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One major goal of production system design is to decide on space requirements in the plant. In this phase, detailed information about the supply chain network (e.g. which suppliers deliver which parts) is often unavailable. Nevertheless, typical decisions in supply chain management, like the definition of replenishment processes and quantities or make-or-buy decisions, impact space requirements and the capital investment in raw materials. Therefore, it should be considered in factory and production planning. This research article proposes a simulation approach for a production simulation in which raw material replenishment is integrated to evaluate the capital investment and space requirements for raw materials.