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An inexpensive UV-LED photoacoustic based real-time sensor-system detecting exhaled trace-acetone

  • n this research we present a low-cost system for breath acetone analysis based on UV-LED photoacoustic spectroscopy. We considered the end-tidal phase of exhalation, which represents the systemic concentrations of volatile organic compounds (VOCs) – providing clinically relevant information about the human health. This is achieved via the development of a CO2-triggered breath sampling system, which collected alveolar breath over several minutes in sterile and inert containers. A real-time mass spectrometer is coupled to serve as a reference device for calibration measurements and subsequent breath analysis. The new sensor system provided a 3σ detection limit of 8.3 ppbV and an NNEA of 1.4E-9 Wcm 1Hz 0.5. In terms of the performed breath analysis measurements, 12 out of 13 fell within the error margin of the photoacoustic measurement system, demonstrating the reliability of the measurements in the field.

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Metadaten
Author:Jonas Pangerl, Pritam Sukul, Thomas RückORCiD, Patricia Fuchs, Stefan Weigl, Wolfram Miekisch, Rudolf Bierl, Frank-Michael Matysik
URN:urn:nbn:de:bvb:898-opus4-71279
DOI:https://doi.org/10.1016/j.pacs.2024.100604
ISSN:2213-5979
Parent Title (English):Photoacoustics
Publisher:Elsevier
Document Type:Article
Language:English
Year of first Publication:2024
Publishing Institution:Ostbayerische Technische Hochschule Regensburg
Release Date:2024/04/16
Tag:Acetone; Breath analysis; Photoacoustic spectroscopy; Real-time mass-spectrometry; UV-LED
Volume:38
Article Number:100604
Pagenumber:12
Note:
Corresponding author der OTH Regensburg: Jonas Pangerl
Institutes:Fakultät Angewandte Natur- und Kulturwissenschaften
Fakultät Angewandte Natur- und Kulturwissenschaften / Sensorik-Applikationszentrum (SappZ)
Begutachtungsstatus:peer-reviewed
OpenAccess Publikationsweg:Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium
Corresponding author der OTH Regensburg
research focus:Sensorik
Funding:DEAL Elsevier
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International