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Risk factors for ulcerative colitis-associated colorectal cancer A retrospective cohort study

  • Inflammatory bowel disease is associated with an increased risk of colorectal cancer. The study aims to identify the risk factors for ulcerative colitis-colorectal cancer and to perform a survival curve analysis of the outcome. This retrospective cohort study included 254 patients from March 2016 to October 2017. Age, age at diagnosis, follow-up time, smoking status, and family history of colorectal cancer were analyzed as risk factors for colorectal cancer. The mean patient age was 46.6 +/- 16.9 years; 5.5% of the patients were smokers and 49.6% had pancolitis. Six patients (2.36%) had colorectal cancer, which was associated with age at diagnosis (odds/hazard ratio 1.059 [95% confidence interval: 1.001-1.121];P = .04), family history of colorectal cancer (12.992 [1.611-104.7];P = .02), and follow-up time (0.665 [0.513-0.864];P = .002). Active smoking was the main identified risk factor, after both logistic (8.477 [1.350-53.232];P = .02) and Cox proportional-hazards (32.484 [2.465-428.1];P = .008) regression analysis. The risk of colorectal cancer was 3.17% at 10 years and 4.26% at 20 years of follow-up. Active smoking and family history were identified as risk factors for colorectal cancer. These findings should aid the early identification of patients who require vigorous surveillance, and prevent exposure to risk factors.

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Metadaten
Author:Elen Farinelli de Campos Silva, Julio Pinheiro Baima, Jaqueline Ribeiro de Barros, Suzana Tanni, Thomas SchreckORCiD, Rogerio Saad-Hossne, Ligia Yukie Sassaki
DOI:https://doi.org/10.1097/MD.0000000000021686
Parent Title (English):Medicine
Subtitle (German):A retrospective cohort study
Publisher:Lippincott
Document Type:Article
Language:English
Year of first Publication:2020
Release Date:2022/01/31
Tag:ALCOHOL; CONSENSUS; INFLAMMATORY-BOWEL-DISEASE; MECHANISMS; METAANALYSIS; NATURAL-HISTORY; PREVALENCE; PROGRESSION; colorectal cancer; risk factors; smoking; ulcerative colitis
Volume:99
Issue:32
Article Number:e21686
First Page:1
Last Page:6
Institutes:Fakultät Betriebswirtschaft
Begutachtungsstatus:peer-reviewed
OpenAccess Publikationsweg:Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium
research focus:Lebenswissenschaften und Ethik
Licence (German):Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International
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