Photoacoustic Trace-Analysis of Breath Isoprene and Acetone Via Interband- and Quantum Cascade Lasers
- This research presents two laser-based photoacoustic approaches for analyzing exhaled breath isoprene and acetone. The integration of a PTR-ToF-MS as a reference device ensured the reliability and accuracy of the PAS systems that is based on an ICL for isoprene and a QCL for acetone detection. The calibration yielded limits of detection of 26.9 ppbV and 1.7 ppbV, respectively, and corresponding normalized noise equivalent absorption coefficients (NNEAs) of 5.0E-9 Wcm-1Hz-0.5 and 4.9E-9 Wcm-1Hz-0.5. Laboratory as well as real breath sample measurements from alveolar breath revealed a robust system performance, with only one outlier within the static isoprene measurements. However, discrepancies emerged under dynamic breath sampling conditions, emphasizing the need for further optimization. Especially by knowing the dynamic nature and endogenous origin of exhaled isoprene our findings highlight the potential of breath analysis for non-invasive physio-metabolic and pathophysiological monitoring towards point-of-care devices.
Author: | Jonas Pangerl, Pritam Sukul, Thomas RückORCiD, Lukas Escher, Wolfram Miekisch, Rudolf Bierl, Frank-Michael Matysik |
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DOI: | https://doi.org/10.2139/ssrn.4834735 |
Publisher: | Elsevier / SSRN |
Document Type: | Preprint |
Language: | English |
Year of first Publication: | 2024 |
Release Date: | 2024/07/03 |
Tag: | acetone breath analysis/profiling; isoprene; photoacoustic spectroscopy; real-time mass spectroscopy |
Institutes: | Fakultät Angewandte Natur- und Kulturwissenschaften |
Fakultät Angewandte Natur- und Kulturwissenschaften / Sensorik-Applikationszentrum (SappZ) | |
research focus: | Sensorik |
Licence (German): |