<?xml version="1.0" encoding="utf-8"?>
<export-example>
  <doc>
    <id>268</id>
    <completedYear/>
    <publishedYear>2018</publishedYear>
    <thesisYearAccepted/>
    <language>eng</language>
    <pageFirst/>
    <pageLast/>
    <pageNumber>48</pageNumber>
    <edition/>
    <issue/>
    <volume/>
    <type>bachelorthesis</type>
    <publisherName/>
    <publisherPlace/>
    <creatingCorporation/>
    <contributingCorporation/>
    <belongsToBibliography>0</belongsToBibliography>
    <completedDate>2018-08-06</completedDate>
    <publishedDate>--</publishedDate>
    <thesisDateAccepted>2018-07-20</thesisDateAccepted>
    <title language="eng">45S5 Bioglass scaffold coated with a drug loaded mesoporous bioactive glass for bone tissue engineering</title>
    <abstract language="eng">Bioactive glass scaffold is a promising substitute of the bone grafts in bone tissue engineering. To improve its potential in bone repair, it needs to be more mechanically stable and provide a controlled drug delivery. Thus, 45S5 Bioglass® scaffolds that are fabricated via a foam replication technique, are coated with the amine-functionalized mesoporous bioactive glass nanoparticles by the slurry dip coating method. These nanoparticles are able to load the therapeutic biomolecules in their mesopores in size range of 2-50 nm and release the drug at a controlled rate when they are exposed to a physiological fluid. The compressive strength of the scaffolds is improved by coating them with gelatin, a biocompatible polymer. The influence of these modifications on the bioactivity of the scaffolds is analyzed by immersing them in the simulated body fluid for up to 21 days. FTIR and XRD analysis confirms that the coating of bioglass nanoparticles and gelatin does not inhibit the formation of the hydroxyapatite layer, while it improves the drug loading capacity and mechanical strength of the scaffolds.</abstract>
    <identifier type="urn">urn:nbn:de:hbz:1383-opus4-2689</identifier>
    <licence>CC BY-NC-ND 4.0 International - Namensnennung-Nicht kommerziell-Keine Bearbeitungen</licence>
    <author>Hyeryeon Oh</author>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bone tissue engineering</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Bioactive glass</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Scaffolds</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Drug delivery</value>
    </subject>
    <subject>
      <language>eng</language>
      <type>uncontrolled</type>
      <value>Mesoporous bioactive glass</value>
    </subject>
    <collection role="institutes" number="">Fakultät Technologie und Bionik</collection>
    <thesisPublisher>Hochschule Rhein-Waal</thesisPublisher>
    <thesisGrantor>Hochschule Rhein-Waal</thesisGrantor>
    <file>https://opus4.kobv.de/opus4-rhein-waal/files/268/Oh_Hyeryeon_Bachelor Thesis.pdf</file>
  </doc>
</export-example>
