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Tissue-engineered vessel grafts have to mimic the biomechanical properties of native blood vessels. Manufacturing processes often condition grafts to adapt them to the target flow conditions. Graft stiffness is influenced by material properties and dimensions and determines graft compliance. This proof-of-concept study evaluated a contact-free method to monitor biomechanical properties without compromising sterility. Forced vibration response analysis was performed on human umbilical vein (HUV) segments mounted in a buffer-filled tubing system. A linear motor and a dynamic signal analyser were used to excite the fluid by white noise (0-200 Hz). Vein responses were read out by laser triangulation and analysed by fast Fourier transformation. Modal analysis was performed by monitoring multiple positions of the vessel surface. As an inverse model of graft stiffening during conditioning, HUV were digested proteolytically, and the course of natural frequencies (NFs) was monitored over 120 min. Human umbilical vein showed up to five modes with NFs in the range of 5-100 Hz. The first natural frequencies of HUV did not alter over time while incubated in buffer (p = 0.555), whereas both collagenase (-35%, p = 0.0061) and elastase (-45%, p < 0.001) treatments caused significant decreases of NF within 120 min. Decellularized HUV showed similar results, indicating that changes of the extracellular matrix were responsible for the observed shift in NF. Performing vibration response analysis on vessel grafts is feasible without compromising sterility or integrity of the samples. This technique allows direct measurement of stiffness as an important biomechanical property, obviating the need to monitor surrogate parameters. Copyright (C) 2016 John Wiley & Sons, Ltd.
Risk and reliability criteria are well established in many industrial sectors such as the offshore, chemi- cal or nuclear industries. Comparative risk thresholds have been specified to allow a responsible organization or regulator to identify activities, which impose an acceptable level of risk concerning the participating individuals, or society as a whole. The scope of this contribution is to present target reliability criteria based on acceptable human safety levels. Application of theoretical principles is illustrated by examples of railway engineering structures. Initially it is shown how civil engineering structures for which human safety criteria play a role are classified according to Eurocodes. Examples include bridges, tunnels or station buildings. The general concepts for risk acceptance are then briefly reviewed, particularly in their relation to the target reliability criteria. The distinction between the two types of criteria is made: group risk and the acceptance criterion based on the Life Quality Index LQI approach introduced by ISO 2394:2015. The differences between the criteria for new and existing structures are discussed. The application is illustrated by an example of a bridge crossing an important railway line. It appears that while benefits and costs of a private stakeholder or public authority are reflected by economic optimisation, the society should define the limits for human safety to achieve uniform risks for various daily-life activities and across different industrial sectors. Keywords: group risk, human safety, individual risk, Life Quality Index, railway, risk acceptance, structure, target reliability