Magnetic Resonance Imaging and Computational Fluid Dynamics of High Frequency Oscillatory Ventilation (HFOV)

  • In order to better understand the mechanisms of gas transport during High Frequency Oscillatory Ventilation (HFOV) Magnetic Resonance Imaging (MRI) with contrast gases and numerical flow simulations based on Computational Fluid Dynamics(CFD) methods are performed. Validation of these new techniques is conducted by comparing the results obtained with simplified models of the trachea and a first lung bifurcation as well as in a cast model of the upper central airways with results achieved from conventional fluid mechanical measurement techniques like e.g. Laser Doppler Anemometry (LDA). Further it is demonstrated that MRI of experimental HFOV is feasible and that Hyperpolarized 3He allows for imaging the gas re-distribution inside the lung. Finally, numerical results of oscillatory flow in a 3rd generation model of the lung as well as the impact of endotracheal tubes on the flow regime development in a trachea model are presented.

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Author:Alexander-Wigbert K. Scholz, Lars KrenkelORCiDGND, Maxim Terekhov, Janet Friedrich, Julien Rivoire, Rainer Köbrich, Ursula Wolf, Daniel Kalthoff, Matthias David, Claus Wagner, Laura Maria Schreiber
Parent Title (English):Fundamental Medical and Engineering Investigations on Protective Artificial Respiration
Place of publication:Berlin, Heidelberg
Editor:Ernst Heinrich Hirschel, Wolfgang Schröder, Kozo Fujii, Werner Haase, Bram Leer, Michael A. Leschziner, Maurizio Pandolfi, Jacques Periaux, Arthur Rizzi, Bernard Roux, Yurii I. Shokin, Michael Klaas, Edmund Koch, Wolfgang Schröder
Document Type:Part of a Book
Year of first Publication:2011
Release Date:2022/12/10
Tag:Central Airway; Computational Fluid Dynamics Simulation; Laser Doppler Anemometry; Magnetic Resonance Imaging Measurement; computational fluid dynamics
First Page:107
Last Page:128
Andere Schriftenreihe:Notes on Numerical Fluid Mechanics and Multidisciplinary Design ; 116
Institutes:Fakultät Maschinenbau
Fakultät Maschinenbau / Labor Biofluidmechanik
Publication:Externe Publikationen
research focus:Digitalisierung
Licence (German):Keine Lizenz - Es gilt das deutsche Urheberrecht: § 53 UrhG