Assisting Barrett's esophagus identification using endoscopic data augmentation based on Generative Adversarial Networks

  • Barrett's esophagus figured a swift rise in the number of cases in the past years. Although traditional diagnosis methods offered a vital role in early-stage treatment, they are generally time- and resource-consuming. In this context, computer-aided approaches for automatic diagnosis emerged in the literature since early detection is intrinsically related to remission probabilities. However, they still suffer from drawbacks because of the lack of available data for machine learning purposes, thus implying reduced recognition rates. This work introduces Generative Adversarial Networks to generate high-quality endoscopic images, thereby identifying Barrett's esophagus and adenocarcinoma more precisely. Further, Convolution Neural Networks are used for feature extraction and classification purposes. The proposed approach is validated over two datasets of endoscopic images, with the experiments conducted over the full and patch-split images. The application of Deep Convolutional Generative Adversarial Networks for the data augmentation step and LeNet-5 and AlexNet for the classification step allowed us to validate the proposed methodology over an extensive set of datasets (based on original and augmented sets), reaching results of 90% of accuracy for the patch-based approach and 85% for the image-based approach. Both results are based on augmented datasets and are statistically different from the ones obtained in the original datasets of the same kind. Moreover, the impact of data augmentation was evaluated in the context of image description and classification, and the results obtained using synthetic images outperformed the ones over the original datasets, as well as other recent approaches from the literature. Such results suggest promising insights related to the importance of proper data for the accurate classification concerning computer-assisted Barrett's esophagus and adenocarcinoma detection.

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Metadaten
Author:Luis Antonio de SouzaORCiD, Leandro A. Passos, Robert Mendel, Alanna EbigboORCiD, Andreas Probst, Helmut Messmann, Christoph PalmORCiDGND, João Paulo PapaORCiD
DOI:https://doi.org/10.1016/j.compbiomed.2020.104029
Parent Title (English):Computers in Biology and Medicine
Publisher:Elsevier
Document Type:Article
Language:English
Year of first Publication:2020
Release Date:2020/10/23
Tag:Adenocarcinoma; Barrett's esophagus; Generative adversarial networks; Machine learning
GND Keyword:Maschinelles Lernen; Neuronales Netz; Adenocarcinom; Speiseröhrenkrebs; Diagnose
Volume:126
Pagenumber:12 Seiten
Institutes:Fakultät Informatik und Mathematik
Regensburg Center of Health Sciences and Technology - RCHST
Regensburg Medical Image Computing - ReMIC
Dewey Decimal Classification:0 Informatik, Informationswissenschaft, allgemeine Werke
6 Technik, Medizin, angewandte Wissenschaften