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CD44-v6 concentrations in carcinoma of the uterine cervix: lack of prognostic significance

  • Several kinds of cellular adhesion molecules, like different splicing variants of CD 44, have gained important as prognostic or markers for metastatic disease. Fresh frozen samples from 64 cervical carcinoma (CX) were stored in liquid nitrogen and examined using ELISA-technique, testing the prognostic impact. Normal cervical tissue served as control. CD 44-v6 concentration, was significant elevated in tumor tissue, when compared to the controls (P=0.04). There was no correlation to tumor stage (P=0.61), lymphovascular space involvement (P=0.075) or pelvic lymph node involvement (P=0.81). The CD 44-v6 concentration was not informative regarding recurrence-free and overall survival. Contrary to immunohistochemistry, the quantification of CD 44-v6 using ELISA-technique does not provide any further information.

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Metadaten
Author:Lars-Christian Horn, Georgios RaptisORCiDGND, Uta Fischer, Bettina Hentschel, U. Köhler, Christine E. Richter, Rosemarie Martin
DOI:https://doi.org/10.1007/s00404-005-0039-5
Parent Title (English):Archives of Gynecology and Obstetrics
Document Type:Article
Language:English
Year of first Publication:2005
Release Date:2020/06/05
GND Keyword:Gebärmutterhalskrebs; Antigen CD44
Volume:273
Issue:2
First Page:104
Last Page:106
Institutes:Fakultät Informatik und Mathematik
Fakultät Informatik und Mathematik / Labor eHealth (eH)
Begutachtungsstatus:peer-reviewed
Publication:Externe Publikationen
research focus:Lebenswissenschaften und Ethik