Preferred stereoselective brain uptake of D-serine
- Although it has long been presumed that d-amino acids are uncommon in mammalians, substantial amounts of free d-serine have been detected in the mammalian brain. d-Serine has been demonstrated to be an important modulator of glutamatergic neurotransmission and acts as an agonist at the strychnine-insensitive glycine site of N-methyl-d-aspartate receptors. The blood-to-brain transfer of d-serine is thought to be extremely low, and it is assumed that d-serine is generated by isomerization of l-serine in the brain. Stimulated by the observation of a preferred transport of the d-isomer of proline at the blood–brain barrier, we investigated the differential uptake of [3H]-d-serine and [3H]-l-serine in the rat brain 1 h after intravenous injection using quantitative autoradiography. Surprisingly, brain uptake of [3H]-d-serine was significantly higher than that of [3H]-l-serine, indicating a preferred transport of the d-enantiomer of serine at the blood–brain barrier. This finding indicates that exogenous d-serine may have a direct influence on glutamatergic neurotransmission and associated diseases.
Author: | Dagmar Bauer, Kurt Hamacher, Stefan Bröer, Dirk Pauleit, Christoph PalmORCiDGND, Karl Zilles, Heinz H. Coenen, Karl-Josef Langen |
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DOI: | https://doi.org/10.1016/j.nucmedbio.2005.07.004 |
Parent Title (English): | Nuclear Medicine and Biology |
Subtitle (English): | a modulator of glutamatergic neurotransmission |
Document Type: | Article |
Language: | English |
Year of first Publication: | 2005 |
Release Date: | 2020/03/18 |
Tag: | Amino acid transport; Blood–brain barrier; NMDA receptors; d/l-serine |
GND Keyword: | Aminosäuren; Gehirn; Blut-Hirn-Schranke; Aufnahme |
Volume: | 32 |
Issue: | 8 |
First Page: | 793 |
Last Page: | 797 |
Institutes: | Fakultät Informatik und Mathematik |
Fakultät Informatik und Mathematik / Regensburg Medical Image Computing (ReMIC) | |
Dewey Decimal Classification: | 0 Informatik, Informationswissenschaft, allgemeine Werke |
Publication: | Externe Publikationen |
research focus: | Lebenswissenschaften und Ethik |