durchgeführt. Dazu wurden aktuell tätige und examinierte Pflegekräfte und Physiotherapeut:innen ab 18 Jahren mittels Schnee-ballverfahren rekrutiert. Zur Erhebung der Gesundheitskompetenz wurde der Fragebogen HLS19-Q12-DE verwendet, sowie einzelne Skalen des COPSOQ und dem SOC-L9 zur Erfassung des Stres-serlebens und des Kohärenzgefühls. Darüber hinaus wurden einzelne Items aus der GEDA-Studie 2019 des Robert Koch- Instituts zur Erfassung des gesundheitsbezogenen Verhaltens einbezogen. Zur Datenauswertung wurden uni- und bivariate deskriptive Analysen vorgenommen, aber keine Rück-schlüsse auf die Grundgesamtheit gezogen. Ergebnisse: Im Rahmen der Fragebogenerhebung konnte eine Stichprobengröße von n = 124 erzielt werden, welche sich in 62,1 % Physiotherapeut:innen und 37,9 % Pflegekräfte teilt. Es zeigt sich eine durchschnittlich problematische Gesundheitskompetenz der Stichprobe und dichotomisiert weisen 68,6 % der Befragten eine geringe Gesundheitskompetenz auf, wobei mehr Pflegekräfte eine hohe Gesundheitskompetenz aufweisen als die Physiothera-peut:innen. Das Stresserleben beider Berufsgruppen ist vergleichbar und insgesamt setzt die Mehrzahl aller Befragten mindestens drei von fünf gesundheitsförderlichen Verhaltensweisen um (mind. Tägli-cher Obst- und Gemüseverzehr, aktuelles Nichtrauchen, risikoarmer Alkoholkonsum, Körpergewicht im Normalbereich, körperliche Betätigung nach WHO-Empfehlung), wobei dies mehr Physiothera-peut:innen als Pflegekräften gelingt. Im Rahmen der bivariaten Analyse zeigten sich in beiden Berufs-gruppen nur schwache Korrelationen zwischen der Gesundheitskompetenz und den Variablen des Stresserlebens sowie des gesundheitsbezogenen Verhaltens, wobei Letzteres lediglich das Bewe-gungsverhalten und den Alkoholkonsum umfasst. Schlussfolgerung: In der hier vorliegenden Arbeit kann die Gesundheitskompetenz als personale- bzw. als Handlungsressource interpretiert werden, die problemzentrierte Bewältigungsansätze unterstützt und als prototypische Selbststeuerungsaufgabe das Stresserleben und das gesundheitsbezogene Verhalten der Fachkräfte in geringer Weise beeinflusst. Das reine Wissen über gesundheitsbezogene Aspekte reicht jedoch nicht aus, um das Stresserleben und das Gesundheitsverhalten der Fachkräfte zu verbessern. An dieser Stelle kann die Gesundheits-kompetenz somit nicht als alleinige unabhängige Variable identifiziert werden, sondern stellt lediglich den Teil eines Ganzen aller Einflussfaktoren auf die abhängigen Variablen dieser Arbeit dar. Die Er-gebnisse legen nahe, dass zukünftige Bemühungen zur Steigerung der Gesundheitskompetenz der Fachkräfte erforderlich sind und dabei sowohl die individuelle, organisatorische und politische Ebene berücksichtigt werden sollte.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-20848</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Lena Bongers</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Gesundheitskompetenz</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Gesundheitsverhalten</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Gesundheitsfachberuf</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Belastung</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Stress</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Pflege</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Physiotherapie</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2084/Masterarbeit_Bongers_Gesundheitskompetenz.pdf</file>
  </doc>
  <doc>
    <id>2082</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>researchdata</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-10-31</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Does antibiotic use contribute to biofilm resistance in sink drains? A case study from four German hospital wards.</title>
    <abstract language="eng">As biofilms are known to harbour (multi-)resistant species, their presence in health settings must be considered critical. Although there is evidence that bacteria spread from drains to the outside, there is still a lack of research data focusing on drain biofilms from hospitals.&#13;
We sampled biofilms from various wards of Helios Hospital Krefeld (Germany), where comprehensive antibiotic consumption data were available. Biofilms were analysed by cell counting, isolation of relevant bacterial groups and genetic and phenotypical resistance parameters. Data were correlated with the prescribed antibiotics of the respective ward. Furthermore, an ex-situ biofilm model was employed to investigate the influence of sub-inhibitory antibiotics on the bacterial community and the prevalence of class 1 integrons.&#13;
Our results show, that every ward harboured medically relevant bacterial species. While no significant differences were found in cell counts, the median prevalence of the resistance marker gene intI1 correlated with the amount of prescribed antibiotics. In contrast, phenotypical resistances showed no similar tendency. In addition, melting curve analysis data and changes in intI1 prevalence show that the composition of the bacterial community shifted depending on the biofilm and antibiotic.&#13;
Based on our results we conclude, that sub-inhibitory concentrations of antibiotics have no general effect on biofilms in terms of bacterial community shift and occurrence of antibiotic resistant species. The effect depends on the initial composition of the bacterial community, the antibiotic used and the intrinsic bacterial resistance e.g. prevalence of class 1 integrons.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-20820</identifier>
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    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Nicole van Leuven</author>
    <author>Ralf Lucassen</author>
    <author>Anna Dicks</author>
    <author>Patrick Braß</author>
    <author>André Lipski</author>
    <author>Dirk Bockmühl</author>
    <collection role="ddc" number="57">Biowissenschaften; Biologie</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2082/SequencingResults.zip</file>
  </doc>
  <doc>
    <id>2066</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-10-07</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-08-09</thesisDateAccepted>
    <title language="eng">Assessing the Viability of Cassava and Corn-Derived Bioethanol to Enhance Sustainable Energy Transition and Energy Security in the West African Region</title>
    <abstract language="eng">This thesis assesses the viability of cassava and corn/maize-derived bioethanol to enhance sustainable energy transition and energy security in the West African region. With the region facing significant energy challenges, including reliance on fossil fuels, limited access to electricity and high energy costs, bioethanol offers a promising alternative. The study evaluates the physical feasibility, yield differences, resource requirements, environmental impact, and socioeconomic implications of using these crops for bioethanol production. A comprehensive methodology involving laboratory experiments and literature review is employed. &#13;
Results demonstrate that cassava has a higher bioethanol yield than maize, with more efficient enzymatic hydrolysis and fermentation processes. Additionally, cassava’s adaptability to marginal lands, lower water usage, and reduced greenhouse gas emissions make it a more sustainable feedstock. Economically, cassava-based bioethanol production is more cost-effective and has better market integration due to the established supply chain in the region. However, the social implications, particularly food security concerns necessitate careful consideration and the development of integrated food and fuel production systems.&#13;
The study concludes that cassava holds significant potential for bioethanol production in West Africa, providing a sustainable economically viable solution for the region’s energy needs. Recommendations are made for policymakers, investors, and stakeholders to optimize the use of cassava and maize for bioethanol production, emphasizing the importance of balancing biofuel with food security and rural development</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-20668</identifier>
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    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-SA 4.0 International - Namensnennung-Nicht kommerziell-Weitergabe unter gleichen Bedingungen</licence>
    <author>Maxwell Tchoffo Achu</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2066/Thesis_Maxwell_Tchoffo_achu_27477.pdf</file>
  </doc>
  <doc>
    <id>2034</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>80</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-09-06</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-07-15</thesisDateAccepted>
    <title language="deu">Über die antidepressiven Effekte sportlicher Aktivität: Eine Metaanalyse klinischer Studien zu potenziellen Wirkmechanismen</title>
    <abstract language="deu">In dieser Bachelorarbeit wurde untersucht, wie körperliche Aktivität als adjuvante oder nicht-pharmakologische Therapie bei Depressionen eingesetzt werden kann. Es wurden sowohl die antidepressiven Effekte als auch potenzielle Wirkmechanismen analysiert. Der theoretische Teil beleuchtet Depressionen, neurobiologische Prozesse sowie gängige Behandlungsansätze. &#13;
Die Ergebnisse einer systematischen Literaturrecherche zeigen, dass körperliche Aktivität positive Effekte auf depressive Symptome, die maximale Sauerstoffaufnahme (VO2) und die Schlafqualität hat. Insbesondere individuelle Programme sind wirksam. &#13;
Es wurden die Vor- und Nachteile der Sporttherapie erörtert, sowie Empfehlungen für zukünftige Forschung gegeben.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-20348</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <licence>CC BY-SA 4.0 International - Namensnennung-Weitergabe unter gleichen Bedingungen</licence>
    <author>Trong Khang Tommy Vu</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Sport</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Depression</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Antidepressiva</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Effekte</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Bewegung</value>
    </subject>
    <collection role="ddc" number="57">Biowissenschaften; Biologie</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/2034/Bachelorarbeit_29192_Unterschrift.pdf</file>
  </doc>
  <doc>
    <id>1972</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>74</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-07-14</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Schneller Nachweis der Methicillin-Resistenz  bei Staphylokokken-Isolaten Vergleich verschiedener Methoden</title>
    <abstract language="deu">Methicillin Resistente Staphylococcus aureus (MRSA) gehören zu gefürchteten Erregern eines bunten Bildes von Infektionen, die bis zu einer Sepsis reichen können. &#13;
Eines der größten Probleme von MRSA ist die hohe Pathogenität und die Entwicklung von zusätzlichen Resistenzen gegenüber weiteren Antibiotikaklassen. Die schnelle Identifizierung von MRSA und das Anlegen eines Antibiogramms ist daher entscheidend für eine frühe Therapie-Empfehlung und damit verbunden eine optimale Behandlung des Patienten. Aufgrund dessen wird in der vorliegenden Arbeit nach weiteren Möglichkeiten in der mikrobiologischen Diagnostik gesucht, um die Zeitspanne zwischen dem ersten Laborverdacht auf eine MRSA-Infektion und der spezifischen Antibiotikatherapie nach der Erregeridentifizierung zu reduzieren. Dazu wurden zwei verschiedene Methoden (MRSA-polymerase chain reaction (PCR) und Penicillin-Bindeprotein 2a (PBP2a)-Schnelltest), bezüglich ihrer Leistungsdaten mitdem Goldstandard zum Nachweis der Methicillin-Resistenz (VITEK-2 und Cefoxitin� Bestätigungstest) verglichen. Die klinischen Isolate für die experimentelle Durchführung stammen aus Blutkulturflaschen und Abstrichen von intraoperativen Wunden. Insgesamt wurden 74 Isolate retrospektiv getestet, darunter 26 (35%) MRSA� Isolate, 24 (32,5%) Methicillin-sensibler Staphylococcus aureus-Stämme und 24 (32,5%) Koagulase-negative Staphylokokken (KnS). In der MRSA-PCR kam es zu 15 (20%) fraglichen Ergebnissen, weshalb die Methode für eine zuverlässige Routinediagnostik nicht geeignet erschien. Nach Ausschluss der fraglichen Ergebnisse hatte die PCR einen positiven prädiktiven Wert (PPW) von lediglich 65,7%. Die Sensitivität lag bei 92,9%, die Spezifität bei 93,5% und der negative prädiktive Wert (NPW) bei 99,0%. Der Schnelltest besaß eine Spezifität und einen PPW von 100%, eine Sensitivität von 97,3% und einen NPW von 99,6%. Des Weiteren ergaben sich zusätzliche Vorteile bei der Verwendung des Schnelltestes durch die kürzere Laufzeit, den geringeren Kostenaufwand und die Einfachheit der Durchführung. Der ermittelte Zeitgewinn durch PCR oder Schnelltest betrug im Vergleich zum VITEK-2 zwischen 15 und 23,8 Stunden, was für die betroffenen Patienten von erheblichen klinischem Vorteil war. Zusammenfassend hatte der PBP2a-Schnelltest sowohl für S. aureus- als für KnS-Isolate bessere Leistungsdaten als die verwendete MRSA-PCR und wurde deshalb in die Routinediagnostik des Labors eingeführt.</abstract>
    <abstract language="eng">Methicillin-resistant Staphylococcus aureus (MRSA) are among the feared pathogens of a colourful picture of infections that can range up to sepsis. One of the biggest problems of MRSA is its high pathogenicity and the development of additional resistance to other classes of antibiotics. The rapid identification of MRSA and the &#13;
creation of an antibiogram is therefore crucial for an early recommendation of therapy and therefore an optimal treatment of the patient. For this reason, the present work seeks further possibilities in microbiological diagnostics in order to reduce the time span between the first laboratory suspicion of MRSA infection and the specific antibiotic therapy after pathogen identification. For this purpose, two different methods (MRSA� polymerase chain reaction (PCR) and penicillin-binding protein 2a (PBP2a) rapid test) were compared with the gold standard for the detection of methicillin resistance (VITEK-2 and cefoxitin confirmatory test). The clinical isolates oft he study were derived from blood culture bottles and swabs from intraoperative wounds. A total of 74 isolates were retrospectively tested including 26 (35%) MRSA, 24 (32.5%) methicillin� sensitive Staphylococcus aureus and 24 (32.5%) coagulase-negative staphylococci(CnS). In the MRSA-PCR 15 (20%) questionable results were obtained, which is why the method did not appear suitable for reliable routine diagnostics. After excluding the results in question, the PCR had a positive predictive value (PPV) of only 65.7%. The sensitivity was 92.9%, the specificity was 93.5% and the negative predictive value (NPV) was 99.0%. The rapid test showed a specificity and PPV of 100%, a sensitivity of 97.3% and a NPV of 99.6%. In addition, the use of the rapid test has yielded additional benefits in terms of shorter turnaround, lower costs and ease of implementation. The estimated time gain by PCR or rapid test was between 15 and 23.8 hours compared to VITEK-2, which was of significant clinical benefit to the affected patients. In summary, the PBP2a rapid test for both S. aureus and CnS isolates had better performance data than the MRSA-PCR used and was therefore introduced into routine laboratory diagnostics.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-19727</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Marie Tebest</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Methicillin-Resistenz</value>
    </subject>
    <collection role="ddc" number="50">Naturwissenschaften</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1972/BachelorarbeitMarieTebest.pdf</file>
  </doc>
  <doc>
    <id>1959</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>70</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-06-23</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-04-29</thesisDateAccepted>
    <title language="eng">Utilisation of biomass waste as feed for edible  insects and how it can be used to close the food  economy cycle and contribute to food security in  Sub Sahara Africa</title>
    <abstract language="eng">The world is facing a critical challenge in meeting the growing demand for food particularly in developing countries in Sub-Saharan Africa where population growth is outpacing food production. It presents a formidable challenge exacerbated by urbanization, shifting consumption patterns and global disruptions like the COVID-19 pandemic. In response, alternative food sources such as edible insects are gaining traction as sustainable solutions. Edible insects offer comparable nutrition to traditional protein sources while requiring minimal resources for farming. However, unsustainable harvesting practices endanger wild insect populations. To counter this, insect farming emerges as a promising strategy, leveraging efficient conversion rates and organic waste utilization. This paper explores how edible insects can integrate into circular food economies, converting organic waste into valuable resources, bolstering food and feed security, and mitigating waste. Specifically, it examines the potential of insects like black soldier fly larvae, yellow mealworms, houseflies, and house crickets in SSA for waste management and sustainable nutrition. The discussion encompasses insect abundance, waste utilization, economic cycles, and environmental benefits. Furthermore, it explores the quality and quantity of available urban organic waste streams, waste-to-insect combinations, and the socioeconomic implications of insect farming, including gender dynamics and consumer acceptance. The review highlights the need for regulatory frameworks to govern the edible insect industry in SSA and emphasizes the potential of insect farming to contribute to food security, environmental conservation, and economic development in the region.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-19595</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Levi Kipchumba Mutai</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1959/Levi_Mutai_29677_Barchelor_Thesis.pdf</file>
  </doc>
  <doc>
    <id>1944</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>78</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-05-06</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-04-08</thesisDateAccepted>
    <title language="eng">Efficacy of Traditional Chinese Medical DrugsThe Treatment of Common Illnesses in Comparison with Western medicine</title>
    <abstract language="eng">The efficacy of treating common illnesses with traditional Chinese medical drugs has been a subject of growing interest and debate especially when compared to established practices of modern &#13;
Western medicine. The integration of alternative and traditional medicine practices also gains significance as healthcare systems evolve. &#13;
This literature review aims to comprehensively assess and compare the effectiveness of traditional Chinese medical drugs with modern Western medial drugs in addressing common illnesses. Through a systematic analysis of reviewed scientific articles, clinical studies, and relevant literature the effectiveness of traditional Chinese medical drugs will be identified and compared to modern Western medical drugs and treatment options in context of the treatment success rates, symptom relief, adverse effects, and patient satisfaction.&#13;
The study focuses on the herbal based remedies and their traditional therapeutic treatment methods, to illuminate their mechanisms of action and potential therapeutic benefits for a range of common illnesses such as the common cold and flu, digestive disorders, musculoskeletal pain, and skin conditions. Furthermore, the potential synergies between the two practices will be explored, as integrative healthcare becomes increasingly important as a comprehensive approach to patient wellbeing.&#13;
Through a comprehensive analysis of the available medical literature and clinical data, this paper attempts to address the potential of traditional Chinese medical drugs as an alternative or complementary method to modern Western medicine for various common illnesses. The findings may contribute to informed decision-making by healthcare professionals and patients, offering insights into the strengths and limitations of each approach. Additionally, the research aims to foster a deeper understanding of cross-cultural medical practices and their potential integration into contemporary healthcare systems.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-19440</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Clarissa May</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Traditional Chinese medicine</value>
    </subject>
    <collection role="ddc" number="61">Medizin und Gesundheit</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1944/May_Clarissa_Bachelorarbeit.pdf</file>
  </doc>
  <doc>
    <id>1946</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>77</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-05-07</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Medi: A Software System for Improving the Analysis and Interpretation of Medical Tests in Clinical Laboratories.</title>
    <abstract language="eng">The rapid increase in patient numbers and the complexity of clinical information, coupled with a significant lack of assistive technologies for routine procedures, has emphasized the urgent need for innovative technological solutions in clinical laboratories. This need is amplified by the existence of over 238 blood tests, highlighting the challenge of managing and interpreting vast amounts of clinical information and data efficiently.&#13;
&#13;
The primary objective of this research is to evaluate the effectiveness of Medi, a state-of-the-art software system designed to enhance the workflow of medical routine tasks in the pre-testing steps in clinical laboratories. By focusing on routine hematology, biochemistry, and microbiology tests, the study aims to revolutionize clinical laboratory processes, improve diagnostic accuracy, and enhance patient care.&#13;
&#13;
Through an extensive approach regarding specimen collection of blood and the utilization of automated medical devices, this study sheds light on the advantage of Medi to streamline operations within clinical laboratories. The research methodically assesses the impact of Medi on laboratory workflows and patient outcomes, employing a user-centric design to ensure the software meets the practical needs of healthcare professionals.&#13;
&#13;
Medi demonstrated significant improvements in laboratory efficiency, with streamlined workflow. Key findings include the standardization of blood specimen collection procedures, limiting blood-tube-selection errors, and a positive impact on laboratory operations. The software facilitated a more cohesive integration of clinical data, contributing to better-informed decision-making and improved patient care.&#13;
&#13;
By comparing these outcomes with the current state of clinical diagnostics, Medi's introduction represents a transformative shift in laboratory operations. It not only addresses the pressing need for advanced assistive technologies in the clinical laboratory settings but also sets a new standard in patient care. This research underlines the potential of integrating software solutions with existing laboratory technologies, paving the way for a new era in clinical testing.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-19466</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Badran-Mohammednoor Alshaikh</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1946/Alshaikh_28591.pdf</file>
  </doc>
  <doc>
    <id>1940</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>82</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-04-25</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Fermentation of Pyrus communis var. ‘Conference’ with Native Yeasts and Evaluation of Sensory Properties of Produced Pear Distillates</title>
    <abstract language="eng">For several millennia, yeasts are involved in the production of alcoholic beverages via the fermentation process. Yeast metabolism is responsible for the aromatic compounds produced during fermentation. Different yeasts create different aromatic compounds, or different concentrations of compounds during fermentation because of the metabolic differences between yeasts. In this bachelor thesis, the effect of utilizing native yeasts on the sensory properties of the produced alcoholic beverage is evaluated. A total of 83 isolates were obtained from the surface, juice, and 7-days-rested juice of fresh pears of Conference variety. Among these isolates, 19 of them were identified as yeast samples. For native yeast sample used in sensory analysis, among known species in the sample, Saccharomyces cerevisiae has the highest relative abundance, followed by Saccharomyces eubayanus. The odor scores were significantly higher for native yeast sample points than the odor scores of LT8 points. The difference between the total sensory analysis scores was not significant. The results showed that the native yeast performed as good as the commercial yeast in terms of sensory properties, with a significantly better odor perception and higher production of ethanol.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-19405</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-ND 4.0 International - Namensnennung-Keine Bearbeitungen</licence>
    <author>Elif Ezgi Zabun</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Sensory analysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Native yeast</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Saccharomyces spp.</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Saccharomyces cerevisiae</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fruit spirit</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1940/Zabun_BachelorThesis.pdf</file>
  </doc>
  <doc>
    <id>1911</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>75</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-03-12</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Der Effekt kurzkettiger Fettsäuren auf die Darmmikrobiota im Zusammenhang mit Adipositas</title>
    <abstract language="deu">Der demographische Wandel führt zu einer stetig höheren Lebenserwartung der Menschen. Ein erhöhtes Alter birgt das Risiko an einer Vielzahl von Krankheiten zu leiden. Darunter fallen insbesondere Herz Kreislauf¬ Erkrankung und Krebserkrankung. Solche Erkrankung fallen ebenfalls unter die Folge  und Begleiterkrankung einer Adipositas. Die Adipositas ist eine Stoffwechselerkrankung und beschreibt ein erhöhtes Körpergewicht aufgrund eines erhöhten Körperfettanteils. Die Erkrankung kann beispielsweise durch eine Ernährungsumstellung gelindert werden. Die Ernährung kann unter anderem auch die Darmmikrobiota modulieren. Insbesondere Ballaststoffe und die Fermentationsprodukte der Ballaststoffe, die kurzkettigen Fettsäuren, haben einen Einfluss auf die Darmmikrobiota. Aufgrund dessen werden in dieser Arbeit die Effekte der kurzkettigen Fettsäuren auf die Darmmikrobiota insbesondere im Zusammenhang mit der Erkrankung Adipositas untersucht. Die Ursachen einer Adipositas liegen meist in den Lebensweisen der Patienten. Eine erhöhte Energieaufnahme und geringe Bewegung führen zu einem Anstieg des Körperfettanteils und erhöhen zudem das Risiko für Begleiterkrankung, wie Diabetes mellitus Typ 2, koronaren Herzkrankheiten oder auch Depressionen. Insbesondere die konservativen Behandlungsmöglichkeiten zeigen wenig positive Ergebnisse und die Entwicklung neuer Methoden muss Priorität haben. Die Fermentationsprodukte der Ballaststoffe sind die kurzkettigen Fettsäuren. Diese haben sowohl orexigene als auch anorexigene Eigenschaften. Bei der Ausarbeitung der Ergebnisse wurde deutlich, dass die kurzkettigen Fettsäuren bei der Behandlung der Adipositas von großer Bedeutung sein können. Sie beeinflussen wichtige Rezeptoren, die die appetithemmende Hormone PYY und GLP 1 freisetzen und eine überschüssige Nahrungsaufnahme verhindern. Des Weiteren wirken sich die kurzkettigen Fettsäuren positiv auf die Gluconeogenese aus. Zudem konnten verschiedene Studien über Supplementierungen positive Effekte der kurzkettigen Fettsäuren verzeichnen. Dennoch ergaben sich bei der Bearbeitung der Literatur ebenfalls widersprüchliche Ergebnisse. Um die genauen Effekte der kurzkettigen Fettsäuren lückenfrei zu erschließen sind weitere Forschungen und Experimente zwingend notwendig. Die ersten Untersuchungen zeigen aber, dass eine ballaststoffreiche Ernährung und eine erhöhte Konzentration der kurzkettigen Fettsäuren bei der Behandlung und Prävention eine entscheidende Rolle annehmen.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-19117</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Ann-Kathrin Pastoors</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1911/Pastoors_BA.pdf</file>
  </doc>
  <doc>
    <id>1889</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>61</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-02-13</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2024-02-01</thesisDateAccepted>
    <title language="eng">Enrichment of Bacillus anthracis using phage-derived recombinant fusion proteins</title>
    <abstract language="eng">Bacillus anthracis is a rod-shaped, Gram-positive, spore-forming bacterium causing the lethal zoonotic disease anthrax. This disease mainly infects herbivores, but many mammals can be hosts as well, including humans. Multiple cases in history are known, in which human infection resulted either from digestion or handling of contaminated animal products, from industry accidents or bioterrorism attacks. The endospores of B. anthracis are persistent to harsh environmental conditions and can survive in soil for decades, before heavy rains or grazing animals can reemerge the spores again. In appropriate medium, like blood, the spores germinate again to the vegetative cell form. B. anthracis belongs to the “Bacillus cereus group” which shares high genetic similarity, with cases where the virulence plasmids of B. anthracis, which are responsible for the toxin and capsule production, are even shared with other members of this group. Species-specific testing therefore often poses a challenge, because sophisticated equipment and financial investments are needed for a correct diagnosis. Because of appearing new infection cases, a species-specific, rapid and inexpensive method for the detection of B. anthracis is needed.&#13;
Apart from the gold standard of detection of B. anthracis via PCR, receptor-binding protein (RBP) based detection methods are in research for a few years. Bacteriophages (phages) represent the most prevalent biological entities on earth and are viruses targeting bacterial cells. Brown and Cherry isolated a phage named gamma (γ), demonstrating high efficiency in infecting encapsulated bacilli. Notably, the γ phage exhibited sensitivity across nearly all variants of B. anthracis, while members of the B. cereus sensu lato group displayed resistance. The specificity of phages is attributed to their RBPs, which recognize distinct structures on the host cell, inducing the initial step of phage infection. One of these RBPs specific for B. anthracis is BA4079Δ1-127.&#13;
This work aims to produce two recombinant fusion proteins, with two different cellulose-binding domains (CBDs) which were internally linked to the fluorescent reporter protein superfolder green fluorescent protein (sfGFP) and coupled to BA4079Δ1-127. The protein tools would enable binding to B. anthracis and at the same time would allow sequestration to cellulose materials. Because of the fluorescence protein, the sample can be observed by fluorescence microscopy and cells or cellulose bound to the fusion proteins would exhibit green fluorescence. This experimental approach could lead to a new low-cost enrichment tool for B. anthracis cells using the fusions proteins containing CBDs, RBPs and fluorescence proteins.&#13;
The fusion proteins were tested with various cultures of B. anthracis cells, grown under different conditions, as well as different cellulose materials including cotton wool in a syringe, cotton wool fibers, cellulose filters and microcrystalline cellulose. Binding tests showed, that the fusion proteins were not able to connect B. anthracis cells with diverse cellulose materials in a way that cells could be enriched from media. However, both fusion proteins successfully bound to both, cultured B. anthracis cells and different cellulose materials individually.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18899</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-ND 4.0 International - Namensnennung-Keine Bearbeitungen</licence>
    <author>Lena Guttkowski</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bacillus anthracis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Fusion proteins</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bacteriophages</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1889/Guttkowski-Bachelorthesis.pdf</file>
  </doc>
  <doc>
    <id>1874</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>89</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>masterthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-21</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-12-01</thesisDateAccepted>
    <title language="deu">Chrono-Nutrition: Zusammenhang der Nahrungsaufnahme und Schlafqualität bei gesunden Erwachsenen</title>
    <abstract language="deu">Hintergrund:&#13;
Die Inzidenz von Schlafstörungen ist in Deutschland in den letzten Jahren stark gestiegen. Entgegen aktuellen Ernährungsempfehlungen sind vom Effizienzgedanken getrieben unnatürliche Ernährungsmuster entstanden. Das Frühstück wird übersprungen, schnelle Mahlzeiten über den Tag verteilt und große Mahlzeiten am Abend verzehrt. Eine Anpassung der Lebens- und Essgewohnheiten an den zirkadianen Rhythmus des Sonnenlichts kann in der Theorie zu einer Verbesserung der Schlafqualität führen. Lösungsansätze der Chrono-Nutrition wie das frühzeitliche intermittierende Fasten (eTRE), haben bereits nachweislich positive Vorteile für die metabolischen Gesundheit gezeigt. Ein eindeutig positiver Einfluss auf den Schlaf ist jedoch noch umstritten und der Zusammenhang zur Tageszeit wurde ebenfalls unzureichend untersucht.&#13;
&#13;
Methodik:&#13;
Es wurde eine einwöchige Online-Befragung unter gesunden Erwachsenen bis 59 Jahren, ohne Schichtarbeit durchgeführt. Die Fragen bezogen sich auf die Tages- und Ernährungsgewohnheiten sowie der subjektiven Schlafqualität bzw. -dauer.&#13;
&#13;
Ergebnisse:&#13;
225 TN haben erfolgreich an der Befragung teilgenommen und wurden ausgewertet. Es wurden ein signifikant positiver Einfluss der Regelmäßigkeit der Nahrungsaufnahme und ein signifikant negativer Einfluss der Nahrungsaufnahme innerhalb der letzten Stunde vor der Schlafenszeit auf die Schlafqualität festgestellt.&#13;
&#13;
Zusammenfassung:&#13;
Zusammenfassend kann gesagt werden, dass die Regelmäßigkeit der Nahrungsaufnahme und die letzte Mahlzeit einen größeren Effekt auf die Schlafqualität aufweisen als die erste Mahlzeit des Tages.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18747</identifier>
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    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Nico Heilemann</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1874/Masterarbeit_29847_Heilemann_Nico_26_11_2023.pdf</file>
  </doc>
  <doc>
    <id>1871</id>
    <completedYear/>
    <publishedYear>2024</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>researchdata</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2024-01-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Biological and Synthetic Surfactants Increase Class I Integron Prevalence in Ex-Situ Biofilms</title>
    <abstract language="deu">Abstract: The role of biocides in the spread of antimicrobial resistance (AMR) has been ad-dressed but only few studies focus on the impact of surfactants on microbial diversity and AMR, although they are common constituents of cleaners, disinfectants and personal care products and are thus released into the environment in large quantities. In this study, we used an ex situ biofilm model to examine the development of four biofilms exposed to surfactants and analyzed the biofilms for their prevalence of class I integrons (intI1). We furthermore de-termined the bacterial community composition by high-resolution melt analysis and 16S ri-bosomal DNA RNA (16S rRNA) gene sequencing. Depending on the initial intrinsic prevalence of intI1 in the respective ex situ biofilm, Benzalkonium Chloride, Alkylbenzene Sulfonate and Cocamidopropyl Betaine increased intI1 prevalence by an average of up to six fold. For surfac-tants, such as Fatty Alcohol Ethoxylate and the biosurfactants Sophorolipide and Rhamnoli-pide, the mean increase in intI1 prevalence did not exceed two fold. Across all surfactants the increase of intI1 was accompanied by a shift in bacterial community composition. Especially Benzalkonium Chloride, Cocamidopropyl Betaine and Alkylbenzene Sulfonate changed the communities, while Fatty Alcohol Ethoxylate, Sophorolipide and Rhamnolipide had a lower effect on the bacterial biofilm composition.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18712</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Lucassen Ralf</author>
    <author>van Leuven Nicole</author>
    <author>Bockmühl Dirk</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1871/NG-34586.16S.Microbiome_Profiling_Results.tar.zip</file>
  </doc>
  <doc>
    <id>1857</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>119</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-12-29</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-10-30</thesisDateAccepted>
    <title language="deu">Einfluss von Benzalkoniumchlorid auf die Selektion von Bakteriengemeinschaften und die Verbreitung von Resistenzgenen in mit Mikroplastik angereichertem Boden</title>
    <abstract language="deu">Die zunehmende Anreicherung anthropogener Mikroverunreinigungen in der Umwelt hat in jüngster Zeit verstärkte wissenschaftliche Aufmerksamkeit erhalten. Der steigende Eintrag von Mikroplastik in die Umwelt kombiniert mit der Ausbreitung von Resistenzgenen erfordert eine eingehende Analyse ihrer möglichen Interaktionen und Auswirkungen auf die Ökosysteme.&#13;
In dieser Studie stand die Interaktion zwischen Mikroplastik, speziell HDPE, einem nicht biologisch abbaubaren Polymer, und PHBH, eine biologisch abbaubare Alternative, in Kombination mit Benzalkoniumchlorid im Fokus. Ziel war es, deren Einfluss auf die Gemeinschaftsstruktur von Bodenmikroorganismen und die Prävalenz von Antibiotikaresistenzgenen zu untersuchen. Unter Verwendung eines Mikrokosmos- Designs wurden organisch bewirtschaftete Bodenproben mit den vorgenannten Substanzen über drei und sechs Wochen inkubiert. Im Anschluss wurden die Biofilme auf den Mikropartikeln mittels qPCR und ddPCR analysiert, wobei die Abundanz von Bakterien, Pilzen und dem Klasse-1-Integron-Gen untersucht wurde. Die Ergebnisse können nicht bestätigen, dass Benzalkoniumchlorid die Verbreitung von Resistenzgenen oder mikrobielle Gemeinschaftsstrukturen beeinflusst. Im Gegensatz dazu wirkte PHBH als signifikanter Modulator, der die Vielfalt der Pilz- und Bakterientaxa im Biofilm verringerte, jedoch die Gesamtabundanz erhöhte.&#13;
Vor dem Hintergrund dieser Befunde werden die potenziellen ökologischen Implikationen der Mikroplastikverschmutzung deutlich. Es betont die Notwendigkeit vertiefter Forschungen, um die komplexen Wechselwirkungen zwischen Mikroplastik und anderen anthropogenen Kontaminanten in terrestrischen Ökosystemen zu verstehen.</abstract>
    <abstract language="eng">The increasing accumulation of anthropogenic micropollutants in the environment has received greater scientific attention in recent years. The rise of microplastics in the environment combined with the spread of resistance genes requires an in-depth analysis of their potential interactions and impacts on ecosystems.&#13;
This study focused on the interaction between microplastics, specifically HDPE, a non- biodegradable polymer, and PHBH, a biodegradable alternative, in combination with benzalkonium chloride. The aim was to investigate their influence on the community structure of soil microorganisms and the prevalence of antibiotic resistance genes. Using a microcosm design, organically managed soil samples were incubated with the aforementioned substances for three and six weeks. Subsequently, biofilms on the microparticles were analysed using qPCR and ddPCR method, with particular emphasis on the abundance of bacteria, fungi and the class 1 integron gene. The results cannot confirm that benzalkonium chloride influences the dissemination of resistance genes or microbial community structures. In contrast, PHBH acted as a significant modulator, reducing the diversity of fungal and bacterial taxa in the biofilm, but increasing overall abundance.&#13;
Given these results, the potential ecological implications of microplastic pollution become apparent. It emphasises the need for deeper research to understand the complex interactions between microplastics and other anthropogenic contaminants in terrestrial ecosystems.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18573</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC 4.0 International - Namensnennung-Nicht kommerziell</licence>
    <author>Pauline Rohlfing</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1857/Rohlfing_Bachelorarbeit.pdf</file>
  </doc>
  <doc>
    <id>1856</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>70</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-12-26</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-10-27</thesisDateAccepted>
    <title language="eng">Generation and expression of a mutated murine tRNA-guanine transglycosylase variant</title>
    <abstract language="eng">Translation of messenger RNA carrying the nucleic code for protein synthesis is one of the vital bioprocesses of living organisms. This translation is mediated by transfer RNA, which allocates specific amino acids to the growing chain by decoding the genetic code. The tRNAs with the G34U35N36 anticodon sequence are recognised by an enzyme called tRNA-guanine transglycosylase, which catalyses the exchange of guanine with queuine. TGT enzyme is found in all three domains of life and is involved in post-transcriptional modification. TGT is of keen interest in the development of therapeutics against shigellosis, since the genetic inactivation of TGT leads to decreased pathogenicity in Shigella. For understanding the differences between bacterial and eukaryotic TGT, studies have been performed in the past, which show remarkable resemblance. On the contrary, some pronounced structural contrast can also be observed. One prominent difference is that the bacterial TGT contains a short turn of three amino acids, whereas, in eukaryotes, this turn is replaced by an extended loop of more than 45 amino acids. The function of this loop in eukaryotic TGT is not known. The loop is a highly flexible region and, thus, is not structurally solved. To elucidate the function of this loop, a TGT mutant lacking this loop was generated, expressed and purified. TGT mutant was expressed in different bacterial cell strains. For the purification, different chromatography techniques were utilised. The mutation resulted in a low yield of the protein in comparison to the wild-type TGT. This leads to the inference that the loop influences the physicochemical characteristics of the protein.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18560</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <licence>CC BY-NC 4.0 International - Namensnennung-Nicht kommerziell</licence>
    <author>Muhammad Imran Mumtaz</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>RNA-guanine transglycosylase</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Generation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Expression</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Queuine</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Protein purification</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Chromatography</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Site-directed mutagenesis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Protein mutation</value>
    </subject>
    <collection role="ddc" number="57">Biowissenschaften; Biologie</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1856/Mumtaz_MurineQTRT2.pdf</file>
  </doc>
  <doc>
    <id>1850</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>101</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-12-18</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-09-11</thesisDateAccepted>
    <title language="eng">Targeted therapy to overcome the blood-brain barrier in treating Glioblastoma</title>
    <abstract language="eng">Glioblastoma represents a challenge in oncology, characterized by its aggressive nature and resistance to conventional therapies. This thesis conducts a comprehensive examination of Glioblastoma, with a primary focus on advancing therapeutic strategies through precision medicine and sophisticated drug delivery mechanisms. The inquiry starts with an exhaustive analysis of the intricate blood-brain barrier, a vital neurovascular interface critical for understanding drug delivery complexities to the central nervous system. Subsequently, the study delves into Glioblastoma, elucidating its etiological foundations, molecular intricacies, clinical presentations, and existing treatment paradigms.&#13;
The core of this research centers on the exploration of state-of-the-art targeted therapies, encompassing molecular-level targeting, immunotherapeutic modalities, and synergistic therapeutic approaches. It dissects a range of strategies aimed at enhancing drug delivery, including chemical disruption techniques, innovative delivery methodologies, and bioengineered approaches.&#13;
Furthermore, it underscores the transformative potential of nanotechnology, emphasizing nanocarriers as precision tools poised to revolutionize GBM therapy.&#13;
The literature review is conducted meticulously, drawing from renowned databases like PubMed, NCBI, NIH/National Cancer Institute, JSTOR, and BioMed Central. Additionally, reputable national and international health institute websites, along with carefully selected books from the campus library, contribute to the diverse and robust foundation of credible information.&#13;
The discussion segment dissects the challenges inherent in GBM targeted treatment, underscores the burgeoning domain of precision medicine, highlights the paradigm-shifting role of theranostics,&#13;
and outlines a roadmap for future prospects in this intricate landscape.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18504</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Fatma Belkhodja</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1850/Belkhodja.BSc.thesis.pdf</file>
  </doc>
  <doc>
    <id>1834</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>57</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-11-21</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Long-term effects after a short learning event: Evaluation of the effectivity of an ESD (Education for Sustainable Development) module on the importance of pollinating insects</title>
    <abstract language="eng">In order to design a fairer and more sustainable planet, the United Nations have agreed on the Agenda 2030 and the corresponding 17 sustainable development goals (SDGs) as well as the Education for Sustainable Development (ESD) campaign. In order to assess the effectivity of this widely funded campaign, evaluation is in order. While usually larger projects and programs are evaluated, this thesis focuses on whether a short one-time education event can also create long-term learning effects. For a two-hour module on insect and pollinator diversity and their economic importance and conservation, evaluation was performed using empirical questionnaires with statistical analysis as well as participatory evaluation methodology. Statistical analysis shows that knowledge, skills and motivation increase strongly directly after the event, but for some part lower significantly after three weeks’ time. Participatory interviews reflect very different developments in the participants, with some only having an increased awareness of the topic but others having implemented conservation measures and networking in their daily lives. Overall, the evaluation shows that long-term effects of short events are only partly observable and different depending on the participating person. There is, however, a potential for further education and activism whose importance should not be underestimated. Accordingly, even though longer programs are surely more effective in creating long-term learning effects and activism, short events can be very efficient as a gateway into many sustainability topics and should be part of ESD.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18347</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-ND 4.0 International - Namensnennung-Keine Bearbeitungen</licence>
    <author>Alina Martin</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>ESD</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>BNE</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pollinators</value>
    </subject>
    <collection role="ddc" number="63">Landwirtschaft</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1834/Martin_ESD_Evaluation.pdf</file>
  </doc>
  <doc>
    <id>1832</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>52</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-11-19</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Identification of Cas9-nickase Fusions that Promote HDR-mediated Genome Editing</title>
    <abstract language="eng">At the heart of this project was the exploration and improvement of the CRISPR/Cas9 gene editing platform with the goal of enhancing efficiency and ensuring safety. The research carried out was primarily concerned with testing and developing a gene editing system that bypasses the need for double strand breaks (DSBs). Given that DSBs are the most damaging events for a cell and pose a major safety risk in genome editing, eliminating them was a key focus of the project. The project aimed to increase the frequency of homology directed repair (HDR) while simultaneously decreasing non homologous end joining (NHEJ), thereby improving the accuracy of genome editing.&#13;
&#13;
The methodology involved the use of a Cas9 protein fused to factors involved in DNA repair. Based on previous evidence that this strategy improves the HDR mediated repair of a Cas9 induced DSB, intention here was to apply the same strategy to Cas9 nickases for a safer alternative to standard genome editing procedures.&#13;
&#13;
A Cas9 nuclease can be transformed into a Cas9 nickase (nCas9) that cuts only one strand of DNA by mutating one of the two nuclease domains of the Cas9 either via a D10A point mutation for RuvC or an H840A for HNH. Preliminary experiments had shown that using nickases could reduce the occurrence of DSBs at both target and non target sites. However, because genome editing efficiency of nickases is limited, the project focused on amplifying nickase induced HDR frequency by fusing the D10A nCas9 with DNA repair factors that guide the repair of single strand breaks via HDR.&#13;
&#13;
Experiments evaluated the ability of each Cas9 nickase to direct the resolution of single strand breaks via HDR. An eGFP or mCherry cassette under its own promoter was employed as a reporter gene to measure the success of the transfection. The experiments were performed in three genomic loci, namely AAVS1, CLYBL, and H2AX. The degree of eGFP or mCherry expression after 14 days, as quantified by flow cytometry, was used to estimate the knock in success.&#13;
&#13;
The results obtained support the hypothesis that fusing D10A nCas9 with selected DNA repair factors leads to an increase in the knock in efficiencies as compared to the unmodified nCas9. The choice of the promoter used to express the nuclease, either CMV or CAG, did not seem to influence the knock in efficiencies. Instead, the type of repair template used did influence the knock in efficiencies with nicked plasmid templates contributing to greater HDR levels than non nicked ones. Knock in efficiencies of Cas9 nickases varied depending on which locus they were tested in.&#13;
&#13;
More research remains to be done to test alternative Cas9 nickase fusions. However, this approach represents a promising direction for the creation of a more efficient and safer gene editing instrument for clinical use.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18322</identifier>
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    <licence>Bestimmungen des deutschen Urheberrechts</licence>
    <author>Julia Erkkilä</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1832/Thesis_Julia_Erkkilae.pdf</file>
  </doc>
  <doc>
    <id>1823</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>110</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>masterthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-11-02</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-10-26</thesisDateAccepted>
    <title language="eng">Innovative Solutions to Waste Management: A Case Study of Lagos State, Nigeria.</title>
    <abstract language="eng">Lagos State, Nigeria’s most populous city, experiences a continuous increase in its population, resulting in a substantial rise in waste generation from various sources including households, industries, and commercial activities. Unfortunately, the existing waste management infrastructure and practices within the state remain inadequate, giving rise to environmental pollution, health hazards, and the deterioration of urban landscapes. Thus, this study explores innovative and sustainable solutions for waste management in Lagos State. Specifically, this study focuses on two important waste categories; Municipal Solid Waste and Sewage Waste.&#13;
This study includes a thorough examination of the existing waste management practices in Lagos State through visits and interviews conducted with the relevant waste management authorities within the state. In pursuit of possible solutions to address Lagos State waste challenges, this study draws insights from the waste management practices established in Germany, with a particular focus on Cologne.&#13;
Additionally, this study evaluates the feasibility and potential effectiveness of implementing these practices in Lagos State.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18239</identifier>
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    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Adetola Idowu</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1823/Idowu_thesis.pdf</file>
  </doc>
  <doc>
    <id>1814</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>99</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
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    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-10-03</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-09-15</thesisDateAccepted>
    <title language="eng">The use of biocatalysis in the diagnosis and treatment of colorectal cancer (CRC)</title>
    <abstract language="eng">Colorectal cancer is a significant global health burden. Early-stage colorectal cancer is asymptomatic, which, coupled with the fact that later stages of CRC have a very low prognosis, and that current methods of diagnosis and treatment significantly impact the patient, exploring alternate ways to diagnose and treat CRC is vital.&#13;
Biocatalysis is the use of naturally found catalysts such as nanozymes and enzymes in order to catalyze reactions. Due to their characteristics and uses, biocatalysts are seen as promising alternatives to current methods of CRC diagnosis and therapy.&#13;
This research-based bachelor thesis aims to summarize and analyze current traditional and biocatalytic methods that exist to diagnose and treat CRC, in order to seek the potential of biocatalysis in this field, as well as discuss its current state and its future in comparison to currently implemented methods. It provides an extensive overview of traditional and biocatalytic approaches to diagnosis and therapy, considering important factors such as efficacy, sensitivity, selectivity, cost, and safety.&#13;
The thesis also delves into the use of biocatalysis for important points such as the early diagnosis of CRC, and the challenges faced during development, regulation, and monetary concerns. Through careful analysis of the strengths and limitations of techniques in the field, as well as personal opinions on the future of research, conclusions on given hypotheses regarding biocatalysis in CRC diagnosis and therapies were presented and included strong support for the unquestionable potential of biocatalysis use in cancer healthcare, while highlighting possibilities to tap into that potential by scrutinizing their equally as unquestionable current limitations.&#13;
Overall, this thesis aspires to contribute, on however minuscule a scale, towards the advancement of CRC diagnosis and therapy approaches, with the ambition of improving patient care and prognosis, as well as quality of life for those struggling or who will struggle in the future with the disease, together with their kin who are profoundly affected as well.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18147</identifier>
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    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Basil Mazen Hammoudeh</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Colorectal cancer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cancer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Biocatalysis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Enzymes</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Diagnosis</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Therapy</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1814/BasilHammoudeh_Thesis_FINAL_SIGNED.pdf</file>
  </doc>
  <doc>
    <id>1809</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>120</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>masterthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-09-21</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-07-11</thesisDateAccepted>
    <title language="deu">Vermehrte Inanspruchnahme deutscher Notfallambulanzen - Eine Patientenbefragung im BG Klinikum Duisburg</title>
    <abstract language="deu">Einleitung: Die vermehrte und stetig steigende Inanspruchnahme von Deutschlands Notaufnahmen und das damit einhergehende Crowding innerhalb dieser stellen ein komplexes Problem des Gesundheitssystems dar, welches bereits seit geraumer Zeit konkretes Handeln auf gesundheitspolitischer Ebene fordert (Doan et al., 2019). Die patientenseitigen Beweggründe für die vermehrte Inanspruchnahme wurden dabei bislang nicht hinreichend untersucht (Reinhold et al., 2021). Auf der Grundlage der bisherigen Literatur scheint das Nachfragewachstum jedoch häufig auf Patienten ohne medizinische Notfallindikation zurückzuführen zu &#13;
sein (Durand et al., 2012).&#13;
&#13;
Methode: Im Zeitraum vom 01.10.-30.11.2022 wurde eine quantitative Fragebogenerhebung im BG Klinikum Duisburg durchgeführt. Der Fragebogen besteht aus insgesamt 16 Fragen. Die Datenauswertung basierte dabei auf deskriptiven sowie inferenzstatistischen Analysen und konnte mehrere Unterschiede zwischen einigen Patientengruppen aufdecken. Es wurde ein 95% Konfidenzintervall festgelegt. &#13;
Ergebnisse: Im Rahmen der Fragebogenerhebung konnten 548 gültige Fragebögen erworben werden. Dabei zeigten sich die Gründe für das vermehrte Inanspruchnahme-Verhalten multifaktoriell. In erster Linie zählten hierzu antizipierte Qualitätsvorteile innerhalb der Notaufnahmen im Vergleich zu ambulanten Versorgungseinrichtungen seitens der Patienten sowie insbesondere die Unkenntnis der Bevölkerung über bestehende Gesundheitsdienstleistungen im Notfall, wie bspw. den ärztlichen Bereitschaftsdienst. Ebenso ist ein genereller Rückgang der Gesundheitskompetenz zu verzeichnen. &#13;
Diskussion: Grundsätzlich ist eine fehlende medizinische Notfallindikation bei dem Großteil der Notfallpatienten zu verzeichnen. Das rund um die Uhr zur Verfügung stehende Versorgungsangebot der Notaufnahmen zeigt sich äußerst attraktiv für die Patienten und führt nicht zuletzt zu Bequemlichkeitsentscheidungen. Letztlich muss das ambulante Versorgungssystem ausgebaut, die Bevölkerung besser aufgeklärt und der bestehende Status der Gesundheitskompetenz dadurch gefordert sowie gefördert werden.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18099</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <licence>Bestimmungen des deutschen Urheberrechts</licence>
    <author>Raphaela Peschel</author>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Notaufnahme</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Vermehrte Inanspruchnahme</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Crowding</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Behandlungsdringlichkeit</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Gesundheitskompetenz</value>
    </subject>
    <subject>
      <language>deu</language>
      <type>uncontrolled</type>
      <value>Antizipierte Qualitätsvorteile</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1809/Peschel_Raphaela_Masterarbeit.pdf</file>
  </doc>
  <doc>
    <id>1801</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>46</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
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    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-09-07</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-07-25</thesisDateAccepted>
    <title language="eng">Unravelling mortality of Perca fluviatilis: Meta-analysis and integration into a physiologically structured population model</title>
    <abstract language="eng">Perca fluviatilis is widely distributed food generalist fish across the Europe and Asia  (Couture and Pyle, 2015). As a part of the project by Winkelmann et al. (2022), the continuos physiologically structured population model (cPSPM) of P. fluviatilis was established which appeared to have potential points for improvement. In this study, I attempted to modify mortality function of the population model. Hence based on thorough literature research 4 models for mortality estimation mortality as well as the data of life-traits of perch were found. The models include Hoenig-Then (Then et al., 2015), Pauly-Then (Then et al., 2015), Lorenzen (Lorenzen, 2022). and Weibull probability density function as function of weight dependent mortality. The methods were parametrised via arithmetic average of population specific traits and non-parametric least-square method. As a result, the mortality models were compared to each other as well as to the base model. Further on, each mortality model was integrated into cPSPM and stable population was found. At the end only Lorenzen and Weibull models were analysed. As a result of mortality model comparison, it was found that the difference between these models lies mainly in difference of magnitude. Integration of the models into cPSPM showed the potential correlation between the mortality and reproduction. The comparison of simulations results in similarity in population dynamics of our models with experimental data, with main difference in magnitude. Overall results suggest that every model has reason to be applied, and all of them have their own application. In terms of current cPSPM, it would be suggested to consider population dynamics of perch over multiple years period with different mortality method employed for each year to address the issue of variability of population dynamics on yearly basis.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-18017</identifier>
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    <licence>CC BY-NC 4.0 International - Namensnennung-Nicht kommerziell</licence>
    <author>Georgii Puzachenko</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1801/FINAL.pdf</file>
  </doc>
  <doc>
    <id>1766</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber/>
    <edition/>
    <issue/>
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    <type>conferenceobject</type>
    <publisherName/>
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    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-06-27</completedDate>
    <publishedDate>2023-06-14</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">SUFACHAIN - Sustainable Agroforestry Value Chains in Central Asia</title>
    <abstract language="eng">The agricultural sector represents an important means of livelihood for the rural population in Central Asia, while the region's agricultural and forest landscapes are at risk of degradation due to population growth and economic development. The SUFACHAIN project aims to analyse agroforestry systems and integrate them into local land use systems, while developing products and technologies that contribute to the sustainable use of resources and create local value. In close collaboration with local partners, the project will (1) analyse and design sustainable agroforestry systems, (2) improve quality in the foods made from agroforestry products, (3) develop efficient technologies for the re-use of waste materials from the processing chain, (4) improve transparency along the supply chain, (5) increase local value by valorising selected ecosystem services and (6) develop attractive market niches for agroforestry products.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-17660</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <licence>Bestimmungen des deutschen Urheberrechts</licence>
    <author>Jannike van Bruggen</author>
    <author>Dirk Bockmühl</author>
    <author>Dirk Bruckmann</author>
    <author>Jens Gebauer</author>
    <author>Dirk Reiser</author>
    <author>Florian Wichern</author>
    <author>Dietrich Darr</author>
    <series>
      <title>Beiträge des Forschungs- und Transfertags der Hochschule-Rhein Waal</title>
      <number>03</number>
    </series>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1766/1_SUFACHAIN_Forschungstag14Juni_230609_v2.pdf</file>
  </doc>
  <doc>
    <id>1769</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>82</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-06-29</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="deu">Methodenentwicklung zur Bestimmung des Serumspiegels und der Stabilität von Bupropion und Hydroxy-Bupropion mittels LCMS Orbitrap im Zuge des therapeutischen Drug Monitorings</title>
    <abstract language="eng">Patients undergoing psychiatric treatment are typically treated with a variety of medications, the interactions of which and the resulting impact on the serum concentration levels of the drugs are unpredictable. Such interactions and the occurrence of side effects due to incorrect dosages are also known for the antidepressant bupropion, emphasizing the importance of therapeutic drug monitoring for this medication.&#13;
&#13;
Therefore, this study aimed to develop and validate a method for the determination of serum levels of bupropion and its pharmacologically active major metabolite, hydroxybupropion, using LC-MS. Additionally, due to the low stability of bupropion at room temperature, the influence of this factor on the routine measurements of bupropion patient samples in the laboratory of the LVR-Klinik Viersen pharmacy was also examined.&#13;
&#13;
Various bupropion solutions (dissolved in methanol or human albumin) were prepared for measurement. These solutions were analyzed using an LC-MS "Exactive Plus Orbitrap" with a biphenyl column as the stationary phase and various mobile phases differing in polarity to allow for the generation of a gradient. An electron spray ionization (ESI) method and an Orbitrap detector were used for quantifying the sample concentration.&#13;
&#13;
The measurement of a 0.1 ng/ml bupropion solution and a 0.5 ng/ml hydroxybupropion solution resulted in a signal-to-noise ratio in the mass spectrum that was well above the required 3:1 ratio for background noise subtraction. As the concentration was already below the required detection limit of 0.2 ng/ml for bupropion and 17 ng/ml for hydroxybupropion, no further steps were taken to determine the actual limit of detection for economic reasons since sufficient sensitivity of the LC-MS method was already demonstrated.&#13;
&#13;
The investigations into the recovery rate (WFR) and ion suppression showed that the applied sample preparation (protein precipitation with acetonitrile) did not lead to any relevant loss of content and that no interfering effects from other components of the sample matrix occurred during the measurement. The WFR was determined to be 100 ± 5% for bupropion and 101 ± 4.8% for hydroxybupropion. The examination of ion suppression resulted in a content deviation from the target value of 4 ± 0.2% for bupropion and -9 ± 0.1% for hydroxybupropion.&#13;
&#13;
The linearity of the method was confirmed by measuring a 5-point calibration with a correlation coefficient for the regression line of approximately 0.99 for both analytes. The precision and reproducibility of the method were also confirmed through the evaluation of in-day and day-to-day variation, with a coefficient of variation of &lt;10 for all measurements conducted for both analytes. Thus, a reliable method for the determination of bupropion content using LC-MS was successfully developed and validated. By participating in proficiency testing programs, the method will be further validated and potentially certified in the future.</abstract>
    <abstract language="deu">Patienten in psychiatrischer Behandlung werden in der Regel mit einer Vielzahl von Medikamenten behandelt, deren Wechselwirkungen und der daraus resultierende Einfluss auf die Serumspiegelkonzentration der Arzneistoffe nicht vorhersehbar sind. Auch für das Antidepressivum Bupropion sind solche Wechselwirkungen, sowie das Auftreten von Nebenwirkungen aufgrund falscher Dosierungen in der Therapie bekannt und unterstreichen die Bedeutung des therapeutischen Drug Monitorings für diesen Wirkstoff.&#13;
In dieser Arbeit sollte daher eine Methode zur Serumspiegelbestimmung von Bupropion und seinem pharmakologisch wirksamen Hauptmetaboliten Hydroxy-Bupropion für die LCMS entwickelt und validiert werden. Aufgrund der geringen Stabilität von Bupropion bei Raumtemperatur, sollte zudem überprüft werden, welchen Einfluss dies auf die Routinemessungen von Bupropion-Patientenproben im Labor der Apotheke der LVR-Klinik Viersen hat.&#13;
Es wurden verschiedene Bupropion Lösungen (in Methanol oder Humanalbumin gelöst) für die Vermessung hergestellt. Diese wurden auf einer LCMS „Exactive Plus Orbitrap“ unter Verwendung einer Biphenyl-Säule als stationäre Phase und diverser Fließmittel, die sich in ihrer Polarität unterschieden und so die Erzeugung eines Gradienten ermöglichten, analysiert. Als Ionisationsverfahren kam eine Elektronensprayionisation (ESI), sowie ein Orbitrap-Detektor zur Quantifizierung der Probenkonzentration zum Einsatz.&#13;
Die Vermessung einer 0,1 ng/ml Bupropion-Lösung und einer 0,5 ng/ml Hydroxy-Bupropion-Lösung ergaben ein Signal-Rausch-Verhältnis im Massenspektrum, welches weit über dem erforderlichen 3:1-Verhältnis für die Abhebung vom Hintergrundrauschen lag. Da die Konzentration bereits unterhalb der erforderlichen Messempfindlichkeit von 0,2 ng/ml für Bupropion bzw. 17 ng/ml für Hydroxy-Bupropion lag, wurden aus wirtschaftlichen Gründen keine weiteren Schritte zur Bestimmung der tatsächlichen Nachweisgrenze unternommen, da eine ausreichende Empfindlichkeit der LCMS bereits belegt war. &#13;
Die Untersuchungen zur Wiederfindungsrate (WFR) und der Ionensupression konnten zeigen, dass die verwendete Aufbereitung (Proteinfällung mit Acetonitril) zu keinem relevanten Gehaltsverlust führt und keine störenden Effekte durch andere Bestandteile der Probenmatrix während der Vermessung auftreten. Es ergab sich eine WFR für Bupropion von 100 ± 5 % und für Hydroxy-Bupropion von 101 ± 4,8 %. Bei der Untersuchung zur Ionensuppression kam es zu einer Gehaltsabweichung vom Zielwert von 4 ± 0,2 % für Bupropion und von -9 ± 0,1 % für Hydroxy-Bupropion.&#13;
Die Linearität der Methode wurde durch die Vermessung einer 5-Punkt-Kalibration mit einem Korrelationskoeffizienten für die Regressionsgerade von ~0,99 für beide Analyten bestätigt. Durch die Überprüfung der In-Day- und Day-to-Day-Variation konnte auch die Präzision und Reproduzierbarkeit der Methode bestätigt werden. Dabei ergab sich ein Variationskoeffizient für alle durchgeführten Messungen von &lt;10 für beide Analyten. Somit konnte erfolgreich eine zuverlässige Methode für die Gehaltsbestimmung von Bupropion mittels LCMS entwickelt und validiert werden. Durch das Integrieren von Bupropion in die Teilnahme an Ringversuchen, wird die Methode in Zukunft auch weiter validiert und ggf. zertifiziert werden.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-17690</identifier>
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    <licence>CC BY-NC-SA 4.0 International - Namensnennung-Nicht kommerziell-Weitergabe unter gleichen Bedingungen</licence>
    <author>Tristan Tannhäuser</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1769/Tannhaeuser_Tristan_Bachelorarbeit.pdf</file>
  </doc>
  <doc>
    <id>1768</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
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    <volume/>
    <type>conferenceobject</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-06-14</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Excellent excrement? The potential benefits and  drawbacks of soil amendment with frass</title>
    <abstract language="eng">Insect rearing is a rapidly growing sector in Europe, with larval protein production projected to exceed 1 Mt in 2025. The by-product frass is a mix of larval faeces, exoskeletons and undigested substrate. Given its potential as a soil improver, frass could make insect production a “zero waste” industry. However, its positive reputation has not been thoroughly scrutinized with regard to environmental impacts. We therefore conducted experiments to investigate the effects of frass application on the soil microbial community, release of greenhouse gases and heavy metal availability.&#13;
&#13;
The main conclusions were:&#13;
&#13;
1) Frass is nutritious and can benefit the soil microbial biomass, but rapid loss of C and N reduces its fertiliser and organic amendment potential&#13;
&#13;
2) Co-application of frass with urease inhibitors could allow it to be utilised as a slow-release N fertiliser&#13;
&#13;
3) Concurrent soil amendment of frass with nitrification inhibitors prevents soil nitrite accumulation&#13;
&#13;
4) All frass types tested are suitable as ameliorative amendments to heavy-metal contaminated soils</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-17689</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Conor Watson</author>
    <author>Pauline Rummel</author>
    <author>Lukas Beule</author>
    <author>Charlotte Schlösser</author>
    <author>Michael Hemkemeyer</author>
    <author>Sanja Schwalb</author>
    <author>Timo Preißing</author>
    <author>Jakob Vögerl</author>
    <author>Florian Wichern</author>
    <series>
      <title>Beiträge des Forschungs- und Transfertags der Hochschule-Rhein Waal</title>
      <number>05</number>
    </series>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1768/Watson_2023.pdf</file>
  </doc>
  <doc>
    <id>1749</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>86</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>masterthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-05-30</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-05-02</thesisDateAccepted>
    <title language="eng">Offshore Wind Farms - The new kind of Marine Protected Area for Northern Europe?</title>
    <abstract language="eng">This thesis combines the findings of several publications and studies on the influ- ence of offshore wind farms on marine life, in Northern Europe. The properties and characteristics of this offshore wind farm areas were compared to the characteristics of marine protected areas and differences as well as conformities were highlighted. It is evident, that the negative consequences accompanying the implementation of offshore wind farms are less concise, than the public opinion assumes. Although scientific knowledge gaps in multiple related fields for example, the influence of elec- tromagnetic fields on individuals or the influence of noise on benthos species, are present, offshore wind farms offer chances to contribute positive effects for marine life in terms of de facto protected areas and new possibilities for population growth. The planned extensions of offshore wind farms in geographical relation to marine protected areas could enhance the size of protected areas and connect remote ma- rine protected areas with each other.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-17490</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Sören Schmidt</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1749/Thesis.pdf</file>
  </doc>
  <doc>
    <id>1728</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>deu</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>91</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-04-17</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-03-13</thesisDateAccepted>
    <title language="deu">In vitro Fleisch als Alternative zu konventionellem Fleisch</title>
    <abstract language="deu">Durch die wachsende Weltbevölkerung kommt es zu einem steigenden Fleischkonsum, der mit unerwünschten Folgen für die Umwelt und die Gesundheit sowie das Wohlergehen der Tiere einhergeht. Durch die konventionelle Fleischproduktion entstehen hohe Treibhausgasmengen sowie ein hoher Wasser- und Landverbrauch. Der Verzehr von verarbeitetem und rotem Fleisch erhöht das Krebsrisiko und begünstigt die Entstehung von Herz-Kreislauf-Erkrankungen, Diabetes und Bluthochdruck. Bei der Aufzucht der Tiere werden zur Vermeidung von bakteriellen Infektionen Antibiotika eingesetzt, die Auswirkungen auf die menschliche Gesundheit haben können. Das Wohlergehen der Tiere ist aufgrund des hohen Stressniveaus durch schlechte Haltungsbedingungen nicht gegeben. Zur Verbesserung der Risiken durch konventionell hergestelltes Fleisch werden Alternativen erforscht. Ziel ist es die sensorischen und geschmacklichen Komponenten des konventionellen Fleisches nachzuahmen und eine Verbesserung der Gesundheit, Umwelt und das Wohlergehen der Tiere zu erzeugen. Neben den auf dem Markt erhältlichen pflanzlichen Fleischprodukten, deren Sensorik noch nicht ausgereift ist, befasst sich die Forschung mit der Entwicklung von in vitro Fleisch sowie Fleisch aus dem 3D-Drucker. Die Herstellung von in vitro Fleisch nach dem Tissue Engineering Verfahren entstammt der Stammzellenforschung und Gewebezüchtung. Stammzellen eines Tieres werden entnommen und mithilfe eines Nährmediums, einem Gerüst und einem Bioreaktor zu Geweben kultiviert, die dem konventionellem Fleisch ähneln. Durch das Hinzufügen von Komponenten wie z.B. Vitamine oder gesunde Fette kann die Sensorik und der Geschmack des in vitro Fleisches verbessert werden. Der Verbrauch von Land und die Umweltbelastung durch Treibhausgase sind geringer als bei der konventionellen Fleischherstellung. Dennoch stellen sich bei der in vitro Fleischproduktion noch offene Herausforderungen in Bezug auf die Umwelt, Gesundheit und Sensorik. Damit in vitro Fleisch auf dem Markt zugelassen werden kann, muss die Sicherheit des Produktes gewährleistet sein. Die Verbraucherakzeptanz ist eingeschränkt, da wenig Informationen und Studien zu den Auswirkungen auf die Umwelt und Gesundheit vorliegen, die auf bewiesenen Ergebnissen beruhen. Weitere Forschungen sind nötig, um die Akzeptanz zu erhöhen und die Hürden zu überwinden. Die vorliegende Arbeit soll einen Überblick über den aktuellen Forschungsstand von in vitro Fleisch als Alternative zu konventionellem Fleisch geben.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-17287</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Sabrina Stuckmann</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1728/Stuckmann_Bachelorarbeit.pdf</file>
  </doc>
  <doc>
    <id>1717</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst>102935</pageFirst>
    <pageLast>102935</pageLast>
    <pageNumber/>
    <edition/>
    <issue/>
    <volume/>
    <type>preprint</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-03-07</completedDate>
    <publishedDate>2023-03-07</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">Should forest enterprises formalize? Insight from a multi-dimensional characterization of informal baobab enterprises</title>
    <abstract language="eng">Knowledge of the structure and characteristics of informal forest enterprises is critical to determining the most appropriate course of action for their development and formalization. This study characterizes and develops a typology of informal microenterprises in the Malawian baobab processing sector; and assesses factors influencing their entry into the informal sector. Drawing on the analysis of firm-level data from 305 informal baobab pro- cessors, cost and complexity of registration, smallness (scale) of the business, and necessity-driven motivations were identified as key factors influencing informality. Coupling principal component and cluster analyses, three typologies of informal microenterprises were identified and characterized namely; high performance-survival phase enterprises (type 1), moderate performance-survival phase enterprises (type 2), and low performance-start-up phase enterprises (type 3). Annual net profit (earnings), firm age, and the extent of adoption of formal systems and controls explained the inherent segmentation. The segmentation suggests a dualism compromising of an upper- and lower-tier enterprises characterized by strong involuntary entry into the informal forest sector. For policy implications, we argue that the upper-tier enterprises (types 1 and 2) be targeted with business development programmes to promote their growth while, the lower-tier (type 3) targeted with skills development and social support.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-17172</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>William Kwadwo Dumenu</author>
    <author>Louis Gyekye Appiah</author>
    <author>Carola Paul</author>
    <author>Dietrich Darr</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1717/Dumenu_paper.pdf</file>
  </doc>
  <doc>
    <id>1711</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>49</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-03-26</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-01-09</thesisDateAccepted>
    <title language="eng">PRODUCTION OF IMPROVED OIL PALM BY-PRODUCT (OIL PALM FROND) AS ANIMAL FEED THROUGH SOLID STATE FERMENTATION WITH PLEUROTUS OSTREATUS</title>
    <abstract language="eng">The increasing development and production of oil palm plantation in South-East Asian’s countries has led to the production of large quantities of biomass by-products. These by-products however are mostly fibrous in nature and they can hardly be valuable to be used as animal feed. Oil palm frond (OPF) is one of the oil palm’s by-product which are widely available, yet the utilization is hindered due to its high fibre content. In this study, the oil palm fronds, specifically the petiole part of it will be improved to be used as animal feed using solid state fermentation technique at the Faculty of Sustainable Agriculture (FSA) in Sandakan, Sabah by using Pleurotus ostreatus. The study was carried out to produce 30kg of treated OPF and to see if solid state fermentation technique using the mentioned fungus has the effect on the OPF. Cultivated Pleurotus ostreatus that are ready for inoculation was obtained from FSA fungus collection. It was then inoculated at the FSA general laboratory. For the OPF, they were collected from the oil palm farm in Telupid and they were ground into smaller and fine particles. 650 g of ground OPF was then be filled in the mushroom bag. For each mushroom bag, it was inoculated with one plate of Pleurotus ostreatus, and then all the samples were kept in the Mushroom House for fermentation. Samples were harvested after eight weeks. Dry matter, moisture content, organic matter and ash content of OPF, before and after fermentation were then evaluated in the lab. Dry matter and organic matter of treated OPF were found out to be decreasing while its moisture content and ash content were increasing. Solid state fermentation did take place on the OPF and 30 kg of treated OPF with Pleurotus ostreatus was managed to be produced.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-17118</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY 4.0 International - Namensnennung</licence>
    <author>Dylan Nathaneal Jeory</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Oil palm frond</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Solid state fermentation</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Pleurotus ostreatus</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1711/Jeory.pdf</file>
  </doc>
  <doc>
    <id>1702</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>54</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-03-14</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-02-22</thesisDateAccepted>
    <title language="eng">Advantages and disadvantages of mulching in market garden systems</title>
    <abstract language="eng">The need for sustainable and resilient food production is constantly increasing.  Methods such as cover cropping, the use of mulches and non- or minimal tillage are recommended in large-scale agriculture, yet are not typically found in  standard versions of market gardening, as developed by J.M. Fortier. In order to redesign the market gardening system towards more sustainability, the  advantages and disadvantages of mulching, possible allelopathic effects from  cover crops and mulches, and a possible on-site production of transfer and insitu mulch, were investigated. For this purpose, a literature review was carried  out and afterwards a market garden rotation including cover crops was  designed. The review results suggested that positive (crop-promoting) as well  as negative (crop- and weed-reducing) allelopathy from cover crops exist and  are includable into the system as a form of integrated weed management  system. It was found that the advantages of mulching outweigh the  disadvantages and that it is possible to redesign the market garden system  towards more sustainability.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-17025</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC BY-NC-SA 4.0 International - Namensnennung-Nicht kommerziell-Weitergabe unter gleichen Bedingungen</licence>
    <author>Yvonne Rümmele</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Market gardening</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Allelopathy</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Intercropping</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Cover crops</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mulch</value>
    </subject>
    <collection role="ddc" number="57">Biowissenschaften; Biologie</collection>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1702/ThesisRuemmelePrintversion.pdf</file>
  </doc>
  <doc>
    <id>1696</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>62</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-03-06</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>--</thesisDateAccepted>
    <title language="eng">A Structured Classification and Evaluation of Current and Future Treatments for Systemic Lupus Erythematosus</title>
    <abstract language="eng">Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease that has a variety of manifestations and is therefore difficult to find a treatment for. Several advances have occurred in the field of SLE drug discovery, especially since the publishing of the first Genome Wide-Associated Studies in 2005. More than one hundred loci were found to be involved in the disease. Subsequently, the treatments were aimed towards tackling the pathways that were found after the uses of modern genetic techniques. Historically, the FDA approved only two drugs for treatment until the approval of Belimumab in 2011. Ten years later, two more drugs were approved in the same year, with few more drugs expected to receive approval in the near future. This study aims to evaluate the efficacy of these future drugs in addition to the ones considered to be milestones in the treatment of SLE, finding Anifrolumab to be the most promising drug currently on the market for treatment of moderate to severe SLE and Obinutuzumab to be the drug to watch.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-16960</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC0 1.0 Universell - Gemeinfreiheit (Public Domain)</licence>
    <author>Ahmed Abdelazim</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1696/Abdelazim_Lupus.pdf</file>
  </doc>
  <doc>
    <id>1692</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>62</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-02-27</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2023-02-14</thesisDateAccepted>
    <title language="eng">MESENCHYMAL STEM CELLS (MSC) IN BREAST CANCER TREATMENT: ADVANTAGES AND CHALLENGES OVER TRADITIONAL THERAPIES</title>
    <abstract language="eng">Breast cancer is one of the most prevalent and deadly malignancies in women globally, due to its aggressive behavior and poor response to traditional treatments. Despite the significant improvements in understanding of tumor therapies, efforts to treat patients with advanced cancer are still hampered by the size and heterogeneity of the tumor burden and the development of drug resistance. Therefore, the need for novel therapeutic strategies is essential.&#13;
Mesenchymal stem cells (MSCs) have been studied for a long time with encouraging results in the treatment of metastatic cancers, including breast cancer. The discovery of MSCs' therapeutic abilities to inhibit the growth of cancer, cause cell death, and trigger immune responses served as a catalyst for the development of bioengineered MSCs. The use of MSCs in cell therapy is the subject of numerous investigations now. &#13;
This thesis aimed to summarize the current knowledge on traditional breast cancer treatments and compare them to novel approaches based on MSCs usage. To this end, scientific publications retrieved from databases such as PubMed were selected considering specific inclusion/exclusion criteria and were extensively analyzed. Results obtained underline the potential applications of MSCs for breast cancer treatment, such as using MSCs as carriers of oncolytic viruses, suicide genes, and anticancer medicines to malignancies. Furthermore, challenges and limitations of several MSCs based treatments and MSCs control were evaluated and discussed based on ongoing clinical trials.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-16927</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>CC0 1.0 Universell - Gemeinfreiheit (Public Domain)</licence>
    <author>Olga Chentsova</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>MSC</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mesenchymal stem cells</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Traditional cancer therapies breast cancer</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>BC</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Treatment</value>
    </subject>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1692/Chentsova_MSCs.pdf</file>
  </doc>
  <doc>
    <id>1673</id>
    <completedYear/>
    <publishedYear>2023</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>80</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2023-02-06</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2022-12-27</thesisDateAccepted>
    <title language="eng">Evaluating the potential of mRNA vaccines for human rabies</title>
    <abstract language="eng">To this date, rabies is still one of the most fatal diseases worldwide and generates at least 59,000 deaths per year. Although current vaccines are safe and effective, RNA technology proposes improved vaccines that are potentially able to facilitate eradication of rabies until 2030. In this review, RNA vaccine candidates are evaluated for their potential to be effective against rabies and to be implemented in immunization programs. To understand the relevance of disease prevention, rabies virus and its function in the body is clarified. RNA technology is explained to comprehend its mode of action in the human immune system and its potential to be a vaccine platform. Comparison to existing vaccines showed advantages in several characteristics that are relevant for vaccine approval. RNA vaccines scored better in efficacy, stability, production, and dosing, but there is still room for improvements in terms of safety and tolerability. Theoretical potential is proven, but practical translation of RNA vaccines into clinical candidates requires more attention, as safety and tolerability are the leading limiting factor for approval of any new drug or vaccine. Producing a safe, stable and effective RNA vaccine does not necessarily ensure less rabies deaths, because rabies control strategies heavily rely on proper funding and availability in these rabies endemic region. Nonetheless, RNA vaccine technology offers potential solutions for the elimination of rabies.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-16737</identifier>
    <enrichment key="opus.source">publish</enrichment>
    <enrichment key="opus.doi.autoCreate">false</enrichment>
    <enrichment key="opus.urn.autoCreate">true</enrichment>
    <licence>Bestimmungen des deutschen Urheberrechts</licence>
    <author>Ole Waller</author>
    <collection role="institutes" number="">Fakultät Life Sciences</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/1673/Bachelorthesis_OWaller_25337.pdf</file>
  </doc>
</export-example>
