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Patients with age-related macular degeneration (AMD) or hereditary macular dystrophies (JMD) rely on an efficient use of their peripheral visual field. We trained eight AMD and five JMD patients to perform a texture-discrimination task (TDT) at their preferred retinal locus (PRL) used for fixation. Six training sessions of approximately one hour duration were conducted over a period of approximately 3 weeks. Before, during and after training twelve patients and twelve age-matched controls (the data from two controls had to be discarded later) took part in three functional magnetic resonance imaging (fMRI) sessions to assess training-related changes in the BOLD response in early visual cortex. Patients benefited from the training measurements as indexed by significant decrease (p = 0.001) in the stimulus onset asynchrony (SOA) between the presentation of the texture target on background and the visual mask, and in a significant location specific effect of the PRL with respect to hit rate (p = 0.014). The following trends were observed: (i) improvement in Vernier acuity for an eccentric line-bisection task; (ii) positive correlation between the development of BOLD signals in early visual cortex and initial fixation stability (r = 0.531); (iii) positive correlation between the increase in task performance and initial fixation stability (r = 0.730). The first two trends were non-significant, whereas the third trend was significant at p = 0.014, Bonferroni corrected. Consequently, our exploratory study suggests that training on the TDT can enhance eccentric vision in patients with central vision loss. This enhancement is accompanied by a modest alteration in the BOLD response in early visual cortex.
Hereditary and age-related forms of macular dystrophy (MD) are characterized by loss of cone function in the fovea, leading to central scotomata and eccentric fixation at the so-called preferred retinal locus (PRL). We investigated whether perceptual learning enhances visual abilities at the PRL. We also determined the neural correlates (3-Tesla fMRI) of learning success. Twelve MD patients (eight with age-related macular dystrophy, four with hereditary macular dystrophies) were trained on a texture discrimination task (TDT) over six days. Patients underwent three fMRI sessions (before, during and after training) while performing the TDT (target at PRL or opposite PRL). Reading speed, visual acuity (Vernier task) and contrast sensitivity were also assessed before and after training. With one exception, all patients showed improved performance (i.e. significant decrease in stimulus onset asynchronies and reaction times, significant increase in hit rates) on the TDT. Eight patients also showed moderate increases in reading speed, six patients showed improved thresholds in contrast sensitivity and nine patients showed improved thresholds in a vernier visual acuity task after TDT training. We found an increase in BOLD response in the projections zone of the PRL in the primary visual cortex in nine of twelve patients after training. The change in fMRI signal correlated (r = .8; p = .02) with the patients’ performance enhancements when the target was in the PRL. The results suggest that perceptual learning can enhance eccentric vision and cortical processing in MD patients.
Hereditary and age-related forms of macular dystrophy (MD) are characterized by loss of cone function in the fovea, leading to central scotomata and eccentric fixation at the so-called preferred retinal locus (PRL). We investigated whether perceptual learning enhances visual abilities at the PRL. We also determined the neural correlates (3-Tesla fMRI) of learning success. Twelve MD patients (eight with age-related macular dystrophy, four with hereditary macular dystrophies) were trained on a texture discrimination task (TDT) over six days. Patients underwent three fMRI sessions (before, during and after training) while performing the TDT (target at PRL or opposite PRL). Reading speed, visual acuity (Vernier task) and contrast sensitivity were also assessed before and after training. With one exception, all patients showed improved performance (i.e. significant decrease in stimulus onset asynchronies and reaction times, significant increase in hit rates) on the TDT. Eight patients also showed moderate increases in reading speed, six patients showed improved thresholds in contrast sensitivity and nine patients showed improved thresholds in a vernier visual acuity task after TDT training. We found an increase in BOLD response in the projections zone of the PRL in the primary visual cortex in nine of twelve patients after training. The change in fMRI signal correlated (r = .8; p = .02) with the patients’ performance enhancements when the target was in the PRL. The results suggest that perceptual learning can enhance eccentric vision and cortical processing in MD patients.
We investigated the role of informative feedback on the neural correlates of perceptual learning in a coherent-motion detection paradigm. Stimulus displays consisted of four patches of moving dots briefly (500 ms) presented simultaneously, one patch in each visual quadrant. The coherence level was varied in the target patch from near threshold to high, while the other three patches contained only noise. The participants judged whether coherent motion was present or absent in the target patch. To guarantee central fixation, a secondary RSVP digit-detection task was performed at fixation. Over six training sessions subjects learned to detect coherent motion in a predefined quadrant (i.e., the learned location). Half of our subjects were randomly assigned to the feedback group, where they received informative feedback after each response during training, whereas the other group received non-informative feedback during training that a response button was pressed. We investigated whether the presence of informative feedback during training had an influence on the learning success and on the resulting BOLD response. Behavioral data of 24 subjects showed improved performance with increasing practice. Informative feedback promoted learning for motion displays with high coherence levels, whereas it had little effect on learning for displays with near-threshold coherence levels. Learning enhanced fMRI responses in early visual cortex and motion-sensitive area MT+ and these changes were most pronounced for high coherence levels. Activation in the insular and cingulate cortex was mainly influenced by coherence level and trained location. We conclude that feedback modulates behavioral performance and, to a lesser extent, brain activation in areas responsible for monitoring perceptual learning.
Entwicklung eines Experimentalsystems zur Validierung adaptiver Regelungen mit einem OEM-Steuergerät
(2014)
Im Rahmen des Kooperationsprojektes "ACES" (Integrated Adaption of Linear Controllers for Embedded Systems) ist ein Prüfstand zur Validierung adaptiver Regelungen entwickelt und aufgebaut worden, der das dynamische Verhalten eines Kfz-Antriebstrangs aufweist. Ziel ist es, verschiedene Adaptionsverfahren auf ihre Einsetzbarkeit in OEM-Steuergeräten, die im Automotive-Bereich auf breiter Basis verwendet werden, kostengünstig testen zu können. Das Problem der aktiven Schwingungsdämpfung in Kfz-Antriebssträngen mit unbekannten und veränderlichen mechanischen Parametern stellt eine Pilotanwendung dar. Ein leicht anpassbarer mechanischer Prüfstand dient hierbei als vereinfachtes Modell eines Antriebstrangs. Dieser ist Bestandteil eitles Experimentalsystems mit einer informationstechnischen Architektur, die einen Betrieb engebetteter Regelungssysteme auf verschiedenen Plattformen gestattet. Das flexible mechanische und informationstechnische Design des Experimentalsystems gestattet die Variation von Parametern der zu regelnden Applikation durch leicht austauschbare mechanische Komponenten und gezielte Einbringung von Störgrößen. Zudem kann die Berechnung der Regelungsarchitektur auf einem Industrie-PC oder einem Steuergerät erfolgen. Weitere Vorteile des entwickelten Experimentalsystems sind die Berücksichtigung von Effekten, die aus dem Verhalten realer Sensoren und der CAN-basierten Signalübertragung entstehen. Insbesondere der Einfluss von Wortbreite und Latenz übertragener Signale auf die Adaption von Regelungen kann mit Hilfe des vorgestellten Experimentalsystems eingehend untersucht werden.
Bei Ottomotoren mit Direkteinspritzung besteht beim Kaltstart, den Warmlaufphasen und auch durch den Einfluss anderer Parameter wie z. B. des Einspritzzeitpunkts oder des Einspritzdrucks die Problematik, dass Kraftstoff an die Zylinderlaufbahn aufgetragen wird und sich mit dem Motoröl vermischen kann. Eine Verstärkung dieses Kraftstoffauftrags ist unter anderem der Verschiebung der Motorbetriebspunkte zu höheren Mitteldrücken und damit einem Wirkungsgrad optimaleren Betrieb geschuldet. Eine Veränderung der physikalischen und chemischen Eigenschaften des Motoröls durch die Verdünnung mit Kraftstoff ist die Folge. Durch die Verringerung der Viskosität des Motoröls kann es zu einer verminderten Schmierwirkung des Öls kommen, die im schlimmsten Fall zur Schädigung des Motors führt. Existierende Offline-Analysemethoden die zeitintensive Laboranalysen nach sich ziehen, als auch Online-Messverfahren die nicht den technischen Anforderungen hinsichtlich Genauigkeit und einer kurzen Messdauer entsprechen, stellen aktuell die einzigen Messmethoden zur Bestimmung der Schmierölverdünnung dar. Durch neue Entwicklungstrends bei Ottomotoren ist es jedoch unbedingt notwendig, die Mechanismen des Kraftstoffein- und -austrags in das und aus dem Motoröl genauer zu untersuchen. Mit der an der OTH Regensburg neu entwickelten Messtechnik wurde eine Vorgehensweise erarbeitet, mit der die zeitlichen Verläufe des Kraftstoffein- und -austragsverhaltens bei Ottomotoren quantitativ in kurzer Zeit bestimmt und optimiert werden können.
Especially at cold start and the warm-up operation GDI engines have an issue with oil dilution. Parameters such as injection timing and injection pressure impact the entry of fuel in the engine oil as well. With the adjustment of engine operating points to higher mean effective pressures resulting in downsizing concepts also an additional increase of fuel entry occurs. Fuel gets into the oil pan and is mixed with the engine oil so that the physical and chemical properties of the engine oil are changed. With the reduction of engine oil viscosity due to fuel entry a reduced lubricating effect can be caused. In the worst case damage to the engine occurs, To determine oil dilution online and offline measurement methods exist. A rather long analysis time in the laboratory is a disadvantage of the offline methods. Online methods are not correlating with technical requirements in terms of accuracy and a short measurement time. New trends in the development of gasoline engines require investigations of fuel in oil sorption and desorption processes. A new measurement technique which is developed at the OTH Regensburg enables to determine quantitative fuel in oil sorption and desorption processes. With this technique a procedure was generated to measure the oil dilution at gasoline engines and optimize them in a short time.
Qualification and modification of new polymer powders for laser beam melting using Ulbricht spheres
(2014)
The restricted amount of available materials for Laser Beam Melting (LBM) of polymers is one of the main limitations for expanding the technology. Current qualification methods deal with problems like inadequate powder flowability or high part porosities among others but do not offer a detailed analysis of the important beam-matter-interaction between powder particles and electro-magnetic laser radiation. In this paper, polyethylene powder is qualified for the LBM process and specifically analyzed regarding the optical material properties of the powder for a wavelength of 10.6 μm. By admixing graphite as absorption intensifier the change of the optical material properties and the thereby connected processing parameters are analyzed. Furthermore an explanation approach is given to explain the relation between different transmittances of different powder particles and the optical material properties of the polymer powders.
By simultaneous laser beam melting (SLBM), different polymer powders can be processed to multi-material parts, which offers the potential to enlarge the field of application for conventional LBM. In a SLBM process, a powder bed consisting of different polymers and therefore with different melting and crystallization temperatures is deposited. Besides the use of infrared emitters for preheating the lower melting polymer, a CO2 laser distributes the necessary preheating temperature of the higher melting polymer. In the last step, a thulium fibre laser distributes the energy necessary for melting the two preheated powders simultaneously. In order to analyze the temperature gradients of the process on the powder surface and in deeper layers, a high-resolution thermal imaging system and thermocouples are used.
By using Additive Manufacturing technologies, like Laser Beam Melting (LBM) of polymers, parts can be realized within single days and necessary modifications can be quickly adapted. With increasing complexity, products are often made out of different polymer materials and the need for multi-material parts is an increasing industry requirement, which cannot be fulfilled by the single material parts realizable by LBM. Therefore, Simultaneous Laser Beam Melting (SLBM) as a new Additive Manufacturing technology offers the possibility to build parts consisting of different polymer materials. The realizable parts combine different material properties, like differing stiffness or chemical resistances, within a single part. Up to now, different materials are deposited next to each other on the building platform, thus the boundary surface between the different polymers is orientated perpendicular to the building direction. For this paper, the polymer powders are alternated in building direction. Thus, the boundary surface is orientated horizontally and is larger, both influencing the boundary surface and resulting part properties, which are analyzed by a high-resolution thermal imaging system and by cross sections.