Experimentally validated simulation of coronary stents considering different dogboning ratios and asymmetric stent positioning

  • In-stent restenosis remains a major problem of arteriosclerosis treatment by stenting. Expansion-optimized stents could reduce this problem. With numerical simulations, stent designs/ expansion behaviours can be effectively analyzed. For reasons of efficiency, simplified models of balloon-expandable stents are often used, but their accuracy must be challenged due to insufficient experimental validation. In this work, a realistic stent life-cycle simulation has been performed including balloon folding, stent crimping and free expansion of the balloon-stent-system. The successful simulation and validation of two stent designs with homogenous and heterogeneous stent stiffness and an asymmetrically positioned stent on the balloon catheter confirm the universal applicability of the simulation approach. Dogboning ratio, as well as the final dimensions of the folded balloon, the crimped and expanded stent, correspond well to the experimental dimensions with only slight deviations. In contrast to the detailed stent life-cycle simulation, a displacement-controlled simulation can not predict the transient stent expansion, but is suitable to reproduce the final expanded stent shape and the associated stress states. The detailed stent life-cycle simulation is thus essential for stent expansion analysis/optimization, whereas for reasons of computational efficiency, the displacement-controlled approach can be considered in the context of pure stress analysis.

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Author:Lisa WiesentORCiD, Ulrich Schultheiss, Christof Schmid, Thomas SchratzenstallerORCiD, Aida NonnORCiDGND
Parent Title (English):PlOS One
Document Type:Article
Year of first Publication:2019
Release Date:2020/05/12
Tag:Catheters; Coronary stenting; Deformation; Stent implantation; Stiffness
GND Keyword:Stent; Ballondilatation; Numerische Strömungssimulation
Article Number:e0224026
First Page:1
Last Page:25
Institutes:Fakultät Maschinenbau
Regensburg Center of Biomedical Engineering - RCBE
Fakultät Maschinenbau / Labor Medizinprodukte
Fakultät Maschinenbau / Computational Mechanics and Materials Lab (CMM)
OpenAccess Publikationsweg:Gold Open Access- Erstveröffentlichung in einem/als Open-Access-Medium
research focus:Lebenswissenschaften und Ethik
Licence (German):Creative Commons - CC BY - Namensnennung 4.0 International