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The effect of radiotherapy on fat engraftment for complete breast reconstruction using lipofilling only

  • Purpose Lipofilling has been established as a standard technique for contour enhancement following breast reconstruction. However, there is a paucity in current literature regarding the use of this technique for complete reconstruction of the female breast as an alternative to conventional techniques, such as expander or flap-based procedures. In particular, the influence of pre-operative irradiation for successful reconstruction has rarely been examined in published studies. Here, the authors describe their experience with successful fat injection in pre-radiated breasts in comparison with non-pre-radiated patients. Methods In this retrospective study, we examined a total of 95 lipofilling treatments on 26 patients (28 breasts). All of them experienced mastectomy following breast cancer; local breast defects after partial resection of the gland were not included in this study. In total, 47 lipofilling procedures in 12 non-irradiated patients (14 breasts) and 48 procedures in 14 irradiated women (also 14 breasts) were performed. Per session, approximately 297 +/- 112 cc of adipose tissue was grafted in group A (no radiotherapy) and approximately 259 +/- 93 cc was grafted in group B (radiotherapy). Results Among the group of women without pre-operative radiation, 71% of breast reconstructions limited to lipofilling only showed constant engraftment of fat tissue with a successful reconstructive result, whereas only 21% of the patients with pre-radiated breasts showed complete reconstruction of the breast with a permanent fat in-growth. Conclusion Preoperative radiotherapy significantly impedes successful completion of breast reconstructions planned only by autologous fat transfer. Patients should be selected individually and carefully for complete breast reconstruction using lipofilling only.

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Metadaten
Author:Norbert Heine, Andreas EigenbergerORCiD, Vanessa BrebantORCiD, Sally Kempa, Stephan Seitz, Lukas PrantlORCiD, Britta Kuehlmann
DOI:https://doi.org/10.1007/s00404-022-06610-4
Parent Title (English):Archives of Gynecology and Obstetrics
Publisher:Springer
Document Type:Article
Language:English
Year of first Publication:2022
Release Date:2022/09/16
Tag:Breast augmentation; Breast cancer; CANCER; Fat graft; Lipofilling; OUTCOMES; PLATELET-RICH PLASMA; RADIATION-THERAPY; RECIPIENT-SITE; Radiotherapy; Reconstruction
Pagenumber:7
Institutes:Fakultät Maschinenbau
Begutachtungsstatus:peer-reviewed
research focus:Lebenswissenschaften und Ethik
OpenAccess Publikationsweg:Hybrid Open Access - OA-Veröffentlichung in einer Subskriptionszeitschrift/-medium
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International