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- Fakultät Maschinenbau (69)
- Regensburg Center of Biomedical Engineering - RCBE (18)
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Begutachtungsstatus
- peer-reviewed (42)
A prototype of a thermal insulation system to offer high selectivity of the solar gain regarding the solar incidence angle (SATIS) was applied to a typical solid brick masonry for existing buildings in Germany. Light conducting elements (LCEs) inclined at 19 ° were incorporated in SATIS, which equals the average solar noon angle in southern Germany during winter. The entire wall construction was experimentally investigated in a differential climatic chamber test bench at four different irradiation angles according to a dynamic test procedure. In addition, a conventional wall construction (CWC) has been measured. At SATIS’ design angle of 19 °, the SATIS wall construction shows a solar gain (SG) of 394.5 Wh/m², while the SG of the CWC amounts to only 25.4 Wh/m². The validated transient model of the SATIS wall construction showed that, at the end of the irradiation period of the dynamic test procedure (8 h), the solar heat penetrates to a depth of 253 mm and 111 mm inside the 385 mm thick brick wall masonry at the irradiation angles of 19 ° and 50 °, respectively. During the same time, the stored solar energy at 50 ° amounts to only 24.4 % of that stored at 19 °.
Background:
Brain lesions in language-related cortical areas remain a challenge in the clinical routine. In recent years the resting-state fMRI (rs-fMRI) was shown to be a feasible method for preoperative language assessment. The aim of this study was to examine whether language-related resting-state components, which have been obtained using a data-driven independent-component-based identification algorithm, can be supportive in determining language dominance in the left or right hemisphere.
Methods:
Twenty patients suffering from brain lesions close to supposed language relevant cortical areas were included. Rs-fMRI and task-based (tb-fMRI) were performed for the purpose of preoperative language assessment. Tb-fMRI included a verb generation task with an appropriate control condition (a syllable switching task) to decompose language critical and language supportive processes. Subsequently, the best fitting ICA component for the resting-state language network (RSLN) referential to general linear models (GLMs) of the tb-fMRI (including models with and without linguistic control conditions) was identified using an algorithm based on the Dice-index.
Results:
The RSLNs associated with GLMs using a linguistic control condition led to significantly higher laterality indices than GLM baseline contrasts. LIs derived from GLM contrasts with and without control conditions alone did not differ significantly.
Conclusion:
In general, the results suggest that determining language dominance in the human brain is feasible both with tb-fMRI and rs-fMRI, and in particular, the combination of both approaches yields a higher specificity in preoperative language assessment. Moreover, we can conclude that the choice of the language mapping paradigm is crucial for the mentioned benefits.
This short survey reviews the recent literature on the relationship between the brain structure and its functional dynamics. Imaging techniques such as diffusion tensor imaging (DTI) make it possible to reconstruct axonal fiber tracks and describe the structural connectivity (SC) between brain regions. By measuring fluctuations in neuronal activity, functional magnetic resonance imaging (fMRI) provides insights into the dynamics within this structural network. One key for a better understanding of brain mechanisms is to investigate how these fast dynamics emerge on a relatively stable structural backbone. So far, computational simulations and methods from graph theory have been mainly used for modeling this relationship. Machine learning techniques have already been established in neuroimaging for identifying functionally independent brain networks and classifying pathological brain states. This survey focuses on methods from machine learning, which contribute to our understanding of functional interactions between brain regions and their relation to the underlying anatomical substrate.
Brain lesions in language-related cortical areas remain a challenge in the clinical routine. In recent years, the resting-state fMRI (RS-fMRI) was shown to be a feasible method for preoperative language assessment. The aim of this study was to examine whether language-related resting-state components, which have been obtained using a data-driven independent-component-based identification algorithm, can be supportive in determining language dominance in the left or right hemisphere. Twenty patients suffering from brain lesions close to supposed language-relevant cortical areas were included. RS-fMRI and task-based (TB-fMRI) were performed for the purpose of preoperative language assessment. TB-fMRI included a verb generation task with an appropriate control condition (a syllable switching task) to decompose language-critical and language-supportive processes. Subsequently, the best fitting ICA component for the resting-state language network (RSLN) referential to general linear models (GLMs) of the TB-fMRI (including models with and without linguistic control conditions) was identified using an algorithm based on the Dice index. Thereby, the RSLNs associated with GLMs using a linguistic control condition led to significantly higher laterality indices than GLM baseline contrasts. LIs derived from GLM contrasts with and without control conditions alone did not differ significantly. In general, the results suggest that determining language dominance in the human brain is feasible both with TB-fMRI and RS-fMRI, and in particular, the combination of both approaches yields a higher specificity in preoperative language assessment. Moreover, we can conclude that the choice of the language mapping paradigm is crucial for the mentioned benefits.
The paper deals with the investigation of magneto-sensitive elastomers(MSE) and their application in technical actuator systems. MSE consist of an elasticmatrix containing suspended magnetically soft and/or hard particles. Additionally,they can also contain silicone oil, graphite particles, thermoplastic components, etc.,in various concentrations in order to tune specific properties such as viscosity, con-ductivity and thermoelasticity, respectively. The focuses of investigations are thebeneficial properties of MSE in prototypes for locomotion and manipulation purposesthat possess an integrated sensor function. The research follows the principle of amodel-based design, i.e. the working steps are ideation, mathematical modelling,material characterization as well as building first functional models (prototypes). Thedeveloped apedal (without legs) and non-wheeled locomotion systems use the inter-play between material deformations and the mechanical motion in connection with theissues of control and stability. Non-linear friction phenomena lead to a monotonousforward motion of the systems. The aim of this study is the design of such mechanicalstructures, which reduce the control costs. The investigations deal with the movementand control of‘intelligent’mechanisms, for which the magnetically field-controlledparticle-matrix interactions provide an appropriate approach. The presented grippersenclose partially gripped objects, which is an advantage for handling sensitive objects.Form-fit grippers with adaptable contour at the contact area enable a uniform pressuredistribution on the surface of gripped objects. Furthermore, with the possibility ofactive shape adaptation, objects with significantly differing geometries can be gripped.To realise the desired active shape adaptation, the effect of field-induced plasticity ofMSE is used. The first developed prototypes mainly confirm the functional principles assuch without direct application. For this, besides the ability of locomotion andmanipulation itself, further technological possibilities have to be added to the systems.
Efficient earthquake simulation of stiff and high DOF bridge expansion joint models with Python
(2021)
Various types of seismic protection devices has been developed to protect structures like bridges from collapse during an earthquake event, such as hydraulic or metallic hysteresis dampers and spherical pendulum bearings. The expansion joints however, which are already included in most large-span bridges, are not considered as an
earthquake protection device regardless of the significant friction forces they produce. These friction forces can be seen as damping forces between the shaking environment and the oscillating bridge. To investigate the effect of those damping forces during different earthquake loads, a multibody dynamics simulation model of the expansion joints will be created. This model should be accurate enough to represent the generation of the damping forces and effects of the geometric setup of the expansion joints. Because large expansion joints for large-span bridges are of special interest, the number of degrees of freedom (DOF) becomes very high. Because this models include stiff bushings, implicit solvers need to be used to gain a stable simulation. Expansion joints are almost unique constructions for every specific bridge, which requires a automated model generation. Because of its excellent modules for numerical mathematics, the scripting language Python is used. To create an efficient simulation model, several optimization techniques such as Just-In-Time (JIT) compilation and parallelization are implemented and tested.
Maintenance strategies of drivetrains either focus on cases of failure or act preventively. The case of failure of a single element within a drivetrain can lead to the failure of the whole machinery or even an entire production line. A maintenance strategy, which focuses only on the case of failure, holds therefore economic risks. A preventive maintenance strategy can lead to replacements of intact components, because one strictly relies on fix maintenance intervals. The useful life of these replaced components is not fully utilized. A further development is the combination of one or two maintenance strategies mentioned above with condition monitoring (CM) in addition. CM monitors crucial components of the machinery. If CM indicates first signs of maloperation, unusual signals or amplitudes, one can initiate maintenance. The significance of a CM relies on the amount, placement and positioning of sensors. In reality, placement and positioning is restricted by design space and operation conditions. Current Research at HSA aims on the development of a predictive maintenance strategy, which combines CM with a realtime-capable digital twin. The latter bases on a multibody system and can be considered as a virtual CM. Within this, the CM provides boundary conditions and realtime validation for the digital twin. The virtual CM suffers no restrictions such as design space and operation conditions. It is able to predict the behavior of the drivetrain at any time, at any place, in any resolution. The data provided by the virtual CM can be used to reevaluate maximum utilization of components and therefore it can be used to set up a predictive maintenance strategy. To investigate the possibilities of this predicitve maintenance strategy further, a drivetrain test bench has been developed at HSA from scratch. The main component is a modular, three-stage gearbox which allows different setups of parameters in which e.g. center distance, bearing concepts and transmission ratio can be changed and modified. Several high fidelity sensors provide CM in realtime. The Paper will focus on the comparison of real and virtual signals and shows first results of validations in frequency domain.
Beim Kauf eines Pkw wird der akustische Qualitätseindruck eines Fahrzeugantriebstrangs stetig relevanter. Die wahrgenommene Geräuschqualität des Motoraggregates nimmt hierbei eine Schlüsselrolle ein. Aufgrund der Ausprägung einzelner Störgeräusche wird jene Geräuschqualität negativ beeinflusst. Diese als unangenehm empfundenen Geräuschkomponenten gilt es im Rahmen der Fahrzeugentwicklung
weiter zu reduzieren, wobei die Identifikation und Bewertung störender Geräuschanteile am Motorgesamtgeräusch Voraussetzungen für eine effektive Akustikoptimierung sind. Vor allem das impulshafte Tickergeräusch wird bei Otto-DI-Motoren als besonders lästig eingestuft, weswegen dieser Beitrag darauf abzielt, die tickernden Geräuschanteile aus dem Gesamtgeräusch zu analysieren und zu bewerten. Hierzu wurde eine empirische Formel entwickelt, welche die tickernden Geräuschanteile in ihrer Intensität in Grenzen einstufen kann. Diese ist rein empfindungsbasiert und besteht aus der Impulshaftigkeit, der Lautheit sowie der Schärfe des Motorgesamtgeräusches.
Wie auch bei anderen psychoakustischen Bewertungsskalen wurde die Benotung von 1 (sehr tickernd) bis 10 (nicht tickernd) vorgenommen. Anhand von Hörversuchen mithilfe einer Expertenjury konnte die Tickergeräuschbewertungsformel anschließend verifiziert werden. Hiernach kann präzise ausgesagt werden, in welchen Motorkennfeldbereichen das Tickergeräusch die Angenehmheit des Motorgesamtgeräusches untergräbt.
Die Verschärfung der Abgasgesetzgebung sowie die politischen und gesellschaftlichen Forderungen an eine nachhaltige Mobilität zwingen die Automobilindustrie zur Entwicklung komplexer, hochpräziser mechatronischer Antriebssysteme. Die zunehmende Präzision der mechatronischen Komponenten führt dabei in der Regel zu einer
Zunahme der Strukturanregung und damit zu einer Erhöhung der Störgeräusche. Das so genannte Tickern des Kraftstoffeinspritzsystems hat im Vergleich zum Restmotorgeräusch einen niedrigeren Schalldruckpegel. Dennoch führt der impulshaltige und hochfrequente Geräuschcharakter zu einem Mangel in der Komfort- und Qualitäts-
32 wahrnehmung. Um die Geräuschqualität von raftstoffeinspritzsystemen als Frontloading-Maßnahme zu identifizieren, wurde ein Systemprüfstand entwickelt, der die Körper- und Luftschallabstrahlung des Einspritzsystems in seriennaher Konfiguration abbildet.
In diesem Beitrag werden Maßnahmen zur akustischen Optimierung von Einspritzsystemen und deren Auswirkungen auf die Robustheit im Systembetrieb diskutiert. Der Fokus liegt dabei auf dem Motorleerlauf, da an diesem Betriebspunkt das Tickern der Injektoren und der Hochdruckpumpe durch den geringen Maskierungseffekt anderer Geräusche am deutlichsten wahrzunehmen ist. Dazu wurden die Einspritzparameter im Vollmotorbetrieb erfasst und auf den Systemprüfstand transferiert. Durch ein spezielles Entwicklungssteuergerät war es möglich, die Parameter zu modifizieren, deren Einfluss auf das akustische Verhalten zu quantifizieren und darauf aufbauend NVHoptimierte
Ansteuerstrategien zu definieren. Zur Robustheitsbewertung der NVHoptimierten Ansteuerstrategien wurden Schlüsselfunktionen des Einspritzsystems unter variierenden Randbedingungen im Systembetrieb analysiert.
Bei Zugschwellversuchen kann sowohl die Amplituden- als auch die Mittelspannung frei eingestellt werden. Für eine zusammenfassende Auswertung müssen Amplituden- und Mittelspannungen durch eine einzige sogenannte äquivalente Spannung ersetzt werden. Die Bestimmung dieser äquivalenten Spannung setzt die Kenntnis des sogenannten Mittelspannungseinflusses voraus, der sich von Material zu Material unterscheidet. Aus der Literatur werden die gängigen Modelle zur Beschreibung des Mittelspannungseinflusses bei metallischen Werkstoffen vorgestellt. Daraus werden erstmals geeignete Modelle für Seildrähte abgeleitet. Dadurch lassen sich für Seildrähte die ertragbaren Lastwechselzahlen bei Zugschwellversuchen zuverlässig abschätzen und damit eine allgemeine Beschreibung ihres Materialermüdungsverhaltens angeben.
Einleitung:
Blutdruck gilt als sogenannter Vitalparameter als einer der grundlegenden Indikatoren für den Gesundheitszustand einer Person. Sowohl zu niedriger als auch zu hoher Blutdruck kann lebensbedrohend sein, letzerer ist darüber hinaus ein Risikofaktor insbesondere für Herz-Kreislauferkrankungen, die trotz wichtiger Fortschritte in der Behandlung immer noch die häufigste Todesursache in Deutschland darstellen. Die Hämodynamik, also die raumzeitliche Dynamik des Blutflusses, und der Gefäßzustand sind eng verbunden mit dem Blutdruck und ebenfalls von hoher klinischer Relevanz, u.a. zur Identifikation von Durchblutungsstörungen und ungünstigen Druckverteilungen der Gefäßwand. Innovationen in der Messtechnik als auch in der Datenanalyse bieten heute neue Möglichkeiten der Erfassung und Bewertung von Blutdruck, Hämodynamik und Gefäßzustand [1], [2], [3], [4].
Methodik:
In einer gemeinsamen Workshopserie der AG Medizinische Bild- und Signalverarbeitung der GMDS und des Fachausschusses Biosignale der DGBMT werden wir neue Ansätze und Lösungen für Mess- und Analyseverfahren zu Blutdruck und -fluss sowie zum Gefäßzustand vorstellen und diskutieren. Dabei stehen im ersten Workshop auf der GMDS Jahrestagung Bildbasierte Verfahren im Zentrum, während der zweite Workshop auf der DGBMT Jahrestagung den Fokus auf Biosignalbasierten Verfahren legt. Es werden aktuelle Forschungsergebnisse vorgestellt und diskutiert. Es sind jeweils mehrere Vorträge geplant mit ausreichend Zeit zur Diskussion. Folgende Vorträge sind geplant (Arbeitstitel):
Sebastian Zaunseder: Videobasierte Erfassung des Blutdrucks
Anja Hennemuth: A Visualization Toolkit for the Analysis of Aortic Anatomy and Pressure Distribution
Lars Krenkel: Numerische Analyse der Rupturwahrscheinlichkeit zerebraler Aneurysmata
Susanne Schnell: Messung des Blutflusses und hämodynamischer Parameter mit 4D flow MRI: Möglichkeiten und Herausforderungen
Ergebnisse:
Ziel des Workshops ist die Identifikation von innovativen Ansätzen und neuen Methoden zur qualitativen und quantitativen Bestimmung von hämodynamischen Parametern sowie deren kritische Bewertung durch die Community für die Eignung in der klinischen Entscheidungsunterstützung.
Diskussion:
Der Workshop leistet inhaltlich einen Beitrag zu zentralen Aspekten für die Herz-Kreislauf-Medizin. Er bringt dabei Expertise aus verschiedenen Bereichen zusammen und schlägt die Brücke zwischen Kardiologie, Medizininformatik und Medizintechnik.
Schlussfolgerung:
Innovative Technologien aus Medizintechnik und Informatik ermöglichen zunehmend einfache und raumzeitlich aufgelöste Erfassung und Bewertung wichtiger Informationen zur Unterstützung von Diagnose und Therapieverfolgung.
[1] Zaunseder S, Trumpp A, Wedekind D, Malberg H. Cardiovascular assessment by imaging photoplethysmography - a review. Biomed Tech (Berl). 2018 Oct 25;63(5):617–34.
[2] Huellebrand M, Messroghli D, Tautz L, Kuehne T, Hennemuth A. An extensible software platform for interdisciplinary cardiovascular imaging research. Comput Methods Programs Biomed. 2020 Feb;184:105277.
[3] Schmitter S, Adriany G, Waks M, Moeller S, Aristova M, Vali A, et al. Bilateral Multiband 4D Flow MRI of the Carotid Arteries at 7T. Magn Reson Med. 2020 Oct;84(4):1947–60.
[4] Birkenmaier C, and Krenkel, L. Flow in Artificial Lungs. In: New Results in Numerical and Experimental Fluid Mechanics XIII. Contributions to the 22nd STAB/DGLR Symposium. Springer; 2021.
The tightening of the emission legislation and political and social demands for sustainable mobility are forcing the automotive industry to develop complex, high precision mechatronic drive systems. The increasing precision of mechatronic components generally leads to an increase in structural excitation and thus to a rise in noise. The so-called ticking of the fuel injection system has a rather low sound pressure level compared to the residual engine noise. Nevertheless, the impulsive and high frequency noise character leads to a decline concerning the perception of comfort and sound quality. In order to identify the sound quality of fuel injection systems as a frontloading measure, a system test bench has been developed which represents the structure-borne and airborne sound radiation of the stand-alone injection system in a close to series configuration. In this paper, measures for the acoustic optimization of injection systems and their effects on the robustness of the system are discussed. The focus is on engine idling, since at this operating point the ticking of the injectors and high-pressure pump can be perceived most clearly due to the low masking effects of other noise sources. For this purpose, the injection parameters were measured during full engine operation and transferred to the system test bench. By using a special development control unit, it was possible to modify the parameters, quantify their influence on the acoustic behavior and, based on this, define NVH optimized control strategies. For the robustness evaluation of the NVH optimized control strategies, key functions of the injection system were analyzed under varying boundary conditions in system operation on an injection rate test bench.
Convolutional Neural Networks for Approximation of Internal Non-Newtonian Multiphase Flow Fields
(2021)
Neural networks (NNs) as an alternative method for universal approximation of differential equations have proven to be computationally efficient and still sufficiently accurate compared to established methods such as the finite volume method (FVM). Additionally, analysing weights and biases can give insights into the underlying physical laws. FVM and NNs are both based upon spacial discretisation. Since a Cartesian and equidistant grid is a raster graphics, image-to-image regression techniques can be used to predict phase velocity fields as well as particle and pressure distributions from simple mass flow boundary conditions. The impact of convolution layer depth and number of channels of a ConvolutionDeconvolution Regression Network (CDRN), on prediction performance of internal non-Newtownian multiphase flows is investigated. Parametric training data with 2055 sets is computed using FVM. To capture significant non-Newtownian effects of a particle-laden fluid (e.g. blood) flowing through small and non-straight channels, an Euler-Euler multiphase approach is used. The FVM results are normalized and mapped onto an equidistant grid as supervised learning target. The investigated NNs consist of n= {3, 5, 7} corresponding encoding/decoding blocks and different skip connections. Regardless of the convolution depth (i.e. number of blocks), the deepest spacial down-sampling via strided convolution is adjusted to result in a 1 × 1 × f · 2nfeature map, with f = {8, 16, 32}. The prediction performance expressed is as channel-averaged normalized root mean squared error (NRMSE). With a NRMSE of < 2 · 10-3, the best preforming NN has f = 32 initial feature maps, a kernel size of k = 4, n = 5 blocks and dense skip connections. Average inference time from this NN takes < 7 · 10-3s. Worst accuracy at NRMSE of approx 9 · 10-3is achieved without any skips, at k = 2, f = 16 and n = 3, but deployment takes only < 2 · 10-3s Given an adequate training, the prediction accuracy improves with convolution depth, where more features have higher impact on deeper NNs. Due to skip connections and batch normalisation, training is similarly efficient, regardless of the depth. This is further improved by blocks with dense connections, but at the price of a drastically larger model. Depending on geometrical complexity, spacial resolution is critical, as it increases the number of learnables and memory requirements massively.
Podcast "Irgendwas mit Logistik", Folge 82: Automatisierungstechnik richtig und fair abnehmen
(2021)
Professoren wird häufig unterstellt Theoretiker zu sein. Das haben wir zum Anlass genommen, um gemeinsam mit Stefan Galka, Professor an der OTH Regensburg, im Irgendwas mit Logistik Podcast über ein ziemlich praktisches Thema zu sprechen - Inbetriebnahmen von Automatisierungstechnik. Stefan, Jens und Thomas zäumen das Pferd von hinten auf und versuchen zu klären, wer welche Verantwortungen und (ggf. verdeckten) Interessen bei der Realisierung von technischen Gewerken hat, welche Richtlinien bei der Durchführung helfen können und definieren gemeinsam, wie die Inbetriebnahme zum Erfolg wird.
Digital twins are arousing great interest in both science and industry. There are a large number of papers that demonstrate and evaluate the potential of Digital Twins in different application areas. However, it must be noted that there is still no uniform definition of Digital Twins. This paper first examines the concept of Digital Twins and highlight how they differ in level, compared with other digital models. The focus of this paper lies in the conceptual development of a digital twin in order picking systems. The described approach in the paper aims at supporting the operational control in order picking systems. Both the architectural structure and the functions, e.g. the simulation, are described in detail. Overall, this thesis shows the benefits of Digital Twins. However, some functional extensions are still needed before the full potential can be achieved.
The minitrack contains contributions with a focus on modeling and decision making in manufacturing and logistics in the context of Industry 4.0.
Cyber-physical systems integrate the real world and the virtual world. For example, customer decisions and supply disruptions which directly influence manufacturing and logistics systems require immediate decisions in terms of planning and controlling the manufacturing and logistics systems. In order to immediately respond to these dynamics, models must have the capability to support decision making in manufacturing as well as in internal and external logistics in real-time. Two of the Mintrack papers describe concepts and models for digital twins. One paper provides an adaptive scheduling framework for solving multi-objective hybrid flow shop scheduling problems and one paper investigates matrix production systems and with their requirements and impacts on logistics planning.
Fluctuations of material properties are one reason for the occurrence of cracks and waviness in series production of car body parts. Especially fluctuating tribological conditions have an effect on the friction behavior and thus on the material flow. So far fluctuating material properties are not considered in the standard FE-simulation and consequently not in the tool design. In order to enhance the accuracy of the simulation result and thus improve the tool design regarding a robust process, the appearance of batch fluctuations has to be consistently understood. Therefore, the impact of varying lubricant quantities and roughness have been investigated. Several batches have been analyzed to identify the main influencing parameter regarding the friction behavior. Flat strip-drawing tests have been performed to determine the friction coefficient. The investigations have been performed by using material from the series production, as delivered. Since the amount of lubricant turns out to be the main influencing factor, the characteristics and appearance of the lubricant distribution has been analyzed in a further step. The analysis has shown that the distribution of the lubricant changes within one coil over the coil width and length. In addition, the time of storage has been identified as one main influencing factor on the homogeneity of the lubricant distribution over the coil width. Based on these findings, a method has been developed to map the series production conditions regarding the friction conditions in the simulation. Hence, simulations were performed using a side frame blank with different friction conditions, to investigate the impact on the forming result. The results reveal that by considering realistically existing tribological conditions, more scrap is to be expected compared to the conventional simulation. This leads to the conclusion that previous simulation results are too optimistic. Consequently, the introduced method offers the potential to optimize the tool design by considering fluctuating tribological conditions already in the process of development. Thus, it is possible to reduce scrap and increase productivity.
Degradation and release of tannic acid from an injectable tissue regeneration bead matrix in vivo
(2021)
The development of multifunctional biomaterials as both tissue regeneration and drug delivery devices is currently a major focus in biomedical research. Tannic Acid (TA), a naturally occurring plant polyphenol, displays unique medicinal abilities as an antioxidant, an antibiotic, and as an anticancer agent. TA has applications in biomaterials acting as a crosslinker in polymer hydrogels improving thermal stability and mechanical properties. We have developed injectable cell seeded collagen beads crosslinked with TA for breast reconstruction and anticancer activity following lumpectomy. This study determined the longevity of the bead implants by establishing a degradation time line and TA release profile in vivo. Beads crosslinked with 0.1% TA and 1% TA were compared to observe the differences in TA concentration on degradation and release. We found collagen/TA beads degrade at similar rates in vivo, yet are resistant to complete degradation after 16 weeks. TA is released over time in vivo through diffusion and cellular activity. Changes in mechanical properties in collagen/TA beads before implantation to after 8 weeks in vivo also indicate loss of TA over a longer period of time. Elastic moduli decreased uniformly in both 0.1% and 1% TA beads. This study establishes that collagen/TA materials can act as a drug delivery system, rapidly releasing TA within the first week following implantation. However, the beads retain TA long term allowing them to resist degradation and remain in situ acting as a cell scaffold and tissue filler. This confirms its potential use as an anticancer and minimally invasive breast reconstructive device following lumpectomy.
The prediction of structure-borne noise using numerical methods has a crucial influence during the development process of modern passenger cars. In order to minimise the dynamic forces from the chassis transferred to the body structure, multibody simulation (MBS) can be used. The link between the road surface and the chassis is established by the tyre and its own structural dynamic characteristics. Therefore, it is substantial and the main goal of the present paper to investigate the Noise, Vibration and Harshness (NVH) performance of two commercial physical tyre models available and commonly used in the market. The intention is to point out what kind of results (up-to-date) a user of these structural dynamic tyre models, namely FTire and CDtire/3D, will get with a focus on NVH. The authors strictly follow the established process of how to obtain the fitted tyre property files, as any other user of FTire and CDTire currently does. This process includes a measurement campaign of the real tyre and a subsequent fitting of the tyre property file. The fitting in this case is provided by the tyre model developers themselves, namely cosin and Fraunhofer ITWM. The tyre models are then integrated into the MBS software MSC.Adams where their performance will be assessed based on measured wheel-hub forces in the time and frequency domain up to 300 Hz.
A feasible possibility to develop planar reconfigurable mechanisms is introduced in this work. Applying the tensegrity principle to common four-bar linkages allows a controllable change between two configurations of the mechanism. These two states correspond to different working spaces which vary regarding to the kinematic and mechanical properties. Therefore, the reconfiguration of the mechanism enables two different operation modes. Hence, this kind of mechanism enables the advantageous properties of conventional linkages with an additional enhanced adaptability of the kinematic and mechanic behavior. Beside the conceptual design of such tensegrity-based mechanisms, a reconfigurable four-bar parallel linkage is considered exemplarily. Numerical simulations are evaluated focusing on the kinematic behavior and the structural mechanics of this mechanism. Especially the reconfiguration of the mechanism by changing between two different working spaces is considered. The simulation results clarify the benefit of utilizing the tensegrity principle in mechanism theory. Adding only a few members to the original linkage enables a reconfigurable mechanism with comparable complexity.
The use of alternative fuels in high-power non-road mobile machinery (NRMM) combustion engines is a possible way to substitute fossil fuel. By using pure vegetable oil fuels, like rapeseed oil fuel (DIN 51605), the greenhouse gases can be reduced effectively. Due to the differences in physical and chemical properties, a modification of the engine control unit calibration is necessary to adapt the working process on the fuel. Without modifications, the engine power output with rapeseed oil fuel is lower than with diesel fuel because of the smaller energy content. By adapting the engine settings, like the injection fuel mass, the power loss can be compensated but it accompanies with a higher fuel consumption. The engine emissions at part load conditions show, that there are benefits in particle emissions by using rapeseed oil at similar NOx emissions. Therefore, a design of experiment setup was initiated on a selected engine operation point to determine the effects of further parameters, like rail pressure, manifold pressure and injection pattern, on the process and to see the potential of an optimized calibration.
Ein interdisziplinäres Forschungsprojekt der Ostbayerischen Hochschule Regensburg untersucht, inwiefern Telemedizin und digitale Anwendungen die Therapie und Pflege von Menschen mit Schlaganfall in ihrem häuslichen Umfeld unterstützen, ihre Lebensqualität beeinflussen und die intersektorale Versorgung verbessern kann.
Blood flow in channels of varying diameters <500μm exhibits strong non-linear effects. Multiphase finite volume approaches are feasible, but still computationally costly. Here, the feasibility of applying convolutional neural networks for blood flow prediction in artificial lungs is investigated. Training targets are precomputed using an Eulerian two-phase approach. To match with experimental data, the interphase drag and lift, as well as intraphase shear-thinning are adapted. A recursively branching regression network and convolution/deconvolution networks with plain skip connections and densely connected skips are investigated. A priori knowledge is incorporated in the loss functional to prevent the network from learning non-physical solutions. Inference from neural networks is approximately six orders of magnitude faster than the classical finite volume approach. Even if resulting in comparably coarse flow fields, the neural network predictions can be used as close to convergence initial solutions greatly accelerating classical flow computations.
This work presents a novel concept to develop mobile robots enabling crawling locomotion in tubular environment. Chain-like systems are designed by serial cascading a uniform tensegrity module. Inspired by the movement of worms in nature, an undulating shape change of the system is targeted to generate locomotion. The shape changeability of an exemplary tensegrity module due to internal actuation is examined in simulations and experiments. A prototype consisting of these tensegrity modules is manufactured and the locomotion principle is verified in experiments. Comparing to existing prototypes this approach enables an enhanced compliance due to the modular assembly of tensegrity structures.
The development of new technologies like advanced driver assistance systems or automated driving requires a flexible simulation environment of sufficient complexity. In general this flexibility is not provided by commercial software packages. This paper presents a three-dimensional and nonlinear hand-made model for heavy commercial vehicles including tractor and trailer as well as tractor and semitrailer combinations that can be used in different simulation environments, as well as in real-time applications. As typical for trucks, the torsional flexibility of the frame and a suspended driver's cabin are taken into account. The design kinematics makes it possible to handle different and quite complex axle suspensions very efficiently. Appropriate force elements are used to model various couplings between tractor and trailer or tractor and semitrailer, respectively. The virtual test truck environment (VTT) coded in ANSI C is extremely portable and can easily be embedded in commercial simulation packages like MATLAB/Simulink. It includes the TMeasy tyre model and offers flexible interfaces to third-party software tools.
All known locomotion principles are limited respective to environmental conditions. Often, the occurrence of obstacles or gaps means the break-off for the operating motion systems. For such circumstances, a controllable jumping locomotion is required to cross these barriers. However, this locomotion demands sophisticated requirements to the actuation. The abrupt actuation is commonly realized by high dynamic actuators or complex mechanisms. In this work, a simple solution utilizing the multistability of a compliant tensegrity structure is described. Therefore, a two-dimensional tensegrity structure featuring four stable equilibria is considered. Based on bifurcation analyses a feasible actuation to control the current equilibrium configuration is derived. Changing between selected equilibrium states enables a great difference in potential energy, which yields a jumping motion of the structure. Based on numerical simulations a suitable actuation strategy is chosen to overcome obstacle and steps by jumping forward or backward, respectively. The theoretical approach is examined experimentally with a prototype of the multistable tensegrity structure.
(c) 2020 Elsevier Ltd. All rights reserved.
All known locomotion principles are limited respective to environmental conditions. Often, the occurrence of obstacles or gaps means the break-off for the operating motion systems. For such circumstances, a controllable jumping locomotion is required to cross these barriers. However, this locomotion demands sophisticated requirements to the actuation. The abrupt actuation is commonly realized by high dynamic actuators or complex mechanisms. In this work, a simple solution utilizing the multistability of a compliant tensegrity structure is described. Therefore, a two-dimensional tensegrity structure featuring four stable equilibria is considered. Based on bifurcation analyses a feasible actuation to control the current equilibrium configuration is derived. Changing between selected equilibrium states enables a great difference in potential energy, which yields a jumping motion of the structure. Based on numerical simulations a suitable actuation strategy is chosen to overcome obstacle and steps by jumping forward or backward, respectively. The theoretical approach is examined experimentally with a prototype of the multistable tensegrity structure.
The development of reconfigurable planar four-bar linkages by applying the tensegrity principle is considered. Conventional quadrilateral linkages enable two operation modes differing in the kinematic behavior. However, a change between these states is not possible due to the geometric constraints. To enable a reconfiguration between the different modes one-sided limited nonholonomic constraints are introduced in this work. This issue is realized by applying ropes that cannot resist compression. However, to guarantee an appropriate load case in operation a prestress within the mechanism is required. Hence, the linkage is extended to a tensegrity-based mechanism. The structural dynamics are derived using the LAGRANGE formalism and the structural behavior is evaluated using numerical simulations. Furthermore, a prototype of an exemplary tensegrity-based mechanism is manufactured and experiments regarding the mechanical properties, in particular the reconfiguration, are performed. The results suggest the potential benefit of applying the tensegrity principle within conventional planar four-bar linkages.
Abrasive wear limits the lifetime of many machine components. Most empirical models relate the abrasive wear resistance to material hardness. In reality, however, other material properties are also influencing as scratch abrasion damage follows from a highly complex stress trajectory upon scratching. Numerical (finite element) simulation of scratch abrasion requires the use of a material damage model, which translates this stress trajectory into material degradation and removal. Most damage models include the first two stress invariants. However, fully incorporating the complex stress trajectories that occur during scratch abrasion may require damage models with dependence of the third deviatoric parameter (Lode angle). This paper serves as an a-priori study to evaluate the stress states that may occur during scratch abrasion. Three mechanisms (ploughing, wedging, cutting) are considered. Hereto, the results of an extensive parametric study using elastic-plastic finite element simulations of a scratch indentation process are discussed. Complex, non-proportional variations in stress state values are observed to occur during scratch abrasion. Distinct stress state trajectories are identified for the three abovementioned mechanisms. These variations are critically discussed to motivate a selection of suitable damage models for rigorous finite element analysis of the wear processes associated with scratch abrasion.
"Topographic Shift": a new digital approach to evaluating topographic changes of the female breast
(2021)
Purpose
To assess precise topographic changes of the breast, objective documentation and evaluation of pre- and postoperative results are crucial. New technologies for mapping the body using digital, three-dimensional surface measurements have offered novel ways to numerically assess the female breast. Due to the lack of clear demarcation points of the breast contour, the selection of landmarks on the breast is highly dependent on the examiner, and, therefore, is prone to error when conducting before-after comparisons of the same breast. This study describes an alternative to volumetric measurements, focusing on topographic changes of the female breast, based on three-dimensional scans.
Method
The study was designed as an interventional prospective study of 10 female volunteers who had planned on having aesthetic breast augmentation with anatomical, textured implants. Three dimensional scans of the breasts were performed intraoperatively, first without and then with breast implants. The topographic change was determined as the mean distance between two three-dimensional layers before and after augmentation. This mean distance is defined as the Topographic Shift. Results The mean implant volume was 283 cc (SD = 68.6 cc, range = 210-395 cc). The mean Topographic Shift was 7.4 mm (SD = 1.9 mm, range = 4.8-10.7 mm). The mean Topographic Shifts per quadrant were: I: 8.0 mm (SD = 3.3 mm); II: 9.2 mm (SD = 3.1 mm); III: 6.9 mm (SD = 3.5 mm); IV: 1.9 mm (SD = 4.3 mm).
Conclusion
The Topographic Shift, describing the mean distance between two three-dimensional layers (for example before and after a volume changing therapy), is a new approach that can be used for assessing topographic changes of a body area. It was found that anatomical, textured breast implants cause a topographic change, particularly on the upper breast, in quadrant II, the decollete.
The growing efforts for the development of clean and efficient energy systems require the use of a multi-disciplinary approach and the integration of multiple generation appliances. Among the fields that can be considered enabling technologies, adsorption systems for air conditioning and thermal energy storages, are constantly increasing their maturity. However, for a proper design and integration of such systems, there is the need for a simulation framework that is reliable and computationally convenient. In the present paper, the implementation of a dynamic model for adsorption systems is presented, which includes different components (adsorber, phase changer, sorption materials) and is structured as a library. Modelica language and the commercial software Dymola (R) are used for the analysis. Data for different heat exchangers and working pairs are calibrated using experimental results and the calibrated model is subsequently used for the design of an adsorber based on a plate heat exchanger for thermal energy storage applications. The results proved that the model is fast and can reproduce experimental results with good accuracy, thus being a useful tool for the design and optimization of the different components of sorption systems.
One of the fundamental challenges in L-PBF of filigree geometries, such as aortic stents used in biomedical applications, is the requirement for a robust yet easily removable support structure that allows each component to be successfully fabricated without distortion. To solve this challenge, an integrative experimental approach was attempted in the present study by identifying an optimal support structure design and an optimized support removal strategy for this design. The specimens were manufactured using four different support structure designs based on the geometry exposed to the laser beam during the L-PBF. Support removal procedures included sand blasting (SB), glass bead blasting (GB), and electrochemical polishing (ECP). The two best-performing designs (line and cross) were chosen due to shorter lead times and lower material consumption. As an additional factor that indicates a stable design, the breaking load requirement to remove the support structures was determined. A modified line support with a 145° included angle was shown to be the best support structure design in terms of breaking load, material consumption, and manufacturing time. All three procedures were used to ensure residue-free support removal for this modified line support design, with ECP proving to be the most effective.
To reduce particulate emissions, the use of particulate filters in diesel engines is meanwhile state of the art, while the integration of such systems in gasoline engines is now also necessary in order to comply with today's regulations. Over its lifetime, a gasoline particulate filter (GPF) collects ash components of fuel, lubrication oil, and materials originating from the catalytic coating and from engine abrasion. In the development and application process, synthetic ashing from GPFs is challenging. The ash of the lubrication oil can be increased in various ways, like oil-doped fuel, a separate oil burner, or changes in the piston-cylinder system of the engine. However, these methods show major disadvantages. For this reason, an improved approach is presented in this study, which allows a quick response to changes in combustion (e.g., engine knocking) and producing ash, which is more realistic due to its primary particle size and the density of ash plugs, in a shorter time. Therefore, an approach to accelerate ash loading by active oil injection using a multi-point injection (MPI) system is introduced. With the help of this methodology, an ashing capacity of 1.21 g/h is implemented, which is a high rate compared to other investigations. The primary particle size (evaluated by means of a transmission electron microscope), is in the same size range as those detected at the full-load curve during regular operation. A computer tomographic (CT) analysis of the incinerated particulate filter also shows that a very high density of ash plugs can be realized, which has also been found in the literature for real applications. In addition, with the help of a mass spectrometer (MS) and an intermediate weighing of the particulate filter, the current ash loading of the GPF could be determined with an accuracy of 1%.
The current analyses present results of running ductile fracture propagation in high strength X100 line pipe steels under the influence of anisotropy. Mechanical anisotropy is commonly available in pipe products as a result of the manufacturing process, especially, those subjected to hot/cold-worked deformation. The outcomes of the present analyses show that its effect on the behavior of running ductile fracture in cracked pipes undergoing depressurization is meaningful. For instance, the Crack-Tip Opening Angle (CTOA) not only exhibits a strong dependence to the pipe's diameter size, but also to the material's anisotropy nature when compared to a hypothetical isotropic material. Moreover, laboratory scale tests such as those performed on Battelle Drop Weight Tear (BDWT) samples provide useful information about initiation of ductile crack propagation when the anisotropy features are taken into account in the material description.
Insulation of thermal energy storage tanks is fundamental to reduce heat losses and to achieve high energy storage efficiency. Although water tanks were extensively studied in the literature, the enhancement of the insulation quality is often overlooked. The use of vacuum insulation has the potential to significantly reduce heat losses without affecting the dimension of the storage system. This paper shows for the first time the results of the heat losses tests done for a 0.535 m3 water tank for residential building applications built with a double wall vacuum insulation. The different tests show that the rate of heat losses strictly depends on the temperature distribution inside the tank at the beginning of the experiment. Compared to a conventional water tank insulated with conventional materials, the U-value of the lateral surface was reduced by almost three times (from 1.05 W/K·m2 to 0.38 W/K·m2) using vacuum insulation. However, the bottom part, which is usually used to place the support parts and the piping, is the critical design part of those tanks acting as a thermal bridge with the ambient and enhancing heat losses.
A numerical parameter sensitivity analysis of the design parameters of the recently published solar selective thermal insulation system (SATIS) has been carried out to enhance its thermal and optical properties. It turned out that the insulation properties of SATIS can be effectively improved by reducing the length of the glass closure element. Increasing the area share of the light conducting elements (LCEs) and decreasing their length-to-diameter (L/D) ratio were identified as key parameters in order to increase the solar gain. Two SATIS variants were compared with the same wall insulation without SATIS in a yearly energetic performance assessment. The SATIS variant with 10 mm length of the closure element, 44.2% area share of LCE, as well as front and rear diameters of 12 mm/9 mm shows an 11.8% lower transmission heat loss over the heating period than the wall insulation without SATIS. A new methodology was developed to enable the implementation of the computed solar gains of SATIS in 1D simulation tools. The result is a radiant heat flow map for integration as a heat source in 1D simulation models. A comparison between the 1D and 3D models of the inside wall heat fluxes showed an integral yearly agreement of 98%.
A newly-developed solar active thermal insulation system (SATIS) is introduced with the main objective to accomplish a highly-dependent total solar transmittance on the irradiation angle. SATIS is also designed to obtain the maximum transmittance at a prescribed design irradiation angle and to reduce it remarkably at higher irradiation angles. A purely mineral thermal insulation plaster with micro hollow glass spheres is applied to manufacture the investigated SATIS prototype. Light-conducting elements (LCEs) have been introduced into SATIS and suitable closing elements have been applied. The SATIS prototype has been investigated both experimentally and numerically. It turned out that the contributions of conduction, radiation and convection to the effective thermal conductivity of SATIS, without the closing elements (49 mWmK), amount to 86.2%, 13.2% and 0.6%, respectively. The angle-dependent short-wave radiation exchange within the LCE has been investigated via ray tracing. At the incidence angle of 19% (design angle), 27% of the radiation within the LCE is absorbed by the absorber plate, resulting in measured and computed total solar energy transmittances of 11.2%/11.7%, respectively. For a typical summer irradiation angle of 60%, 98% of the incident radiation is absorbed by the surfaces at the entrance of the LCE. The corresponding total solar energy transmittance amounts to 2.9%.
What commonalities are there in sustainable or unsustainable heating practices in five high-income, high-emitting western European countries? What preferences do a nationally representative sample of the public in these countries hold towards low-carbon options? It is imperative that climate policy researchers and practitioners grapple with the difficulty of decarbonizing heat, which remains the largest single end-use service worldwide and which accounts about half of total final energy consumption. Based on a comparative assessment of five representative national surveys in Germany (N = 2009), Italy (N = 2039), Spain (N = 2038), Sweden (N = 2023), and the United Kingdom (N = 2000), this study explores the demographics and geography of household heat decarbonisation in Europe. By analyzing our country level data as well as our combined sample of 10,109 respondents, it investigates how people conceive of the purposes of low-carbon heat, their preferences for particular forms of heat supply, and their (at times odd) practices of heat consumption and temperature settings. Grounded in its original data, the study organizes its findings inductively across the five themes of literacy (heating knowledge, awareness and control), sustainability (heating practices, dynamics and conflicts), temperature (heating satisfaction and preferences), desirability of change (low-carbon heating priorities, business models and trust), and culture (country and national variation). The study also explores intersections between these dimensions, using multivariate analysis, as well as how preferences differ according to varying types of actors as well as geography and space.
The present work aims at the thermodynamic analysis of different working pairs in adsorption heat transformers (AdHT) for low-temperature waste heat upgrade in industrial processes. Two different AdHT configurations have been simulated, namely with and without heat recovery between the adsorbent beds. Ten working pairs, employing different adsorbent materials and four different refrigerants, have been compared at varying working boundary conditions. The effects of heat recovery and the presence of a temperature gradient for heat transfer between sinks/sources and the AdHT components have been analyzed. The achieved results demonstrate the possibility of increasing the overall performance when internal heat recovery is implemented. They also highlight the relevant role played by the existing temperature gradient between heat transfer fluids and components, that strongly affect the real operating cycle of the AdHT and thus its expected performance. Both extremely low, i.e., 40-50 degrees C, and low (i.e., 80 degrees C) waste heat source temperatures were investigated at variable ambient temperatures, evaluating the achievable COP and specific energy. The main results demonstrate that optimal performance can be achieved when 40-50 K of temperature difference between waste heat source and ambient temperature are guaranteed. Furthermore, composite sorbents demonstrated to be the most promising adsorbent materials for this application, given their high sorption capacity compared to pure adsorbents, which is reflected in much higher achievable specific energy.
The use of non-conventional materials is nowadays of much interest in scientific community. Magneto-rheological elastomers are hybrid materials, which in presence of magnetic fields state a change in their mechanical properties. They are composed by an elastomeric matrix with embedded magnetic particles. One of the most attractive features of these materials is that as soon as the magnetic field is removed from the material, the original mechanical properties are completely recovered, with negligible differences in comparison to the original state. This paper focuses on the study of magnetic characteristics of these smart materials, such as relative permeability and demagnetizing factors, for samples with different volume concentration of ferromagnetic particles.
This work aims at investigating the reduction/oxidation (redox) reaction kinetics on iron oxide pellets under different operating conditions of thermochemical hydrogen storage. In order to reduce the iron oxide pellets (90% Fe2O3, 10% stabilizing cement), hydrogen (H2) is applied in different concentrations with nitrogen (N2), as a carrier gas, at temperatures between between 700 ∘C and 900 ∘C, thus simulating the charging phase. The discharge phase is triggered by the flow of a mixture out of steam (H2O) and N2 at different concentrations in the same temperature range, resulting in the oxidizing of the previously reduced pellets. All investigations were carried out in a thermo-gravimetric analyzer (TGA) with a flow rate of 250mL/min. To describe the obtained kinetic results, a simplified analytical model, based on the linear driving force model, was developed. The investigated iron oxide pellets showed a stable redox performance of 23.8% weight reduction/gain, which corresponds to a volumetric storage density of 2.8kWh/(L bulk), also after the 29 performed redox cycles. Recalling that there is no H2 stored during the storage phase but iron, the introduced hydrogen storage technology is deemed very promising for applications in urban areas as day-night or seasonal storage for green hydrogen.
Simulationsbasierte Untersuchung der Grenzproduktivität von Robotern in einem AutoStore-Lagersystem
(2021)
Axles with leaf spring suspension systems are still a popular choice in many commercial vehicles. However, leaf springs are not in perfect conformity to standard multibody vehicle models because they combine guidance and suspension in one single element. Combining standard multibody vehicle models with sophisticated finite element leaf spring models results in rather complex and computing time-consuming solutions. Purely kinematic models, defined by lookup tables or the design kinematics approach, cover only some but not all features of the leaf spring suspension. As shown here, the five-link model, which incorporates a quasi-static solution of the leaf spring compliance, provides a very practical model. It is comparatively lean and provides results of sufficient accuracy in the whole application range.
In this work, a tensegrity structure with spatially curved members is applied as rolling locomotion system. The actuation of the structure allows a variation of the originally cylindrical shape to a conical shape. Moreover, the structure is equipped with internal movable masses to control the position of the center of mass of the structure. To control the locomotion system a reliable actuation strategy is required. Therefore, the kinematics of the system considering the nonholonomic constraints are derived in this paper. Based on the resulting insight in the locomotion behavior a feasible actuation strategy is designed to control the trajectory of the system. To verify this approach kinematic analyses are evaluated numerically. The simulation data confirm the path following due to an appropriate shape change of the tensegrity structure. Thus, this system enables a two-dimensional rolling locomotion.
Ergonomic workplaces lead to fewer work-related musculoskeletal disorders and thus fewer sick days. There are various guidelines to help avoid harmful situations. However, these recommendations are often rather crude and often neglect the complex interaction of biomechanical loading and psychological stress. This study investigates whether machine learning algorithms can be used to predict mechanical and stress-related muscle activity for a standardized motion. For this purpose, experimental data were collected for trunk movement with and without additional psychological stress. Two different algorithms (XGBoost and TensorFlow) were used to model the experimental data. XGBoost in particular predicted the results very well. By combining it with musculoskeletal models, the method shown here can be used for workplace analysis but also for the development of real-time feedback systems in real workplace environments.
Results of WICOVIR Gargle Pool PCR Testing in German Schools Based on the First 100,000 Tests
(2021)
Background:
Opening schools and keeping children safe from SARS-CoV-2 infections at the same time is urgently needed to protect children from direct and indirect consequences of the COVID-19 pandemic. To achieve this goal, a safe, efficient, and cost-effective SARS-CoV-2 testing system for schools in addition to standard hygiene measures is necessary.
Methods:
We implemented the screening WICOVIR concept for schools in the southeast of Germany, which is based on gargling at home, pooling of samples in schools, and assessment of SARS-CoV-2 by pool rRT-PCR, performed decentralized in numerous participating laboratories. Depooling was performed if pools were positive, and results were transmitted with software specifically developed for the project within a day. Here, we report the results after the first 13 weeks in the project.
Findings:
We developed and implemented the proof-of-concept test system within a pilot phase of 7 weeks based on almost 17,000 participants. After 6 weeks in the main phase of the project, we performed >100,000 tests in total, analyzed in 7,896 pools, identifying 19 cases in >100 participating schools. On average, positive children showed an individual CT value of 31 when identified in the pools. Up to 30 samples were pooled (mean 13) in general, based on school classes and attached school staff. All three participating laboratories detected positive samples reliably with their previously established rRT-PCR standard protocols. When self-administered antigen tests were performed concomitantly in positive cases, only one of these eight tests was positive, and when antigen tests performed after positive pool rRT-PCR results were already known were included, 3 out of 11 truly positive tests were also identified by antigen testing. After 3 weeks of repetitive WICOVIR testing twice weekly, the detection rate of positive children in that cohort decreased significantly from 0.042 to 0.012 (p = 0.008).
Interpretation:
Repeated gargle pool rRT-PCR testing can be implemented quickly in schools. It is an effective, valid, and well-received test system for schools, superior to antigen tests in sensitivity, acceptance, and costs.
Biomechanical Analysis of the Right Elevated Glenohumeral Joint in Violinists during Legato-Playing
(2021)
BACKGROUND:
Many statistics reveal that violin players suffer most often from musculoskeletal disorders compared to musicians of other instrument groups. A common phenomenon, especially observed in violin beginners, is the tendency to elevate the right shoulder during playing the violin. This can probably lead to serious disorders in long-term practice with repetitive movements.
OBJECTIVE:
For this reason, this study investigated the relationship between the right shoulder elevation and the force in the right glenohumeral joint during violin playing. It was hypothesized that the forces in the right glenohumeral joint are higher during playing with the right shoulder raised compared to playing in normal posture.
METHODS:
Motion capture data from four experienced violinists was recorded and processed by means of musculoskeletal simulation to get the force and elevation angle while playing with raised shoulder and in normal position.
RESULTS:
The results indicate that the absolute values of the resulting force, as well as the forces in the mediolateral, inferosuperior, and anteroposterior directions, are higher in playing the violin with the shoulder raised than in a normal posture.
CONCLUSIONS: Elevating the right shoulder while playing the violin may pose a potential problem.
Regarding the prevention of injuries and rehabilitation of the human hand, musculoskeletal simulations using an inverse dynamics approach allow for insights of the muscle recruitment and thus acting forces on the hand. Currently, several hand models from various research groups are in use, which are mainly validated by the comparison of numerical and anatomical moment arms. In contrast to this validation and model-building technique by cadaver studies, the aim of this study is to further validate a recently published hand model [1] by analyzing numerically calculated muscle activities in comparison to experimentally measured electromyographical signals of the muscles. Therefore, the electromyographical signals of 10 hand muscles of five test subjects performing seven different hand movements were measured. The kinematics of these tasks were used as input for the hand model, and the numerical muscle activities were computed. To analyze the relationship between simulated and measured activities, the time difference of the muscle on- and off-set points was calculated, which resulted in a mean on- and off-set time difference of 0.58 s between the experimental data and the model. The largest differences were detected for movements that mainly addressed the wrist. One major issue comparing simulated and measured muscle activities of the hand is cross-talk. Nevertheless, the results show that the hand model fits the experiment quite accurately despite some limitations and is a further step toward patient-specific modeling of the upper extremity.
Musculoskeletal lower back load of accoucheurs during childbirth – A pilot and feasibility study
(2021)
Introduction: Back problems represent one of the leading causes of accouchers' work-related musculoskeletal morbidities. The correct execution of birth-related maneuvers including manual perineal protection is crucial not only for the mother and child but also for obstetricians and midwives to reduce any strain on their musculoskeletal system. Therefore, the overall aim of this study was to test the feasibility of determining the effect of different accouchers' postures (standing and kneeling) on their musculoskeletal system.
Methods: The biomechanical analysis is based on musculoskeletal simulations that included motion recordings of real deliveries as well as deliveries conducted on a birthing simulator. These simulations were then used to determine individual joints' loads.
Results: In the kneeling posture, both a low intra-operator variability and a lower average maximum load of the lower back was observed. For the standing position the spine load was reduced by pivoting the elbow on the accouchers' thigh, which in turn was associated with a significantly greater load on the shoulder joint.
Conclusion: The study demonstrated the feasibility of our technique to assess joints loads. It also provided initial data indicating that a posture that reduces spinal flexion and tilt, achieved in this study by the kneeling, can significantly reduce the strain on the practitioner's musculoskeletal system.
With the progress in modern medicine, it was possible to significantly reduce the risks of birth for mother and child. One aspect that has received less attention so far is the risk of injury to the accoucheurs (obstetricians and midwives) during the birth process. Indeed, studies indicate that 92% of midwives suffer from musculoskeletal disorders, with the lower back being the main cause of complaints (72%). The aim of this study was to investigate two commonly used postural techniques used by accoucheurs during childbirth and to analyze the resulting load on the lower back using the AnyBodyTM musculoskeletal simulation software.
Evaluation of muscle recruitment and muscle models in musculoskeletal simulation of dynamic motion
(2021)
Musculoskeletal simulation plays an increasingly important role in sports biomechanics. In the last years, the field of application widened from orthopaedics and ergonomics to sports [1]. A muscle recruitment algorithm with a quadratic objective function is usually used to calculate muscle activity in dynamic movements. The agreement of calculated and measured thigh muscle activity has already been investigated [2]. They found a strong agreement for sprinting and running, while the correlation decreased for side-cutting manoeuvres. Nevertheless, the influence of different muscle recruitment criteria on muscle activity in dynamic musculoskeletal simulations is currently unknown. Hence, this study aimed to analyse the effect of different muscle recruitment criteria and muscle models on the correlation of numerical and measured muscle activity in highly dynamic movements.
Outputs of musculoskeletal models should be considered probabilistic rather than deterministic as they are affected by inaccuracies and estimations associated with the development of the model. One of these uncertainties being critical for modeling arises from the determination of the muscles' line of action and the physiological cross-sectional area. Therefore, the aim of this study was to evaluate the outcome sensitivity of model predictions from a musculoskeletal hand model in comparison to the uncertainty of these input parameters. For this purpose, the kinematics and muscle activities of different hand movements (abduction of the fingers, abduction of the thumb, and flexion of the thumb) were recorded. One thousand simulations were calculated for each movement using the Latin hypercube sampling method with a corresponding variation of the muscle origin/insertion points and the cross-sectional area. Comparing the standard hand to simulations incorporating uncertainties of input parameters shows no major deviations in on- and off-set time point of muscle activities. About 60% of simulations are located within a ± 30% interval around the standard model concerning joint reaction forces. The comparison with the variation of the input data leads to the conclusion that the standard hand model is able to provide not over-scattered outcomes and, therefore, can be considered relatively stable. These results are of practical importance to the personalization of a musculoskeletal model with subject-specific bone geometries and hence changed muscle line of action.
Static pelvic tilt impacts functional cup position in total hip arthroplasty (THA). In the current study we investigated the effect of kinematic pelvic changes on cup position. In the course of a prospective controlled trial postoperative 3D-computed tomography (CT) and gait analysis before and 6 and 12 months after THA were obtained in 60 patients. Kinematic pelvic motion during gait was measured using Anybody Modeling System. By fusion with 3D-CT, the impact of kinematic pelvic tilt alterations on cup anteversion and inclination was calculated. Furthermore, risk factors correlating with high pelvic mobility were evaluated. During gait a high pelvic range of motion up to 15.6° exceeding 5° in 61.7% (37/60) of patients before THA was found. After surgery, the pelvis tilted posteriorly by a mean of 4.0 ± 6.6° (p < .001). The pelvic anteflexion led to a mean decrease of −1.9 ± 2.2° (p < .001) for cup inclination and −15.1 ± 6.1° (p < .001) for anteversion in relation to the anterior pelvic plane (APP). Kinematic pelvic changes resulted in a further change up to 2.3° for inclination and up to 12.3° for anteversion. In relation to the preoperative situation differences in postoperative cup position ranged from −4.4 to 4.6° for inclination and from −7.8 to 17.9° for anteversion, respectively. Female sex (p < .001) and normal body weight (p < .001) correlated with high alterations in pelvic tilt. Kinematic pelvic changes highly impact cup anteversion in THA. Surgeons using the APP as reference should aim for a higher anteversion of about 15° due to the functional anteflexion of the pelvis during gait.
Embodiment theories have proposed a reciprocal relationship between emotional state and bodily reactions. Besides large body postures, recent studies have found emotions to affect rather subtle bodily expressions, such as slumped or upright sitting posture. This study investigated back muscle activity as an indication of an effect of positive and negative emotions on the sitting position. The electromyography (EMG) activity of six back muscles was recorded in 31 healthy subjects during exposure to positive and negative affective pictures. A resting period was used as a control condition. Increased muscle activity patterns in the back were found during the exposure to negative emotional stimuli, which was mainly measured in the lumbar and thorax regions. The positive emotion condition caused no elevated activity. The findings show that negative emotions lead to increased differential muscle activity in the back and thus corroborate those of previous research that emotion affects subtle bodily expressions.
Application of a Krylov subspace method for an efficient solution of acoustic transfer functions
(2021)
Solving acoustic radiation problems, arising from systems including fluid–structure interaction, is of interest in many engineering applications. Computing frequency response functions over a large frequency range is a concern in such applications. A method which solves the Helmholtz equation for multiple frequencies in one step is the matrix-Padé-via-Lanczos connection for unsymmetric systems, as presented by Wagner et al. [1]. The present work is based on Ref. [1] and presents a method for efficiently computing frequency responses over a frequency range for coupled structural-acoustic problems, where the structure and the acoustic near field are discretized with finite elements and an analytical Dirichlet-to-Neumann map approximates the far field. The method is based on a Krylov-subspace projection technique which derives a matrix-valued Padé approximation for a restricted area in the near field and the pressure field on a spherical boundary. On the spherical boundary, where the finite domain is truncated, the non-local modified Dirichlet-to-Neumann operator is applied as a low-rank update matrix. The present contribution extends this method and incorporates new techniques for a more stable model reduction through the Lanczos algorithm and a novel weighted adaptive windowing technique. Further, structural damping is incorporated, for computing the acoustic radiation of a harmonically excited plate. These computed results are compared with acoustic measurements in an anechoic chamber and verified with computational results obtained with a commercial code that uses the perfectly matched layer method.
Production of optical and medical devices makes high demands on cleanliness, precision, visual appearance and reliability. Advantages of laser transmission welding – contactless input of energy, high precision, no adhesives and no particle formation – can be fully exploited for this use. For absorber-free welding, lasers emitting in the polymers’ intrinsic absorption spectrum between 1.6 μm and 2 μm are used. Focusing the laser beam with high NA provides large intensity gradients inside the specimen and enables selective fusing of the joining zone without affecting the surface. Since a molten upper surface leads to visible and palpable irregularities and causes warpage, the verticalexpansion of the weld seam is crucial. To meet the high quality and reliability required in the medical and optical industry, online monitoring of the seam is necessary. The aim of this work is the localization and evaluation of the weld seam using pyrometry. First, the emitted thermal radiation is computed, enabling signal analysis regarding origin and spectrum. Thus, assessment of measurement spectrum and forecast of the signal in dependence on seam shape and position is possible. Finally, welding tests with Topas 8007-04 are performed at 200 mm/s feed rate and monitored with 100 kHz. The comparison of tracked data with thin-cuts demonstrates that weld seam localization by pyrometry is possible, enabling online assessment of the process.
Längst gibt es altersgerechte digitale Assistenzsysteme. Doch sind Umfang und Geschwindigkeit ihrer Verbreitung sowohl in Pflegeeinrichtungen als auch in privaten Haushalten weitgehend unbekannt. Informationen zu tatsächlich eingesetzten Systemen, realisierten Umsätzen und Marktvolumen sind kaum zu finden. Obwohl es viele Vermutungen hinsichtlich der Hindernisse bei der Einführung altersgerechter Assistenzsysteme gibt, sind auch hier verlässliche Aussagen rar. Die Beiträge des Bandes liefern auf Basis empirischer Untersuchungen und theoretischer Überlegungen Antworten und zeigen auf, wie vielgestaltig die Faktoren sind, die die Diffusion altersgerechter Assistenzsysteme hemmen oder fördern.