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In 2015 we began a sub-challenge at the EndoVis workshop at MICCAI in Munich using endoscope images of exvivo tissue with automatically generated annotations from robot forward kinematics and instrument CAD models. However, the limited background variation and simple motion rendered the dataset uninformative in learning about which techniques would be suitable for segmentation in real surgery. In 2017, at the same workshop in Quebec we introduced the robotic instrument segmentation dataset with 10 teams participating in the challenge to perform binary, articulating parts and type segmentation of da Vinci instruments. This challenge included realistic instrument motion and more complex porcine tissue as background and was widely addressed with modfications on U-Nets and other popular CNN architectures [1].
In 2018 we added to the complexity by introducing a set of anatomical objects and medical devices to the segmented classes. To avoid over-complicating the challenge, we continued with porcine data which is dramatically simpler than human tissue due to the lack of fatty tissue occluding many organs.
In a variety of tomographic applications, data cannot be fully acquired, leading to severely underdetermined image reconstruction. Conventional methods result in reconstructions with significant artifacts. In order to remove these artifacts, regularization methods have to be applied that incorporate additional information. An important example is TV reconstruction which is well known to efficiently compensate for missing data and well reduces reconstruction artifacts. At the same time, however, tomographic data is also contaminated by noise, which poses an additional challenge. The use of a single regularizer within a variational regularization framework must therefore account for both the missing data and the noise. However, a single regularizer may not be ideal for both tasks. For example, the TV regularizer is a poor choice for noise reduction over different scales, in which case ℓ1 curvelet regularization methods work well. To address this issue, in this paper we introduce a novel variational regularization framework that combines the advantages of two different regularizers. The basic idea of our framework is to perform reconstruction in two stages, where the first stage mainly aims at accurate reconstruction in the presence of noise, and the second stage aims at artifact reduction. Both reconstruction stages are connected by a data proximity condition. The proposed method is implemented and tested for limited-view CT using a combined curvelet-TV approach. We define and implement a curvelet transform adapted to the limited view problem and demonstrate the advantages of our approach in a series of numerical experiments in this context.
Trace gas analysis in breath is challenging due to the vast number of different components. We present a highly sensitive quantum cascade laser based photoacoustic setup for breath analysis. Scanning the range between 8260 and 8270 nm with a spectral resolution of 48 pm, we are able to quantify acetone and ethanol within a typical breath matrix containing water and CO2. We photoacoustically acquired spectra within this region of mid-infra-red light and prove that those spectra do not suffer from non-spectral interferences. The purely additive behavior of a breath sample spectrum was verified by comparing it with the independently acquired single component spectra using Pearson and Spearman correlation coefficients. A previously presented simulation approach is improved and an error attribution study is presented. With a 3σ detection limit of 6.5 ppbV in terms of ethanol and 250 pptV regarding acetone, our system is among the best performing presented so far.
We present a paradigm for characterization of artifacts in limited data tomography problems. In particular, we use this paradigm to characterize artifacts that are generated in reconstructions from limited angle data with generalized Radon transforms and general filtered backprojection type operators. In order to find when visible singularities are imaged, we calculate the symbol of our reconstruction operator as a pseudodifferential operator.
Friction has long been an important issue in multibody dynamics. Static friction models apply appropriate regularization techniques to convert the stick inequality and the non-smooth stick-slip transition of Coulomb’s approach into a continuous and smooth function of the sliding velocity. However, a regularized friction force is not able to maintain long-term stick. That is why, dynamic friction models were developed in the last decades. The friction force depends herein not
only on the sliding velocity but also on internal states. The probably best known representative, the LuGre friction model, is based on a fictitious bristle but realizes a too simple approximation. The recently published second order dynamic friction model describes the dynamics of a fictitious bristle more accurately. Its performance is compared here to stick-slip friction models, developed and launched not long ago by commercial multibody software packages.
With an atmospheric concentration of approximately 2000 parts per billion (ppbV, 10−9) methane (CH4) is the second most abundant greenhouse gas (GHG) in the atmosphere after carbon dioxide (CO2). The task of long-term and spatially resolved GHG monitoring to verify whether climate policy actions are effective, is becoming more crucial as climate change progresses. In this paper we report the CH4 concentration readings of our photoacoustic (PA) sensor over a five day period at Hohenpeißenberg, Germany. As a reference device a calibrated cavity ringdown spectrometer Picarro G2301 from the meteorological observatory was employed. Trace gas measurements with photoacoustic instruments promise to provide low detection limits at comparably low costs. However, PA devices are often susceptible to cross-sensitivities related to environmental influences. The obtained results show that relaxation effects due to fluctuating environmental conditions, e.g. ambient humidity, are a non-negligible factor in PA sensor systems. Applying algorithm compensation techniques, which are capable of calculating the influence of relaxational effects on the photoacoustic signal, increase the accuracy of the photoacoustic sensor significantly. With an average relative deviation of 1.11 % from the G2301, the photoacoustic sensor shows good agreement with the reference instrument.
An Inexpensive Uv-Led Photoacoustic Based Real-Time Sensor-System Detecting Exhaled Trace-Acetone
(2024)
In this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents the systemic concentrations of volatile organic compounds (VOCs) – providing clinically relevant information about the human health. This is achieved via the development of a CO2-triggered breath sampling system, which collected alveolar breath over several minutes in sterile and inert containers. A real-time mass spectrometer is coupled to serve as a reference device for calibration measurements and subsequent breath analysis. The new sensor system provided a 3σ detection limit of 6.4 ppbV and an NNEA of 1.1E-9 Wcm-1Hz-0.5. In terms of the performed breath analysis measurements, 12 out of 13 fell within the error margin of the photoacoustic measurement system, demonstrating the reliability of the measurements in the field.
Abstract Background Most medical students are in contact with the pharmaceutical or medical device industry during their studies. Medical schools play an important role in protecting students from undue commercial influence and educating them about pharmaceutical marketing practices. Such influence has been shown to affect later prescribing behaviour with potential adverse effects for patient care. While in North America, many medical schools formulated and implemented conflicts of interest (COI) policies, only few such institutional policies have been reported in Germany. We aimed to analyze the quantity and quality of policies and curricula on COI at medical schools across Germany. Methods We collected relevant COI policies and teaching activities by conducting a search of the websites of all 38 German medical schools using standardized keywords for COI policies and teaching. Further, we surveyed all medical schools’ dean’s offices and adapted a scoring system for obtained results with 13 categories based on prior similar studies. Results We identified relevant policies for one medical school via the web-search. The response rate of the deans’ survey was 16 of 38 (42.1%). In total, we identified COI-related policies for 2 of 38 (5.3%) German medical schools, yet no policy was sufficient to address all COI-related categories that were assessed in this study. The maximum score achieved was 12 of 26. 36 (94.7%) schools scored 0. No medical school reported curricular teaching on COI. Conclusion Our results indicate a low level of action by medical schools to protect students from undue commercial influence. No participating dean was aware of any curriculum or instruction on COI at their respective school. The German Medical Students Association and international counterparts have called for a stronger focus on COI in the classroom. We conclude that for German medical schools there is still a long way to go.
Inverse problems are inherently ill-posed and therefore require regularization techniques to achieve a stable solution. While traditional variational methods have wellestablished theoretical foundations, recent advances in machine learning based approaches have shown remarkable practical performance. However, the theoretical foundations of learning-based methods in the context of regularization are still underexplored. In this paper, we propose a general framework that addresses the current gap between learning-based methods and regularization strategies. In particular, our approach emphasizes the crucial role of data consistency in the solution of inverse problems and introduces the concept of data-proximal null-space networks as a key component for their solution. We provide a complete convergence analysis by extending the concept of regularizing null-space networks with data proximity in the visual part. We present numerical results for limited-view computed tomography to illustrate the validity of our framework.
Determinants of household electricity consumption measured by smart meters found by the authors in a scoping review were analyzed for the example of Germany utilizing the 2018 Survey of Income and Expenditure. All variables identified in the scoping review were covered in the survey (number and type of appliances, sociodemographic, and dwelling-related aspects). One can therefore use this large representative data set to test these relationships for German households. Expenditure on electricity is considered an indicator of household electricity consumption. The determinants show weak to moderate correlations with energy expenditure in bivariate analyses. The multivariate analysis shows effects of household-specific, dwelling-related, and appliance-specific factors. Models considering only one aspect overestimate this effect. Thus, all three aspects should be considered simultaneously when explaining residential electricity consumption. The largest effects are found for electricity as the main energy source for heating, the number of household members, as well as their presence at home. While household structure plays an important part in explaining residential energy consumption, dwelling and appliance-related aspects influence it as well. The latter aspects may be influenced by appropriate policy measures.