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An Inexpensive Uv-Led Photoacoustic Based Real-Time Sensor-System Detecting Exhaled Trace-Acetone

  • In this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents the systemic concentrations of volatile organic compounds (VOCs) – providing clinically relevant information about the human health. This is achieved via the development of a CO2-triggered breath sampling system, which collected alveolar breath over several minutes in sterile and inert containers. A real-time mass spectrometer is coupled to serve as a reference device for calibration measurements and subsequent breath analysis. The new sensor system provided a 3σ detection limit of 6.4 ppbV and an NNEA of 1.1E-9 Wcm-1Hz-0.5. In terms of the performed breath analysis measurements, 12 out of 13 fell within the error margin of the photoacoustic measurement system, demonstrating the reliability of the measurements in the field.

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Metadaten
Author:Jonas Pangerl, Pritam Sukul, Thomas RückORCiD, Patricia Fuchs, Stefan Weigl, Wolfram Miekisch, Rudolf Bierl, Frank-Michael Matysik
DOI:https://doi.org/10.2139/ssrn.4724198
Publisher:Elsevier
Document Type:Preprint
Language:English
Year of first Publication:2024
Release Date:2024/04/16
Tag:UV-LED; acetone; breath analysis; photoacoustic spectroscopy; real-time mass-spectrometry
Note:
Der Aufsatz wurde peer-reviewed unter folgender DOI veröffentlicht: https://doi.org/10.1016/j.pacs.2024.100604
Institutes:Fakultät Angewandte Natur- und Kulturwissenschaften
Fakultät Angewandte Natur- und Kulturwissenschaften / Sensorik-Applikationszentrum (SappZ)
research focus:Sensorik
Licence (German):Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG