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Der Beitrag zeigt Ergebnisse einer Begleitstudie zur Restaurierung und energetischen Modernisierung des historischen genossenschaftlichen Wohnquartiers Margaretenau in Regensburg im Projekt MAGGIE. Bei der Gestaltung von Wohnungen und Gelegenheiten für die soziale Einbettung im Quartier wird eine altersgerechte Perspektive eingenommen. Die Darstellung der schriftlichen standardisierten Haushaltsbefragung (n = 195) nimmt die Lebenssituation älterer Menschen ab 65 Jahren in den Fokus. Dazu werden die Themenbereiche Haushaltsstruktur, altersgerechtes Wohnen und Gemeinschaftseinrichtungen präsentiert. Neben der aktuellen Wohnsituation wurden Pläne und Wünsche für das zukünftige Wohnen abgefragt. Im Alter schwindet die Bereitschaft für Veränderungen, was sich am Wunsch zum Altern in der bisherigen Wohnung und Verbleib im Wohnquartier zeigt. Das Interesse am barrierereduzierten Wohnen ist bei älteren Haushalten geringer als bei jüngeren. Es zeigt sich ein überdurchschnittlich hohes Maß an lokalem Sozialkapital, wobei kein signifikanter Unterschied zwischen jüngeren und älteren Haushalten besteht.
This study examines attitudes toward assisted reproductive technologies (ART) among immigrant women and non-migrants in Germany. The social relevance of ART is increasing in Western countries due to overall low birth rates, a high rate of childlessness, and a gap between the desired and the actual numbers of children. Previous literature has been scarce, however, on attitudes toward ART, and immigrant minorities have rarely been included in studies on ART.
Our working hypotheses are drawn from theoretical considerations on political socialisation and cultural integration. The analysis is based on data collected in a pilot study in 2014 and 2015. The sample includes 960 women aged 18 to 50 living in Germany. About 81 percent of the sample are immigrants who originate from Turkey, Poland, the Balkan countries, or countries of the (Russian) Commonwealth of Independent States (CIS). We study the social norm to use ART to have a child, the personal attitude of whether a woman would use ART herself, and the methods that they would consider for their own use.
Our results show that ART is overall socially acceptable, and the majority of women said that they would use it if necessary. There is significant variation between the origin groups, however. Non-migrants show the lowest acceptance rates and migrants from Poland and Turkey the highest approval. There is also variation in the ART procedures considered for use with the migrants more approving of heterologous methods than non-migrants. The differences between the origin groups diminish only partly when controlling for further explanatory variables, i.e. gender-role attitudes, religiosity, and socio-demographic characteristics of the respondents.
We conclude that attitudes toward ART are shaped less by socio-demographic characteristics, but rather by cultural factors and the socialization in the migrants’ countries of origin. The diversity in attitudes toward ART by cultural background should be acknowledged in research and public discourses on ART as well as in regulating policies.
Die Weiterbildung an Hochschulen ist an evidenzbasierten Daten interessiert, um Aussagen über die Wirksamkeit von eigenen Angeboten treffen zu können. Oftmals unklar ist, was unter Wirksamkeit verstanden werden kann und welche Voraussetzungen gegeben sein müssen, damit die Weiterbildungen Wirkung entfalten. Der Beitrag stellt eine Studie vor, die beide Aspekte adressiert und Aussagen unterschiedlicher Beteiligter am Weiterbildungsgeschehen wiedergibt. Angebotsseitig wurden Weiterbildungsverantwortliche sowie Lehrpersonen der Hochschule befragt. Nachfrageseitig wurden Teilnehmende berufsbegleitender Studiengänge und Unternehmensvertreter*innen aus ausgewählten Branchen einbezogen. Die erhobenen qualitativen Daten wurden inhaltsanalytisch analysiert und induktiv zu Kategorien zusammengefasst. Die Ergebnisse zeigen insgesamt fünf Oberkategorien auf, die die Wirksamkeit abbilden: (1) Erfolgreicher Praxistransfer; (2) Erwerb von Kenntnissen, Fähigkeiten und Kompetenzen; (3) Strategischer Nutzen; (4) Sozialer/kultureller Nutzen und (5) Resonanz der Teilnehmenden auf die wissenschaftliche Weiterbildung. Die Voraussetzungen lassen sich ebenfalls in fünf Kategorien abbilden: (a) teilnehmenden-, (b) unternehmens-, (c) angebots-, (d) hochschul- und (e) markt-/umfeldbezogene Faktoren. Im Beitrag werden nach der Darstellung der Studienergebnisse Schlussfolgerungen für die Weiterbildungspraxis in Hinblick auf die Themen Evaluation, Theorie-Praxis-Transfer und Marketing/Zielgruppenspezifische Kommunikation diskutiert.
Utility of Smartphone-based Three-dimensional Surface Imaging for Digital Facial Anthropometry
(2024)
Background
The utilization of three-dimensional (3D) surface imaging for facial anthropometry is a significant asset for patients undergoing maxillofacial surgery. Notably, there have been recent advancements in smartphone technology that enable 3D surface imaging.
In this study, anthropometric assessments of the face were performed using a smartphone and a sophisticated 3D surface imaging system.
Methods
30 healthy volunteers (15 females and 15 males) were included in the study. An iPhone 14 Pro (Apple Inc., USA) using the application 3D Scanner App (Laan Consulting Corp., USA) and the Vectra M5 (Canfield Scientific, USA) were employed to create 3D surface models. For each participant, 19 anthropometric measurements were conducted on the 3D surface models. Subsequently, the anthropometric measurements generated by the two approaches were compared. The statistical techniques employed included the paired t-test, paired Wilcoxon signed-rank test, Bland–Altman analysis, and calculation of the intraclass correlation coefficient (ICC).
Results
All measurements showed excellent agreement between smartphone-based and Vectra M5-based measurements (ICC between 0.85 and 0.97). Statistical analysis revealed no statistically significant differences in the central tendencies for 17 of the 19 linear measurements. Despite the excellent agreement found, Bland–Altman analysis revealed that the 95% limits of agreement between the two methods exceeded ±3 mm for the majority of measurements.
Conclusion
Digital facial anthropometry using smartphones can serve as a valuable supplementary tool for surgeons, enhancing their communication with patients. However, the proposed data suggest that digital facial anthropometry using smartphones may not yet be suitable for certain diagnostic purposes that require high accuracy.
Companies often use specially-designed production systems and change them from time to time. They produce small batches in order to satisfy specific demands with the least tardiness. This imposes high demands on high-performance scheduling algorithms which can be rapidly adapted to changes in the production system. As a solution, this paper proposes a generic approach: solutions were obtained using a widely-used commercially-available tool for solving linear optimization models, which is available in an Enterprise Resource Planning System (in the SAP system for example) or can be connected to it. In a real-world application of a flow shop with special restrictions this approach is successfully used on a standard personal computer. Thus, the main implication is that optimal scheduling with a commercially-available tool, incorporated in an Enterprise Resource Planning System, may be the best approach.
Companies often use specially-designed production systems and change them from time to time. They produce small batches in order to satisfy specific demands with the least tardiness. This imposes high demands on high-performance scheduling algorithms which can be rapidly adapted to changes in the production system. As a solution, this paper proposes a generic approach: solutions were obtained using a widely-used commercially-available tool for solving linear optimization models, which is available in an Enterprise Resource Planning System (in the SAP system for example) or can be connected to it. In a real-world application of a flow shop with special restrictions this approach is successfully used on a standard personal computer. Thus, the main implication is that optimal scheduling with a commercially-available tool, incorporated in an Enterprise Resource Planning System, may be the best approach.
Unified Methodology to Identify the Potential Application of Seasonal Sorption Storage Technology
(2020)
In this study, the definition of a new methodology for a preliminary evaluation of the working boundary conditions under which a seasonal thermal energy storage (STES) system operates is described. The approach starts by considering the building features as well as the reference heating system in terms of solar thermal collectors’ technology, ambient heat sinks/source, and space heating distribution systems employed. Furthermore, it is based on a deep climatic analysis of the place where the STES needs to be installed, to identify both winter and summer operating conditions. In particular, the STES energy density is evaluated considering different space heating demands covered by the STES (ranging from 10% up to 60%). The obtained results demonstrate that this approach allows for the careful estimation of the achievable STES density, which is varies significantly both with the space heating coverage guaranteed by the STES as well as with the ambient heat source/sink that is employed in the system. This confirms the need for careful preliminary analysis to avoid the overestimation of the STES material volume. The proposed approach was then applied for different climatic conditions (e.g., Germany and Sweden) and the volume of one of the most attractive composite sorbent materials reported in the literature, i.e., multi-wall carbon nanotubes (MWCNT)-LiCl, using water as the working fluid, needed for covering the variable space heating demand in a Nearly Zero Energy Building (NZEB) was calculated. In the case of Swedish buildings, it ranges from about 3.5 m3 when 10% of the space heating demand is provided by the STES, up to 11.1 m3 when 30% of the space heating demand is provided by the STES.
Ultrafast time resolved reflection high energy electron diffraction with tilted pump pulse fronts
(2013)
We present time-resolved RHEED from a laser excited Pb(111) surface using a pulse front tilter for the compensation of the velocity mismatch of electrons and light. The laser pulses with tilted fronts were characterized by a spatially resolving cross correlator. The response of the surface upon excitation was observed to be less than 2 ps.
Mechanical cues such as extracellular matrix stiffness and movement have a major impact on cell differentiation and function. To replicate these biological features in vitro, soft substrata with tunable elasticity and the possibility for controlled surface translocation are desirable. Here we report on the use of ultra-soft (Young’s modulus <100 kPa) PDMS-based magnetoactive elastomers (MAE) as suitable cell culture substrata. Soft non-viscous PDMS (<18 kPa) is produced using a modified extended crosslinker. MAEs are generated by embedding magnetic microparticles into a soft PDMS matrix. Both substrata yield an elasticity-dependent (14 vs. 100 kPa) modulation of α-smooth muscle actin expression in primary human fibroblasts. To allow for static or dynamic control of MAE material properties, we devise low magnetic field (≈40 mT) stimulation systems compatible with cell-culture environments. Magnetic field-instigated stiffening (14 to 200 kPa) of soft MAE enhances the spreading of primary human fibroblasts and decreases PAX-7 transcription in human mesenchymal stem cells. Pulsatile MAE movements are generated using oscillating magnetic fields and are well tolerated by adherent human fibroblasts. This MAE system provides spatial and temporal control of substratum material characteristics and permits novel designs when used as dynamic cell culture substrata or cell culture-coated actuator in tissue engineering applications or biomedical devices.
Significant deformations of bodies made from compliant magnetoactive elastomers (MAE) in magnetic fields make these materials promising for applications in magnetically controlled actuators for soft robotics. Reported experimental research in this context was devoted to the behaviour in the quasi-static magnetic field, but the transient dynamics are of great practical importance. This paper presents an experimental study of the transient response of apparent longitudinal and transverse strains of a family of isotropic and anisotropic MAE cylinders with six different aspect ratios in time-varying uniform magnetic fields. The time dependence of the magnetic field has a trapezoidal form, where the rate of both legs is varied between 52 and 757 kA/(s·m) and the maximum magnetic field takes three values between 153 and 505 kA/m. It is proposed to introduce four characteristic times: two for the delay of the transient response during increasing and decreasing magnetic field, as well as two for rise and fall times. To facilitate the comparison between different magnetic field rates, these characteristic times are further normalized on the rise time of the magnetic field ramp. The dependence of the normalized characteristic times on the aspect ratio, the magnetic field slew rate, maximum magnetic field values, initial internal structure (isotropic versus anisotropic specimens) and weight fraction of the soft-magnetic filler are obtained and discussed in detail. The normalized magnetostrictive hysteresis loop is introduced, and used to explain why the normalized delay times vary with changing experimental parameters.
The aim of this study is to model launch vehicles with focus on 3-DOF trajectory optimization using a modular approach. Despite the large number of operational launch vehicles, they usually consist of basic components and subsystems. In other words, a launch vehicle is an assembly of stages, which in turn is divided into propellant system and engine, and the engine is an assembly of basic components such as pumps, turbines, combustion chamber, and nozzle. To allow future extension and reuse of the codes, a modular structure using object-oriented programming is used. Two formulations of state equations of the trajectory and two optimization methods are described. The launch vehicle performance will be measured by payload mass for a given mission. The simulations of the VLS-1, Ariane 5 and VLS-Alfa were performed and showed good agreement with the literature.
Small and medium-sized enterprises (SMEs) increasingly need to manage nformation technology (IT) effectively in order to remain competitive. However, compared to larger organizations, SMEs often face challenges in terms of resources and employer attractiveness, and regularly do not have the need to employ a Chief Information Officer (CIO) on a full-time basis. To address this issue, a growing number of global experts have begun to provide CIO services on a part-time basis for multiple clients simultaneously. This approach allows SMEs to tap into the expertise of experienced IT leaders at a fraction of the cost and without committing to long-term arrangements. While these professionals, known as “Fractional CIOs”, have proven their value in the field, there has been a lack of academic research on this emerging trend. Therefore, we carried out a comprehensive research project between 2020 and 2023, involving 62 Fractional CIOs from 10 countries. The research produced a definition, different types of engagements, and success factors for Fractional CIOs and their engagements. This paper summarizes these findings for a wider audience of academics and practitioners.
The translation of poetry is a complex, multifaceted challenge: the translated text should communicate the same meaning, similar metaphoric expressions, and also match the style and prosody of the original poem. Research on machine poetry translation is existing since 2010, but for four reasons it is still rather insufficient:
1. The few approaches existing completely lack any knowledge about current developments in both lyric theory and translation theory.
2. They are based on very small datasets.
3. They mostly ignored the neural learning approach that superseded the long-standing dominance of phrase-based approaches within machine translation.
4. They have no concept concerning the pragmatic function of their research and the resulting tools.
Our paper describes how to improve the existing research and technology for poetry translations in exactly these four points. With regards to 1) we will describe the “Poetics of Translation”. With regards to 2) we will introduce the Worlds largest corpus for poetry translations from lyrikline. With regards to 3) we will describe first steps towards a neural machine translation of poetry. With regards to 4) we will describe first steps towards the development of a poetry translation mapping system.
In simultaneous interpreting, human experts incrementally construct and extend partial hypotheses about the source speaker’s message, and start to verbalize a corresponding message in the target language, based on a partial translation – which may have to be corrected occasionally. They commence the target utterance in the hope that they will be able to finish understanding the source speaker’s message and determine its translation in time for the unfolding delivery. Of course, both incremental understanding and translation by humans can be garden-pathed, although experts are able to optimize their delivery so as to balance the goals of minimal latency, translation quality and high speech fluency with few corrections. We investigate the temporal properties of both translation input and output to evaluate the tradeoff between low latency and translation quality. In addition, we estimate the improvements that can be gained with a tempo-elastic
speech synthesizer.
Background:
Reliable, time- and cost-effective, and clinician-friendly diagnostic tools are cornerstones in facial palsy (FP) patient management. Different automated FP grading systems have been developed but revealed persisting downsides such as insufficient accuracy and cost-intensive hardware. We aimed to overcome these barriers and programmed an automated grading system for FP patients utilizing the House and Brackmann scale (HBS).
Methods:
Image datasets of 86 patients seen at the Department of Plastic, Hand, and Reconstructive Surgery at the University Hospital Regensburg, Germany, between June 2017 and May 2021, were used to train the neural network and evaluate its accuracy. Nine facial poses per patient were analyzed by the algorithm.
Results:
The algorithm showed an accuracy of 100%. Oversampling did not result in altered outcomes, while the direct form displayed superior accuracy levels when compared to the modular classification form (n = 86; 100% vs. 99%). The Early Fusion technique was linked to improved accuracy outcomes in comparison to the Late Fusion and sequential method (n = 86; 100% vs. 96% vs. 97%).
Conclusions:
Our automated FP grading system combines high-level accuracy with cost- and time-effectiveness. Our algorithm may accelerate the grading process in FP patients and facilitate the FP surgeon’s workflow.
Purpose:
Total body irradiation (TBI) in extended source surface distance (SSD) is a common treatment technique before hematopoietic stem cell transplant. The lungs are organs at risk, which often are treated with a lower dose than the whole body.
Methods:
This can be achieved by the application of blocks. Three-dimensional (3D) printers are a modern tool to be used in the production process of these blocks.
Results:
We demonstrate the applicability of a specific printer and printing material, describe the process, and evaluate the accuracy of the product.
Conclusion:
The blocks and apertures were found to be applicable in clinical routine.
Three-dimensional Medical Printing and Associated Legal Issues in Plastic Surgery: A Scoping Review
(2023)
Three-dimensional printing (3DP) represents an emerging field of surgery. 3DP can facilitate the plastic surgeon’s workflow, including preoperative planning, intraoperative assistance, and postoperative follow-up. The broad clinical application spectrum stands in contrast to the paucity of research on the legal framework of 3DP. This imbalance poses a potential risk for medical malpractice lawsuits. To address this knowledge gap, we aimed to summarize the current body of legal literature on medical 3DP in the US legal system. By combining the promising clinical use of 3DP with its current legal regulations, plastic surgeons can enhance patient safety and outcomes.
The present work aims at the thermodynamic analysis of different working pairs in adsorption heat transformers (AdHT) for low-temperature waste heat upgrade in industrial processes. Two different AdHT configurations have been simulated, namely with and without heat recovery between the adsorbent beds. Ten working pairs, employing different adsorbent materials and four different refrigerants, have been compared at varying working boundary conditions. The effects of heat recovery and the presence of a temperature gradient for heat transfer between sinks/sources and the AdHT components have been analyzed. The achieved results demonstrate the possibility of increasing the overall performance when internal heat recovery is implemented. They also highlight the relevant role played by the existing temperature gradient between heat transfer fluids and components, that strongly affect the real operating cycle of the AdHT and thus its expected performance. Both extremely low, i.e., 40-50 degrees C, and low (i.e., 80 degrees C) waste heat source temperatures were investigated at variable ambient temperatures, evaluating the achievable COP and specific energy. The main results demonstrate that optimal performance can be achieved when 40-50 K of temperature difference between waste heat source and ambient temperature are guaranteed. Furthermore, composite sorbents demonstrated to be the most promising adsorbent materials for this application, given their high sorption capacity compared to pure adsorbents, which is reflected in much higher achievable specific energy.
Frequency conversion (FC) and type-II parametric down-conversion (PDC) processes serve as basic building blocks for the implementation of quantum optical experiments: type-II PDC enables the efficient creation of quantum states such as photon-number states and Einstein–Podolsky–Rosen (EPR)-states. FC gives rise to technologies enabling efficient atom–photon coupling, ultrafast pulse gates and enhanced detection schemes. However, despite their widespread deployment, their theoretical treatment remains challenging. Especially the multi-photon components in the high-gain regime as well as the explicit time-dependence of the involved Hamiltonians hamper an efficient theoretical description of these nonlinear optical processes. In this paper, we investigate these effects and put forward two models that enable a full description of FC and type-II PDC in the high-gain regime. We present a rigorous numerical model relying on the solution of coupled integro-differential equations that covers the complete dynamics of the process. As an alternative, we develop a simplified model that, at the expense of neglecting time-ordering effects, enables an analytical solution. While the simplified model approximates the correct solution with high fidelity in a broad parameter range, sufficient for many experimental situations, such as FC with low efficiency, entangled photon-pair generation and the heralding of single photons from type-II PDC, our investigations reveal that the rigorous model predicts a decreased performance for FC processes in quantum pulse gate applications and an enhanced EPR-state generation rate during type-II PDC, when EPR squeezing values above 12 dB are considered.
Theoretical Modeling of Magnetoactive Elastomers on Different Scales: A State-of-the-Art Review
(2022)
A review of the latest theoretical advances in the description of magnetomechanical effects and phenomena observed in magnetoactive elastomers (MAEs), i.e., polymer networks filled with magnetic micro- and/or nanoparticles, under the action of external magnetic fields is presented. Theoretical modeling of magnetomechanical coupling is considered on various spatial scales: from the behavior of individual magnetic particles constrained in an elastic medium to the mechanical properties of an MAE sample as a whole. It is demonstrated how theoretical models enable qualitative and quantitative interpretation of experimental results. The limitations and challenges of current approaches are discussed and some information about the most promising lines of research in this area is provided. The review is aimed at specialists involved in the study of not only the magnetomechanical properties of MAEs, but also a wide range of other physical phenomena occurring in magnetic polymer composites in external magnetic fields.
The purpose of this study was to empirically analyze the sports background, personality dimensions, attitudes, and social competencies of adult head coaches and young assistant coaches involved in the German Einfach Fußball ( Just Soccer) program, which promotes the participation of pupils with intellectual disabilities in soccer/sports and society. Methods. The study recruited 28 head coaches and 29 assistant coaches who completed a questionnaire battery of standardized instruments (NEO Five-Factor Inventory, Interpersonal Reactivity Index, Social Self-Efficacy) as well as self-developed instruments. Analysis of the data involved descriptive and inferential statistical procedures. A descriptive comparison of the assistant coaches with a normative sample of males aged 16–20 years was performed. Results. The head coaches were found with little soccer/sports experience with persons with disabilities prior to participation in the Just Soccer program. However, the majority were familiar with these persons through personal/vocational contacts. Overall, the head coaches were differentiated by formal coaching levels and playing backgrounds, with very few holding any additional formal qualifications in special education. The assistant coaches pre
sented below average scores in the analyzed five personality dimensions when compared with the normative sample. Their attitudes
and social competencies did not change during their 8-month involvement in Just Soccer . Conclusions. The findings highlight
the important role of the coaching staff in the success of the Just Soccerprogram. coaches involved in such activities should be familiarized with needs of people with disabilities, be stress-resistant, and possess a balanced set of personality traits. In addition, the results suggest that such individuals should be coaches/players from conventional soccer clubs instead of special school physical education teachers.
The SMOOTH-robot is a mobile robot that-due to its modularity-combines a relatively low price with the possibility to be used for a large variety of tasks in a wide range of domains. In this article, we demonstrate the potential of the SMOOTH-robot through three use cases, two of which were performed in elderly care homes. The robot is designed so that it can either make itself ready or be quickly changed by staff to perform different tasks. We carefully considered important design parameters such as the appearance, intended and unintended interactions with users, and the technical complexity, in order to achieve high acceptability and a sufficient degree of utilization of the robot. Three demonstrated use cases indicate that such a robot could contribute to an improved work environment, having the potential to free resources of care staff which could be allocated to actual care-giving tasks. Moreover, the SMOOTH-robot can be used in many other domains, as we will also exemplify in this article.
In this paper, the risks of a Smart Factory are to be examined and structured in order to be able to evaluate the status of the Smart Factory. This thesis thus serves as an overview of the technical components of a Smart Factory and the associated risks. The study takes a holistic view of the smart factory. The results show that the greatest need for action lies in the technological field. Thus, the topics of standardization, information security, availability of IT infrastructure, availability of fast internet and complex systems were prioritized. The organizational and financial risks, which also play an important role in a Smart Factory transformation, are addressed.
BACKGROUND:
This planning study compares different radiotherapy techniques for patients with pituitary adenoma, including flatness filter free mode (FFF), concerning plan quality and secondary malignancies for potentially young patients. The flatness filter has been described as main source of photon scatter.
MATERIAL AND METHODS:
Eleven patients with pituitary adenoma were included. An Elekta Synergy™ linac was used in the treatment planning system Oncentra® and for the measurements. 3D plans, IMRT, and VMAT plans and non-coplanar varieties were considered. The plan quality was evaluated regarding homogeneity, conformity, delivery time and dose to the organs at risk. The secondary malignancy risk was calculated from dose volume data and from measured dose to the periphery using different models for carcinoma and sarcoma risk.
RESULTS:
The homogeneity and conformity were nearly unchanged with and without flattening filter, neither was the delivery time found substantively different. VMAT plans were more homogenous, conformal and faster in delivery than IMRT plans. The secondary cancer risk was reduced with FFF both in the treated region and in the periphery. VMAT plans resulted in a higher secondary brain cancer risk than IMRT plans, but the risk for secondary peripheral cancer was reduced. Secondary sarcoma risk plays a minor role. No advantage was found for non-coplanar techniques. The FFF delivery times were not shortened due to additional monitor units needed and technical limitations. The risk for secondary brain cancer seems to depend on the irradiated volume. Secondary sarcoma risk is much smaller than carcinoma risk in accordance to the results of the atomic bomb survivors. The reduction of the peripheral dose and resulting secondary malignancy risk for FFF is statistically significant. However, it is negligible in comparison to the risk in the treated region.
CONCLUSION:
Treatments with FFF can reduce secondary malignancy risk while retaining similar quality as with flattening filter and should be preferred. VMAT plans show the best plan quality combined with lowest peripheral secondary malignancy risk, but highest level of second brain cancer risk. Taking this into account VMAT FFF seems the most advantageous technique for the treatment of pituitary adenomas with the given equipment.
Mg and Mg alloys are becoming more and more of interest for several applications. In the case of biomaterial applications, a special interest exists due to the fact that a predictable degradation should be given. Various investigations were made to characterize and predict the corrosion behavior in vitro and in vivo. Mostly, the simple oxidation of Mg to Mg2+ ions connected with adequate hydrogen development is assumed, and the negative difference effect (NDE) is attributed to various mechanisms and electrochemical results. The aim of this paper is to compare the different views on the corrosion pathway of Mg or Mg alloys and to present a neglected pathway based on thermodynamic data as a guideline for possible reactions combined with experimental observations of a delay of visible hydrogen evolution during cyclic voltammetry. Various reaction pathways are considered and discussed to explain these results, like the stability of the Mg+ intermediate state, the stability of MgH2 and the role of hydrogen overpotential. Finally, the impact of MgH2 formation is shown as an appropriate base for the prediction of the degradation behavior and calculation of the corrosion rate of Mg and Mg alloys.
We compute the Fourier expansion of Hecke operators on vector-valued modular forms for the Weil representation associated to a lattice L. The Hecke operators considered in this paper include operators T(p^2l) where p is a prime dividing the level of the lattice L. Additionally, an explicit formula for a general type of Gauss sum associated to a lattice L drops out as a by-product.
Autologous lipotransfer is a promising method for tissue regeneration, because white adipose tissue contains a heterogeneous cell population, including mesenchymal stem cells, endothelial cells, immune cells, and adipocytes. In order to improve the outcome, adipose tissue can be processed before application. In this study, we investigated changes caused by mechanical processing.
Lipoaspirates were processed using sedimentation, first-time centrifugation, shear-force homogenization, and second-time centrifugation. The average adipocyte size, stromal vascular cell count, and adipocyte depot size were examined histologically at every processing step. In addition, the adipose derived stem cells (ADSCs) were isolated and differentiated osteogenically and adipogenically. While homogenization causes a disruption of adipocyte depots, the shape of the remaining adipocytes is not changed. On average, these adipocytes are smaller than the depot adipocytes, they are surrounded by the ECM, and therefore mechanically more stable. The volume loss of adipocyte depots leads to a significant enrichment of stromal vascular cells such as ADSCs. However, the mechanical processing does not change the potential of the ADSCs to differentiate adipogenically or steogenically. It thus appears that mechanically processed lipoaspirates are promising for the reparation of even mechanically stressed tissue as that found in nasolabial folds. The changes resulting from the processing correspond more to a filtration of mechanically less stable components than to a manipulation of the tissue.
Companies listed on the stock market must devote a great deal of attention to their market position. They must increase their competitive advantage in the undeniably key process of the issuance of stocks. As the issuance of preferred stocks has increased after the last crisis and in the current period of low interest rates in Europe, they are becoming more favoured investment instruments, we decided to analyse the real properties of preferred stocks in Europe in order to increase the efficiency of joint-stock companies. Using a dataset comprising all companies having both common and preferred stocks issued and traded on European markets between 2009- 2016, we determined the relationship of risk (measured by beta coefficients) and price volatility among common and preferred stocks and bonds in Europe. Our findings show beta coefficients of preferred stocks as systematically lower than beta coefficients of common stocks. Considering a difference of up to 10% as negligible, however, preferred stocks showed a similar or higher beta coefficient than corresponding common stocks of the same company in 53% of cases, whereas for 33% of cases, the difference is only ±10%. Coefficients of variation in prices showed a similar relationship, with only a negligible portion of preferred stocks bearing fixed (stable) dividends. This result implies that currently traded preferred stocks in Europe in fact do not possess such characteristics they are typically said to have, and in many cases they incur as comparable a risk as do common stocks. This essential information should help to increase the efficiency and competitiveness of joint-stock companies.
To broaden the operational scope of monetary policy, several authors suggest cash abolition as an appropriate means of breaking through the zero lower-bound. We argue that the welfare costs of bypassing the zero lower-bound by getting rid of cash entirely are analytically equivalent to negative interest rates on cash holdings. Using a money-in-the-utility-function model, we measure in two ways the welfare loss consumers as money holders would be forced to bear once the zero lower-bound is broken: in terms of the amount needed to compensate consumers (compensated variation), and as excess burden (deadweight loss) imposed on the economy as a whole. We calibrated the model for the euro area and for Germany. Our findings suggest that the welfare losses of negative interest rates incurred by consumers as holders of cash and transaction balances (M3) are large and enduring, notably if implemented in the current low-interest rate environment.
The dependence of the resonant direct magnetoelectric effect on temperature is studied experimentally in planar composite structures. Samples of rectangular shapes with dimensions of 5 mm x 20 mm employed ferromagnetic layers of either an amorphous (metallic glass) alloy or nickel with a thickness of 20-200 m and piezoelectric layers of single crystalline langatate material or lead zirconate titanate piezoelectric ceramics with a thickness of 500 m. The temperature of the samples was varied in a range between 120 and 390 K by blowing a gaseous nitrogen stream around them. It is shown that the effective characteristics of the magnetoelectric effectsuch as the mechanical resonance frequency f(r), the quality factor Q and the magnitude of the magnetoelectric coefficient (E) at the resonance frequencyare contingent on temperature. The interrelations between the temperature changes of the characteristics of the magnetoelectric effect and the temperature variations of the following material parametersYoung's modulus Y, the acoustic quality factor of individual layers, the dielectric constant epsilon, the piezoelectric modulus d of the piezoelectric layer as well as the piezomagnetic coefficients ((n)) of the ferromagnetic layerare established. The effect of temperature on the characteristics of the nonlinear magnetoelectric effect is observed for the first time. The results can be useful for designing magnetoelectric heterostructures with specified temperature characteristics, in particular, for the development of thermally stabilized magnetoelectric devices.
Telenursing bei Schlaganfall
(2022)
The currently still high fossil energy demand is forcing the glass industry to search for innovative approaches for the reduction in CO2 emissions and the integration of renewable energy sources. In this paper, a novel power-to-methane concept is presented and discussed for this purpose. A special focus is on methods for the required CO2 capture from typical flue gases in the glass industry, which have hardly been explored to date. To close this research gap, process simulation models are developed to investigate post-combustion CO2 capture by absorption processes, followed by a techno-economic evaluation. Due to reduced flue gas volume, the designed CO2 capture plant is found to be much smaller (40 m3 absorber column volume) than absorption-based CO2 separation processes for power plants (12,560 m3 absorber column volume). As there are many options for waste heat utilization in the glass industry, the waste heat required for CO2 desorption can be generated in a particularly efficient and cost-effective way. The resulting CO2 separation costs range between 41 and 42 EUR/t CO2, depending on waste heat utilization for desorption. These costs are below the values of 50–65 EUR/t CO2 for comparable industrial applications. Despite these promising economic results, there are still some technical restrictions in terms of solvent degradation due to the high oxygen content in flue gas compositions. The results of this study point towards parametric studies for approaching these issues, such as the use of secondary and tertiary amines as solvents, or the optimization of operating conditions such as stripper pressure for further cost reductions potential.
If citizens actively participate in the process of collecting empirical data, as a key element of empirically oriented scientific projects, this can be seen as a contribution to an open and citizen-oriented science. Such participation can be supported by providing technical tools. The paper therefore presents examples of participatory sensing as the provision of affordable sensors for measuring environmental parameters as well as wearable technologies for recording quantified vital data and physiological states. Conceptually, the provision of data collected with these tools can be understood as a commons – with all opportunities and risks associated with such goods. After describing examples of participatory sensing and wearable technologies, the authors identify potential challenges and outline technical and organizational approaches to solve them.
This paper concerns recent research into the autonomous formation of micro-structures in low carbonyl iron powder (CIP) concentration magneto active polymers (MAP). Higher concentrations of CIP show an isotropic distribution of magnetic filler throughout the entire sample, while autonomous structure formation is possible at mass concentrations lower than 3%. The formation of micro-toroids commences as CIP concentration approaches 1% wt. Further development of coherent rings with a defined order follow as CIP concentrations increase toward 2% wt, whilst exceeding 3% wt leads to the same isotropic distribution found in higher concentration MAP. Structured samples containing between 1% wt and 3% wt CIP were investigated using X-Ray tomography where solitary structures could clearly be observed. The ring structures represent microinductivities whose geometries can be manipulated during fabrication. In addition, these structures are magnetic field sensitive. This is not only relevant to applications in the GHz and THz areas but recent research has revealed implications for optical, thermal, acoustic and even chemical MAP sensors. (C) 2019 Author(s).
Steps on Steps
(2022)
Frequency-dependent capacitance C(ω) is a rapid and reliable method for the determination of the state-of-charge (SoC) of electrochemical storage devices. The state-of-the-art of SoC monitoring using impedance spectroscopy is reviewed, and complemented by original 1.5-year long-term electrical impedance measurements of several commercially available supercapacitors. It is found that the kinetics of the self-discharge of supercapacitors comprises at least two characteristic time constants in the range of days and months. The curvature of the Nyquist curve at frequencies above 10 Hz (charge transfer resistance) depends on the available electric charge as well, but it is of little use for applications. Lithium-ion batteries demonstrate a linear correlation between voltage and capacitance as long as overcharge and deep discharge are avoided.
For lithium iron phosphate batteries (LFP) in aerospace applications, impedance spectroscopy is applicable in the flat region of the voltage-charge curve. The frequency-dependent pseudocapacitance at 0.15 Hz is presented as useful state-of-charge (SOC) and state-of-health (SOH) indicator. For the same battery type, the prediction error of pseudocapacitance is better than 1% for a quadratic calibration curve, and less than 36% for a linear model. An approximately linear correlation between pseudocapacitance and Ah battery capacity is observed as long as overcharge and deep discharge are avoided. We verify the impedance method in comparison to the classical constant-current discharge measurements. In the case of five examined lithium-ion chemistries, the linear trend of impedance and SOC is lost if the slope of the discharge voltage curve versus SOC changes. With nickel manganese cobalt (NMC), high impedance modulus correlates with high SOC above 70%.
We discuss the spectral structure and decomposition of multi-photon states. Ordinarily 'multi-photon states' and 'Fock states' are regarded as synonymous. However, when the spectral degrees of freedom are included this is not the case, and the class of 'multi-photon' states is much broader than the class of 'Fock' states. We discuss the criteria for a state to be considered a Fock state. We then address the decomposition of general multi-photon states into bases of orthogonal eigenmodes, building on existing multi-mode theory, and introduce an occupation number representation that provides an elegant description of such states. This representation allows us to work in bases imposed by experimental constraints, simplifying calculations in many situations. Finally we apply this technique to several example situations, which are highly relevant for state of the art experiments. These include Hong–Ou–Mandel interference, spectral filtering, finite bandwidth photo-detection, homodyne detection and the conditional preparation of Schrödinger kitten and Fock states. Our techniques allow for very simple descriptions of each of these examples.
The method of loci is one, if not the most, efficient mnemonic encoding strategy. This spatial mnemonic combines the core cognitive processes commonly linked to medial temporal lobe (MTL) activity: spatial and associative memory processes. During such processes, fMRI studies consistently demonstrate MTL activity, while electrophysiological studies have emphasized the important role of theta oscillations (3–8 Hz) in the MTL. However, it is still unknown whether increases or decreases in theta power co-occur with increased BOLD signal in the MTL during memory encoding. To investigate this question, we recorded EEG and fMRI separately, while human participants used the spatial method of loci or the pegword method, a similarly associative but nonspatial mnemonic. The more effective spatial mnemonic induced a pronounced theta power decrease source localized to the left MTL compared with the nonspatial associative mnemonic strategy. This effect was mirrored by BOLD signal increases in the MTL. Successful encoding, irrespective of the strategy used, elicited decreases in left temporal theta power and increases in MTL BOLD activity. This pattern of results suggests a negative relationship between theta power and BOLD signal changes in the MTL during memory encoding and spatial processing. The findings extend the well known negative relation of alpha/beta oscillations and BOLD signals in the cortex to theta oscillations in the MTL.
We investigate the spatial nonlinear localization of light on a quasi-plane-wave background with a harmonic perturbation induced by modulation instability in a quadratic nonlinear optical medium. In particular, we demonstrate experimentally the excitation of deterministic Akhmediev breathers and thus the growth-decay dynamics of modulation instability in a LiNbO3 slab waveguide. The results should stimulate new interest in modulation instability, extreme events, turbulence, recurrence, and supercontinuum generation in quadratic nonlinear optics.
We investigate the reconstruction problem of limited angle tomography. Such problems arise naturally in applications like digital breast tomosynthesis, dental tomography, electron microscopy, etc. Since the acquired tomographic data is highly incomplete, the reconstruction problem is severely ill-posed and the traditional reconstruction methods, e.g. filtered backprojection (FBP), do not perform well in such situations.
To stabilize the reconstruction procedure additional prior knowledge about the unknown object has to be integrated into the reconstruction process. In this work, we propose the use of the sparse regularization technique in combination with curvelets. We argue that this technique gives rise to an edge-preserving reconstruction. Moreover, we show that the dimension of the problem can be significantly reduced in the curvelet domain. To this end, we give a characterization of the kernel of the limited angle Radon transform in terms of curvelets and derive a characterization of solutions obtained through curvelet sparse regularization. In numerical experiments, we will show that the theoretical results directly translate into practice and that the proposed method outperforms classical reconstructions.
Owing to increasingly stringent emission limits, particulate filters have become mandatory for gasoline-engine vehicles. Monitoring their soot loading is necessary for error-free operation. The state-of-the-art differential pressure sensors suffer from inaccuracies due to small amounts of stored soot combined with exhaust gas conditions that lead to partial regeneration. As an alternative approach, radio-frequency-based (RF) sensors can accurately measure the soot loading, even under these conditions, by detecting soot through its dielectric properties. However, they face a different challenge as their sensitivity may depend on the engine operation conditions during soot formation. In this article, this influence is evaluated in more detail. Various soot samples were generated on an engine test bench. Their dielectric properties were measured using the microwave cavity perturbation (MCP) method and compared with the corresponding sensitivity of the RF sensor determined on a lab test bench. Both showed similar behavior. The values for the soot samples themselves, however, differed significantly from each other. A way to correct for this cross-sensitivity was found in the influence of exhaust gas humidity on the RF sensor, which can be correlated with the engine load. By evaluating this influence during significant humidity changes, such as fuel cuts, it could be used to correct the influence of the engineon the RF sensor.
Sustainable production includes economic, environmental, and social aspects. However, social sustainability has received less attention, especially compared to the economic aspects. Next to technical and organizational measures, social improvements within supply chains can also be achieved through suitable production planning. Within production planning, production programs are determined, and the assignment of available resources (e.g., employees) is specified. Thus, the utilization and workload of employees are defined. This systematic literature review investigates to what extent such employee-related social aspects are reflected in production planning and discusses whether economic aspects dominate them. For this, a Scopus database search was carried out and 76 identified approaches were analyzed and categorized regarding the occurring employee-related social aspects and their implementation. Thus far, the approaches mainly consider single aspects on single planning levels. A consideration of a broad set of aspects along the entire production planning has rarely been studied. In particular, health and safety aspects are considered on the levels of assembly line balancing and job rotation. However, their impact is primarily determined by the specific settings of the decision-maker. To support decision-makers, only a few studies have investigated the effects based on real application scenarios. Further potential might be an extended modeling of social and economic interdependencies and a consideration of employee-related social aspects in medium- to long-term production planning.
Smart Stiction
(2019)
Soft robotics could loosely be described as the engineering science of expanded dexterity through controllable flexibility. The exploitation of controllable compliance through the judicious choice of soft flexible members, as opposed to a finite number of rigid kinematic joints, can result in greater dexterity without compromising simplicity. One example is the replacement of segmented mechanical legs with simple compliant material eruciform prolegs. To achieve this in robotics, without introducing additional mechanical joints, mobile surfaces with switchable coefficients of friction is essential. This paper explains how, using silicone based smart materials, the rapid alternation between kinematic and static friction (stiction) may be achieved.
Background:
The aim of the study was to compare the two irradiation modes with (FF) and without flattening filter (FFF) for three different treatment techniques for simultaneous integrated boost radiation therapy of patients with right sided breast cancer.
Methods:
An Elekta Synergy linac with Agility collimating device is used to simulate the treatment of 10 patients. Six plans were generated in Monaco 5.0 for each patient treating the whole breast and a simultaneous integrated boost (SIB) volume: intensity modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT) and a tangential arc VMAT (tVMAT), each with and without flattening filter. Plan quality was assessed considering target coverage, sparing of the contralateral breast, the lungs, the heart and the normal tissue. All plans were verified by a 2D-ionisation-chamber-array and delivery times were measured and compared. The Wilcoxon test was used for statistical analysis with a significance level of 0.05.
Results:
Significantly best target coverage and homogeneity was achieved using VMAT FFF with V95% = (98.7 +/- 0.8) % and HI = (8.2 +/- 0.9) % for the SIB and V95% = (98.3 +/- 0.7) % for the PTV, whereas tVMAT showed significantly lowest doses to the contralateral organs at risk with a D-mean of (0.7 +/- 0.1) Gy for the contralateral lung, (1.0 +/- 0.2) Gy for the contralateral breast and (1.4 +/- 0.2) Gy for the heart. All plans passed the gamma evaluation with a mean passing rate of (99.2 +/- 0.8) %. Delivery times were significantly reduced for VMAT and tVMAT but increased for IMRT, when FFF was used. Lowest delivery times were observed for tVMAT FFF with (1:20 +/- 0:07) min.
Conclusion:
Balancing target coverage, OAR sparing and delivery time, VMAT FFF and tVMAT FFF are considered the preferable of the investigated treatment options in simultaneous integrated boost irradiation of right sided breast cancer for the combination of an Elekta Synergy linac with Agility and the treatment planning system Monaco 5.0.
Thermo-mechanical simulation offers great opportunities to optimize welding processes of plastics. For realistic simulation, the temperature dependent mechanical properties need to be implemented from ambient temperature to temperatures above the flow temperature. Standard test methods are insufficient for characterization in the entire temperature range because close to the flow temperature the material is too soft for tensile tests and too stiff for rheometry. Therefore, an optimization strategy is developed, that determines unknown material parameters by testing in welding simulations. The unknown parameters are iteratively adjusted to minimize the mismatch between computed and measured set-paths. Thus, important process characteristics are calculated realistically, enabling the computer aided assessment of the weld quality.
Simulation and Techno-Economic Analysis of a Power-to-Hydrogen Process for Oxyfuel Glass Melting
(2021)
As an energy-intensive industry sector, the glass industry is strongly affected by the increasingly stringent climate protection targets. As established combustion-based production systems ensure high process stability and glass quality, an immediate switch to low greenhouse gas emission processes is difficult. To approach these challenges, this work investigates a step-by-step integration of a Power-to-Hydrogen concept into established oxyfuel glass melting processes using a simulation approach. This is complemented by a case study for economic analysis on a selected German glass industry site by simulating the power production of a nearby renewable energy park and subsequent optimization of the power-to-hydrogen plant performance and capacities. The results of this study indicate, that the proposed system can reduce specific carbon dioxide emissions by up to 60%, while increasing specific energy demand by a maximum of 25%. Investigations of the impact of altered combustion and furnace properties like adiabatic flame temperature (+25 °C), temperature efficiency (∆ξ = −0.003) and heat capacity flow ratio (∆zHL = −0.009) indicate that pure hydrogen-oxygen combustion has less impact on melting properties than assumed so far. Within the case study, high CO2 abatement costs of 295 €/t CO2-eq. were determined. This is mainly due to the insufficient performance of renewable energy sources. The correlations between process scaling and economic parameters presented in this study show promising potential for further economic optimization of the proposed energy system in the future.
Over the past few years, ontology merging, and ontology semantic alignment has gained significant interest as research topics in automotive application domain for finding solutions to semantic data heterogeneity. To accomplish the complex and novel vehicle service requirements such as autonomous driving, V2X (Vehicle-to-Vehicle communication), etc. the automotive applications involve collaborations of several platform-specific data from heterogeneous enterprises component frameworks and consequently there has been increase in data interoperability issues. At the application component level, data interoperability relies on the semantic alignment or mapping between the various component framework interfaces data models represented as XML schemas (XSD). With the XML schemas being the preferred standard for the interface description exchange between most of the automotive application domain components, however, the data interoperability between the semantically equivalent but structurally different data constructs of multiple heterogeneous XSDs stands as a challenge in the absence of an ontology-based approach. To confront this crucial requirement for data interoperability and to increase in effect the reuse of existing components through their interfaces, we propose an approach to semantically map the various component framework interface data models when expressed as ontology schemas, based on the exploration of semantic synergies. The transformation between XSD and RDF (Resource Description Framework) schema representations and the use of queries over the ontology schemas for semantic mapping are demonstrated including a real-world case study.
Men treated for localized prostate cancer by radiotherapy have often a remaining life span of 10 yr or more. Therefore, the risk for secondary malignancies should be taken into account. Plans for ten patients were evaluated which had been performed on an Oncentra (R) treatment planning system for a treatment with an Elekta Synergy (TM) linac with Agility (TM) head. The investigated techniques involved IMRT and VMTA with and without flattening filter. Different dose response models were applied for secondary carcinoma and sarcoma risk in the treated region and also in the periphery. As organs at risk we regarded for carcinoma risk urinary bladder, rectum, colon, esophagus, thyroid, and for sarcoma risk bone and soft tissue. The excess absolute risk (EAR) was found very similar in the treated region for both techniques (IMRT and VMAT) and also for both with and without flattening filter. The secondary sarcoma risk resulted about one magnitude smaller than the secondary carcinoma risk. The EAR to the peripheral organs was statistically significant reduced by application of the flattening filter free mode concerning the flattening filter as main source of scattered dose. Application of flattening filter free mode can thus support to reduce second malignancy risk for patients with localized prostate cancer.
Pediatric patients suffering from ependymoma are usually treated with cranial or craniospinal three-dimensional (3D) conformal radiotherapy (3DCRT). Intensity-modulated techniques spare dose to the surrounding tissue, but the risk for second malignancies may be increased due to the increase in low-dose volume. The aim of this study is to investigate if the flattening filter free (FFF) mode allows reducing the risk for second malignancies compared to the mode with flattening filter (FF) for intensity-modulated techniques and to 3DCRT. A reduction of the risk would be advantageous for treating pediatric ependymoma. 3DCRT was compared to intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) with and without flattening filter. Dose-volume histograms (DVHs) were compared to evaluate the plan quality and used to calculate the excess absolute risk (EAR) to develop second cancer in the brain. Dose verification was performed with a two-dimensional (2D) ionization chamber array and the out-of-field dose was measured with an ionization chamber to determine the EAR in peripheral organs. Delivery times were measured. Both VMAT and IMRT achieved similar plan quality in terms of dose sparing in the OAR and higher PTV coverage as compared to 3DCRT. Peripheral dose in low-dose region, which is proportional to the EAR in organs located in this region, for example, gonads, bladder, or bowel, could be significantly reduced using FFF. The lowest peripheral EAR and lowest delivery times were hereby achieved with VMATFFF . The EAR calculated based on DVH in the brain could not be reduced using FFF mode. VMATFFF improved the target coverage and homogeneity and kept the dose in the OAR similar compared to 3DCRT. In addition, delivery times were significantly reduced using VMATFFF . Therefore, for radiotherapy of ependymoma patients, VMATFFF may be considered advantageous for the combination of Elekta Synergy linac and Oncentra External Beam planning system used in this study.
Companies use special designed flow shops, in order to satisfy specific demands. Products need to be transported (from one station to the next station) by a crane and the way of working of this crane excludes the intermediate storage (of a work piece). In addition, the way of working restricts the set of feasible schedules even more than the no-buffer restriction discussed in the literature in the case of limited storage. Since this scheduling problem is integrated in the usual hierarchical planning, the tardiness is minimised. A linear optimisation model is presented to provide a formal description of this NP-hard problem. It is also used to explain the performance of priority rule based heuristic solutions on small test problems. In detail, priority rules as well as a priority rule based branch and bound procedure are analysed; priority rules are regarded, because a priority rule is still the standard procedure for on-line scheduling in industrial practise. Out of successful priority rules in the literature the best one is identified by an extensive simulative investigation. An improved look-ahead is realised by a restricted search over all possible schedules.
Risk factors for ulcerative colitis-associated colorectal cancer A retrospective cohort study
(2020)
Inflammatory bowel disease is associated with an increased risk of colorectal cancer. The study aims to identify the risk factors for ulcerative colitis-colorectal cancer and to perform a survival curve analysis of the outcome. This retrospective cohort study included 254 patients from March 2016 to October 2017. Age, age at diagnosis, follow-up time, smoking status, and family history of colorectal cancer were analyzed as risk factors for colorectal cancer. The mean patient age was 46.6 +/- 16.9 years; 5.5% of the patients were smokers and 49.6% had pancolitis. Six patients (2.36%) had colorectal cancer, which was associated with age at diagnosis (odds/hazard ratio 1.059 [95% confidence interval: 1.001-1.121];P = .04), family history of colorectal cancer (12.992 [1.611-104.7];P = .02), and follow-up time (0.665 [0.513-0.864];P = .002). Active smoking was the main identified risk factor, after both logistic (8.477 [1.350-53.232];P = .02) and Cox proportional-hazards (32.484 [2.465-428.1];P = .008) regression analysis. The risk of colorectal cancer was 3.17% at 10 years and 4.26% at 20 years of follow-up. Active smoking and family history were identified as risk factors for colorectal cancer. These findings should aid the early identification of patients who require vigorous surveillance, and prevent exposure to risk factors.
Results of WICOVIR Gargle Pool PCR Testing in German Schools Based on the First 100,000 Tests
(2021)
Background:
Opening schools and keeping children safe from SARS-CoV-2 infections at the same time is urgently needed to protect children from direct and indirect consequences of the COVID-19 pandemic. To achieve this goal, a safe, efficient, and cost-effective SARS-CoV-2 testing system for schools in addition to standard hygiene measures is necessary.
Methods:
We implemented the screening WICOVIR concept for schools in the southeast of Germany, which is based on gargling at home, pooling of samples in schools, and assessment of SARS-CoV-2 by pool rRT-PCR, performed decentralized in numerous participating laboratories. Depooling was performed if pools were positive, and results were transmitted with software specifically developed for the project within a day. Here, we report the results after the first 13 weeks in the project.
Findings:
We developed and implemented the proof-of-concept test system within a pilot phase of 7 weeks based on almost 17,000 participants. After 6 weeks in the main phase of the project, we performed >100,000 tests in total, analyzed in 7,896 pools, identifying 19 cases in >100 participating schools. On average, positive children showed an individual CT value of 31 when identified in the pools. Up to 30 samples were pooled (mean 13) in general, based on school classes and attached school staff. All three participating laboratories detected positive samples reliably with their previously established rRT-PCR standard protocols. When self-administered antigen tests were performed concomitantly in positive cases, only one of these eight tests was positive, and when antigen tests performed after positive pool rRT-PCR results were already known were included, 3 out of 11 truly positive tests were also identified by antigen testing. After 3 weeks of repetitive WICOVIR testing twice weekly, the detection rate of positive children in that cohort decreased significantly from 0.042 to 0.012 (p = 0.008).
Interpretation:
Repeated gargle pool rRT-PCR testing can be implemented quickly in schools. It is an effective, valid, and well-received test system for schools, superior to antigen tests in sensitivity, acceptance, and costs.
In this work, the resonance enhancement of magnetoelectric (ME) coupling at the two lowest bending resonance frequencies was investigated in layered cantilever structures comprising a magnetoactive elastomer (MAE) slab and a commercially available piezoelectric polymer multilayer. A cantilever was fixed at one end in the horizontal plane and the magnetic field was applied horizontally. Five composite structures, each containing an MAE layer of different thicknesses from 0.85 to 4 mm, were fabricated. The fundamental bending resonance frequency in the absence of a magnetic field varied between roughly 23 and 55 Hz. It decreased with the increasing thickness of the MAE layer, which was explained by a simple theory. The largest ME voltage coefficient of about 7.85 V/A was measured in a sample where the thickness of the MAE layer was ≈2 mm. A significant increase in the bending resonance frequencies in the applied DC magnetic field of 240 kA/m up to 200% was observed. The results were compared with alternative designs for layered multiferroic structures. Directions for future research were also discussed.
It is shown that the critical exponent for the effective shear modulus of a composite medium where a compliant polymer matrix is filled with ferromagnetic particles may significantly depend on the external magnetic field. The physical consequence of this dependence is the critical behavior of the relative magnetorheological effect.
The Applied Research Conference which is held every year at another University of Applied Sciences in Bavaria is the main event for all students in the Master of Applied Research program. They come together to present their work in oral presentations and full papers, which are published in the proceedings, as well as poster presentations of the students after their 1st semester. For sure it is interesting for Professors and interested people to see the results of upcoming scientists and researchers. Due to the Corona pandemic, this year it is not possible to organize the conference as usual in presence. We have to refrain from face-to-face discussions, having together a cup of coffee. We as Professors at the OTH Regensburg wanted to give our students the chance to finish this semester successfully – despite all limitations due to the pandemic situation. Therefore we decided to organize the RARC 2020 – Regensburg Applied Research Conference 2020 – for the Master of Applied Research students of OTH Regensburg as an online conference. However, for a Technical University the situation is rather a challenge than a problem. Using a variety of online tools for teaching during this semester, we have enough experience to find a setup for RARC2020. We received 28 submissions for full papers, which were peer reviewed and 26 of them were accepted – you will find them in this proceedings, and they will be presented orally on July 31st, 2020. Additionally, there are 22 posters which will be presented on the same day. During the Plenary Opening Session, after a welcome by our President Prof. Dr. Wolfgang Baier we will have 3 Keynote speakers:
Prof. Dr. phil. habil. Karsten Weber: Erkenntnistheorie für Ingenieure
Prof. em. Georg Scharfenberg: 11 Years Master of Applied Research Alumnis
Veronika Fetzer: Entrepreneurship
Usually, torque vectoring is used to reduce a significant understeer behavior at high speed cornering. Thus, providing larger vehicles with a sportive touch. Even on typical front wheel driven cars torque vectoring control is available now. Torque vectoring is nearly a standard on electric driven vehicles. Complex control and optimization strategies are applied to improve the maneuverability in particular or to enhance the driving behavior and reduce the energy consumption in addition. This paper shows, that a quite simple strategy will enhance the maneuverability and simultaneously reduce the cornering resistance in sharp bends. At first, a case study with a fully non-linear and three-dimensional vehicle model is performed. It turned out that a full drive torque shift to the outer wheels improves the maneuverability and reduces the cornering resistance in addition. This results are verified by an optimization performed with a simpler four-wheeled handling model. Here, the front steering angles and the driving torques at each of the four wheels are considered as free parameters. Minimizing the cornering resistance by taking the equations of motion for the four-wheeled handling model as constraints will deliver an optimal set of parameters then.
A surface relief grating with a period of 30 mu m is embossed onto the surface of magnetoactive elastomer (MAE) samples in the presence of a moderate magnetic field of about 180 mT. The grating, which is represented as a set of parallel stripes with two different amplitude reflectivity coefficients, is detected via diffraction of a laser beam in the reflection configuration. Due to the magnetic-field-induced plasticity effect, the grating persists on the MAE surface for at least 90 h if the magnetic field remains present. When the magnetic field is removed, the diffraction efficiency vanishes in a few minutes. The described effect is much more pronounced in MAE samples with larger content of iron filler (80 wt%) than in the samples with lower content of iron filler (70 wt%). A simple theoretical model is proposed to describe the observed dependence of the diffraction efficiency on the applied magnetic field. Possible applications of MAEs as magnetically reconfigurable diffractive optical elements are discussed. It is proposed that the described experimental method can be used as a convenient tool for investigations of the dynamics of magnetically induced plasticity of MAEs on the micrometer scale.
Based on previous work by our group with manual annotation of visible Barrett oesophagus (BE) cancer images, a real-time deep learning artificial intelligence (AI) system was developed. While an expert endoscopist conducts the endoscopic assessment of BE, our AI system captures random images from the real-time camera livestream and provides a global prediction (classification), as well as a dense prediction (segmentation) differentiating accurately between normal BE and early oesophageal adenocarcinoma (EAC). The AI system showed an accuracy of 89.9% on 14 cases with neoplastic BE.
OBJECTIVES:
To assess the quantity and evaluate the quality of policies and curricula focusing on conflicts of interests (COI) at medical schools across Germany.
DESIGN:
Cross-sectional study, survey of medical schools, standardised web search.
SETTING:
Medical schools, Germany.
PARTICIPANTS:
38 German medical schools. - INTERVENTIONS: We collected relevant COI policies, including teaching activities, by conducting a search of the websites of all 38 German medical schools using standardised keywords for COI policies and teaching. Further, we surveyed all medical schools' dean's offices. Finally, we adapted a scoring system for results we obtained with 13 categories based on prior similar studies. MAIN OUTCOMES AND MEASURES:
Presence or absence of COI-related policies, including teaching activities at medical school. The secondary outcome was the achieved score on a scale from 0 to 26, with high scores representing restrictive policies and sufficient teaching activities.
RESULTS:
We identified relevant policies for one medical school via the web search. The response rate of the deans' survey was 16 of 38 (42.1%). In total, we identified COI-related policies for 2 of 38 (5.3%) German medical schools, yet no policy was sufficient to address all COI-related categories that were assessed in this study. The maximum score achieved was 12 of 26. 36 (94.7%) schools scored 0. No medical school reported curricular teaching on COI.
CONCLUSIONS:
Our results indicate a low level of action by medical schools to protect students from undue commercial influence. No participating dean was aware of any curriculum or instruction on COI at the respective school and only two schools had policies in place. The German Medical Students Association and international counterparts have called for a stronger focus on COI in the classroom. We conclude that for German medical schools, there is still a long way to go.
Field emitter arrays (FEAs) are a promising component for novel vacuum micro- and nanoelectronic devices, such as microwave power amplifiers or fast-switching X-ray sources. However, the interrelated mechanisms responsible for FEA degradation and failure are not fully understood. Therefore, we present a measurement method for quantitative observation of individual emission sites during integral operation using a low-cost, commercially available CMOS imaging sensor. The emission and degradation behavior of three differently doped FEAs is investigated in current-regulated operation. The measurements reveal that the limited current of the p-doped emitters leads to an activation of up to 55% of the individual tips in the array, while the activation of the n-type FEA stopped at around 30%. This enhanced activation results in a more continuous and uniform current distribution for the p-type FEA. An analysis of the individual emitter characteristics before and after a constant current measurement provides novel perspectives on degradation behavior. A burn-in process that trims the emitting tips to an integral current-specific ideal field enhancement factor is observed. In this process, blunt tips are sharpened while sharp tips are dulled, resulting in homogenization within the FEA. The methodology is described in detail, making it easily adaptable for other groups to apply in the further development of promising FEAs.
The purpose of this study was to evaluate the quality of surface contouring of chondromalacic cartilage by bipolar radio frequency energy using different treatment patterns in an animal model, as well as examining the impact of the treatment onto chondrocyte viability by two different methods. Our experiments were conducted on 36 fresh osteochondral sections from the tibia plateau of slaughtered 6-month-old pigs, where the thickness of the cartilage is similar to that of human wrist cartilage. An area of 1 cm(2) was first treated with emery paper to simulate the chondromalacic cartilage. Then, the treatment with RFE followed in 6 different patterns. The osteochondral sections were assessed for cellular viability (live/dead assay, caspase (cell apoptosis marker) staining, and quantitative analysed images obtained by fluorescent microscopy). For a quantitative characterization of none or treated cartilage surfaces, various roughness parameters were measured using confocal laser scanning microscopy (Olympus LEXT OLS 4000 3D). To describe the roughness, the Root-Mean-Square parameter (Sq) was calculated. A smoothing effect of the cartilage surface was detectable upon each pattern of RFE treatment. The Sq for native cartilage was Sq=3.8 +/- 1.1 mu m. The best smoothing pattern was seen for two RFE passes and a 2-second pulsed mode (B2p2) with an Sq=27.3 +/- 4.9 mu m. However, with increased smoothing, an augmentation in chondrocyte death up to 95% was detected. Using bipolar RFE treatment in arthroscopy for small joints like the wrist or MCP joints should be used with caution. In the case of chondroplasty, there is a high chance to destroy the joint cartilage.
Brain lesions in language-related cortical areas remain a challenge in the clinical routine. In recent years, the resting-state fMRI (RS-fMRI) was shown to be a feasible method for preoperative language assessment. The aim of this study was to examine whether language-related resting-state components, which have been obtained using a data-driven independent-component-based identification algorithm, can be supportive in determining language dominance in the left or right hemisphere. Twenty patients suffering from brain lesions close to supposed language-relevant cortical areas were included. RS-fMRI and task-based (TB-fMRI) were performed for the purpose of preoperative language assessment. TB-fMRI included a verb generation task with an appropriate control condition (a syllable switching task) to decompose language-critical and language-supportive processes. Subsequently, the best fitting ICA component for the resting-state language network (RSLN) referential to general linear models (GLMs) of the TB-fMRI (including models with and without linguistic control conditions) was identified using an algorithm based on the Dice index. Thereby, the RSLNs associated with GLMs using a linguistic control condition led to significantly higher laterality indices than GLM baseline contrasts. LIs derived from GLM contrasts with and without control conditions alone did not differ significantly. In general, the results suggest that determining language dominance in the human brain is feasible both with TB-fMRI and RS-fMRI, and in particular, the combination of both approaches yields a higher specificity in preoperative language assessment. Moreover, we can conclude that the choice of the language mapping paradigm is crucial for the mentioned benefits.
Background:
Brain lesions in language-related cortical areas remain a challenge in the clinical routine. In recent years the resting-state fMRI (rs-fMRI) was shown to be a feasible method for preoperative language assessment. The aim of this study was to examine whether language-related resting-state components, which have been obtained using a data-driven independent-component-based identification algorithm, can be supportive in determining language dominance in the left or right hemisphere.
Methods:
Twenty patients suffering from brain lesions close to supposed language relevant cortical areas were included. Rs-fMRI and task-based (tb-fMRI) were performed for the purpose of preoperative language assessment. Tb-fMRI included a verb generation task with an appropriate control condition (a syllable switching task) to decompose language critical and language supportive processes. Subsequently, the best fitting ICA component for the resting-state language network (RSLN) referential to general linear models (GLMs) of the tb-fMRI (including models with and without linguistic control conditions) was identified using an algorithm based on the Dice-index.
Results:
The RSLNs associated with GLMs using a linguistic control condition led to significantly higher laterality indices than GLM baseline contrasts. LIs derived from GLM contrasts with and without control conditions alone did not differ significantly.
Conclusion:
In general, the results suggest that determining language dominance in the human brain is feasible both with tb-fMRI and rs-fMRI, and in particular, the combination of both approaches yields a higher specificity in preoperative language assessment. Moreover, we can conclude that the choice of the language mapping paradigm is crucial for the mentioned benefits.
Organizations are under increasing pressure to develop applications within budget and time at high quality. Therefore, multiple organizations adopt Low Code Development Platforms (LCDP) to develop applications faster and cheaper compared to traditional application development. However, current research on LCDP adoption lacks empirical grounding as well as a deeper understanding of the importance of adoption drivers and inhibitors. We conducted semi-structured interviews and a Delphi study with seventeen experts to address these gaps. As a result, we identified twelve drivers and nineteen inhibitors for adopting LCDPs. We show that the experts have a consensus on the most and the least important drivers and inhibitors for LCDP adoption. Yet, the ranking of the drivers and inhibitors between the most and least important is highly context dependent. For some drivers and inhibitors, the experts’ ranking is similar to academic literature, whereas, for others, it differs. In conclusion, the study at hand empirically validates drivers and inhibitors for LCDP adoption, adds six new drivers and six new inhibitors to the body of knowledge, and analyses the importance of these factors.
Germany's energy transition, known as 'Energiewende', was always very progressive. However, it came technically to a halt at the question of large-scale, seasonal energy storage for wind and solar, which was not available. At the end of the 2000s, we combined our knowledge of both electrical and process engineering, imitated nature by copying photosynthesis and developed Power-to-Gas by combining water electrolysis with CO2-methanation to convert water and CO2 together with wind and solar power to synthetic natural gas. Storing green energy by coupling the electricity with the gas sector using its vast TWh-scale storage facility was the solution for the biggest energy problem of our time. This was the first concept that created the term 'sector coupling' or 'sectoral integration'. We first implemented demo sites, presented our work in research, industry and ministries, and applied it in many macroeconomic studies. It was an initial idea that inspired others to rethink electricity as well as eFuels as an energy source and energy carrier. We developed the concept further to include Power-to-Liquid, Power-to-Chemicals and other ways to 'convert' electricity into molecules and climate-neutral feedstocks, and named it 'Power-to-X'at the beginning of the 2010s.
In this report, the dry delivery of polyamide 12 powders by vibrating capillary steel nozzles is investigated and discussed regarding its potential for powder layer preparation in Laser Beam Melting. Therefore, a setup including a steel nozzle assembled on a piezoelectric actuator is presented, which enables the precise control over very small powder quantities by vibration excitation. An analysis reveals that the mass flow through the nozzle can be adjusted by the vibration modes in a certain range depending on the nozzle's specifications, whereas the vibration modes themselves show a complicated behaviour. Using a positioning system in combination with the vibrating nozzle, single-layer patterns consisting of polyamide 12 are produced and characterized regarding surface homogeneity and selectivity using a laser stripe sensor.
Non-road sectors, such as agriculture and construction machinery, require high energy densities and flexibility in use, which is why diesel engines are mainly used. The use of climate-neutral fuels, produced from renewable energies, such as Oxymethylene Ether (OME) as a diesel substitute, can significantly reduce CO2 and pollutant emissions in these sectors. In addition to CO2 neutrality, OME also offers improved combustion characteristics compared to diesel fuel, eliminating the soot–NOx trade-off and thus enabling new opportunities in engine design and calibration. In this paper, the combustion of pure OME on a close-to-production, single-cylinder non-road diesel engine with a pump–line–nozzle injection system is analyzed. A variation of the center of combustion at constant power output was performed for diesel and OME at different operating points. Two injectors were investigated with OME. A study on ignition delay and a detailed thermodynamic analysis was carried out. In addition, the exhaust emissions CO, NOx, VOC, as well as particulate-matter, -number and -size distributions were measured. With OME, a significantly shorter ignition delay as well as a shortened combustion duration could be observed, despite a longer injection duration. In addition, the maximum injection pressure increases. VOC and CO emissions are reduced. Particulate matter was reduced by more than 99% and particle number (>10 nm) was reduced by multiple orders of magnitude. The median of the particle size distribution shifts from 60 to 85 nm (diesel) into a diameter range of sub 23 nm (OME). A significant reduction of NOx emissions with OME enables new degrees of freedom in engine calibration and an efficiency advantage without hardware adaption.
Der Beitrag fokussiert die Bedeutung von Zeit für die politische Erwachsenenbildung. Angesichts aktueller soziokultureller und sozioökonomischer Herausforderungen - besonders: der Ökonomisierung und Beschleunigung im Kontext von Bildung und Lernen - ergeben sich eine ganze Reihe von drängenden Zeitfragen. Der Bedeutung von Zeit wird in der Erwachsenenbildung und der Politischen Bildung jedoch bisher wenig Aufmerksamkeit geschenkt. Aus diesem Grund wird diese Fragestellung im Beitrag vertieft. Erstens werden die Situation der politischen Erwachsenenbildung und zweitens der Forschungsstand untersucht. Ausgehend von den Befunden werden drittens drei Zugänge herausgearbeitet, welche die Bedeutung von Zeit für die politische Erwachsenenbildung sichtbar machen: Politische Bildung als Prozess und Verzögerung sowie Zeit als Gegenstand, um die Zeitlichkeit von Gesellschaft und Politik zu verstehen und zu beurteilen, um sich an der Gestaltung der Zeitstrukturen zu beteiligen. Der Beitrag endet mit einem Ausblick und offenen Fragen, die sich an die zeittheoretischen Überlegungen anschließen.
The article focusses on the importance of time for the political adult education. Current socio-cultural and socio-economic challenges – in particular: the commodification and acceleration in the context of education and learning – results in a wide range of pressing time issues. However the adult education und the political education pay little attention to the importance of time. For this reason, this issue will be deepened in the article. First, the situation of the political adult education and secondly, the state of research are examined. On the base of the findings, three approaches are pointed out, which emphasize the importance of time for the political adult education: political education as a process and as a deceleration and also as a subject to understand and judge the temporality of politics and society as a necessary condition to participate in shaping the time structures. The paper ends with an outlook and open-ended questions, which adjoin the time theoretical considerations.
Physical Education with Eduball Stimulates Non-Native Language Learning in Primary School Students
(2022)
Although the neuronal mechanisms of action and cognition are related, the division of intellectual and physical lessons is standard in schools. This is surprising, because numerous studies show that integrating physical education (PE) with teaching content stimulates critical skills. For example, several experiments indicate that Eduball-based PE (i.e., lessons in a sports hall during which students play team mini-games with educational balls with printed letters, numbers, and other signs) develops mathematical and language competencies. At the same time, the Eduball method does not slow down learners' physical development. However, we have little knowledge about the effects of such techniques on non-native language learning. Consequently, the absence of incorporating core academic subjects into PE in dual-language schools or during foreign language education is exceptionally high. Here, we replicated the Eduball experiment, but with the goal of testing this method for non-native language learning. Thus, the intervention occurred in a dual-language primary school and we evaluated second language (L2) learning. As before, we used the technique of parallel groups (experimental and control); in both groups, there were three 45-min PE classes per week. In the experimental class, two of them were held using Eduball. After a half-year experiment, children from the experimental group (one second-grade, N = 14) improved their non-native language skills significantly more than their peers from the control group (one second-grade, N = 12). These findings demonstrate that Eduball-type intervention stimulates non-native language learning in children. Hence, our report suggests that specific body training forms can support L2 learning.
This study investigates the vibration reduction of tall wind-excited buildings using a tuned mass damper (TMD) with an inerter (TMDI). The performance of the TMDI is computed as a function of the floor to which the inerter is grounded as this parameter strongly influences the vibration reduction of the building and for the case when the inerter is grounded to the earth whereby the absolute acceleration of the corresponding inerter terminal is zero. Simulations are made for broadband and harmonic excitations of the first three bending modes, and the conventional TMD is used as a benchmark. It is found that the inerter performs best when grounded to the earth because, then, the inerter force is in proportion to the absolute acceleration of only the pendulum mass, but not to the relative acceleration of the two inerter terminals, which is demonstrated by the mass matrix. However, if the inerter is grounded to a floor below the pendulum mass, the TMDI only outperforms the TMD if the inerter is grounded to a floor within approximately the first third of the building’s height. For the most realistic case, where the inerter is grounded to a floor in the vicinity of the pendulum mass, the TMDI performs far worse than the classical TMD.
In recent years, the Tuned Mass Damper with inerter (TMDI) has received significant attention. The inerter is defined to exert a force that is in proportion to the relative acceleration of the two inerter terminals. Here, two TMDI topologies are investigated. The conventional topology is given by the inerter being in parallel to the spring and viscous damper of the TMDI. The other topology is the serial arrangement of spring, inerter and viscous damper being in parallel to the stiffness of the mass spring oscillator of the TMDI. While the first topology intends to increase the inertial force of the TMDI, the second topology aims at producing an additional degree of freedom. The considered TMDI concepts are simulated for harmonic and random excitations, with parameters set according to those described in the literature and with numerically optimized parameters which minimize the primary structure displacement response. The classical TMD is used as a benchmark. The findings are twofold. The conventional TMDI with typical inertance ratio of 1% and the very small value of 0.02% performs significantly worse than the classical TMD with the same mass ratio. In contrast, the TMDI with an additional degree of freedom can improve the mitigation of the primary structure if the inertance ratio is set very small and if the TMDI parameters are numerically optimized.
In the context of a "Smart Grid" research project, together with industrial partners, the OTH-Regensburg realized an intelligent medium-voltage grid in the local area. Goal was to improve the current voltage regulation and to counter the problems with inconsistent energy feed-in of decentralized renewable energy producers. In this paper we discuss the possibilities of using 3rd generation (3G) cellular networks (UMTS) as basic technology to communicate the voltage-levels within a medium-voltage grid. We build an experimental
hardware setup to generate data-traffic as specified for the smart
grid. By analyzing the performance of 3G cellular networks in
terms of transmission latency and rate of failure, we tried to
evaluate the usability of this technology for such critical data
exchange. Though mobile communication in its structure is not
specified for the use of transmitting such infrastructure critical
data, the results show a promising high reliability with low
transmission latency. The experiments served just to test a
fragment of the conditions of use in a real scenario. An expanded
test scope is needed to further analyze the performance of mobile
radio for automatic control in smart grids. In the end the results
discussed in this paper led to a successful prototype of an
intelligent medium-voltage grid with mobile radio as communication technology
Patients with age-related macular degeneration (AMD) or hereditary macular dystrophies (JMD) rely on an efficient use of their peripheral visual field. We trained eight AMD and five JMD patients to perform a texture-discrimination task (TDT) at their preferred retinal locus (PRL) used for fixation. Six training sessions of approximately one hour duration were conducted over a period of approximately 3 weeks. Before, during and after training twelve patients and twelve age-matched controls (the data from two controls had to be discarded later) took part in three functional magnetic resonance imaging (fMRI) sessions to assess training-related changes in the BOLD response in early visual cortex. Patients benefited from the training measurements as indexed by significant decrease (p = 0.001) in the stimulus onset asynchrony (SOA) between the presentation of the texture target on background and the visual mask, and in a significant location specific effect of the PRL with respect to hit rate (p = 0.014). The following trends were observed: (i) improvement in Vernier acuity for an eccentric line-bisection task; (ii) positive correlation between the development of BOLD signals in early visual cortex and initial fixation stability (r = 0.531); (iii) positive correlation between the increase in task performance and initial fixation stability (r = 0.730). The first two trends were non-significant, whereas the third trend was significant at p = 0.014, Bonferroni corrected. Consequently, our exploratory study suggests that training on the TDT can enhance eccentric vision in patients with central vision loss. This enhancement is accompanied by a modest alteration in the BOLD response in early visual cortex.
Hereditary and age-related forms of macular dystrophy (MD) are characterized by loss of cone function in the fovea, leading to central scotomata and eccentric fixation at the so-called preferred retinal locus (PRL). We investigated whether perceptual learning enhances visual abilities at the PRL. We also determined the neural correlates (3-Tesla fMRI) of learning success. Twelve MD patients (eight with age-related macular dystrophy, four with hereditary macular dystrophies) were trained on a texture discrimination task (TDT) over six days. Patients underwent three fMRI sessions (before, during and after training) while performing the TDT (target at PRL or opposite PRL). Reading speed, visual acuity (Vernier task) and contrast sensitivity were also assessed before and after training. With one exception, all patients showed improved performance (i.e. significant decrease in stimulus onset asynchronies and reaction times, significant increase in hit rates) on the TDT. Eight patients also showed moderate increases in reading speed, six patients showed improved thresholds in contrast sensitivity and nine patients showed improved thresholds in a vernier visual acuity task after TDT training. We found an increase in BOLD response in the projections zone of the PRL in the primary visual cortex in nine of twelve patients after training. The change in fMRI signal correlated (r = .8; p = .02) with the patients’ performance enhancements when the target was in the PRL. The results suggest that perceptual learning can enhance eccentric vision and cortical processing in MD patients.
Background:
People with aphasia (PWA) often suffer from reduced participation and quality of life. Nevertheless, there are currently only a few specific interventions that respond to this problem. Participation and quality of life could be increased by interacting with peers who have similar experiences. Digital social networks could stimulate an autonomous interaction. However, digital social networks need to be adapted to the specific needs of PWA. Therefore, a participatory, agile process involving the target group should be chosen to develop such a olution, i.e., an app. The research project consists of a total of three phases. In the first phase—app development—the app was developed and programmed including the target group. In the second phase—app testing—the usability and user-friendliness of the app were evaluated with four PWA. In the third phase—feasibility and preliminary effcacy—that will be described in the article, the impact of the app on PWA will be evaluated.
Aims:
The overarching aim of our study is to provide preliminary effcacy of the intervention. Digital social interaction with other PWA can lead to increased social integration. In addition to digital interaction, personal encounters between PWA should be encouraged. As a result, we expect an improvement in quality of life of PWA. Additionally, we focus on identification of the most appropriate measurements to discover changes associated with the intervention.
Methods:
The evaluation, which is described in this paper, takes place in a pre-test - post-test design with a total of n = 48 PWA. Participants will be recruited in regional clusters to facilitate face-to-face meetings. Half of the participants will be assigned to the delayed intervention group and the other half to the immediate intervention group. Participants in the delayed intervention group will go through a 3-month waiting period before using the app, while the participants of the immediate intervention group will start using the app for 3 months right away. Inclusion criteria are the presence of chronic aphasia (at least 6 months) and possession of a smartphone with internet access. Questionnaires on quality of life (SAQOL-39, GHQ-12), depression (GDS, DISCs), communicative participation (CPIB), and social support (F-SozU) will be conducted at inclusion (t0), after 3 months of app use (t1), and after another 3 months for follow-up (t2). Participants in the delayed intervention group will be assessed twice before the intervention, before the 3-month waiting period (t0a) and after the waiting period (t0b). In addition to the quantitative measures, interviews will take place with 6 to 8 selected participants after 3 months of app use. Responses will be analysed using Thematic Analysis.
Discussion:
The app will be the first social network tool that is systematically developed with PWA. Initial indications from the first phases are that the app can be used by PWA, so that the evaluation of this app version can take place in the third phase. Results of this study can provide an initial indication of whether social network support is a suitable intervention. Findings will help provide information on the feasibility of digital connectivity for PWA. Preliminary findings on its impact on the participation and quality of life of PWA could be made available.
Background:
Pediatricians are important sources of information for parents regarding their children's health. During the COVID-19 pandemic, pediatricians faced a variety of challenges regarding information uptake and transfer to patients, practice organization and consultations for families. This qualitative study aimed at shedding light on German pediatricians’ experiences of providing outpatient care during the first year of the pandemic.
Methods:
We conducted 19 semi-structured, in-depth interviews with pediatricians in Germany from July 2020 to February 2021. All interviews were audio recorded, transcribed, pseudonymized, coded, and subjected to content analysis.
Results:
Pediatricians felt able to keep up to date regarding COVID-19 regulations. However, staying informed was time consuming and onerous. Informing the patients was perceived as strenuous, especially when political decisions had not been officially communicated to pediatricians or if the recommendations were not supported by the professional judgment of the interviewees. Some felt that they were not taken seriously or adequately involved in political decisions. Parents were reported to consider pediatric practices as sources of information also for non-medical inquiries. Answering these questions was time consuming for the practice personnel and involved non-billable hours. Practices had to adapt their set-up and organization immediately to the new circumstances of the pandemic, which proved costly and laborious as well. Some changes in the organization of routine care, such as the separation of appointments for patients with acute infection from preventive appointments, were perceived as positive and effective by some study participants. Telephone and online consultations were established at the beginning of the pandemic and considered helpful for some situations, whereas for others these methods were deemed insufficient (e.g. for examinations of sick children). All pediatricians reported reduced utilization mainly due to a decline in acute infections. However, preventive medical check-ups and immunization appointments were reported to be mostly attended.
Conclusion:
Positive experiences of reorganizing pediatric practice should be disseminated as “best practices” in order to improve future pediatric health services. Further research could show how some of these positive experiences in reorganizing care during the pandemic are to be maintained by pediatricians in the future.
Instructors of English for Special Purposes often describe the challenge of determining which specific content and competencies to address in their courses. After all, it is the focus on technical subject matter which students expect to differentiate engineering ESP from standard EFL. Yet ESP instructors, who frequently have a background in fields such as applied linguistics or education, often receive little input from technical specialists as to which specialist topics are most relevant to their target domain.
Our research indicates that ESP instructors in higher education can leverage a valuable resource to enrich teaching effectiveness: students who have already gained professional experience. As part of a longitudinal study at two universities of applied sciences (UAS) in southern Germany, engineering students at the beginning of their first semester of compulsory technical English participate in an online survey. The course participants provide relevant biographical information such as work experience and evaluate the perceived importance of a selection of skills and applications for a Technical English course.
The surveys, administered in October 2016 and October 2017 and encompassing nearly 1000 respondents, provide compelling insights. Analysis reveals conclusive correlations between the perceived importance of course components and students' declared level of previous work experience. Listening comprehension, reading comprehension, process description, and test and measurement are topics whose importance correlates positively with work experience level. In addition, there are clear trends relating work experience level with the importance of the reading and writing of technical documents as well as communication and interaction.
This data provides empirically-founded criteria for selecting the topics to include in the scope of a Technical English course for engineers, informed by the judgment of students with occupational experience. Additionally, recognizing that students with work experience have legitimate practitioner credibility allows instructors to identify and select relevant subject matter in concordance with experienced students' learning objectives. ESP learners will profit greatly from cultivating skills with proven practical applicability.
Background: For surgical fixation of bone fractures of the human hand, so-called Kirschner-wires (K-wires) are drilled through bone fragments. Due to the minimally invasive drilling procedures without a view of risk structures like vessels and nerves, a thorough training of young surgeons is necessary. For the development of a virtual reality (VR) based training system, a three-dimensional (3D) printed phantom hand is required. To ensure an intuitive operation, this phantom hand has to be realistic in both, its position relative to the driller as well as in its haptic features. The softest 3D printing material available on the market, however, is too hard to imitate human soft tissue. Therefore, a support-material (SUP) filled metamaterial is used to soften the raw material. Realistic haptic features are important to palpate protrusions of the bone to determine the drilling starting point and angle. An optical real-time tracking is used to transfer position and rotation to the training system.
Methods: A metamaterial already developed in previous work is further improved by use of a new unit cell. Thus, the amount of SUP within the volume can be increased and the tissue is softened further. In addition, the human anatomy is transferred to the entire hand model. A subcutaneous fat layer and penetration of air through pores into the volume simulate shiftability of skin layers. For optical tracking, a rotationally symmetrical marker attached to the phantom hand with corresponding reference marker is developed. In order to ensure trouble-free position transmission, various types of marker point applications are tested.
Results: Several cuboid and forearm sample prints lead to a final 30 centimeter long hand model. The whole haptic phantom could be printed faultless within about 17 hours. The metamaterial consisting of the new unit cell results in an increased SUP share of 4.32%. Validated by an expert surgeon study, this allows in combination with a displacement of the uppermost skin layer a good palpability of the bones. Tracking of the hand marker in dodecahedron design works trouble-free in conjunction with a reference marker attached to the worktop of the training system.
Conclusions: In this work, an optically tracked and haptically correct phantom hand was developed using dual-material 3D printing, which can be easily integrated into a surgical training system.
Onlinetherapie für Menschen mit Aphasie - Tipps und Hinweise zur Anwendung im therapeutischen Alltag
(2023)
Production of optical and medical devices makes high demands on cleanliness, precision, visual appearance and reliability. Advantages of laser transmission welding – contactless input of energy, high precision, no adhesives and no particle formation – can be fully exploited for this use. For absorber-free welding, lasers emitting in the polymers’ intrinsic absorption spectrum between 1.6 μm and 2 μm are used. Focusing the laser beam with high NA provides large intensity gradients inside the specimen and enables selective fusing of the joining zone without affecting the surface. Since a molten upper surface leads to visible and palpable irregularities and causes warpage, the verticalexpansion of the weld seam is crucial. To meet the high quality and reliability required in the medical and optical industry, online monitoring of the seam is necessary. The aim of this work is the localization and evaluation of the weld seam using pyrometry. First, the emitted thermal radiation is computed, enabling signal analysis regarding origin and spectrum. Thus, assessment of measurement spectrum and forecast of the signal in dependence on seam shape and position is possible. Finally, welding tests with Topas 8007-04 are performed at 200 mm/s feed rate and monitored with 100 kHz. The comparison of tracked data with thin-cuts demonstrates that weld seam localization by pyrometry is possible, enabling online assessment of the process.
Hot pressing of pure Ti and cast iron under vacuum formed a ~15 μm wide TiC-layer through the thermoreactive diffusion process. Nanoindentation testing of the TiC-layer revealed average hardness and elastic
modulus values of ~35 GPa and ~400 GPa, respectively. High-resolution indentation mapping indicated hardness change across the boundary with peak values observed within the TiC-layer. Solid state high temperature diffusion holds significant potential for developing uniform hard coatings on pure Ti/Ti-alloys.
This work aims at investigating the kinetic mechanisms of the reduction/oxidation (redox) reactions of iron oxide/iron pellets under different operating conditions. The reaction principle is the basis of a thermochemical hydrogen storage system. To simulate the charging phase, a single pellet consisting of iron oxide (90% Fe2O3, 10% stabilising cement) is reduced with different hydrogen (H2) concentrations at temperatures between 600 and 800 °C. The discharge phase is initiated by the oxidation of the previously reduced pellet by water vapour (H2O) at different concentrations in the same temperature range. In both reactions, nitrogen (N2) is used as a carrier gas. The redox reactions have been experimentally measured in a thermogravimetric analyser (TGA) at a flow rate of 250 mL/min. An extensive literature review has been conducted on the existing reactions’ kinetic mechanisms along with their applicability to describe the obtained results. It turned out that the measured kinetic results can be excellently described with the so-called shrinking core model. Using the geometrical contracting sphere reaction mechanism model, the concentration- and temperature-dependent reduction and oxidation rates can be reproduced with a maximum deviation of less than 5%. In contrast to the reduction process, the temperature has a smaller effect on the oxidation reaction kinetics, which is attributed to 71% less activation energy (Ea,Re=56.9 kJ/mol versus Ea,Ox=16.0 kJ/mol). The concentration of the reacting gas showed, however, an opposite trend: namely, to have an almost twofold impact on the oxidation reaction rate constant compared to the reduction rate constant.
Finite element (FE)–based studies of preoperative processes such as folding,pleating, and stent crimping with a comparison with experimental inflation tests are not yet available. Therefore, a novel workflow is presented in which residual stresses of balloon folding and pleating, as well as stent crimping, and the geometries of all contact partners were ultimately implemented in an FE code to simulate stent expansion by using an implicit solver. The numerical results demonstrate that the incorporation of residual stresses and strains experienced during the production step significantly increased the accuracy of the subsequent simulations, especially of the stent expansion model. During the preoperative processes, stresses inside the membrane and the stent material also reached a rather high level. Hence, there can be no presumption that balloon catheters or stents are undamaged before the actual surgery. The implementation of the realistic geometry, in particular the balloon tapers, and the blades of the process devices improved the simulation of the expansion mech-anisms, such as dogboning, concave bending, or overexpansion of stent cells. This study shows that implicit solvers are able to precisely simulate the mentioned preoperative processes and the stent expansion procedure without a preceding manipulation of the simulation time or physical mass.
This work aims at investigating the reduction/oxidation (redox) reaction kinetics on iron oxide pellets under different operating conditions of thermochemical hydrogen storage. In order to reduce the iron oxide pellets (90% Fe2O3, 10% stabilizing cement), hydrogen (H2) is applied in different concentrations with nitrogen (N2), as a carrier gas, at temperatures between between 700 ∘C and 900 ∘C, thus simulating the charging phase. The discharge phase is triggered by the flow of a mixture out of steam (H2O) and N2 at different concentrations in the same temperature range, resulting in the oxidizing of the previously reduced pellets. All investigations were carried out in a thermo-gravimetric analyzer (TGA) with a flow rate of 250mL/min. To describe the obtained kinetic results, a simplified analytical model, based on the linear driving force model, was developed. The investigated iron oxide pellets showed a stable redox performance of 23.8% weight reduction/gain, which corresponds to a volumetric storage density of 2.8kWh/(L bulk), also after the 29 performed redox cycles. Recalling that there is no H2 stored during the storage phase but iron, the introduced hydrogen storage technology is deemed very promising for applications in urban areas as day-night or seasonal storage for green hydrogen.
Hydrogen storage based on the repeated reduction and oxidation (redox) reactions of iron oxide/iron composites represents a promising technology. This work is dedicated to studying the influence of the amount of water added during the pelletizing process on the cycle stability and structure of iron oxide pellets. The storage composites were prepared from iron oxide (Fe2O3) and 10 wt.-% support material (cement) with different amounts of water (18 and 33 wt.-%) in a laboratory-scale pelletizing disk. To evaluate the cycle stability of the composites, the kinetics of the redox reactions were experimentally measured at 800 ∘
C in an atmosphere of 50% N2 and 50% H2 (reduction) or 50% steam (oxidation), respectively. Moreover, the structure of the pellets was analyzed by micro-computed tomography scans. It turned out that pellets with higher water contents attained faster kinetics and a higher cycle stability. The sample with the least water content (18 wt.-%) needed about 26 min and 19 min to reach a conversion rate of 80% during the reduction and oxidation reactions of the sixth redox cycle, respectively. In contrast, the sample with the highest water content (33 wt.-%) could achieve the same conversion rate after 18 min (reduction) and 13 min (oxidation) during the ninth redox cycle.
Today, ubiquitous mobile devices have not only arrived but entered the safety critical domain. There, systems are about to be controlled where human health or even human life is put at risk. For example, in automation systems first ideas surface to control parts of the system via a COTS smartphone. Another example is the idea to control the autonomous parking function of a car via a COTS smartphone too. As beneficial and convenient these ideas are on the first thought, on the second thought, dangers of these approaches become obvious. Especially in case of failures the system’s safety has to be maintained. The open question is how to achieve this mandatory requirement with COTS components, e.g. smartphones that are not developed following the development process necessary for safetycritical systems. This paper presents a concept to reliably detect human interaction while activating safety critical functions via COTS mobile devices. Thus a means is provided to detect erroneous activation requests for the safetycritical function.
Old wine in new wineskins?
(2013)
In the mid 2000s, a fundamental labour market reform has been carried out in Germany. The so-called Hartz-reforms were supposed to implement the paradigms of “activation” and “individual responsibility”. It was also discussed, whether in this context the “adult worker model” and more gender equality in the labour market should and could be achieved. This article clarifies the reforms ambivalent impact on women: there is a stronger but only partial labour market inclusion predominantly into the low-wage sector. Women´s responsibility in private care remains unchanged. Besides, in both fields, gender equality is not only a matter of quantity but also of quality. In other words, it is not about work inclusion at any cost, but rather the circumstances for female employment must be critically analyzed. The labour market reforms have so far done little to oppose the gender specific structures of the labour market.