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Homogeneous Light Source for Surface Plasmon Resonance Imaging

  • We describe how to build a homogeneous light source for Surface Plasmon Resonance Imaging (SPRi) which mainly finds its applications in pharmaceutical screening and biotechnology so far. SPR spectroscopy is a label-free, non-destructive and highly sensitive measurement principle for detecting changes in the refractive index in close vicinity of a gold surface. A transfer of this technology to a miniaturized sensor will broaden the range of possible applications. Commercial SPR assays are mainly working with a small number of sensing spots. In contrast, the SPR imaging system shown here will allow the use of an array of many sensing spots. In combination with chemical receptors designed as an artificial nose or an electronic tongue, the simultaneous detection of many analytes is envisioned. So far, lasers or other inhomogeneous light sources were used to illuminate the sensing surface, which is decreasing the systems sensitivity. We show a compact ( 300mm2) homogeneous top hat profile. The combination of a high bit-resolution camera with our new light source enables a reflectivity based surface plasmon resonance imaging system with a high refractive index unit (RIU) resolution.

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Metadaten
Author:Peter Hausler, Simon JobstORCiD, Johannes Fischer, Carina Roth, Rudolf Bierl
DOI:https://doi.org/10.5220/0009168701630167
Parent Title (English):PHOTOPTICS 2020: proceedings of the 8th International Conference on Photonics, Optics and Laser Technology, Valletta, Malta, February 27-29, 2020
Publisher:SCITEPRESS - Science and Technology Publications
Document Type:conference proceeding (article)
Language:English
Year of first Publication:2020
Release Date:2021/03/05
Tag:Micro-opto-electro-mechanical Systems; Miniaturization; SPR-imaging; Sensor; Surface Plasmon Resonance Spectroscopy
First Page:163
Last Page:167
Institutes:Fakultät Angewandte Natur- und Kulturwissenschaften
Fakultät Angewandte Natur- und Kulturwissenschaften / Sensorik-Applikationszentrum (SappZ)
research focus:Produktion und Systeme
Licence (German):Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International