An inexpensive UV-LED photoacoustic based real-time sensor-system detecting exhaled trace-acetone
- n this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents the systemic concentrations of volatile organic compounds (VOCs) – providing clinically relevant information about the human health. This is achieved via the development of a CO2-triggered breath sampling system, which collected alveolar breath over several minutes in sterile and inert containers. A real-time mass spectrometer is coupled to serve as a reference device for calibration measurements and subsequent breath analysis. The new sensor system provided a 3σ detection limit of 8.3 ppbV and an NNEA of 1.4E-9 Wcm 1Hz 0.5. In terms of the performed breath analysis measurements, 12 out of 13 fell within the error margin of the photoacoustic measurement system, demonstrating the reliability of the measurements in the field.
Author: | Jonas Pangerl, Pritam Sukul, Thomas RückORCiD, Patricia Fuchs, Stefan Weigl, Wolfram Miekisch, Rudolf Bierl, Frank-Michael Matysik |
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URN: | urn:nbn:de:bvb:898-opus4-71279 |
DOI: | https://doi.org/10.1016/j.pacs.2024.100604 |
ISSN: | 2213-5979 |
Parent Title (English): | Photoacoustics |
Publisher: | Elsevier |
Document Type: | Article |
Language: | English |
Year of first Publication: | 2024 |
Publishing Institution: | Ostbayerische Technische Hochschule Regensburg |
Release Date: | 2024/04/16 |
Tag: | Acetone; Breath analysis; Photoacoustic spectroscopy; Real-time mass-spectrometry; UV-LED |
Volume: | 38 |
Article Number: | 100604 |
Pagenumber: | 12 |
Note: | Corresponding author der OTH Regensburg: Jonas Pangerl |
Institutes: | Fakultät Angewandte Natur- und Kulturwissenschaften |
Fakultät Angewandte Natur- und Kulturwissenschaften / Sensorik-Applikationszentrum (SappZ) | |
Begutachtungsstatus: | peer-reviewed |
OpenAccess Publikationsweg: | Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium |
Corresponding author der OTH Regensburg | |
research focus: | Sensorik |
Funding: | DEAL Elsevier |
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |