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Real-time adaptive input design for the determination of competitive adsorption isotherms in liquid chromatography

  • The adaptive input design (also called online redesign of experiments) for parameter estimation is very effective for the compensation of uncertainties in nonlinear processes. Moreover, it enables substantial savings in experimental effort and greater reliability in modeling. We present theoretical details and experimental results from the real-time adaptive optimal input design for parameter estimation. The case study considers separation of three benzoate by reverse phase liquid chromatography. Following a receding horizon scheme, adaptive D-optimal input designs are generated for a precise determination of competitive adsorption isotherm parameters. Moreover, numerical techniques for the regularization of arising ill-posed problems, e.g. due to scarce measurements, lack of prior information about parameters, low sensitivities and parameter correlations are discussed. The estimated parameter values are successfully validated by Frontal Analysis and the benefits of optimal input designs are highlighted when compared to various standard/heuristic input designs in terms of parameter accuracy and precision.

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Metadaten
Author:Tilman Barz, Diana C. López C., Stefan KörkelGND, Sebastian F. Walter
DOI:https://doi.org/10.1016/j.compchemeng.2016.07.009
Parent Title (English):Computers and Chemical Engineering
Publisher:Elsevier
Document Type:Article
Language:English
Year of first Publication:2016
Release Date:2022/12/03
Volume:94
First Page:104
Last Page:116
Institutes:Fakultät Informatik und Mathematik
Publication:Externe Publikationen
research focus:Produktion und Systeme
Licence (German):Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG
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