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Cell-Enriched Lipotransfer (CELT) Improves Tissue Regeneration and Rejuvenation without Substantial Manipulation of the Adipose Tissue Graft

  • The good availability and the large content of adult stem cells in adipose tissue has made it one of the most interesting tissues in regenerative medicine. Although lipofilling is one of the most frequent procedures in plastic surgery, the method still struggles with high absorption rates and volume losses of up to 70%. Therefore, many efforts have been made to optimize liposuction and to process the harvested tissue in order to increase fat graft retention. Because of their immunomodulatory properties, their cytokine secretory activity, and their differentiation potential, enrichment with adipose tissue-derived stem cells was identified as a promising tool to promote transplant survival. Here, we review the important parameters for lipofilling optimization. Finally, we present a new method for the enrichment of lipoaspirate with adipose tissue-derived stem cells and discuss the parameters that contribute to fat graft survival.

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Metadaten
Author:Lukas PrantlORCiD, Andreas EigenbergerORCiD, Ruben Reinhard, Andreas Siegmund, Kerstin Heumann, Oliver FelthausORCiD
DOI:https://doi.org/10.3390/cells11193159
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/36231121
Parent Title (English):Cells
Publisher:MDPI
Document Type:Article
Language:English
Year of first Publication:2022
Release Date:2022/10/29
Volume:11
Issue:19
First Page:1
Last Page:11
Institutes:Fakultät Maschinenbau
Regensburg Center of Biomedical Engineering - RCBE
Begutachtungsstatus:peer-reviewed
OpenAccess Publikationsweg:Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium
research focus:Lebenswissenschaften und Ethik
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International