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The impact of anatomical uncertainties on the predictions of a musculoskeletal hand model – a sensitivity study

  • Outputs of musculoskeletal models should be considered probabilistic rather than deterministic as they are affected by inaccuracies and estimations associated with the development of the model. One of these uncertainties being critical for modeling arises from the determination of the muscles' line of action and the physiological cross-sectional area. Therefore, the aim of this study was to evaluate the outcome sensitivity of model predictions from a musculoskeletal hand model in comparison to the uncertainty of these input parameters. For this purpose, the kinematics and muscle activities of different hand movements (abduction of the fingers, abduction of the thumb, and flexion of the thumb) were recorded. One thousand simulations were calculated for each movement using the Latin hypercube sampling method with a corresponding variation of the muscle origin/insertion points and the cross-sectional area. Comparing the standard hand to simulations incorporating uncertainties of input parameters shows no major deviations in on- and off-set time point of muscle activities. About 60% of simulations are located within a ± 30% interval around the standard model concerning joint reaction forces. The comparison with the variation of the input data leads to the conclusion that the standard hand model is able to provide not over-scattered outcomes and, therefore, can be considered relatively stable. These results are of practical importance to the personalization of a musculoskeletal model with subject-specific bone geometries and hence changed muscle line of action.

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Metadaten
Author:Maximilian MelznerORCiD, Franz Suess, Sebastian DendorferORCiD
DOI:https://doi.org/10.1080/10255842.2021.1940974
ISSN:1476-8259
Parent Title (English):Computer Methods in Biomechanics and Biomedical Engineering
Publisher:Taylor & Francis
Document Type:Article
Language:English
Year of first Publication:2021
Release Date:2021/06/29
GND Keyword:Biomechanik; Simulation
Volume:25
Issue:2
First Page:156
Last Page:164
Note:
Corresponding author: Maximilian Melzner
Institutes:Fakultät Maschinenbau
Regensburg Center of Biomedical Engineering - RCBE
Regensburg Center of Health Sciences and Technology - RCHST
Fakultät Maschinenbau / Labor Biomechanik (LBM)
Begutachtungsstatus:peer-reviewed
research focus:Lebenswissenschaften und Ethik
OpenAccess Publikationsweg:Hybrid Open Access - OA-Veröffentlichung in einer Subskriptionszeitschrift/-medium
Corresponding author der OTH Regensburg
Licence (German):Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International